| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Mori, Y Yoshiyama, M Waragai, K Yoshikawa, T Yamad. [Distribution of amyloid precursor protein mRNA in Alzheimer brain tissues]. No to shinkei = Brain and nerve. vol 49. issue 9. 1998-01-09. PMID:9310996. |
a cdna probe constructed by polymerase chain reaction for app, which was not specific for a particular isoform, gave punctate staining and showed a clear localization not only in neurons but in astrocytes in all brains, as well as in the reactive microglia associated with senile plaques in alzheimer disease. |
1998-01-09 |
2023-08-12 |
human |
| D M Paresce, H Chung, F R Maxfiel. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. The Journal of biological chemistry. vol 272. issue 46. 1997-12-11. PMID:9361021. |
microglia are immune system cells associated with senile plaques containing beta-amyloid (abeta) in alzheimer's disease. |
1997-12-11 |
2023-08-12 |
Not clear |
| D M Paresce, H Chung, F R Maxfiel. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. The Journal of biological chemistry. vol 272. issue 46. 1997-12-11. PMID:9361021. |
although microglia are an integral part of senile plaques, their role in the development of alzheimer's disease is not known. |
1997-12-11 |
2023-08-12 |
Not clear |
| D M Paresce, H Chung, F R Maxfiel. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. The Journal of biological chemistry. vol 272. issue 46. 1997-12-11. PMID:9361021. |
microglia bind and internalize microaggregates of abeta that resemble those present in dense alzheimer's disease plaques. |
1997-12-11 |
2023-08-12 |
Not clear |
| A Sasaki, H Yamaguchi, A Ogawa, S Sugihara, Y Nakazat. Microglial activation in early stages of amyloid beta protein deposition. Acta neuropathologica. vol 94. issue 4. 1997-11-14. PMID:9341931. |
using single and double immunostaining methods with a panel of microglia markers and antibodies against a beta and amyloid beta protein precursor (app), we examined the cerebrum and cerebella of both alzheimer's disease (ad) and non-demented subjects obtained at autopsy. |
1997-11-14 |
2023-08-12 |
human |
| S W Barger, A D Harmo. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature. vol 388. issue 6645. 1997-09-12. PMID:9278049. |
the ability of sapp-alpha to activate microglia was blocked by prior incubation of the protein with apolipoprotein e3 but not apolipoprotein e4, a variant associated with an increased risk for alzheimer's. |
1997-09-12 |
2023-08-12 |
Not clear |
| K Ishizuka, T Kimura, R Igata-yi, S Katsuragi, J Takamatsu, T Miyakaw. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry and clinical neurosciences. vol 51. issue 3. 1997-08-27. PMID:9225377. |
identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of alzheimer's disease. |
1997-08-27 |
2023-08-12 |
mouse |
| K Ishizuka, T Kimura, R Igata-yi, S Katsuragi, J Takamatsu, T Miyakaw. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry and clinical neurosciences. vol 51. issue 3. 1997-08-27. PMID:9225377. |
reactive microglia and inflammatory factors were reported to be present in beta-amyloid deposits (senile plaques) in alzheimer's disease, suggesting the presence of mcp-1 in senile plaques. |
1997-08-27 |
2023-08-12 |
mouse |
| K Ishizuka, T Kimura, R Igata-yi, S Katsuragi, J Takamatsu, T Miyakaw. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry and clinical neurosciences. vol 51. issue 3. 1997-08-27. PMID:9225377. |
monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with alzheimer's disease. |
1997-08-27 |
2023-08-12 |
mouse |
| J G Sheng, R E Mrak, W S Griffi. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta neuropathologica. vol 94. issue 1. 1997-08-19. PMID:9224523. |
neuritic plaque evolution in alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. |
1997-08-19 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta neuropathologica. vol 94. issue 1. 1997-08-19. PMID:9224523. |
activated microglia, overexpressing the potent neuroactive cytokine interleukin-1, have been implicated as a driving force in the evolution of diffuse amyloid deposits into diagnostic neuritic plaques in alzheimer's disease. |
1997-08-19 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta neuropathologica. vol 94. issue 1. 1997-08-19. PMID:9224523. |
to evaluate this role further, we used double-label immunohistochemistry to classify and quantify plaque-associated and non-plaque-associated activated interleukin-1-immunoreactive microglia in parahippocampal tissue from 11 patients with alzheimer's disease. |
1997-08-19 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta neuropathologica. vol 94. issue 1. 1997-08-19. PMID:9224523. |
these findings show preferential association of primed microglia with diffuse amyloid deposits and imply that microglial transformation from primed, to enlarged, to phagocytic types occurs in concert with the evolution of amyloid plaques from diffuse amyloid deposits to the neuritic beta-amyloid plaque forms in alzheimer's disease. |
1997-08-19 |
2023-08-12 |
Not clear |
| C Bonaiuto, P P McDonald, F Rossi, M A Cassatell. Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia. Journal of neuroimmunology. vol 77. issue 1. 1997-07-28. PMID:9209268. |
an increasing body of evidence suggests that amyloid-beta (a beta) peptides and microglia are crucially involved in the pathogenesis of alzheimer's disease. |
1997-07-28 |
2023-08-12 |
human |
| S Du Yan, H Zhu, J Fu, S F Yan, A Roher, W W Tourtellotte, T Rajavashisth, X Chen, G C Godman, D Stern, A M Schmid. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 10. 1997-06-05. PMID:9144231. |
in alzheimer disease (ad), neurons are thought to be subjected to the deleterious cytotoxic effects of activated microglia. |
1997-06-05 |
2023-08-12 |
Not clear |
| W J Streit, D L Spark. Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. Journal of molecular medicine (Berlin, Germany). vol 75. issue 2. 1997-05-28. PMID:9083930. |
studies suggesting a link between alzheimer's disease and heart disease led us to study microglia immunohistochemically, using monoclonal antibody ln-3, in age-matched nondemented humans with and without heart disease. |
1997-05-28 |
2023-08-12 |
human |
| M P Mattson, S W Barger, K Furukawa, A J Bruce, T Wyss-Coray, R J Mark, L Muck. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain research. Brain research reviews. vol 23. issue 1-2. 1997-05-23. PMID:9063586. |
the links between these three factors include: their responses to injury; their interactive effects on astrocytes, microglia and neurons; their ability to induce cytoprotective responses in neurons; and their association with cytopathological alterations in alzheimer's disease. |
1997-05-23 |
2023-08-12 |
mouse |
| A Klegeris, D G Walker, P L McGee. Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha. Brain research. vol 747. issue 1. 1997-05-14. PMID:9042534. |
immunological mechanisms, including stimulation of brain microglia and elevation of various inflammatory cytokines, have been implicated in the pathogenesis of alzheimer's disease, where accumulation of beta-amyloid peptide (a beta) is one of its main pathological features. |
1997-05-14 |
2023-08-12 |
human |
| D W Dickso. The pathogenesis of senile plaques. Journal of neuropathology and experimental neurology. vol 56. issue 4. 1997-05-01. PMID:9100663. |
subsequent to deposition of a beta 1-42 and then growth of the amyloid with precipitation of soluble a beta 1-40, in an alzheimer disease-specific process, sp increasingly become associated with activated microglia and reactive astrocytes. |
1997-05-01 |
2023-08-12 |
Not clear |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
these results, which are the first evidence of apoe mrna localization to microglia in vivo and the control of apoe expression in brain cells by estrogens, are discussed in terms of the possible protective role of e2 in alzheimer's disease and prior findings that emphasize the expression of apoe mrna in astrocytes within the brain. |
1997-04-07 |
2023-08-12 |
rat |