| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
alpha1-antichymotrypsin, an inflammatory protein overexpressed in alzheimer's disease brain, induces tau phosphorylation in neurons. |
2006-12-11 |
2023-08-12 |
mouse |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
as was previously found for alzheimer's disease, brains from patients with non-alzheimer's tauopathies exhibited an enhanced expression of act, which correlated with the level of tau hyperphosphorylation. |
2006-12-11 |
2023-08-12 |
mouse |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
this result was further confirmed by the finding that addition of purified act induced the same alzheimer's disease-related tau hyperphosphorylation in cortical neurons cultured in vitro. |
2006-12-11 |
2023-08-12 |
mouse |
| Katharina Buerger, Michael Ewers, Tuula Pirttilä, Raymond Zinkowski, Irina Alafuzoff, Stefan J Teipel, John DeBernardis, Daniel Kerkman, Cheryl McCulloch, Hilkka Soininen, Harald Hampe. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:17012293. |
csf phosphorylated tau protein correlates with neocortical neurofibrillary pathology in alzheimer's disease. |
2006-12-11 |
2023-08-12 |
Not clear |
| Katharina Buerger, Michael Ewers, Tuula Pirttilä, Raymond Zinkowski, Irina Alafuzoff, Stefan J Teipel, John DeBernardis, Daniel Kerkman, Cheryl McCulloch, Hilkka Soininen, Harald Hampe. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:17012293. |
hyperphosphorylated tau protein (p-tau) in csf is a core biomarker candidate of alzheimer's disease. |
2006-12-11 |
2023-08-12 |
Not clear |
| Uta Keil, Susanne Hauptmann, Astrid Bonert, Isabel Scherping, Anne Eckert, Walter E Mülle. Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations. Journal of Alzheimer's disease : JAD. vol 9. issue 2. 2006-12-06. PMID:16873961. |
alzheimer's disease is characterized by two major pathological hallmarks: extracellular plaques consisting of amyloid beta peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2006-12-06 |
2023-08-12 |
mouse |
| Ismael Santa-María, Mar Pérez, Félix Hernández, Jesús Avila, Francisco J Moren. Characteristics of the binding of thioflavin S to tau paired helical filaments. Journal of Alzheimer's disease : JAD. vol 9. issue 3. 2006-12-06. PMID:16914838. |
paired helical filaments (phf) from alzheimer's disease (ad) patients, (whose main component is the microtubule associated protein, tau) bind to thioflavins. |
2006-12-06 |
2023-08-12 |
Not clear |
| D Allan Butterfield, Marzia Perluigi, Rukhsana Sultan. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. European journal of pharmacology. vol 545. issue 1. 2006-12-01. PMID:16860790. |
neuropathologically, alzheimer's disease is defined by the accumulation of extracellular amyloid protein deposited senile plaques and intracellular neurofibrillary tangles made of abnormal and hyperphosphorylated tau protein, regionalized neuronal death, and loss of synaptic connections within selective brain regions. |
2006-12-01 |
2023-08-12 |
Not clear |
| Olivier Blard, Thierry Frébourg, Dominique Campion, Magalie Lecourtoi. Inhibition of proteasome and Shaggy/Glycogen synthase kinase-3beta kinase prevents clearance of phosphorylated tau in Drosophila. Journal of neuroscience research. vol 84. issue 5. 2006-11-28. PMID:16878320. |
tauopathies, including alzheimer's disease (ad), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. |
2006-11-28 |
2023-08-12 |
drosophila_melanogaster |
| Peleg M Horowitz, Nichole LaPointe, Angela L Guillozet-Bongaarts, Robert W Berry, Lester I Binde. N-terminal fragments of tau inhibit full-length tau polymerization in vitro. Biochemistry. vol 45. issue 42. 2006-11-28. PMID:17042504. |
the polymerization of the microtubule-associated protein, tau, into insoluble filaments is a common thread in alzheimer's disease and in a variety of frontotemporal dementias. |
2006-11-28 |
2023-08-12 |
Not clear |
| Jin-Hu Guo, Hai-Peng Cheng, Long Yu, Shouyuan Zha. Natural antisense transcripts of Alzheimer's disease associated genes. DNA sequence : the journal of DNA sequencing and mapping. vol 17. issue 2. 2006-11-28. PMID:17076261. |
present work investigated the presence of nats of alzheimer's disease associated genes including presenilin1, presenilin2, bace1, bace2, app, apoe, tau (mapt), prion, alpha-synuclein (snca), nicastrin, pen2, aph1a, aph1b as well as cd147 (basigin), and the results revealed that app, bace2, aph1a, tau, cd147 and alpha-synuclein contain natural antisense transcripts. |
2006-11-28 |
2023-08-12 |
Not clear |
| A Z Herskovits, P Davie. The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16766195. |
the regulation of tau phosphorylation by pctaire 3: implications for the pathogenesis of alzheimer's disease. |
2006-11-27 |
2023-08-12 |
Not clear |
| A Z Herskovits, P Davie. The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16766195. |
in the course of alzheimer's disease, phosphorylated tau aggregates to form paired helical filaments, highly ordered filamentous structures that accumulate within neurons and contribute to the formation of neurofibrillary tangles. |
2006-11-27 |
2023-08-12 |
Not clear |
| A Z Herskovits, P Davie. The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16766195. |
the resurgence of cell cycle proteins is an important mechanism in alzheimer's disease (ad), and we propose that pctaire 3 is a phf-associated kinase that modulates tau phosphorylation. |
2006-11-27 |
2023-08-12 |
Not clear |
| F Liu, Z Liang, C X Gon. Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease. Panminerva medica. vol 48. issue 2. 2006-11-27. PMID:16953147. |
hyperphosphorylation of tau and protein phosphatases in alzheimer disease. |
2006-11-27 |
2023-08-12 |
Not clear |
| F Liu, Z Liang, C X Gon. Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease. Panminerva medica. vol 48. issue 2. 2006-11-27. PMID:16953147. |
aggregation of abnormal hyperphosphorylated tau to neurofibrillary tangles in affected neurons is one of the hallmarks for alzheimer disease (ad). |
2006-11-27 |
2023-08-12 |
Not clear |
| Tetyana Duka, Milan Rusnak, Robert E Drolet, Valeriy Duka, Christophe Wersinger, John L Goudreau, Anita Sidh. Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 13. 2006-11-27. PMID:17077307. |
many neurodegenerative diseases associated with functional tau dysregulation, including alzheimer's disease (ad) and other tauopathies, also show alpha-synuclein (alpha-syn) pathology, a protein associated with parkinson's disease (pd) pathology. |
2006-11-27 |
2023-08-12 |
mouse |
| Tetsuro Murakami, Erwan Paitel, Takeshi Kawarabayashi, Masaki Ikeda, M Azhar Chishti, Christopher Janus, Etsuro Matsubara, Atsushi Sasaki, Toshitaka Kawarai, Amie L Phinney, Yasuo Harigaya, Patrick Horne, Nobuaki Egashira, Kenichi Mishima, Amanda Hanna, Jing Yang, Katsunori Iwasaki, Mitsuo Takahashi, Michihiro Fujiwara, Koichi Ishiguro, Catherine Bergeron, George A Carlson, Koji Abe, David Westaway, Peter St George-Hyslop, Mikio Shoj. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. The American journal of pathology. vol 169. issue 4. 2006-11-24. PMID:17003492. |
these transgenic mice may aid therapeutic development for ftdp-17 and other diseases featuring accumulations of four-repeat tau, such as alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy. |
2006-11-24 |
2023-08-12 |
mouse |
| Alan M Pittman, Hon-Chung Fung, Rohan de Silv. Untangling the tau gene association with neurodegenerative disorders. Human molecular genetics. vol 15 Spec No 2. 2006-11-20. PMID:16987883. |
pathological tau protein inclusions have long been recognized to define the diverse range of neurodegenerative disorders called the tauopathies, which include alzheimer's disease (ad), progressive supranuclear palsy (psp) and frontotemporal lobar degeneration. |
2006-11-20 |
2023-08-12 |
Not clear |
| Michel Goedert, Maria Grazia Spillantin. A century of Alzheimer's disease. Science (New York, N.Y.). vol 314. issue 5800. 2006-11-20. PMID:17082447. |
amyloid-beta and tau make up the plaques and tangles of alzheimer's disease, where these normally soluble proteins assemble into amyloid-like filaments. |
2006-11-20 |
2023-08-12 |
Not clear |