| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Ard, G M Cole, J Wei, A P Mehrle, J D Fratki. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. Journal of neuroscience research. vol 43. issue 2. 1996-10-30. PMID:8820967. |
microglia were also cultured on unfixed cryostat sections of human brain tissue containing alzheimer's plaques. |
1996-10-30 |
2023-08-12 |
human |
| H Fukumoto, A Asami-Odaka, N Suzuki, T Iwatsub. Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 1. 1996-09-24. PMID:8731377. |
to gain insight into the role of microglia in the formation of senile plaques (sp), especially in the generation of the two major molecular species of amyloid beta protein (a beta) with different carboxyl (c)-termini, a beta 40 and a beta 42(43), we conducted double immunolabelling studies on tissue sections from the brains of alzheimer's disease (ad) and non-demented aged individuals using antibodies to the c-termini of a beta and ferritin, a marker for microglia. |
1996-09-24 |
2023-08-12 |
Not clear |
| S D Yan, X Chen, J Fu, M Chen, H Zhu, A Roher, T Slattery, L Zhao, M Nagashima, J Morser, A Migheli, P Nawroth, D Stern, A M Schmid. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. vol 382. issue 6593. 1996-09-23. PMID:8751438. |
amyloid-beta peptide is central to the pathology of alzheimer's disease, because it is neurotoxic--directly by inducing oxidant stress, and indirectly by activating microglia. |
1996-09-23 |
2023-08-12 |
Not clear |
| J El Khoury, S E Hickman, C A Thomas, L Cao, S C Silverstein, J D Loik. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. vol 382. issue 6593. 1996-09-23. PMID:8751442. |
a pathological hallmark of alzheimer's disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. |
1996-09-23 |
2023-08-12 |
human |
| M T Roe, D V Dawson, C M Hulette, G Einstein, B J Crai. Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease. Journal of neuropathology and experimental neurology. vol 55. issue 3. 1996-09-20. PMID:8786395. |
microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in alzheimer's disease. |
1996-09-20 |
2023-08-12 |
Not clear |
| M T Roe, D V Dawson, C M Hulette, G Einstein, B J Crai. Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease. Journal of neuropathology and experimental neurology. vol 55. issue 3. 1996-09-20. PMID:8786395. |
the functional significance of microglia found in neuritic plaques in alzheimer's disease (ad) remains a source of controversy. |
1996-09-20 |
2023-08-12 |
Not clear |
| H Akiyama, C Schwab, H Kondo, H Mori, F Kametani, K Ikeda, P L McGee. Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein. Neuroscience letters. vol 206. issue 2-3. 1996-09-12. PMID:8710178. |
granular structures that are recognized by antibodies specific for the c-terminal but not the n-terminal sequences of the beta-amyloid protein (a beta) fragments are present in a subset of microglia and astrocytes in alzheimer brain tissue. |
1996-09-12 |
2023-08-12 |
Not clear |
| W A Jefferies, M R Food, R Gabathuler, S Rothenberger, T Yamada, O Yasuhara, P L McGee. Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin. Brain research. vol 712. issue 1. 1996-09-11. PMID:8705294. |
reactive microglia specifically associated with amyloid plaques in alzheimer's disease brain tissue express melanotransferrin. |
1996-09-11 |
2023-08-12 |
Not clear |
| F L Van Muiswinkel, R Veerhuis, P Eikelenboo. Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity. Journal of neurochemistry. vol 66. issue 6. 1996-07-01. PMID:8632171. |
activated microglia, often associated with neuritic amyloid plaques in the alzheimer's disease brain, are likely to contribute to the progression of the disease process, e.g., by releasing neurotoxic reactive oxygen and/or nitrogen intermediates. |
1996-07-01 |
2023-08-12 |
rat |
| R H Christie, M Freeman, B T Hyma. Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. The American journal of pathology. vol 148. issue 2. 1996-03-11. PMID:8579103. |
expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in alzheimer's disease. |
1996-03-11 |
2023-08-12 |
human |
| J L Goodwin, E Uemura, J E Cunnic. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548305. |
these findings warrant a further investigation into the role of microglia in the neurodegeneration of alzheimer's disease via nitric oxide toxicity induced by the synergistic action of beta-amyloid and a costimulatory factor. |
1996-02-20 |
2023-08-12 |
rat |
| I R Mackenzie, C Hao, D G Muno. Role of microglia in senile plaque formation. Neurobiology of aging. vol 16. issue 5. 1996-02-01. PMID:8532113. |
to assess the role of microglial cells in senile plaque (sp) formation, we examined the density and distribution of microglia in the temporal neocortex of three groups of nondemented individuals, chosen to represent sequential stages of sp formation (no sp, n = 14; diffuse plaques (dp) only, n = 12; both dp and neuritic plaques (np), n = 14) and patients with alzheimer's disease (ad, n = 11). |
1996-02-01 |
2023-08-12 |
Not clear |
| G N Groom, L Junck, N L Foster, K A Frey, D E Kuh. PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 36. issue 12. 1996-01-25. PMID:8523106. |
to further elucidate the role of cellular inflammation and microgliosis in alzheimer's disease during life, we used pet and [11c]pk 11195, a peripheral benzodiazepine receptor ligand known to bind avidly to microglia. |
1996-01-25 |
2023-08-12 |
human |
| J Peiffer, J Gehrman. Ludwig Merzbacher (1875-1942): the man behind the disease. Brain pathology (Zurich, Switzerland). vol 5. issue 3. 1996-01-19. PMID:8520731. |
while working in alois alzheimer's laboratory in munich in 1906/1907, ludwig merzbacher analyzed in great detail the reaction patterns of these cells, which are nowadays known as reactive microglia, and already attempted to elucidate their function in brain pathology. |
1996-01-19 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494597. |
interleukin-1 alpha-immunoreactive (il-1 alpha+) microglia are prominent components of neuritic plaques in alzheimer's disease, and may be important in the evolution of neuritic plaques from diffuse amyloid deposits. |
1996-01-11 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494597. |
no activated il-1 alpha+ microglia, tau 2+ neuritic plaques, or activated astrocytes were observed in cerebellum of these alzheimer patients. |
1996-01-11 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494597. |
these regional relationships between activated il-1 alpha+ microglia, tau 2+ neuritic plaques, and activated astrocytes, together with the established functions of il-1, support a causal association between the overexpression of il-1 and the evolution of beta-amyloid deposits into neuritic plaques in alzheimer's disease. |
1996-01-11 |
2023-08-12 |
Not clear |
| N S Peress, E Perill. Differential expression of TGF-beta 1, 2 and 3 isotypes in Alzheimer's disease: a comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains. Journal of neuropathology and experimental neurology. vol 54. issue 6. 1995-12-14. PMID:7595653. |
ramified microglia labeled selectively, as in the alzheimer brains, with the tgf-beta 2 antibody. |
1995-12-14 |
2023-08-12 |
mouse |
| M Hartwi. Immune ageing and Alzheimer's disease. Neuroreport. vol 6. issue 9. 1995-10-19. PMID:7669985. |
the development of highly activated microglia appears to be sufficient to induce the inflammatory neurotoxic process characteristic of the brain in alzheimer's disease. |
1995-10-19 |
2023-08-12 |
Not clear |
| D Giulian, L J Haverkamp, J Li, W L Karshin, J Yu, D Tom, X Li, J B Kirkpatric. Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochemistry international. vol 27. issue 1. 1995-10-05. PMID:7655344. |
senile plaques stimulate microglia to release a neurotoxin found in alzheimer brain. |
1995-10-05 |
2023-08-12 |
human |