| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paolo d'Errico, Melanie Meyer-Luehman. Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-22. PMID:33061903. |
mechanisms of pathogenic tau and aβ protein spreading in alzheimer's disease. |
2020-10-22 |
2023-08-13 |
Not clear |
| Paolo d'Errico, Melanie Meyer-Luehman. Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-22. PMID:33061903. |
alzheimer's disease (ad) is pathologically defined by extracellular accumulation of amyloid-β (aβ) peptides generated by the cleavage of amyloid precursor protein (app), strings of hyperphosphorylated tau proteins accumulating inside neurons known as neurofibrillary tangles (nfts) and neuronal loss. |
2020-10-22 |
2023-08-13 |
Not clear |
| Sujin Kim, Yunkwon Nam, Soo Jung Shin, Yong Ho Park, Seong Gak Jeon, Jin-Il Kim, Min-Jeong Kim, Minho Moo. The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-10-22. PMID:33071750. |
although the major causative factors of alzheimer's disease (ad) are the accumulation of amyloid β and hyperphosphorylated tau, ad can also be caused by metabolic dysfunction. |
2020-10-22 |
2023-08-13 |
Not clear |
| Klara Zubčić, Patrick R Hof, Goran Šimić, Maja Jazvinšćak Jembre. The Role of Copper in Tau-Related Pathology in Alzheimer's Disease. Frontiers in molecular neuroscience. vol 13. 2020-10-22. PMID:33071757. |
all tauopathies, including alzheimer's disease (ad), are characterized by the intracellular accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively affect microtubule stability. |
2020-10-22 |
2023-08-13 |
Not clear |
| Jou-Man Huang, Fang-I Huang, Chia-Ron Yan. Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimer's Disease Models. Journal of natural products. vol 82. issue 7. 2020-10-21. PMID:31291099. |
moscatilin ameliorates tau phosphorylation and cognitive deficits in alzheimer's disease models. |
2020-10-21 |
2023-08-13 |
Not clear |
| Barbara E Stopschinski, Talitha L Thomas, Sourena Nadji, Eric Darvish, Linfeng Fan, Brandon B Holmes, Anuja R Modi, Jordan G Finnell, Omar M Kashmer, Sandi Estill-Terpack, Hilda Mirbaha, Hung S Luu, Marc I Diamon. A synthetic heparinoid blocks Tau aggregate cell uptake and amplification. The Journal of biological chemistry. vol 295. issue 10. 2020-10-20. PMID:31974166. |
tau aggregation underlies neurodegeneration in alzheimer's disease and related tauopathies. |
2020-10-20 |
2023-08-13 |
Not clear |
| Muhammad Ikram, Tae Ju Park, Tahir Ali, Myeong Ok Ki. Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer's and Parkinson's Disease: Insight into the Role of Nrf-2 and A2AR Signaling. Antioxidants (Basel, Switzerland). vol 9. issue 9. 2020-10-20. PMID:32971922. |
according to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine a2a, thereby regulating the accumulation of aβ; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as α-synuclein, in alzheimer's and parkinson's diseases. |
2020-10-20 |
2023-08-13 |
Not clear |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer's disease. Human molecular genetics. vol 29. issue 2. 2020-10-19. PMID:31814000. |
ca2+-permeable trpv1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of alzheimer's disease. |
2020-10-19 |
2023-08-13 |
mouse |
| Denglei Ma, Yi Luo, Rui Huang, Zirun Zhao, Qi Wang, Lin Li, Lan Zhan. Cornel Iridoid Glycoside Suppresses Tau Hyperphosphorylation and Aggregation in a Mouse Model of Tauopathy through Increasing Activity of PP2A. Current Alzheimer research. vol 16. issue 14. 2020-10-19. PMID:31902362. |
rtg4510 mice are transgenic mice expressing p301l mutant tau and have been developed as an animal model of tauopathy including alzheimer's disease (ad). |
2020-10-19 |
2023-08-13 |
mouse |
| Hiroshi Ikenuma, Hiroko Koyama, Naoya Kajino, Yasuyuki Kimura, Aya Ogata, Junichiro Abe, Yasuhiro Kawasumi, Takashi Kato, Akihiko Takashima, Kengo Ito, Masaaki Suzuk. Synthesis of (R,S)-isoproterenol, an inhibitor of tau aggregation, as an Bioorganic & medicinal chemistry letters. vol 29. issue 16. 2020-10-15. PMID:31311732. |
synthesis of (r,s)-isoproterenol, an inhibitor of tau aggregation, as an (r,s)-isoproterenol inhibits the formation of toxic granular tau oligomers associated with neuronal loss and development of cognitive disorders, and is an attractive drug candidate for alzheimer's disease. |
2020-10-15 |
2023-08-13 |
Not clear |
| Hang-Rai Kim, Peter Lee, Sang Won Seo, Jee Hoon Roh, Minyoung Oh, Jungsu S Oh, Seung Jun Oh, Jae Seung Kim, Yong Jeon. Comparison of Amyloid β and Tau Spread Models in Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 10. 2020-10-13. PMID:30566579. |
comparison of amyloid β and tau spread models in alzheimer's disease. |
2020-10-13 |
2023-08-13 |
Not clear |
| Hang-Rai Kim, Peter Lee, Sang Won Seo, Jee Hoon Roh, Minyoung Oh, Jungsu S Oh, Seung Jun Oh, Jae Seung Kim, Yong Jeon. Comparison of Amyloid β and Tau Spread Models in Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 10. 2020-10-13. PMID:30566579. |
tau and amyloid β (aβ), 2 key pathogenic proteins in alzheimer's disease (ad), reportedly spread throughout the brain as the disease progresses. |
2020-10-13 |
2023-08-13 |
Not clear |
| Naoto Takenoshita, Soichiro Shimizu, Hidekazu Kanetaka, Hirofumi Sakurai, Ryo Suzuki, Takashi Miwa, Masato Odawara, Kenji Ishii, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Haruo Hany. Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results. Journal of Alzheimer's disease : JAD. vol 71. issue 1. 2020-10-13. PMID:31356213. |
classification of clinically diagnosed alzheimer's disease associated with diabetes based on amyloid and tau pet results. |
2020-10-13 |
2023-08-13 |
Not clear |
| Naoto Takenoshita, Soichiro Shimizu, Hidekazu Kanetaka, Hirofumi Sakurai, Ryo Suzuki, Takashi Miwa, Masato Odawara, Kenji Ishii, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Haruo Hany. Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results. Journal of Alzheimer's disease : JAD. vol 71. issue 1. 2020-10-13. PMID:31356213. |
in this study, we classified patients with clinically diagnosed alzheimer's disease (ad) associated with dm into subgroups based on their amyloid and tau accumulation patterns on positron emission tomography (pet), and analyzed the differences in clinical features and brain imaging findings between the subgroups. |
2020-10-13 |
2023-08-13 |
Not clear |
| Wenbo Zhu, Xuefei Wei, Yanyang Wang, Jingjing Li, Lu Peng, Kui Zhang, Bing Ba. Effects of U1 Small Nuclear Ribonucleoprotein Inhibition on the Expression of Genes Involved in Alzheimer's Disease. ACS omega. vol 5. issue 39. 2020-10-13. PMID:33043209. |
deposition and dysfunction of u1 small nuclear ribonucleoprotein (snrnp) have been revealed in alzheimer's disease (ad), but whether u1 is involved in the amyloid precursor protein (app) and tau pathways remains unclear. |
2020-10-13 |
2023-08-13 |
Not clear |
| Seokjo Kang, Sung Min Son, Sung Hoon Baik, Jinhee Yang, Inhee Mook-Jun. Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31256134. |
increased levels of total tau (t-tau) and hyperphosphorylated tau (p-tau) proteins in the cerebrospinal fluid of alzheimer's disease (ad) patients are well documented and strongly correlate with ad pathology. |
2020-10-09 |
2023-08-13 |
human |
| Jagan A Pillai, Aaron Bonner-Jackson, Lynn M Bekris, Jiri Safar, Jim Bena, James B Leveren. Highly Elevated Cerebrospinal Fluid Total Tau Level Reflects Higher Likelihood of Non-Amnestic Subtype of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 4. 2020-10-09. PMID:31306137. |
highly elevated cerebrospinal fluid total tau level reflects higher likelihood of non-amnestic subtype of alzheimer's disease. |
2020-10-09 |
2023-08-13 |
Not clear |
| Jagan A Pillai, Aaron Bonner-Jackson, Lynn M Bekris, Jiri Safar, Jim Bena, James B Leveren. Highly Elevated Cerebrospinal Fluid Total Tau Level Reflects Higher Likelihood of Non-Amnestic Subtype of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 4. 2020-10-09. PMID:31306137. |
cerebrospinal fluid (csf) levels of total tau (t-tau) protein are thought to reflect the intensity of the neuronal damage in neurodegeneration, including alzheimer's disease (ad). |
2020-10-09 |
2023-08-13 |
Not clear |
| Xinxin Fu, Tingting Qin, Jiayu Yu, Jie Jiao, Zhanqiang Ma, Qiang Fu, Xueyang Deng, Shiping M. Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice. CNS & neurological disorders drug targets. vol 18. issue 7. 2020-10-09. PMID:31389320. |
the core pathogenesis of alzheimer's disease includes the aggregation of hyperphosphorylated tau and abnormal amyloid-β generation. |
2020-10-09 |
2023-08-13 |
mouse |
| Jihoon Jeong, Hyung Joon Park, Bo-Ram Mun, Ju Kyong Jang, Yong Moon Choi, Won-Seok Cho. JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model. PloS one. vol 15. issue 8. 2020-10-09. PMID:32791516. |
jbpos0101 regulates amyloid beta, tau, and glial cells in an alzheimer's disease model. |
2020-10-09 |
2023-08-13 |
mouse |