| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Bowser, S Reill. Expression of FAC1 in activated microglia during Alzheimer's disease. Neuroscience letters. vol 253. issue 3. 1999-06-07. PMID:9792236. |
expression of fac1 in activated microglia during alzheimer's disease. |
1999-06-07 |
2023-08-12 |
Not clear |
| R Bowser, S Reill. Expression of FAC1 in activated microglia during Alzheimer's disease. Neuroscience letters. vol 253. issue 3. 1999-06-07. PMID:9792236. |
the presence of reactive microglia and astrocytes is a common observation in alzheimer's disease brain. |
1999-06-07 |
2023-08-12 |
Not clear |
| F González-Scarano, G Baltuc. Microglia as mediators of inflammatory and degenerative diseases. Annual review of neuroscience. vol 22. 1999-06-04. PMID:10202538. |
in this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: hiv, multiple sclerosis, and alzheimer's disease. |
1999-06-04 |
2023-08-12 |
human |
| D Paris, T Town, T A Parker, J Tan, J Humphrey, F Crawford, M Mulla. Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism. Experimental neurology. vol 157. issue 1. 1999-06-03. PMID:10222124. |
inhibition of alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cgmp-dependent mechanism. |
1999-06-03 |
2023-08-12 |
rat |
| L Morelli, G H Giambartolomei, M I Prat, E M Castañ. Internalization and resistance to degradation of Alzheimer's A beta 1-42 at nanomolar concentrations in THP-1 human monocytic cell line. Neuroscience letters. vol 262. issue 1. 1999-05-06. PMID:10076859. |
microglial cell involvement in alzheimer's disease has been related to amyloid beta (a beta) internalization, the release of inflammatory cytokines and the development of neuritic plaques. |
1999-05-06 |
2023-08-12 |
human |
| R N Kalari. Microglia and Alzheimer's disease. Current opinion in hematology. vol 6. issue 1. 1999-03-30. PMID:9915549. |
microglia and alzheimer's disease. |
1999-03-30 |
2023-08-12 |
Not clear |
| R N Kalari. Microglia and Alzheimer's disease. Current opinion in hematology. vol 6. issue 1. 1999-03-30. PMID:9915549. |
microglia play a major role in the cellular response associated with the pathological lesions of alzheimer's disease. |
1999-03-30 |
2023-08-12 |
Not clear |
| D Kapl, K A Rudolph. [New pharmacologic aspects in the neurologic profile of propentofylline (Karsivan ad us. vet.)]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. vol 26. issue 5. 1999-03-15. PMID:9931990. |
in experimental models of vascular dementia and/or alzheimer's disease it improves cognitive functions, inhibits inflammatory processes as well as excessive activation of microglia, formation of free radicals, cytocines and abnormal amyloid precursor proteins (app). |
1999-03-15 |
2023-08-12 |
human |
| B L Fiebich, M Hüll, K Lieb, G Schumann, M Berger, J Baue. Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. Journal of neural transmission. Supplementum. vol 54. 1999-03-11. PMID:9850935. |
these results suggest a possible link between the release of pgs from activated microglia and the astrocytic synthesis of il-6, which itself may affect neuronal cells, as hypothesized for alzheimer's disease. |
1999-03-11 |
2023-08-12 |
human |
| M Nakai, K Hojo, T Taniguchi, A Terashima, T Kawamata, T Hashimoto, K Maeda, C Tanak. PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia. Neuroreport. vol 9. issue 15. 1999-02-25. PMID:9855300. |
microglia are activated by amyloid beta (abeta) in vivo and in vitro, and abeta-activated microglia may be involved in the pathogenesis of alzheimer's disease (ad). |
1999-02-25 |
2023-08-12 |
Not clear |
| A M Maye. Therapeutic implications of microglia activation by lipopolysaccharide and reactive oxygen species generation in septic shock and central nervous system pathologies: a review. Medicina. vol 58. issue 4. 1999-02-04. PMID:9816700. |
a growing body of research supports involvement of activated brain microglia in brain pathologies caused by infectious diseases, trauma, tumors, ischemia, alzheimer's disease, parkinson's disease, down's syndrome, multiple sclerosis and aids. |
1999-02-04 |
2023-08-12 |
Not clear |
| A McRae, E A Ling, P Schubert, K Rudolph. Properties of activated microglia and pharmacologic interference by propentofylline. Alzheimer disease and associated disorders. vol 12 Suppl 2. 1999-02-02. PMID:9769025. |
the cerebrospinal fluid (csf) of alzheimer disease (ad) patients contains antibodies that recognize activated microglia in the developing rat and in the ischemic gerbil brain. |
1999-02-02 |
2023-08-12 |
rat |
| J M Long, A N Kalehua, N J Muth, J M Hengemihle, M Jucker, M E Calhoun, D K Ingram, P R Mouto. Stereological estimation of total microglia number in mouse hippocampus. Journal of neuroscience methods. vol 84. issue 1-2. 1999-01-26. PMID:9821640. |
microglia are brain cells of considerable interest because of their role in cns inflammatory responses and strong association with neuritic plaques in alzheimer's disease (ad). |
1999-01-26 |
2023-08-12 |
mouse |
| D Giulian, L J Haverkamp, J Yu, W Karshin, D Tom, J Li, A Kazanskaia, J Kirkpatrick, A E Rohe. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease. The Journal of biological chemistry. vol 273. issue 45. 1998-12-10. PMID:9792685. |
the beta-amyloid peptide 1-42 (abeta1-42), a major component of neuritic and core plaques found in alzheimer's disease, activates microglia to kill neurons. |
1998-12-10 |
2023-08-12 |
human |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in alzheimer's disease. |
1998-12-07 |
2023-08-12 |
Not clear |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
activated microglia overexpressing interleukin-1 (il-1) are prominent neuropathological features of alzheimer's disease. |
1998-12-07 |
2023-08-12 |
Not clear |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
we used computerized image analysis to determine the number of il-1 alpha-immunoreactive (il-1 alpha +) microglia in cytoarchitectonic layers of parahippocampal gyrus (brodmann's area 28) of alzheimer and control patients. |
1998-12-07 |
2023-08-12 |
Not clear |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
for cortical layers i and ii, the numbers of il-1 alpha + microglia were similar in alzheimer and control patients. |
1998-12-07 |
2023-08-12 |
Not clear |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
for layers iii-vi, the numbers of il-1 alpha + microglia were higher than that seen in layers i-ii for both alzheimer and control patients. |
1998-12-07 |
2023-08-12 |
Not clear |
| J G Sheng, W S Griffin, M C Royston, R E Mra. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathology and applied neurobiology. vol 24. issue 4. 1998-12-07. PMID:9775393. |
moreover, for layers iii-vi, the number of il-1 alpha + microglia in alzheimer patients was significantly greater than that in control patients (relative alzheimer values of threefold for layer iii-v and twofold for layer vi; p < 0.05 in each case). |
1998-12-07 |
2023-08-12 |
Not clear |