| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Chung, M I Brazil, T T Soe, F R Maxfiel. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. The Journal of biological chemistry. vol 274. issue 45. 1999-12-13. PMID:10542270. |
in alzheimer's disease brain, activated microglia are concentrated in regions of compact amyloid deposits that contain the 39-43-amino acid abeta peptide. |
1999-12-13 |
2023-08-12 |
Not clear |
| T Yamada, Y Tsujioka, J Taguchi, M Takahashi, Y Tsuboi, I Moroo, J Yang, W A Jefferie. Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease. Brain research. vol 845. issue 1. 1999-12-10. PMID:10529437. |
melanotransferrin is produced by senile plaque-associated reactive microglia in alzheimer's disease. |
1999-12-10 |
2023-08-12 |
human |
| F Huang, M Buttini, T Wyss-Coray, L McConlogue, T Kodama, R E Pitas, L Muck. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. The American journal of pathology. vol 155. issue 5. 1999-11-30. PMID:10550330. |
the class a scavenger receptor (sr) is expressed on reactive microglia surrounding cerebral amyloid plaques in alzheimer's disease (ad). |
1999-11-30 |
2023-08-12 |
mouse |
| M P Marzolo, R von Bernhardi, N C Inestros. Mannose receptor is present in a functional state in rat microglial cells. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518112. |
because there is evidence suggesting that manr could mediate some of the nonenzymatic effects of acetilcholinesterase (ache) and the enzyme seems to be involved in alzheimer's disease (ad), we looked for manr in microglia, evaluating the functionality of the receptor. |
1999-11-23 |
2023-08-12 |
human |
| J Hu, L J Van Eldi. Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain research. vol 842. issue 1. 1999-11-19. PMID:10526094. |
a prominent feature of alzheimer's disease (ad) pathology is an abundance of activated glia (astrocytes and microglia) in close proximity to the amyloid plaques. |
1999-11-19 |
2023-08-12 |
rat |
| A V Yermakova, J Rollins, L M Callahan, J Rogers, M K O'Banio. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. Journal of neuropathology and experimental neurology. vol 58. issue 11. 1999-11-17. PMID:10560656. |
cyclooxygenase-1 in human alzheimer and control brain: quantitative analysis of expression by microglia and ca3 hippocampal neurons. |
1999-11-17 |
2023-08-12 |
human |
| B L Fiebich, T J Hofer, K Lieb, M Huell, R D Butcher, G Schumann, K Schulze-Osthoff, J Baue. The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471086. |
since cytokines such as interleukin-1 (il-1) or interleukin-6 (il-6) as well as acute-phase proteins such as alpha1-anti-chymotrypsin (act) participate in the etiopathology of alzheimer's disease (ad), we were interested whether tepoxalin is able to inhibit the synthesis of these immunomodulators in primary rat microglia and astrocytes as well as in the human astrocytoma cell line u373 mg. we found that tepoxalin markedly inhibits il-1beta-induced il-6 and act synthesis in astrocytes and the synthesis of il-1beta and il-6 in lipopolysaccharide (lps)-stimulated microglial cells. |
1999-10-25 |
2023-08-12 |
human |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
these results suggest that, at the pathological sites where extracellular k+ concentration may increase, the activation of microglia by amyloid-beta peptide causes an increase in extracellular glutamate concentration via reverse glutamate transporter, and therefore this mechanism may contribute to the pathogenesis of neuronal dysfunction and death in alzheimer's disease. |
1999-10-08 |
2023-08-12 |
rat |
| G M Cole, W Beech, S A Frautschy, J Sigel, C Glasgow, M D Ar. Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. Journal of neuroscience research. vol 57. issue 4. 1999-09-09. PMID:10440900. |
an inflammatory response involving activated microglia in neuritic beta-amyloid plaques is found in alzheimer's disease (ad) brain. |
1999-09-09 |
2023-08-12 |
rat |
| A Klegeris, D G Walker, P L McGee. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428420. |
there is mounting evidence that inflammatory processes, including activation of microglia, are upregulated in alzheimer's disease. |
1999-09-03 |
2023-08-12 |
human |
| P J Kingham, M L Cuzner, J M Pococ. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428049. |
senile plaques of alzheimer's brain are characterized by activated microglia and immunoreactivity for the peptide chromogranin a. |
1999-08-13 |
2023-08-12 |
rat |
| D Giulia. Microglia and the immune pathology of Alzheimer disease. American journal of human genetics. vol 65. issue 1. 1999-08-05. PMID:10364511. |
microglia and the immune pathology of alzheimer disease. |
1999-08-05 |
2023-08-12 |
Not clear |
| M O McCarron, J A Nicoll, J Stewart, J W Ironside, D M Mann, S Love, D I Graham, D Dewa. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411341. |
we performed immunohistochemistry for amyloid beta-protein (a beta), apoe, cystatin c, and activated microglia, and examined the morphology of cortical and leptomeningeal vessels in 37 caa-related hemorrhage (caah), 26 alzheimer disease (ad) patients, and 20 controls. |
1999-07-27 |
2023-08-12 |
Not clear |
| G Stoll, S Jande. The role of microglia and macrophages in the pathophysiology of the CNS. Progress in neurobiology. vol 58. issue 3. 1999-07-20. PMID:10341362. |
in alzheimer's disease activated microglia appear to be involved in plaque formation. |
1999-07-20 |
2023-08-12 |
human |
| D W Dickso. Microglia in Alzheimer's disease and transgenic models. How close the fit? The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362785. |
microglia in alzheimer's disease and transgenic models. |
1999-07-14 |
2023-08-12 |
Not clear |
| M Stalder, A Phinney, A Probst, B Sommer, M Staufenbiel, M Jucke. Association of microglia with amyloid plaques in brains of APP23 transgenic mice. The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362792. |
microglia are a key component of the inflammatory response in the brain and are associated with senile plaques in alzheimer's disease (ad). |
1999-07-14 |
2023-08-12 |
mouse |
| P E Lipsk. The clinical potential of cyclooxygenase-2-specific inhibitors. The American journal of medicine. vol 106. issue 5B. 1999-07-08. PMID:10390128. |
further, cox-2 expression may be up-regulated at certain sites: in the kidney during sodium restriction; in the microglia of cognitive centers within the hippocampus and cortex in alzheimer's disease; and in intestinal adenomas and colon tumors. |
1999-07-08 |
2023-08-12 |
human |
| L Meda, P Baron, E Prat, E Scarpini, G Scarlato, M A Cassatella, F Ross. Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. Journal of neuroimmunology. vol 93. issue 1-2. 1999-07-01. PMID:10378868. |
taken together, these data indicate that a beta-phagocyte interaction can drive a different response towards cytokine production by monocytes and microglia, with a particular proinflammatory trend, and further support a role for a beta deposition as a triggering factor of inflammatory events in alzheimer's disease. |
1999-07-01 |
2023-08-12 |
mouse |
| M Johnstone, A J Gearing, K M Mille. A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. Journal of neuroimmunology. vol 93. issue 1-2. 1999-07-01. PMID:10378882. |
alzheimer's disease (ad) is the commonest form of adult onset dementia and is characterised neuropathologically by the accumulation of plaques containing beta-amyloid (a beta) fibrils, reactive astrocytes, activated microglia, and leukocytes. |
1999-07-01 |
2023-08-12 |
Not clear |
| A Garlind, A Brauner, B Höjeberg, H Basun, M Schultzber. Soluble interleukin-1 receptor type II levels are elevated in cerebrospinal fluid in Alzheimer's disease patients. Brain research. vol 826. issue 1. 1999-06-16. PMID:10216202. |
proinflammatory cytokines such as interleukin-1 (il-1), interleukin-6 (il-6) and tumour necrosis factor-alpha (tnf-alpha) have been found in activated microglia in the vicinity of amyloid plaques in alzheimer's disease brain. |
1999-06-16 |
2023-08-12 |
human |