| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adam P Mecca, Ming-Kai Chen, Ryan S O'Dell, Mika Naganawa, Takuya Toyonaga, Tyler A Godek, Joanna E Harris, Hugh H Bartlett, Wenzhen Zhao, Emmie R Banks, Gessica S Ni, Kelly Rogers, Jean Dominique Gallezot, Jim Ropchan, Paul R Emery, Nabeel B Nabulsi, Brent C Vander Wyk, Amy F T Arnsten, Yiyun Huang, Richard E Carson, Christopher H van Dyc. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology of aging. vol 111. 2021-12-28. PMID:34963063. |
association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early alzheimer's disease. |
2021-12-28 |
2023-08-13 |
human |
| Kejia Zhang, Zehui Sun, Xinyu Chen, Yifan Zhang, Angyang Guo, Yan Zhan. Intercellular transport of Tau protein and β-amyloid mediated by tunneling nanotubes. American journal of translational research. vol 13. issue 11. 2021-12-27. PMID:34956469. |
moreover, we investigated the transport of the tau protein and β-amyloid (aβ), which are both closely related to alzheimer's disease (ad) pathology, through tnts. |
2021-12-27 |
2023-08-13 |
Not clear |
| Maeva Dhaynaut, Giulia Sprugnoli, Davide Cappon, Joanna Macone, Justin S Sanchez, Marc Normandin, Nicolas Guehl, Giacomo Koch, Rachel Paciorek, Ann Connor, Daniel Press, Keith Johnson, Alvaro Pascual-Leone, Georges El-Fakhri, Emiliano Santarnecch. Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series. Journal of Alzheimer's disease : JAD. 2021-12-27. PMID:34958021. |
impact of 40 hz transcranial alternating current stimulation on cerebral tau burden in patients with alzheimer's disease: a case series. |
2021-12-27 |
2023-08-13 |
mouse |
| Maeva Dhaynaut, Giulia Sprugnoli, Davide Cappon, Joanna Macone, Justin S Sanchez, Marc Normandin, Nicolas Guehl, Giacomo Koch, Rachel Paciorek, Ann Connor, Daniel Press, Keith Johnson, Alvaro Pascual-Leone, Georges El-Fakhri, Emiliano Santarnecch. Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series. Journal of Alzheimer's disease : JAD. 2021-12-27. PMID:34958021. |
alzheimer's disease (ad) is characterized by diffuse amyloid-β (aβ) and phosphorylated tau (p-tau) aggregates as well as neuroinflammation. |
2021-12-27 |
2023-08-13 |
mouse |
| Yan-Yan Xue, Yi-He Chen, Rong-Rong Lin, Hui-Fen Huang, Zhi-Ying Wu, Qing-Qing Ta. Alzheimer's disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment. Neuroscience letters. 2021-12-27. PMID:34958910. |
alzheimer's disease susceptibility locus in cd2ap is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment. |
2021-12-27 |
2023-08-13 |
drosophila_melanogaster |
| CatarinaB Ferreira, Mikael Marttinen, Joana E Coelho, Kaisa M A Paldanius, Mari Takalo, Petra Mäkinen, Luukas Leppänen, Catarina Miranda-Lourenço, João Fonseca-Gomes, Sara R Tanqueiro, Sandra H Vaz, Rita F Belo, Ana Maria Sebastião, Ville Leinonen, Hilkka Soininen, Ian Pike, Annakaisa Haapasalo, Luísa V Lopes, Alexandre de Mendonça, Maria José Diógenes, Mikko Hiltune. S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5. Neurobiology of disease. 2021-12-26. PMID:34954322. |
alzheimer's disease (ad) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2021-12-26 |
2023-08-13 |
mouse |
| Erica Staurenghi, Serena Giannelli, Gabriella Testa, Barbara Sottero, Gabriella Leonarduzzi, Paola Gamb. Cholesterol Dysmetabolism in Alzheimer's Disease: A Starring Role for Astrocytes? Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943002. |
in recent decades, the impairment of cholesterol metabolism in the pathogenesis of alzheimer's disease (ad) has been intensively investigated, and it has been recognized to affect amyloid β (aβ) production and clearance, tau phosphorylation, neuroinflammation and degeneration. |
2021-12-24 |
2023-08-13 |
Not clear |
| Hossam M Abdallah, Nesrine S El Sayed, Alaa Sirwi, Sabrin R M Ibrahim, Gamal A Mohamed, Nora O Abdel Rashee. Mangostanaxanthone IV Ameliorates Streptozotocin-Induced Neuro-Inflammation, Amyloid Deposition, and Tau Hyperphosphorylation via Modulating PI3K/Akt/GSK-3β Pathway. Biology. vol 10. issue 12. 2021-12-24. PMID:34943213. |
alzheimer's disease (ad), a progressive neurodegenerative disorder, is characterized by amyloid deposition and neurofibrillary tangles formation owing to tau protein hyperphosphorylation. |
2021-12-24 |
2023-08-13 |
mouse |
| Soha Alali, Gholamhossein Riazi, Mohammad Reza Ashrafi-Kooshk, Sogol Meknatkhah, Shahin Ahmadian, Mohammad Hooshyari Ardakani, Baharak Hosseinkhan. Cannabidiol Inhibits Tau Aggregation In Vitro. Cells. vol 10. issue 12. 2021-12-24. PMID:34944028. |
a hallmark of alzheimer's disease (ad) is the accumulation of tau protein in the brain. |
2021-12-24 |
2023-08-13 |
Not clear |
| Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Ri. (-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944489. |
alzheimer's disease (ad) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (chns) because of intracellular and extracellular aβ aggregates, and hyperphosphorylation of protein tau (p-tau). |
2021-12-24 |
2023-08-13 |
Not clear |
| Giambattista Marotta, Filippo Basagni, Michela Rosini, Anna Minarin. Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways. Current medicinal chemistry. 2021-12-23. PMID:34939537. |
based on these premises, fyn emerges as an attractive target in cancer and neurodegenerative disease therapy, particularly alzheimer disease (ad), based on its activation by aβ via cellular prion protein and its interaction with tau protein. |
2021-12-23 |
2023-08-13 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati, Sandeep Malampati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Benjamin Chun-Kit Tong, King-Ho Cheung, Jie-Qiong Tan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Ju-Xian Song, Min L. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 96. 2021-12-22. PMID:34936968. |
protopine promotes the proteasomal degradation of pathological tau in alzheimer's disease models via hdac6 inhibition. |
2021-12-22 |
2023-08-13 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati, Sandeep Malampati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Benjamin Chun-Kit Tong, King-Ho Cheung, Jie-Qiong Tan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Ju-Xian Song, Min L. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 96. 2021-12-22. PMID:34936968. |
collective evidences have indicated that intracellular accumulation of hyperphosphorylated tau forms neurofibrillary tangles in the brain, which impairs memory, cognition and affects social activities in alzheimer's disease (ad). |
2021-12-22 |
2023-08-13 |
Not clear |
| Daniela Ushizima, Yuheng Chen, Maryana Alegro, Dulce Ovando, Rana Eser, WingHung Lee, Kinson Poon, Anubhav Shankar, Namrata Kantamneni, Shruti Satrawada, Edson Amaro Junior, Helmut Heinsen, Duygu Tosun, Lea T Grinber. Deep Learning for Alzheimer's Disease: Mapping Large-scale Histological Tau Protein for Neuroimaging Biomarker Validation. NeuroImage. 2021-12-21. PMID:34933123. |
deep learning for alzheimer's disease: mapping large-scale histological tau protein for neuroimaging biomarker validation. |
2021-12-21 |
2023-08-13 |
human |
| Daniela Ushizima, Yuheng Chen, Maryana Alegro, Dulce Ovando, Rana Eser, WingHung Lee, Kinson Poon, Anubhav Shankar, Namrata Kantamneni, Shruti Satrawada, Edson Amaro Junior, Helmut Heinsen, Duygu Tosun, Lea T Grinber. Deep Learning for Alzheimer's Disease: Mapping Large-scale Histological Tau Protein for Neuroimaging Biomarker Validation. NeuroImage. 2021-12-21. PMID:34933123. |
abnormal tau inclusions are hallmarks of alzheimer's disease and predictors of clinical decline. |
2021-12-21 |
2023-08-13 |
human |
| Hao-Lun Sun, Fa-Ying Zhou, Dong-Wan Chen, Cheng-Rong Tan, Gui-Hua Zeng, Yu-Hui Liu, Jun Wang, Xian-Le Bu, Yan-Jiang Wang, Hui-Yun Li, Wang-Sheng Ji. The Correlation of Tau Levels with Blood Monocyte Count in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924377. |
the correlation of tau levels with blood monocyte count in patients with alzheimer's disease. |
2021-12-20 |
2023-08-13 |
Not clear |
| Hao-Lun Sun, Fa-Ying Zhou, Dong-Wan Chen, Cheng-Rong Tan, Gui-Hua Zeng, Yu-Hui Liu, Jun Wang, Xian-Le Bu, Yan-Jiang Wang, Hui-Yun Li, Wang-Sheng Ji. The Correlation of Tau Levels with Blood Monocyte Count in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924377. |
recent studies have shown that monocytes can phagocytize the tau protein, which may ameliorate tau-type pathology in alzheimer's disease (ad). |
2021-12-20 |
2023-08-13 |
Not clear |
| Andrew L Zhou, Nidhi Sharda, Vidur V Sarma, Kristen M Ahlschwede, Geoffry L Curran, Xiaojia Tang, Joseph F Poduslo, Krishna R Kalari, Val J Lowe, Karunya K Kandimall. Age-Dependent Changes in the Plasma and Brain Pharmacokinetics of Amyloid-β Peptides and Insulin. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924382. |
age is the most common risk factor for alzheimer's disease (ad), a neurodegenerative disorder characterized by the hallmarks of toxic amyloid-β (aβ) plaques and hyperphosphorylated tau tangles. |
2021-12-20 |
2023-08-13 |
Not clear |
| Stefan J Teipel, Martin Dyrba, Tommaso Ballarini, Frederic Brosseron, Davide Bruno, Katharina Buerger, Nicoleta-Carmen Cosma, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, John D Haynes, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D Metzger, Matthias H Munk, Oliver Peters, Nunzio Pomara, Lukas Preis, Josef Priller, Alfredo Ramírez, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H Schott, Annika Spottke, Eike J Spruth, Michael Wagner, Jens Wiltfang, Frank Jessen, Michael T Henek. Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924387. |
inflammation has been described as a key pathogenic event in alzheimer's disease (ad), downstream of amyloid and tau pathology. |
2021-12-20 |
2023-08-13 |
Not clear |
| Sze Chung Yuen, Simon Ming-Yuen Lee, Siu-Wai Leun. Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer's Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924393. |
neuronal cell cycle re-entry (ccr) is a mechanism, along with amyloid-β (aβ) oligomers and hyperphosphorylated tau proteins, contributing to toxicity in alzheimer's disease (ad). |
2021-12-20 |
2023-08-13 |
Not clear |