| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Giulian, L J Haverkamp, J Li, W L Karshin, J Yu, D Tom, X Li, J B Kirkpatric. Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochemistry international. vol 27. issue 1. 1995-10-05. PMID:7655344. |
senile plaques found in the brains of patients with alzheimer's disease (ad) are surrounded by clusters of reactive microglia. |
1995-10-05 |
2023-08-12 |
human |
| D Giulian, L J Haverkamp, J Li, W L Karshin, J Yu, D Tom, X Li, J B Kirkpatric. Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochemistry international. vol 27. issue 1. 1995-10-05. PMID:7655344. |
highest concentrations of the neurotoxin are in those brain structures most burdened by reactive microglia, suggesting that plaque-activated cells contribute to the neuronal damage and impaired cognition seen in patients with alzheimer's dementia. |
1995-10-05 |
2023-08-12 |
human |
| H Akiyam. Inflammatory response in Alzheimer's disease. The Tohoku journal of experimental medicine. vol 174. issue 3. 1995-06-27. PMID:7539162. |
in alzheimer's disease (ad), microglia become activated. |
1995-06-27 |
2023-08-12 |
Not clear |
| G Münch, Y Taneli, E Schraven, U Schindler, R Schinzel, D Palm, P Riedere. The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. Journal of neural transmission. Parkinson's disease and dementia section. vol 8. issue 3. 1995-06-16. PMID:7748463. |
a beneficial effect of tenilsetam in alzheimer's disease could come from the interference with age-derived crosslinking of amyloid plaques and a decreased inflammatory response by diminished activation of phagocytosing microglia. |
1995-06-16 |
2023-08-12 |
Not clear |
| U Schumacher, E Adam, H Kretzschmar, U Pfülle. Binding patterns of mistletoe lectins I, II and III to microglia and Alzheimer plaque glycoproteins in human brains. Acta histochemica. vol 96. issue 4. 1995-05-18. PMID:7717044. |
binding patterns of mistletoe lectins i, ii and iii to microglia and alzheimer plaque glycoproteins in human brains. |
1995-05-18 |
2023-08-12 |
human |
| L Meda, M A Cassatella, G I Szendrei, L Otvos, P Baron, M Villalba, D Ferrari, F Ross. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature. vol 374. issue 6523. 1995-05-17. PMID:7715705. |
these findings suggest that a beta and ifn-gamma activate microglia to produce reactive nitrogen intermediates and tnf-alpha, and this may have a role in the pathogenesis of neuronal degeneration observed in ageing and alzheimer's disease. |
1995-05-17 |
2023-08-12 |
Not clear |
| U Mönning, R Sandbrink, A Weidemann, R B Banati, C L Masters, K Beyreuthe. Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells. The Journal of biological chemistry. vol 270. issue 13. 1995-05-10. PMID:7706247. |
these observations provide evidence that microglia, which are closely associated with certain amyloid deposits in the brain of alzheimer patients, can play a key role in initial events of amyloidogenesis by initiating accumulation of app and also of amyloidogenic app fragments in response to physiological changes upon brain injury. |
1995-05-10 |
2023-08-12 |
Not clear |
| T Yamada, M A Horisberger, N Kawaguchi, I Moroo, T Toyod. Immunohistochemistry using antibodies to alpha-interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues. Neuroscience letters. vol 181. issue 1-2. 1995-04-27. PMID:7898772. |
these results suggest that increased expression of alpha-ifn in the white matter microglia and appearance of mxa protein in reactive microglia contribute to alzheimer pathology. |
1995-04-27 |
2023-08-12 |
human |
| A Dahlström, A McRae, R Polinsky, L Nee, B Sadasivan, E A Lin. Alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia. Investigations with cell cultures and human cortical biopsies. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888106. |
alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia. |
1995-04-18 |
2023-08-12 |
human |
| S Das, H Potte. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron. vol 14. issue 2. 1995-03-20. PMID:7857652. |
furthermore, unfractionated glial cultures containing both astrocytes and microglia from human cortex (which develops amyloid in alzheimer's disease) spontaneously express il-1 and act as they reach confluence. |
1995-03-20 |
2023-08-12 |
human |
| S Das, H Potte. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron. vol 14. issue 2. 1995-03-20. PMID:7857652. |
the same regional difference in il-1 expression by microglia is seen in vivo in alzheimer's disease. |
1995-03-20 |
2023-08-12 |
human |
| W S Griffin, J G Sheng, S M Gentleman, D I Graham, R E Mrak, G W Robert. Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. Neuroscience letters. vol 176. issue 2. 1995-02-21. PMID:7830934. |
activated microglia containing il-1 alpha-immunoreactive (il-1 alpha +) product were increased 3-fold in number in the acute phase following head injury, a risk factor for later development of alzheimer's disease, and this increase was correlated with a 7-fold increase in the number of neurons with elevated beta-amyloid precursor protein (beta-app) levels (r = 0.78; p < 0.05). |
1995-02-21 |
2023-08-12 |
human |
| C D Muller, V Bocchini, J Giaimis, P Guerrieri, Y Lombard, P Poindro. Functional beta-glucan receptor expression by a microglial cell line. Research in immunology. vol 145. issue 4. 1995-02-16. PMID:7824804. |
diseases where an active role for microglia has been proposed recently include alzheimer's disease, the acquired immune deficiency syndrome (aids) and multiple sclerosis. |
1995-02-16 |
2023-08-12 |
Not clear |
| T Uchihara, H Kondo, H Akiyama, K Iked. Single-laser three-color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque-related structures in post-mortem human brain tissue. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 43. issue 1. 1995-02-13. PMID:7822758. |
in this study we investigated the spatial relationship of blood vessels, reactive microglia, and amyloid beta-protein (a beta) deposits in post-mortem brain tissue of patients with alzheimer's disease. |
1995-02-13 |
2023-08-12 |
human |
| M B Youdim, L Lavi. Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7527888. |
the dramatic proliferation of reactive amoeboid macrophages and microglia seen in sn of pd brains together with os is highly compatible with an inflammatory process, similar to what has been observed in alzheimer's disease and multiple sclerosis brains. |
1995-01-18 |
2023-08-12 |
Not clear |
| P L McGeer, J Rogers, E G McGee. Neuroimmune mechanisms in Alzheimer disease pathogenesis. Alzheimer disease and associated disorders. vol 8. issue 3. 1995-01-12. PMID:7986484. |
these data imply that an autodestructive process is occurring in alzheimer disease, that overactive microglia might be responsible, and that antiinflammatory drugs might be an effective form of therapy. |
1995-01-12 |
2023-08-12 |
Not clear |
| M L Maat-Schieman, A J Rozemuller, S G van Duinen, J Haan, P Eikelenboom, R A Roo. Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. Journal of neuropathology and experimental neurology. vol 53. issue 5. 1994-10-10. PMID:7521904. |
microglia are intimately associated with congophilic plaques in alzheimer's disease (ad), but microglial involvement in diffuse plaque formation is controversial. |
1994-10-10 |
2023-08-12 |
Not clear |
| P L McGeer, D G Walker, H Akiyama, O Yasuhara, E G McGee. Involvement of microglia in Alzheimer's disease. Neuropathology and applied neurobiology. vol 20. issue 2. 1994-09-27. PMID:8072657. |
involvement of microglia in alzheimer's disease. |
1994-09-27 |
2023-08-12 |
Not clear |
| M Nieto-Sampedro, F Mor. Active microglia, sick astroglia and Alzheimer type dementias. Neuroreport. vol 5. issue 4. 1994-07-20. PMID:8003658. |
active microglia, sick astroglia and alzheimer type dementias. |
1994-07-20 |
2023-08-12 |
Not clear |
| H Akiyama, T Nishimura, H Kondo, K Ikeda, Y Hayashi, P L McGee. Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis. Brain research. vol 639. issue 1. 1994-06-16. PMID:7514086. |
expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with alzheimer's disease and amyotrophic lateral sclerosis. |
1994-06-16 |
2023-08-12 |
human |