| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Ohgami, T Kitamoto, R W Shin, Y Kaneko, K Ogomori, J Tateish. Increased senile plaques without microglia in Alzheimer's disease. Acta neuropathologica. vol 81. issue 3. 1991-07-26. PMID:2058362. |
to clarify the association of microglia with senile plaques, the brains from 13 patients with alzheimer's disease (ad) and 23 nondemented aged controls were investigated immunohistochemically by a double-labeling method using anti-beta-protein antiserum and anti-ferritin antibody, which is a recently reported microglia marker. |
1991-07-26 |
2023-08-11 |
Not clear |
| L S Perlmutter, E Barron, H C Chu. Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:2097581. |
morphologic association between microglia and senile plaque amyloid in alzheimer's disease. |
1991-07-19 |
2023-08-11 |
Not clear |
| J Bauer, G König, S Strauss, U Jonas, U Ganter, A Weidemann, U Mönning, C L Masters, B Volk, M Berge. In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells. FEBS letters. vol 282. issue 2. 1991-07-02. PMID:1903718. |
microglia which are consistently associated with alzheimer's disease (ad) senile plaques are part of the mononuclear phagocyte system. |
1991-07-02 |
2023-08-11 |
human |
| H Akiyama, T Kawamata, S Dedhar, P L McGee. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. Journal of neuroimmunology. vol 32. issue 1. 1991-04-17. PMID:1705945. |
a polyclonal antibody to this integrin weakly stained resting microglia in white matter of control brain and strongly stained reactive microglia in both gray and white matter of alzheimer brain. |
1991-04-17 |
2023-08-11 |
Not clear |
| K Selmaj, C S Raine, B Cannella, C F Brosna. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. The Journal of clinical investigation. vol 87. issue 3. 1991-04-10. PMID:1999503. |
no lt or tnf reactivity was detected in alzheimer's or parkinson's disease brain tissues but was present at lower levels in central nervous system (cns) tissue from other inflammatory conditions, except for adrenoleucodystrophy which displayed high levels of lt in microglia. |
1991-04-10 |
2023-08-11 |
Not clear |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
microglia in cerebellar plaques in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
cerebellar amyloid deposits in alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-hla-dr, ln-1, leu-m5 and leukocyte common antigen. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
these results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| H Akiyama, P L McGee. Brain microglia constitutively express beta-2 integrins. Journal of neuroimmunology. vol 30. issue 1. 1990-12-07. PMID:1977769. |
the intensity of expression of each of these antigens was enhanced on reactive microglia in alzheimer disease tissue. |
1990-12-07 |
2023-08-11 |
Not clear |
| H Akiyama, P L McGee. Brain microglia constitutively express beta-2 integrins. Journal of neuroimmunology. vol 30. issue 1. 1990-12-07. PMID:1977769. |
hla-dr was detected on only a few microglia in control tissue, but was intensely expressed on large numbers of reactive microglia in alzheimer tissue. |
1990-12-07 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
reactive microglia express class i and class ii major histocompatibility complex antigens in alzheimer's disease. |
1990-10-23 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
monoclonal antibodies to class i antigens stained reactive microglia weakly to moderately and vascular endothelial cells strongly in alzheimer's gray and white matter. |
1990-10-23 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
in alzheimer cases, hla-dr positive reactive microglia were more numerous and more strongly staining than mhc class i positive reactive microglia but many cells appeared to express both classes of antigen. |
1990-10-23 |
2023-08-11 |
Not clear |
| P Cras, M Kawai, S Siedlak, P Mulvihill, P Gambetti, D Lowery, P Gonzalez-DeWhitt, B Greenberg, G Perr. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. The American journal of pathology. vol 137. issue 2. 1990-09-17. PMID:2117395. |
the greatest concurrence of app immunoreactivity and reactive microglia was seen in the subiculum and area ca1, regions with a high density of congophilic plaques and subject to intense alzheimer's pathology. |
1990-09-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, D W Dickso. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. The American journal of pathology. vol 136. issue 5. 1990-07-09. PMID:1693471. |
in subjects who died of chronic debilitating illness, such as alzheimer's disease and carcinomatosis, anti-hla-dr labeled numerous microglia throughout both the gray and white matter. |
1990-07-09 |
2023-08-11 |
human |
| L A Mattiace, P Davies, D W Dickso. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. The American journal of pathology. vol 136. issue 5. 1990-07-09. PMID:1693471. |
in alzheimer's disease, microglia were aggregated in compact senile plaques, but loosely associated with diffuse amyloid deposits. |
1990-07-09 |
2023-08-11 |
human |
| S Itagaki, P L McGeer, H Akiyama, S Zhu, D Selko. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. Journal of neuroimmunology. vol 24. issue 3. 1989-12-19. PMID:2808689. |
relationship of microglia and astrocytes to amyloid deposits of alzheimer disease. |
1989-12-19 |
2023-08-11 |
human |
| S Itagaki, P L McGeer, H Akiyama, S Zhu, D Selko. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. Journal of neuroimmunology. vol 24. issue 3. 1989-12-19. PMID:2808689. |
the relationship of microglia and astrocytes to deposits of beta-amyloid protein (bap) was studied in alzheimer's disease by immunohistochemistry. |
1989-12-19 |
2023-08-11 |
human |
| F V DeFeudi. Novel therapy for Alzheimer's disease. Neurobiology of aging. vol 10. issue 5. 1989-12-18. PMID:2510040. |
recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the kunitz protease inhibitor (kpi) domain of beta-amyloid precursor protein (app), thereby facilitating deposition of abnormal amyloid filaments in patients with alzheimer's disease (ad). |
1989-12-18 |
2023-08-11 |
Not clear |
| W S Griffin, L C Stanley, C Ling, L White, V MacLeod, L J Perrot, C L White, C Arao. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 19. 1989-11-09. PMID:2529544. |
most interleukin 1-immunoreactive glia in down syndrome and alzheimer disease were classified as microglia. |
1989-11-09 |
2023-08-11 |
human |