| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Postal, Simone Appenzelle. The importance of cytokines and autoantibodies in depression. Autoimmunity reviews. vol 14. issue 1. 2015-02-09. PMID:25242344. |
the association between decreased serotonin levels and excessive glutamatergic activity forms the first biochemical basis for cytokine-induced depression. |
2015-02-09 |
2023-08-13 |
Not clear |
| Eunice Y Yuen, Luye Qin, Jing Wei, Wenhua Liu, Aiyi Liu, Zhen Ya. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25056951. |
synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. |
2015-01-28 |
2023-08-13 |
Not clear |
| Eunice Y Yuen, Luye Qin, Jing Wei, Wenhua Liu, Aiyi Liu, Zhen Ya. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25056951. |
these results have revealed a potential mechanism for the synergy between the serotonin and norepinephrine systems in the regulation of glutamatergic transmission in cortical neurons. |
2015-01-28 |
2023-08-13 |
Not clear |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
despite the potential importance of glutamatergic excitatory synapses in depression-like behavior, modulation of these lhb synapses by monoamines such as serotonin (5ht) is not fully understood at the cellular and molecular level. |
2014-12-15 |
2023-08-12 |
rat |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
therefore, we used whole cell voltage-clamp recording to examine the molecular mechanisms by which 5ht modulates glutamatergic transmission in the lhb. |
2014-12-15 |
2023-08-12 |
rat |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
the present study provides the first evidence that glutamatergic transmission of lhb synapses is inhibited by activation of the 5ht(1b) receptor at the pre-synapse in both acute depression (5ht-ad) and long-term depression (5ht-ltd). |
2014-12-15 |
2023-08-12 |
rat |
| Chemutai Sego, Luciano Gonçalves, Leandro Lima, Isadora C Furigo, Jose Donato, Martin Metzge. Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat. The Journal of comparative neurology. vol 522. issue 7. 2014-11-25. PMID:24374795. |
in contrast, rmtg projections to the dr were more robust, emerged from rmtg neurons enriched in gad67 mrna, and were focally directed to a distinctive dr subdivision immunohistochemically characterized as poor in serotonin and enriched in presumptive glutamatergic neurons. |
2014-11-25 |
2023-08-12 |
rat |
| V H Timerbaev, O V Smimova, P G Genov, O N Olejnikova, O Yu Rebrov. [Assessment of pain relief in patients receiving different variants of multimodal analgesia after major gynecological surgery]. Anesteziologiia i reanimatologiia. issue 2. 2014-09-15. PMID:25055490. |
one way to solve the problem is appearing in daily practice nefopam--centrally acting non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine and also mitigates glutamatergic neurotransmission. |
2014-09-15 |
2023-08-13 |
Not clear |
| Patrick S Hosford, Steve W Mifflin, Andrew G Ramag. 5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade. The Journal of pharmacology and experimental therapeutics. vol 349. issue 2. 2014-07-18. PMID:24618127. |
5-ht release was measured indirectly by changes in the frequency and amplitude of glutamatergic miniature excitatory postsynaptic currents (mepscs) [in the presence of tetrodotoxin (ttx)] and evoked epscs. |
2014-07-18 |
2023-08-12 |
rat |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
this calls for "stacked" interventions, with an ssri base, targeting, if necessary, the glutamatergic, serotonergic, noradrenergic, and histaminergic systems, thereby successively eliminating the inhibitory effects each are capable of exerting on serotonin neurons. |
2014-06-24 |
2023-08-13 |
Not clear |
| L Tran, B K Lasher, K A Young, N B Keel. Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle. Translational psychiatry. vol 3. 2014-06-05. PMID:24002084. |
however, the effects of isolated depletion of 5-ht in the la, and the molecular mechanisms underlying enhanced glutamatergic activity are unknown. |
2014-06-05 |
2023-08-12 |
Not clear |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
based on localization and function, 5-ht can modulate glutamate neurotransmission at least through the 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors, which presents a rational pharmacological opportunity for modulating glutamatergic transmission without the direct use of glutamatergic compounds. |
2014-06-03 |
2023-08-12 |
Not clear |
| T M Eriksson, A Alvarsson, T L Stan, X Zhang, K N Hascup, E R Hascup, J Kehr, G A Gerhardt, J Warner-Schmidt, M Arango-Lievano, M G Kaplitt, S O Ogren, P Greengard, P Svenningsso. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Molecular psychiatry. vol 18. issue 10. 2014-05-29. PMID:23032875. |
notably, 5-ht(1b)r stimulation increased glutamatergic neurotransmission in the hippocampus in p11ko mice, but not in wt mice, as measured by both pre- and postsynaptic criteria. |
2014-05-29 |
2023-08-12 |
mouse |
| Edward C Lauterbach, Jeffrey L Cummings, Preetha Sharone Kuppuswam. Toward a more precise, clinically--informed pathophysiology of pathological laughing and crying. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23518269. |
pag activity is regulated by glutamatergic nmda, muscarinic m1-3, gaba-a, dopamine d2, norepinephrine alpha-1,2, serotonin 5ht1a, 5ht1b/d, and sigma-1 receptors, with an acetylcholine/gaba balance mediating volitional inhibition of the pag. |
2014-05-08 |
2023-08-12 |
Not clear |
| Sepideh Seyedali Mortezaei, Morteza Zendehdel, Vahab Babapour, Keyvan Hasan. The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken. Veterinary research communications. vol 37. issue 4. 2014-05-06. PMID:24006087. |
these results suggest that serotonin as a modulator probably interacts with glutamatergic (via nmda and ampa/kainate receptors) and gabaergic (via gabaa receptor) systems on feeding behavior in chicken. |
2014-05-06 |
2023-08-12 |
chicken |
| Stefano Pallanti, Eric Hollande. Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity. CNS spectrums. vol 19. issue 1. 2014-04-18. PMID:24176028. |
in the therapeutic field, monotherapy with cognitive behavioral therapy (cbt) or selective serotonin reuptake inhibitors (ssris) is recommendable, but combination or augmentation with a dopaminergic or glutamatergic agent is often adopted. |
2014-04-18 |
2023-08-12 |
Not clear |
| Heidi M Rivera, Cynthia L Bethe. Ovarian steroids increase PSD-95 expression and dendritic spines in the dorsal raphe of ovariectomized macaques. Synapse (New York, N.Y.). vol 67. issue 12. 2014-03-25. PMID:23959764. |
increased spinogenesis on serotonin dendrites would facilitate excitatory glutamatergic input and, in turn, increase serotonin neurotransmission throughout the brain. |
2014-03-25 |
2023-08-12 |
monkey |
| Collin Challis, Sheryl G Beck, Olivier Berto. Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat. Frontiers in behavioral neuroscience. vol 8. 2014-03-05. PMID:24596546. |
we first used viral tracing and cre-dependent genetic identification of vmpfc glutamatergic synapses in the drn to determine their topographic distribution in relation to 5-ht and gabaergic subregions and found that excitatory vmpfc projections primarily localized to gaba-rich areas of the drn. |
2014-03-05 |
2023-08-12 |
Not clear |
| Alvaro L García-García, Elisabet Venzala, Natalia Elizalde, M J Ramírez, Ahinoa Urbiola, Joaquin Del Rio, Laurence Lanfumey, Rosa M Torder. Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. vol 70. 2013-11-26. PMID:23168115. |
in addition to the inhibitory 5-ht1a autoreceptors, cortico-raphe glutamatergic descending pathways are suggested to modulate 5-ht activity in the drn. |
2013-11-26 |
2023-08-12 |
mouse |
| Takeshi Inou. [Pharmacotherapy of anxiety disorders]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 114. issue 9. 2013-11-18. PMID:23198599. |
results show that ssris inhibit glutamatergic neurons of the amygdala through increased extracellular serotonin levels. |
2013-11-18 |
2023-08-12 |
Not clear |