| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Banati, G Rothe, G Valet, G W Kreutzber. Detection of lysosomal cysteine proteinases in microglia: flow cytometric measurement and histochemical localization of cathepsin B and L. Glia. vol 7. issue 2. 1993-03-15. PMID:8432559. |
this is particularly interesting as enzymatically active cathepsins have recently been found extracellularly at high levels in the senile plaques of alzheimer's disease, which are known to contain many activated microglia. |
1993-03-15 |
2023-08-12 |
rat |
| J H Su, B J Cummings, C W Cotma. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience. vol 51. issue 4. 1993-02-23. PMID:1488123. |
in addition, within the alzheimer's brains studied, the nuclei of select neurons and a small number of microglia were also immunopositive for heparan sulfate glycosaminoglycan in contrast to controls, where nuclei and neuroglia were immuno-negative. |
1993-02-23 |
2023-08-11 |
Not clear |
| E A Ling, A Dahlström, R J Polinsky, L E Nee, A McRa. Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience. vol 51. issue 4. 1993-02-23. PMID:1488124. |
previous investigations have shown that cerebrospinal fluid from alzheimer's disease patients contains antibodies that recognize the amoeboid microglia--a nascent and active form of microglia in the developing rat brain [mcrae et al. |
1993-02-23 |
2023-08-11 |
rat |
| E A Ling, A Dahlström, R J Polinsky, L E Nee, A McRa. Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience. vol 51. issue 4. 1993-02-23. PMID:1488124. |
the present study extended this to show that the same cerebrospinal fluid from alzheimer's disease patients also labeled the activated microglia and macrophages induced experimentally in adult central nervous system. |
1993-02-23 |
2023-08-11 |
rat |
| E A Ling, A Dahlström, R J Polinsky, L E Nee, A McRa. Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience. vol 51. issue 4. 1993-02-23. PMID:1488124. |
the activated microglia which were closely associated with the soma of the degenerating neurons were intensely immunostained with the cerebrospinal fluid from alzheimer's disease patients. |
1993-02-23 |
2023-08-11 |
rat |
| D W Dickson, S C Lee, L A Mattiace, S H Yen, C Brosna. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia. vol 7. issue 1. 1993-02-23. PMID:8423065. |
microglia and cytokines in neurological disease, with special reference to aids and alzheimer's disease. |
1993-02-23 |
2023-08-12 |
human |
| D W Dickson, S C Lee, L A Mattiace, S H Yen, C Brosna. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia. vol 7. issue 1. 1993-02-23. PMID:8423065. |
microglia are associated with central nervous system (cns) pathology of both alzheimer's disease (ad) and the acquired immunodeficiency syndrome (aids). |
1993-02-23 |
2023-08-12 |
human |
| P L McGeer, T Kawamata, D G Walker, H Akiyama, I Tooyama, E G McGee. Microglia in degenerative neurological disease. Glia. vol 7. issue 1. 1993-02-23. PMID:8423066. |
microglia express many leukocyte surface antigens which are upregulated in such chronic degenerative neurological diseases as alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
1993-02-23 |
2023-08-12 |
Not clear |
| L S Perlmutter, S A Scott, E Barrón, H C Chu. MHC class II-positive microglia in human brain: association with Alzheimer lesions. Journal of neuroscience research. vol 33. issue 4. 1993-02-12. PMID:1484388. |
mhc class ii-positive microglia in human brain: association with alzheimer lesions. |
1993-02-12 |
2023-08-11 |
human |
| L S Perlmutter, S A Scott, E Barrón, H C Chu. MHC class II-positive microglia in human brain: association with Alzheimer lesions. Journal of neuroscience research. vol 33. issue 4. 1993-02-12. PMID:1484388. |
marked increases in mhc class ii-expressing microglia have been shown in many neuropathologic disorders, including alzheimer's disease (ad). |
1993-02-12 |
2023-08-11 |
human |
| J B Davis, H F McMurray, D Schuber. The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. Biochemical and biophysical research communications. vol 189. issue 2. 1993-01-28. PMID:1472019. |
the cellular pathology of alzheimer's disease includes an accumulation of microglia surrounding the amyloid plaques. |
1993-01-28 |
2023-08-11 |
human |
| P H Evans, E Yano, J Klinowski, E Peterhan. Oxidative damage in Alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions. EXS. vol 62. 1993-01-06. PMID:1450585. |
oxidative damage in alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions. |
1993-01-06 |
2023-08-11 |
human |
| J M Rozemuller, P van der Valk, P Eikelenboo. Activated microglia and cerebral amyloid deposits in Alzheimer's disease. Research in immunology. vol 143. issue 6. 1993-01-06. PMID:1455057. |
activated microglia and cerebral amyloid deposits in alzheimer's disease. |
1993-01-06 |
2023-08-11 |
Not clear |
| R W Jacobs, T Duong, A B Scheibe. Immunohistochemical analysis of the basal forebrain in Alzheimer's disease. Molecular and chemical neuropathology. vol 17. issue 1. 1992-11-10. PMID:1388447. |
an immunohistochemical analysis utilizing antibodies to glial fibrillary acid protein (gfap), microglia, beta-amyloid, amyloid p-component, neurofibrillary tangles (nft), and microtubule associated protein-tau (map-tau) was performed on the cholinergic basal forebrain in alzheimer's disease (ad). |
1992-11-10 |
2023-08-11 |
Not clear |
| B J Cummings, J H Su, J W Geddes, W E Van Nostrand, S L Wagner, D D Cunningham, C W Cotma. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. vol 48. issue 4. 1992-08-14. PMID:1378573. |
the predominantly neuronal and neuritic localization of amyloid precursor protein immunoreactivity indicates a neuronal source for much of the amyloid precursor protein observed in alzheimer's disease pathology, and suggests a time-course of plaque development beginning with neuronal amyloid precursor protein accumulation, then deposition into the extracellular space, subsequent processing by astrocytes or microglia, and resulting in beta-amyloid peptide accumulation in plaques. |
1992-08-14 |
2023-08-11 |
human |
| J R Connor, S L Menzies, S M St Martin, E J Mufso. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. Journal of neuroscience research. vol 31. issue 1. 1992-07-29. PMID:1613823. |
although many ferritin-positive oligodendrocytes are present in the alzheimer's tissue, most of the ferritin-containing cells associated with senile plaques and blood vessels are microglia. |
1992-07-29 |
2023-08-11 |
Not clear |
| D M Araujo, C W Cotma. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain research. vol 569. issue 1. 1992-07-24. PMID:1611474. |
the effects of a synthetic homolog of beta-amyloid (beta 1-42) on the secretion of interleukin-1 (il-1) and basic fibroblast growth factor (bfgf) from cultures of microglia and astrocytes, cells that surround beta-amyloid-containing plaques in alzheimer's disease, were examined. |
1992-07-24 |
2023-08-11 |
Not clear |
| P Cras, M Kawai, S Siedlak, G Perr. Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease. Brain research. vol 558. issue 2. 1992-03-17. PMID:1782548. |
microglia are associated with the extracellular neurofibrillary tangles of alzheimer disease. |
1992-03-17 |
2023-08-11 |
Not clear |
| P L McGeer, J Roger. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology. vol 42. issue 2. 1992-03-12. PMID:1736183. |
postmortem analyses of alzheimer's disease (ad) brain tissue reveal reactive microglia expressing high levels of major histocompatibility complex (mhc) glycoproteins, immunoglobulin receptors, and complement receptors; small but significant numbers of t-lymphocytes infiltrating tissue; enhanced cytokine and cytokine receptor expression; and profuse immunoreactivity for complement proteins of the classic pathway colocalized with senile plaques, dystrophic neurites, and some neurofibrillary tangles. |
1992-03-12 |
2023-08-11 |
Not clear |
| H Fillit, W H Ding, L Buee, J Kalman, L Altstiel, B Lawlor, G Wolf-Klei. Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neuroscience letters. vol 129. issue 2. 1992-01-14. PMID:1745413. |
recent investigations have demonstrated a local inflammatory response in alzheimer's disease (ad), including microglia and cytokines. |
1992-01-14 |
2023-08-11 |
Not clear |