| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L N Nilsson, S Das, H Potte. Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578771. |
proinflammatory cytokines and acute phase proteins, such as alpha(1)-antichymotrypsin, are over expressed in microglia and astrocytes in brain regions with abundant mature amyloid plaques, suggesting a glial cell-led brain acute phase response in the alzheimer neuropathology. |
2001-12-28 |
2023-08-12 |
human |
| T Town, J Tan, M Mulla. CD40 signaling and Alzheimer's disease pathogenesis. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578772. |
based on the involvement of microglial activation and brain inflammation in alzheimer's disease pathogenesis, we have investigated co-stimulation of microglia, smooth muscle, and endothelial cells with cd40 ligand in the presence of low doses of freshly solubilized amyloid-beta peptides. |
2001-12-28 |
2023-08-12 |
Not clear |
| E N Benveniste, V T Nguyen, G M O'Keef. Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578773. |
immunological aspects of microglia: relevance to alzheimer's disease. |
2001-12-28 |
2023-08-12 |
Not clear |
| D M Watterson, S Mirzoeva, L Guo, A Whyte, J J Bourguignon, M Hibert, J Haiech, L J Van Eldi. Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578781. |
activated glia (astrocytes and microglia) and their associated neuroinflammatory sequelae have been linked to the disease progression of several neurodegenerative disorders, including alzheimer's disease. |
2001-12-28 |
2023-08-12 |
Not clear |
| M R Dandrea, P A Reiser, N A Gumula, B M Hertzog, P Andrade-Gordo. Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 76. issue 2. 2001-12-04. PMID:11440311. |
inflammation, characterized by the presence of activated microglia and reactive astrocytes (gliosis), has been described in alzheimer's disease (ad). |
2001-12-04 |
2023-08-12 |
Not clear |
| R von Bernhardi, G Ramírez, H Matile, H Döbel. Immobilized amyloid precursor protein constructs: a tool for the in vitro screening of glial cell reactivity. The European journal of neuroscience. vol 14. issue 6. 2001-12-04. PMID:11595033. |
astrocytes and microglia are closely associated with amyloid plaques in alzheimer's disease (ad). |
2001-12-04 |
2023-08-12 |
mouse |
| G P Lim, T Chu, F Yang, W Beech, S A Frautschy, G M Col. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 21. 2001-12-04. PMID:11606625. |
inflammation in alzheimer's disease (ad) patients is characterized by increased cytokines and activated microglia. |
2001-12-04 |
2023-08-12 |
mouse |
| J Satoh, Y Kurod. Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 21. issue 2. 2001-10-25. PMID:11396676. |
both tnf-alpha and il-1, aberrantly produced by activated microglia and astrocytes, play a role in amyloidogenesis and neurodegeneration in the brains of alzheimer's disease (ad) patients, while bdnf synthesized chiefly by neurons has been found to be substantially reduced in ad brains. |
2001-10-25 |
2023-08-12 |
human |
| F Muehlhauser, U Liebl, S Kuehl, S Walter, T Bertsch, K Fassbende. Aggregation-Dependent interaction of the Alzheimer's beta-amyloid and microglia. Clinical chemistry and laboratory medicine. vol 39. issue 4. 2001-10-18. PMID:11388654. |
aggregation-dependent interaction of the alzheimer's beta-amyloid and microglia. |
2001-10-18 |
2023-08-12 |
rat |
| H Hasegawa, M Nakai, S Tanimukai, T Taniguchi, A Terashima, T Kawamata, K Fukunaga, E Miyamoto, K Misaki, H Mukai, C Tanak. Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS. Neuroreport. vol 12. issue 11. 2001-09-20. PMID:11496150. |
in alzheimer disease (ad), activated microglia expressing marcks migrates around senile plaques. |
2001-09-20 |
2023-08-12 |
rat |
| O M Mitrasinovic, G V Perez, F Zhao, Y L Lee, C Poon, G M Murph. Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11387343. |
microglia are important in the inflammatory response in alzheimer's disease (ad). |
2001-09-06 |
2023-08-12 |
mouse |
| H Rempel, L Kusdra, L Pullia. Interleukin-1beta up-regulates expression of neurofilament light in human neuronal cells. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483667. |
elevated expression of interleukin-1 (il-1beta), a pro-inflammatory cytokine secreted by activated microglia, is a pathogenic marker of numerous neurodegenerative processes including alzheimer's disease (ad). |
2001-08-30 |
2023-08-12 |
human |
| S Johnso. Gradual micronutrient accumulation and depletion in Alzheimer's disease. Medical hypotheses. vol 56. issue 6. 2001-08-23. PMID:11399105. |
on the other hand, the risk of developing alzheimer's disease increases considerably with age and it involves neuronal damage by hyperactive microglia (brain macrophages). |
2001-08-23 |
2023-08-12 |
Not clear |
| S Johnso. Gradual micronutrient accumulation and depletion in Alzheimer's disease. Medical hypotheses. vol 56. issue 6. 2001-08-23. PMID:11399105. |
therefore, it is possible that cd also hyperactivates the microglia, playing a role in alzheimer's disease (ad).fe also accumulates in the brain as we age and catalyzes super oxide (o2-) formation, which reacts with nitric oxide (no) to form the very harmful peroxynitrite (onoo-). |
2001-08-23 |
2023-08-12 |
Not clear |
| L F Lue, R Rydel, E F Brigham, L B Yang, H Hampel, G M Murphy, L Brachova, S D Yan, D G Walker, Y Shen, J Roger. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia. vol 35. issue 1. 2001-08-23. PMID:11424194. |
inflammatory repertoire of alzheimer's disease and nondemented elderly microglia in vitro. |
2001-08-23 |
2023-08-12 |
human |
| L F Lue, R Rydel, E F Brigham, L B Yang, H Hampel, G M Murphy, L Brachova, S D Yan, D G Walker, Y Shen, J Roger. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia. vol 35. issue 1. 2001-08-23. PMID:11424194. |
we have previously developed and characterized isolated microglia and astrocyte cultures from rapid (<4 h) brain autopsies of alzheimer's disease (ad) and nondemented elderly control (nd) patients. |
2001-08-23 |
2023-08-12 |
human |
| H L Tiffany, M C Lavigne, Y H Cui, J M Wang, T L Leto, J L Gao, P M Murph. Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11316806. |
potential biological relevance of these results to the neuroinflammation associated with alzheimer's disease was suggested by two additional findings: first, fpr2 mrna could be detected by pcr in mouse brain; second, induction of fpr2 expression correlated with induction of calcium flux and chemotaxis by amyloid-beta in the mouse microglial cell line n9. |
2001-08-16 |
2023-08-12 |
mouse |
| H A Smits, A J van Beelen, N M de Vos, A Rijsmus, T van der Bruggen, J Verhoef, F L van Muiswinkel, H S Notte. Activation of human macrophages by amyloid-beta is attenuated by astrocytes. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 11. 2001-08-16. PMID:11359847. |
in alzheimer's disease, neuritic amyloid-beta plaques along with surrounding activated microglia and astrocytes are thought to play an important role in the inflammatory events leading to neurodegeneration. |
2001-08-16 |
2023-08-12 |
human |
| M Stalder, T Deller, M Staufenbiel, M Jucke. 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid. Neurobiology of aging. vol 22. issue 3. 2001-07-26. PMID:11378249. |
microglia cells are closely associated with compact amyloid plaques in alzheimer's disease (ad) brains. |
2001-07-26 |
2023-08-12 |
mouse |
| M Nakai, S Tanimukai, K Yagi, N Saito, T Taniguchi, A Terashima, T Kawamata, H Yamamoto, K Fukunaga, E Miyamoto, C Tanak. Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia. Neurochemistry international. vol 38. issue 7. 2001-07-12. PMID:11290384. |
the increased accumulation of activated microglia containing amyloid beta protein (abeta) around senile plaques is a common pathological feature in subjects with alzheimer's disease (ad). |
2001-07-12 |
2023-08-12 |
human |