| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G M Cole, M D Ar. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936886. |
differences in apoe-e4, -e3, and -e2 isoforms with respect to abeta binding to lipoproteins and delivery to cells, including microglia, may contribute to the increased risk of alzheimer's disease for people with an apoe4 genotype and to risk reduction with apoe2. |
2000-10-04 |
2023-08-12 |
Not clear |
| D Lorton, J Schaller, A Lala, E De Nardi. Chemotactic-like receptors and Abeta peptide induced responses in Alzheimer's disease. Neurobiology of aging. vol 21. issue 3. 2000-09-07. PMID:10858596. |
evidence suggests that beta-amyloid (abeta) has chemokine-like properties and may act through formyl chemotactic receptors (fpr) to induce pathophysiologically important functional changes in alzheimer's disease (ad) microglia. |
2000-09-07 |
2023-08-12 |
human |
| L G Sheffield, J G Marquis, N E Berma. Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease. Neuroscience letters. vol 285. issue 3. 2000-08-01. PMID:10806312. |
regional distribution of cortical microglia parallels that of neurofibrillary tangles in alzheimer's disease. |
2000-08-01 |
2023-08-12 |
Not clear |
| L G Sheffield, J G Marquis, N E Berma. Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease. Neuroscience letters. vol 285. issue 3. 2000-08-01. PMID:10806312. |
it has been postulated that microglia contribute to the development of neurofibrillary tangles (nft) in alzheimer's disease (ad). |
2000-08-01 |
2023-08-12 |
Not clear |
| G Mehlhorn, M Hollborn, R Schlieb. Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 4-5. 2000-07-17. PMID:10817926. |
beta-amyloid plaque deposition observed in brains from alzheimer patients, might function as immune stimulus for glial/macrophages activation, which is supported by observations of activated microglia expressing interleukin (il)-1beta and elevated il-6 immunoreactivity in close proximity to amyloid plaques. |
2000-07-17 |
2023-08-12 |
mouse |
| D L Gilber. Fifty years of radical ideas. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863525. |
next, carol a. colton and i showed that in the mammalian brain that stimulated microglia produce the superoxide radical anion and its implications in alzheimer's disease is discussed. |
2000-07-13 |
2023-08-12 |
human |
| C A Colton, O N Chernyshev, D L Gilbert, M P Vite. Microglial contribution to oxidative stress in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863548. |
microglia are the cns macrophage and are a primary cellular component of plaques in alzheimer's disease (ad) that may contribute to the oxidative stress associated with chronic neurodegeneration. |
2000-07-13 |
2023-08-12 |
human |
| M I Brazil, H Chung, F R Maxfiel. Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. The Journal of biological chemistry. vol 275. issue 22. 2000-07-11. PMID:10747968. |
effects of incorporation of immunoglobulin g and complement component c1q on uptake and degradation of alzheimer's disease amyloid fibrils by microglia. |
2000-07-11 |
2023-08-12 |
Not clear |
| Y M Arends, C Duyckaerts, J M Rozemuller, P Eikelenboom, J J Hau. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiology of aging. vol 21. issue 1. 2000-07-07. PMID:10794847. |
microglia, amyloid and dementia in alzheimer disease. |
2000-07-07 |
2023-08-12 |
Not clear |
| Y M Arends, C Duyckaerts, J M Rozemuller, P Eikelenboom, J J Hau. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiology of aging. vol 21. issue 1. 2000-07-07. PMID:10794847. |
to elucidate the role of microglia in alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the blessed test score (bts). |
2000-07-07 |
2023-08-12 |
Not clear |
| J I Engelhardt, W D Le, L Siklós, I Obál, K Boda, S H Appe. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Archives of neurology. vol 57. issue 5. 2000-06-01. PMID:10815134. |
the participation of an immune/inflammatory process in the pathomechanism of sporadic alzheimer disease (ad) has been suggested by evidence for activated microglia and the potential therapeutic benefit of anti-inflammatory medication. |
2000-06-01 |
2023-08-12 |
Not clear |
| E Lewandowska, E Bertrand, J Kulczycki, W Lipczyńska-Lojkowska, W Lechowicz, J Stankiewic. Microglia and neuritic plaques in familial Alzheimer's disease induced by a new mutation of presenilin-1 gene. An ultrastructural study. Folia neuropathologica. vol 37. issue 4. 2000-04-27. PMID:10705645. |
microglia and neuritic plaques in familial alzheimer's disease induced by a new mutation of presenilin-1 gene. |
2000-04-27 |
2023-08-12 |
Not clear |
| K T Akama, L J Van Eldi. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713108. |
in alzheimer's disease, beta-amyloid (abeta) plaques are surrounded by activated astrocytes and microglia. |
2000-04-12 |
2023-08-12 |
Not clear |
| P J Kingham, J M Pococ. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737601. |
chromogranin a is up-regulated in the senile plaques of alzheimer's brain and is a novel activator of microglia, transforming them to a neurotoxic phenotype. |
2000-04-11 |
2023-08-12 |
rat |
| S D Webster, A J Yang, L Margol, W Garzon-Rodriguez, C G Glabe, A J Tenne. Complement component C1q modulates the phagocytosis of Abeta by microglia. Experimental neurology. vol 161. issue 1. 2000-03-23. PMID:10683279. |
recent studies showing that microglia internalize the amyloid beta-peptide (abeta) suggest that these cells have the potential for clearing abeta deposits in alzheimer's disease, and mechanisms that regulate the removal of abeta may therefore be of clinical interest. |
2000-03-23 |
2023-08-12 |
rat |
| S L Yates, L H Burgess, J Kocsis-Angle, J M Antal, M D Dority, P B Embury, A M Piotrkowski, K R Brunde. Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693932. |
activated microglia surrounding amyloid beta-containing senile plaques synthesize interleukin-1, an inflammatory cytokine that has been postulated to contribute to alzheimer's disease pathology. |
2000-03-09 |
2023-08-12 |
mouse |
| A Klegeris, P L McGee. Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells. Journal of leukocyte biology. vol 67. issue 1. 2000-02-09. PMID:10648007. |
microglia become activated in a wide range of neurodegenerative disorders, including alzheimer's disease. |
2000-02-09 |
2023-08-12 |
human |
| T A Bayer, R Buslei, L Havas, P Falka. Evidence for activation of microglia in patients with psychiatric illnesses. Neuroscience letters. vol 271. issue 2. 2000-01-21. PMID:10477118. |
additionally alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. |
2000-01-21 |
2023-08-12 |
human |
| T A Bayer, R Buslei, L Havas, P Falka. Evidence for activation of microglia in patients with psychiatric illnesses. Neuroscience letters. vol 271. issue 2. 2000-01-21. PMID:10477118. |
all patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; alzheimer's disease, four patients) in both gray and white matter. |
2000-01-21 |
2023-08-12 |
human |
| J Tan, T Town, D Paris, T Mori, Z Suo, F Crawford, M P Mattson, R A Flavell, M Mulla. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science (New York, N.Y.). vol 286. issue 5448. 2000-01-10. PMID:10600748. |
alzheimer's disease (ad) has a substantial inflammatory component, and activated microglia may play a central role in neuronal degeneration. |
2000-01-10 |
2023-08-12 |
mouse |