| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janine Hochmair, Christian Exner, Christian Betzel, Eckhard Mandelkow, Susanne Wegman. Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310206. |
the positively charged (basic) c-terminal half of tau also mediates the assembly tau into fibrillar aggregates in alzheimer's disease (ad) and tauopathy brains. |
2022-10-31 |
2023-08-14 |
Not clear |
| Solomiia Boyko, Witold K Surewic. Study of Tau Liquid-Liquid Phase Separation In Vitro. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310207. |
aggregation of the microtubule-associated protein tau is one of the major pathogenic events in alzheimer's disease and several other neurodegenerative disorders. |
2022-10-31 |
2023-08-14 |
Not clear |
| Emily Hill, Kevin G Moffat, Mark J Wall, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. A Validated Method to Prepare Stable Tau Oligomers. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310205. |
there is growing evidence that tau oligomers are a major pathological species in a number of tauopathies including alzheimer's disease. |
2022-10-31 |
2023-08-14 |
Not clear |
| Irving E Vega, Andrew Umstea. Liquid-Liquid Phase Separation to Study the Association of Proteins in Solution. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310208. |
recently, we used llps to study the association between two proteins that are co-aggregated in alzheimer's disease brain, tau, and efhd2. |
2022-10-31 |
2023-08-14 |
Not clear |
| Hend M Hassan, Mohamed R Elnagar, Eman Abdelrazik, Mohamed R Mahdi, Eman Hamza, Eman M Elattar, Eman Mohamed ElNashar, Mansour Abdullah Alghamdi, Zainah Al-Qahtani, Khulood Mohammed Al-Khater, Rashid A Aldahhan, Mamdouh ELdesoqu. Neuroprotective effect of naringin against cerebellar changes in Alzheimer's disease through modulation of autophagy, oxidative stress and tau expression: An experimental study. Frontiers in neuroanatomy. vol 16. 2022-10-31. PMID:36312298. |
neuroprotective effect of naringin against cerebellar changes in alzheimer's disease through modulation of autophagy, oxidative stress and tau expression: an experimental study. |
2022-10-31 |
2023-08-14 |
Not clear |
| Julie Pilliod, Maude Gélinas-Faucher, Nicole Lecler. Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage. Frontiers in cell and developmental biology. vol 10. 2022-10-31. PMID:36313558. |
in alzheimer's disease, tau, a microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, and accumulates in the somato-dendritic compartment where it forms insoluble aggregates. |
2022-10-31 |
2023-08-14 |
Not clear |
| Fan Gao, Peng-Fei Zhang, Jing Gao, Jinghui Song, Song Ch. The CCL2 rs4586 SNP Is Associated with Slower Amyloid-β Deposition and Faster Tau Accumulation of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-31. PMID:36314210. |
the ccl2 rs4586 snp is associated with slower amyloid-β deposition and faster tau accumulation of alzheimer's disease. |
2022-10-31 |
2023-08-14 |
Not clear |
| Juan Carlos Polanco, Yevhen Akimov, Avinash Fernandes, Adam Briner, Gabriel Rhys Hand, Marloes van Roijen, Giuseppe Balistreri, Jürgen Göt. CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life science alliance. vol 6. issue 1. 2022-10-31. PMID:36316035. |
the aggregation of the microtubule-associated protein tau is a defining feature of alzheimer's disease and other tauopathies. |
2022-10-31 |
2023-08-14 |
human |
| Juan Carlos Polanco, Yevhen Akimov, Avinash Fernandes, Adam Briner, Gabriel Rhys Hand, Marloes van Roijen, Giuseppe Balistreri, Jürgen Göt. CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life science alliance. vol 6. issue 1. 2022-10-31. PMID:36316035. |
lastly, validation studies with human brain tissue also revealed that several of the identified protein hits are down-regulated in the brains of alzheimer's patients, suggesting that their decreased activity may be required for the emergence or progression of tau pathology in the human brain. |
2022-10-31 |
2023-08-14 |
human |
| Kathryn E Sánchez, Kiran Bhaskar, Gary A Rosenber. Apoptosis-associated speck-like protein containing a CARD-mediated release of matrix metalloproteinase 10 stimulates a change in microglia phenotype. Frontiers in molecular neuroscience. vol 15. 2022-10-28. PMID:36305000. |
inflammation contributes to amyloid-β and tau pathology in alzheimer's disease (ad). |
2022-10-28 |
2023-08-14 |
Not clear |
| Shannon E Hill, Abigail R Esquivel, Santiago Rodriguez Ospina, Lauren M Rahal, Chad A Dickey, Laura J Blai. Chaperoning activity of the cyclophilin family prevents tau aggregation. Protein science : a publication of the Protein Society. vol 31. issue 11. 2022-10-28. PMID:36305768. |
tauopathies, such as alzheimer's disease, are characterized by the misfolding and progressive accumulation of the microtubule associated protein tau. |
2022-10-28 |
2023-08-14 |
Not clear |
| Marina Arcaro, Chiara Fenoglio, Maria Serpente, Andrea Arighi, Giorgio G Fumagalli, Luca Sacchi, Stefano Floro, Marianna D'Anca, Federica Sorrentino, Caterina Visconte, Alberto Perego, Elio Scarpini, Daniela Galimbert. A Novel Automated Chemiluminescence Method for Detecting Cerebrospinal Fluid Amyloid-Beta 1-42 and 1-40, Total Tau and Phosphorylated-Tau: Implications for Improving Diagnostic Performance in Alzheimer's Disease. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289929. |
a novel automated chemiluminescence method for detecting cerebrospinal fluid amyloid-beta 1-42 and 1-40, total tau and phosphorylated-tau: implications for improving diagnostic performance in alzheimer's disease. |
2022-10-27 |
2023-08-14 |
Not clear |
| Marina Arcaro, Chiara Fenoglio, Maria Serpente, Andrea Arighi, Giorgio G Fumagalli, Luca Sacchi, Stefano Floro, Marianna D'Anca, Federica Sorrentino, Caterina Visconte, Alberto Perego, Elio Scarpini, Daniela Galimbert. A Novel Automated Chemiluminescence Method for Detecting Cerebrospinal Fluid Amyloid-Beta 1-42 and 1-40, Total Tau and Phosphorylated-Tau: Implications for Improving Diagnostic Performance in Alzheimer's Disease. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289929. |
recently, a fully automated instrument for the detection of the cerebrospinal fluid (csf) biomarker for alzheimer's disease (ad) (low concentration of amyloid-beta 42 (aβ42), high concentration of total tau (t-tau) and phosphorylated-tau (p-tau181)), has been implemented, namely cleia. |
2022-10-27 |
2023-08-14 |
Not clear |
| Zizhao Ju, Zhuoyuan Li, Jiaying Lu, Fangyang Jiao, Huamei Lin, Weiqi Bao, Ming Li, Ping Wu, Yihui Guan, Qianhua Zhao, Huiwei Zhang, Jiehui Jiang, Chuantao Zu. In Vivo Tau Burden Is Associated with Abnormal Brain Functional Connectivity in Alzheimer's Disease: A Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291289. |
in vivo tau burden is associated with abnormal brain functional connectivity in alzheimer's disease: a |
2022-10-27 |
2023-08-14 |
Not clear |
| Thalia T Dimopoulos, Stephen L P Lippi, Jorge Fernandez Davila, Rachel E Barkey, Erin N Doherty, Jane M Flin. White Button Mushroom ( Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291298. |
white button mushroom ( alzheimer's disease (ad) is characterized by cognitive impairment and the presence of amyloid-β (aβ) plaques and tau tangles. |
2022-10-27 |
2023-08-14 |
mouse |
| Rosalia Bruno, Laura Pirisinu, Geraldina Riccardi, Claudia D'Agostino, Elena De Cecco, Giuseppe Legname, Franco Cardone, Pierluigi Gambetti, Romolo Nonno, Umberto Agrimi, Michele Angelo Di Bar. Gerstmann-Sträussler-Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291746. |
here we investigated: (i) the transmissibility of gss-f198s prions to voles carrying methionine at codon 109 (bvm); (ii) the induction of hyperphosphorylated tau (ptau) in two vole lines, and (iii) compared the phenotype of gss-f198s-induced ptau with ptau induced in bvm following intracerebral inoculation of a familial alzheimer's disease case carrying presenilin 1 mutation (fad-ps1). |
2022-10-27 |
2023-08-14 |
Not clear |
| Elisabeth Kapaki, Foteini Boufidou, Mara Bourbouli, Efstratios-Stylianos Pyrgelis, Vasilios C Constantinides, Cleo Anastassopoulou, George P Paraskeva. Cerebrospinal Fluid Biomarker Profile in TDP-43-Related Genetic Frontotemporal Dementia. Journal of personalized medicine. vol 12. issue 10. 2022-10-27. PMID:36294886. |
cerebrospinal fluid (csf) biomarkers, namely total tau, phospho-tau and amyloid beta peptides, have received much attention specifically regarding alzheimer's disease (ad), since they can detect the biochemical fingerprint of ad and serve as a diagnostic tool for accurate and early diagnosis during life. |
2022-10-27 |
2023-08-14 |
Not clear |
| Carolyn Tallon, Benjamin J Bell, Anjali Sharma, Arindom Pal, Medhinee M Malvankar, Ajit G Thomas, Seung-Wan Yoo, Kristen R Hollinger, Kaleem Coleman, Elizabeth L Wilkinson, Sujatha Kannan, Norman J Haughey, Rangaramanujam M Kannan, Rana Rais, Barbara S Slushe. Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice. Pharmaceutics. vol 14. issue 10. 2022-10-27. PMID:36297501. |
alzheimer's disease (ad) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (ptau), which can spread throughout the brain via extracellular vesicles (evs). |
2022-10-27 |
2023-08-14 |
mouse |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
dysfunctional microglia and tau pathology in alzheimer's disease. |
2022-10-27 |
2023-08-14 |
human |
| Pai-Yi Chiu, Fu-Chi Yang, Ming-Jang Chiu, Wei-Che Lin, Cheng-Hsien Lu, Shieh-Yueh Yan. Relevance of plasma biomarkers to pathologies in Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36289355. |
amyloid plaques and tau tangles are pathological hallmarks of alzheimer's disease (ad). |
2022-10-26 |
2023-08-14 |
human |