| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon Beshara, Brett R Beston, Joshua G A Pinto, Kathryn M Murph. Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins in Adult Rat Visual Cortex. eNeuro. vol 2. issue 6. 2016-09-20. PMID:26730408. |
translation of these results from animal models to the clinic, however, has been challenging because of the lack of understanding of how this selective serotonin reuptake inhibitor affects glutamatergic and gabaergic synaptic mechanisms that are essential for experience-dependent plasticity. |
2016-09-20 |
2023-08-13 |
rat |
| Alexander Barre, Coralie Berthoux, Dimitri De Bundel, Emmanuel Valjent, Joël Bockaert, Philippe Marin, Carine Bécame. Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 10. 2016-08-03. PMID:26903620. |
prefrontal serotonin (5-ht)2a receptors play an essential role in cortical network activity, but the mechanism underlying their modulation of glutamatergic transmission and plasticity at thalamocortical synapses remains largely unexplored. |
2016-08-03 |
2023-08-13 |
mouse |
| Mohammadrasoul Khalkhali, Setareh Aram, Homa Zarrabi, Moosa Kafie, Abtin Heidarzade. Lamotrigine Augmentation Versus Placebo in Serotonin Reuptake Inhibitors-Resistant Obsessive-Compulsive Disorder: A Randomized Controlled Trial. Iranian journal of psychiatry. vol 11. issue 2. 2016-07-20. PMID:27437007. |
this study was designed to evaluate the possible efficacy of lamotrigine, a glutamatergic agent in serotonin reuptake inhibitors-resistant patients with obsessive-compulsive disorder. |
2016-07-20 |
2023-08-13 |
Not clear |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
we show that 5-ht reduces excitatory glutamatergic transmission onto o-lm interneurons. |
2016-07-18 |
2023-08-13 |
rat |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
furthermore, we demonstrate that the reduction of glutamatergic transmission by serotonin is likely to be mediated via a decrease of calcium influx into presynaptic terminals of ca1 pyramidal cells. |
2016-07-18 |
2023-08-13 |
rat |
| Steven C Wyler, W Clay Spencer, Noah H Green, Benjamin D Rood, LaTasha Crawford, Caryne Craige, Paul Gresch, Douglas G McMahon, Sheryl G Beck, Evan Deneri. Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 5. 2016-06-22. PMID:26843655. |
we report a profound disruption of postmitotic expression trajectories in pet-1(-/-) neurons, which prevented postnatal maturation of 5-ht neuron passive and active intrinsic membrane properties, g-protein signaling, and synaptic responses to glutamatergic, lysophosphatidic, and adrenergic agonists. |
2016-06-22 |
2023-08-13 |
mouse |
| Sarah J Judge, Claire Y Savy, Matthew Campbell, Rebecca Dodds, Larissa Kruger Gomes, Grace Laws, Anna Watson, Peter G Blain, Christopher M Morris, Sarah E Gartsid. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26721196. |
together these data indicate that 1) acute op exposure inhibits drn cholinesterase, leading to acetylcholine accumulation, 2) the acetylcholine activates nicotinic receptors on 5-ht neurones and also on glutamatergic neurones, thus releasing glutamate and activating 5-ht neuronal ampa/kainate receptors 3) the increase in 5-ht neuronal activity, and resulting 5-ht release, may lead to 5-ht1a autoreceptor down-regulation. |
2016-05-26 |
2023-08-13 |
rat |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
both the glutamatergic and serotonergic (5-ht) systems are implicated in the modulation of mood and anxiety. |
2016-03-29 |
2023-08-13 |
mouse |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
descending cortical glutamatergic neurons regulate 5-ht neuronal activity in the midbrain raphe nuclei through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) and n-methyl-d-aspartate (nmda) receptors. |
2016-03-29 |
2023-08-13 |
mouse |
| Alka Bali, Shalu Sing. Serotonergic 5-HT6 Receptor Antagonists: Heterocyclic Chemistry and Potential Therapeutic Significance. Current topics in medicinal chemistry. vol 15. issue 17. 2016-02-29. PMID:25915615. |
studies show the involvement of multiple neurotransmitter systems in cognitive enhancement by 5-ht(6)r antagonists including cholinergic, glutamatergic, and gabaergic systems. |
2016-02-29 |
2023-08-13 |
Not clear |
| Fatima M Nathan, Satoshi Ogawa, Ishwar S Parha. Neuronal connectivity between habenular glutamate-kisspeptin1 co-expressing neurons and the raphe 5-HT system. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26250886. |
in the mr region, kiss1 fibers were mainly seen in close association with glutamatergic neurons and only scarcely within gabaergic and 5-ht neurons. |
2016-02-16 |
2023-08-13 |
zebrafish |
| Daniela R de Oliveira, Claudia R Zamberlam, Gizelda M Rêgo, Alberto Cavalheiro, Janete M Cerutti, Suzete M Cerutt. Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and Molecular Approaches. Frontiers in behavioral neuroscience. vol 9. 2016-01-18. PMID:26778988. |
the effects of flavonoids have been correlated with their ability to modulate the glutamatergic, serotoninergic, and gabaergic neurotransmission; the major targets of these substances are n-methyl-d-aspartic acid receptor (nmdars), serotonin type1a receptor (5-ht1ars), and the gamma-aminobutyric acid type a receptors (gabaars). |
2016-01-18 |
2023-08-13 |
rat |
| Hiroshi Kawasak. Spatio-temporal regulation of the formation of the somatosensory system. Development, growth & differentiation. vol 57. issue 3. 2016-01-08. PMID:25832476. |
glutamatergic receptors such as the nmda receptor and mglur5, and molecules related to serotonin such as serotonin transporter and monoamine oxidase a are essential for the formation of barrels. |
2016-01-08 |
2023-08-13 |
mouse |
| John Talpos, Mohammed Shoai. Executive function. Handbook of experimental pharmacology. vol 228. 2015-09-28. PMID:25977083. |
modulation of dopamine, serotonin, and glutamatergic receptors can disrupt executive function, a feature commonly exploited to develop concepts underlying psychiatric disorders. |
2015-09-28 |
2023-08-13 |
human |
| Francisco García-Oscos, Oswaldo Torres-Ramírez, Lu Dinh, Luis Galindo-Charles, Elsy Arlene Pérez Padilla, Juan Carlos Pineda, Marco Atzori, Humberto Salgad. Activation of 5-HT receptors inhibits GABAergic transmission by pre-and post-synaptic mechanisms in layer II/III of the juvenile rat auditory cortex. Synapse (New York, N.Y.). vol 69. issue 3. 2015-09-10. PMID:25482075. |
in this work, we used whole-cell recordings from layer ii/iii of pyramidal neurons in rat brain slices to characterize the influence of 5-ht on inhibitory synaptic activity in the auditory cortex after pharmacological blockade of excitatory glutamatergic transmission. |
2015-09-10 |
2023-08-13 |
rat |
| N N Ivanets, Yu G Tikhonova, M A Kinkulkina, T I Avdeev. [Current state and potential of pharmacogenetic studies in the treatment of depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 3. 2015-08-21. PMID:26171487. |
the following sections of the review are devoted to the above issues: adrenoreceptors, serotonin transporter protein, dopamine transporter protein, monoamine oxidase a, catechol-o-methyltransferase, brain-derived neurotrophic factor, the hypothalamic-pituitary-adrenal system, g-proteins, the glutamatergic system. |
2015-08-21 |
2023-08-13 |
Not clear |
| Yoshinori Suzuki, Emi Kiyokage, Jaerin Sohn, Hiroyuki Hioki, Kazunori Toid. Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb. The Journal of comparative neurology. vol 523. issue 2. 2015-08-04. PMID:25234191. |
through immunolabeling, we also identified vesicular glutamate transporter 3 in 5-ht neurons terminals, indicating possible glutamatergic transmission. |
2015-08-04 |
2023-08-13 |
mouse |
| Shengyuan Ding, Fu-Ming Zho. Serotonin regulation of subthalamic neurons. Reviews in the neurosciences. vol 25. issue 4. 2015-05-26. PMID:24717335. |
via activation of 5-ht1b receptors on the afferent terminals, 5-ht inhibits glutamatergic input to the stn, but the inhibitory effect on gabaergic input is smaller. |
2015-05-26 |
2023-08-13 |
Not clear |
| Shengyuan Ding, Fu-Ming Zho. Serotonin regulation of subthalamic neurons. Reviews in the neurosciences. vol 25. issue 4. 2015-05-26. PMID:24717335. |
third, 5-ht may regulate the stn glutamatergic output by activating presynaptic 5-ht1b receptors, thus reducing burst firing in target neurons. |
2015-05-26 |
2023-08-13 |
Not clear |
| b' Krzysztof \\xc5\\x81abuzek, Sonia Beil, Julia Beil-Gawe\\xc5\\x82czyk, Bo\\xc5\\xbcena Gabryel, Grzegorz Franik, Bogus\\xc5\\x82aw Okopie\\xc5\\x8. The latest achievements in the pharmacotherapy of gambling disorder. Pharmacological reports : PR. vol 66. issue 5. 2015-05-13. PMID:25149985.' |
nowadays, this disorder could also respond to many drugs from different classes such as opioid antagonists, serotonin selective reuptake inhibitors, mood stabilizers, atypical antipsychotics or glutamatergic agents. |
2015-05-13 |
2023-08-13 |
Not clear |