| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingha. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology. Nature communications. vol 13. issue 1. 2022-01-11. PMID:35013236. |
alzheimer's disease (ad) alters astrocytes, but the effect of aß and tau pathology is poorly understood. |
2022-01-11 |
2023-08-13 |
Not clear |
| Tao Zhang, Yongfang Xia, Li Hu, Dongmei Chen, Chen-Ling Gan, Long Wang, Yingxue Mei, Guihua Lan, Xindong Shui, Yuan Tian, Ruomeng Li, Mi Zhang, Tae Ho Le. Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease. International journal of biological sciences. vol 18. issue 2. 2022-01-10. PMID:35002518. |
death-associated protein kinase 1 mediates aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in alzheimer's disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Ellen Grober, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio, Aaron Schultz, Richard B Lipton, Ali Ezzat. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005192. |
to assess the relationship between memory performance defined by the stages of objective memory impairment (somi) system and the alzheimer's disease (ad) atn (amyloid beta [a], pathologic tau [t], and neurodegeneration [n]) biomarker system. |
2022-01-10 |
2023-08-13 |
Not clear |
| Leonardo A Rivera-Rivera, Laura Eisenmenger, Karly A Cody, Thomas Reher, Tobey Betthauser, Robert V Cadman, Howard A Rowley, Cynthia M Carlsson, Nathaniel A Chin, Sterling C Johnson, Kevin M Johnso. Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005194. |
this work investigated the relationship between cerebrovascular disease (cvd) markers and alzheimer's disease (ad) biomarkers of amyloid beta deposition, and neurofibrillary tau tangles in subjects spanning the ad clinical spectrum. |
2022-01-10 |
2023-08-13 |
human |
| James Zou, David Park, Aubrey Johnson, Xinyang Feng, Michelle Pardo, Jeanelle France, Zeljko Tomljanovic, Adam M Brickman, Devangere P Devanand, José A Luchsinger, William C Kreisl, Frank A Provenzan. Deep learning improves utility of tau PET in the study of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005197. |
deep learning improves utility of tau pet in the study of alzheimer's disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| James Zou, David Park, Aubrey Johnson, Xinyang Feng, Michelle Pardo, Jeanelle France, Zeljko Tomljanovic, Adam M Brickman, Devangere P Devanand, José A Luchsinger, William C Kreisl, Frank A Provenzan. Deep learning improves utility of tau PET in the study of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005197. |
positron emission tomography (pet) imaging targeting neurofibrillary tau tangles is increasingly used in the study of alzheimer's disease (ad), but its utility may be limited by conventional quantitative or qualitative evaluation techniques in earlier disease states. |
2022-01-10 |
2023-08-13 |
Not clear |
| Tamunotonye Omoluabi, Sarah E Torraville, Aida Maziar, Abhinaba Ghosh, Kyron D Power, Camila Reinhardt, Carolyn W Harley, Qi Yua. Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2022-01-10. PMID:35005208. |
the earliest abnormality associated with alzheimer's disease (ad) is the presence of persistently phosphorylated pretangle tau in locus coeruleus (lc) neurons. |
2022-01-10 |
2023-08-13 |
human |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006402. |
alzheimer's disease (ad) is known by characteristic features, extracellular burden of amyloid-β and intracellular neuronal tau. |
2022-01-10 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006431. |
g-protein coupled receptor, pi3k and rho signaling pathways regulate the cascades of tau and amyloid-β in alzheimer's disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006431. |
alzheimer's disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of tau protein that forms neurofibrillary tangles (nfts) in neuronal cells. |
2022-01-10 |
2023-08-13 |
Not clear |
| Jacopo Meldoles. Extracellular vesicles (exosomes and ectosomes) play key roles in the pathology of brain diseases. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006460. |
in alzheimer's disease the vesicles can affect the brain by changing their generation and inducing co-release of effective proteins, such aβ and tau, from neurons and astrocytes. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
alzheimer's disease (ad) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Perla H Horta-López, Graciela Mendoza-Franco, Fanny Rodríguez-Cruz, Francisco M Torres-Cruz, Elizabeth Hernández-Echeagaray, Jose J Jarero-Basulto, Jan Rícny, Benjamín Florán Garduño, Francisco Garcia-Sierr. Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer's disease brain. Neuroscience. 2022-01-10. PMID:35007692. |
association of α-1-antichymotrypsin expression with the development of conformational changes of tau protein in alzheimer's disease brain. |
2022-01-10 |
2023-08-13 |
Not clear |
| Perla H Horta-López, Graciela Mendoza-Franco, Fanny Rodríguez-Cruz, Francisco M Torres-Cruz, Elizabeth Hernández-Echeagaray, Jose J Jarero-Basulto, Jan Rícny, Benjamín Florán Garduño, Francisco Garcia-Sierr. Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer's disease brain. Neuroscience. 2022-01-10. PMID:35007692. |
in alzheimer's disease (ad), two mutually exclusive amino-terminal-dependent conformations have been reported to occur during the aggregation of tau protein into neurofibrillary tangles (nfts). |
2022-01-10 |
2023-08-13 |
Not clear |
| Clément Danis, Elian Dupré, Orgeta Zejneli, Raphaëlle Caillierez, Alexis Arrial, Séverine Bégard, Justine Mortelecque, Sabiha Eddarkaoui, Anne Loyens, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Luc Buée, Isabelle Landrie. Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-10. PMID:35007758. |
tau proteins aggregate into filaments in brain cells in alzheimer's disease and related disorders referred to as tauopathies. |
2022-01-10 |
2023-08-13 |
mouse |
| Denise Visser, Sander C J Verfaillie, Emma E Wolters, Emma M Coomans, Tessa Timmers, Hayel Tuncel, Ronald Boellaard, Sandeep S V Golla, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Bart N M van Berckel, Rik Ossenkoppel. Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2022-01-08. PMID:34997294. |
differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset alzheimer's disease. |
2022-01-08 |
2023-08-13 |
Not clear |
| Yi Chen, Joseph Therriault, Jing Luo, Maowen Ba, Hua Zhang, Alzheimer's Disease Neuroimaging Initiativ. Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer's disease. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997710. |
in addition, the diagnostic accuracy of cerebrospinal fluid and plasma neurofilament light for progressive mild cognitive impairment and alzheimer's disease was almost the same as that of cerebrospinal fluid total tau (t-tau). |
2022-01-08 |
2023-08-13 |
human |
| Malin Wennström, Shorena Janelidze, K Peter R Nilsson, Geidy E Serrano, Thomas G Beach, Jeffrey L Dage, Oskar Hansso. Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels. Acta neuropathologica communications. vol 10. issue 1. 2022-01-07. PMID:34991721. |
recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in alzheimer's disease (ad), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. |
2022-01-07 |
2023-08-13 |
Not clear |
| Likui Lu, Xi Yu, Yongle Cai, Miao Sun, Hao Yan. Application of CRISPR/Cas9 in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2022-01-07. PMID:34992519. |
alzheimer's disease (ad) is a progressive and irreversible neurodegenerative disorder clinically characterized by cognitive impairment, abnormal behavior, and social deficits, which is intimately linked with excessive β-amyloid (aβ) protein deposition along with many other misfolded proteins, neurofibrillary tangles formed by hyperphosphorylated tau protein aggregates, and mitochondrial damage in neurons, leading to neuron loss. |
2022-01-07 |
2023-08-13 |
Not clear |
| Qi Wang, Kewei Chen, Yi Su, Eric M Reiman, Joel T Dudley, Benjamin Readhea. Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease. Brain communications. vol 4. issue 1. 2022-01-07. PMID:34993477. |
here, we use a deep learning method to analyse rna-seq data from 1114 brain donors from the accelerating medicines project for alzheimer's disease consortium to characterize post-mortem brain transcriptome signatures associated with amyloid-β plaque, tau neurofibrillary tangles and clinical severity in multiple alzheimer's disease dementia populations. |
2022-01-07 |
2023-08-13 |
Not clear |