| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andis Klegeris, Patrick L McGee. Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiology of aging. vol 23. issue 5. 2003-01-10. PMID:12392782. |
reactive microglia are found in increased numbers in aging brain and are prominently associated with lesions in such age-related degenerative conditions as alzheimer's disease (ad), parkinson's disease (pd) and amyotrophic lateral sclerosis (als). |
2003-01-10 |
2023-08-12 |
human |
| J M Pocock, A C Liddle, C Hooper, D L Taylor, C M Davenport, S C Morga. Activated microglia in Alzheimer's disease and stroke. Ernst Schering Research Foundation workshop. issue 39. 2002-12-06. PMID:12066408. |
activated microglia in alzheimer's disease and stroke. |
2002-12-06 |
2023-08-12 |
Not clear |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with alzheimer's disease. |
2002-11-29 |
2023-08-12 |
Not clear |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
the extent of microglial cell activation (microglial cell load) was estimated by image analysis of ferritin-immunostained sections of frontal cortex from 72 patients with pathologically confirmed alzheimer's disease (ad), and correlated with the amount of pathological tau and amyloid beta protein (abeta), as both abeta(40) and abeta(42) load, in adjacent sections of the same cases. |
2002-11-29 |
2023-08-12 |
Not clear |
| Jeroen J M Hoozemans, Robert Veerhuis, Ingrid Janssen, Evert-Jan van Elk, Annemieke J M Rozemuller, Piet Eikelenboo. The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease. Brain research. vol 951. issue 2. 2002-11-25. PMID:12270500. |
the role of cyclo-oxygenase 1 and 2 activity in prostaglandin e(2) secretion by cultured human adult microglia: implications for alzheimer's disease. |
2002-11-25 |
2023-08-12 |
human |
| S Vogelgesang, E Schroeder, L C Walker, J Pahnke, A Naubereit, R Walther, D Stausske, R W Warzo. Activated microglia do not mediate the early deposition of Abeta in carriers of the apolipoprotein Eepsilon4 allele. Clinical neuropathology. vol 21. issue 3. 2002-11-18. PMID:12049183. |
activated microglia are a prominent component of the senile plaques in end-stage alzheimer's disease, but whether microglia contribute to the initiation of the lesions remains unknown. |
2002-11-18 |
2023-08-12 |
Not clear |
| Jon Infante, Javier Llorca, José Berciano, Onofre Combarro. No synergistic effect between -850 tumor necrosis factor-alpha promoter polymorphism and apolipoprotein E epsilon 4 allele in Alzheimer's disease. Neuroscience letters. vol 328. issue 1. 2002-10-28. PMID:12123862. |
in the brains of alzheimer's disease (ad) patients, microglia cells are activated and produce inflammatory mediators such as tumor necrosis factor-alpha (tnf-alpha). |
2002-10-28 |
2023-08-12 |
human |
| M Fiala, Q N Liu, J Sayre, V Pop, V Brahmandam, M C Graves, H V Vinter. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. European journal of clinical investigation. vol 32. issue 5. 2002-10-18. PMID:12027877. |
in alzheimer's disease brain, the origin of activated microglia has not been determined. |
2002-10-18 |
2023-08-12 |
Not clear |
| D L Taylor, L T Diemel, M L Cuzner, J M Pococ. Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358765. |
chromogranin a, a secretory peptide expressed in amyloid plaques in alzheimer's disease, activates microglia to a reactive neurotoxic phenotype. |
2002-10-18 |
2023-08-12 |
Not clear |
| Olivera M Mitrasinovic, Greer M Murph. Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12032144. |
microglia surrounding a beta plaques in alzheimer's disease and in the appv717f transgenic mouse model of alzheimer's disease have enhanced immunoreactivity for the macrophage colony-stimulating factor receptor (m-csfr), encoded by the proto-oncogene c-fms. |
2002-09-20 |
2023-08-12 |
mouse |
| M I Combrinck, V H Perry, C Cunningha. Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience. vol 112. issue 1. 2002-09-06. PMID:12044467. |
there is anecdotal evidence suggesting that peripheral infections in patients with alzheimer's disease have more severe behavioural consequences than those in otherwise healthy elderly subjects, and it is well known that brain microglia are activated in the elderly and in alzheimer's disease (mcgeer et al., 1987). |
2002-09-06 |
2023-08-12 |
human |
| G Münch, S R Robinso. Potential neurotoxic inflammatory responses to Abeta vaccination in humans. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 7-8. 2002-09-06. PMID:12111445. |
studies in transgenic mouse models of alzheimer's disease suggested the development of a vaccine that would induce the production of antibodies against amyloid-beta (abeta) peptide, which in turn would stimulate microglia to phagocytose and remove senile plaques. |
2002-09-06 |
2023-08-12 |
mouse |
| Yong B Lee, Atsushi Nagai, Seung U Ki. Cytokines, chemokines, and cytokine receptors in human microglia. Journal of neuroscience research. vol 69. issue 1. 2002-09-04. PMID:12111820. |
present results should help in understanding the basic microglial biology, but also the pathophysiology of activated microglia in neurological diseases such as alzheimer disease, parkinson disease, huntington disease, amyotrophic lateral sclerosis, stroke, and neurotrauma. |
2002-09-04 |
2023-08-12 |
human |
| X Bi, C M Gall, J Zhou, G Lync. Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088742. |
increased sequestration was accompanied by two characteristics of early stage alzheimer's disease: elevated concentrations of cathepsin d immunoreactivity and activation of microglia. |
2002-09-03 |
2023-08-12 |
Not clear |
| Onofre Combarros, Jon Infante, Javier Llorca, Nicolás Peña, Carlos Fernández-Viadero, José Bercian. The myeloperoxidase gene in Alzheimer's disease: a case-control study and meta-analysis. Neuroscience letters. vol 326. issue 1. 2002-08-28. PMID:12052532. |
myeloperoxidase (mpo) presence has been demonstrated in microglia associated with senile plaques, and contributes to alzheimer's disease (ad) pathology through oxidation-induced damage. |
2002-08-28 |
2023-08-12 |
human |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
cd36, a class b scavenger receptor, is expressed on microglia in alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. |
2002-07-05 |
2023-08-12 |
mouse |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
a pathological hallmark of alzheimer's disease is the senile plaque, composed of beta-amyloid fibrils, microglia, astrocytes, and dystrophic neurites. |
2002-07-05 |
2023-08-12 |
mouse |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
we also found that cd36 is expressed on microglia and on vascular endothelial cells in the brains of alzheimer's disease patients. |
2002-07-05 |
2023-08-12 |
mouse |
| Jürgen Haas, Brigitte Storch-Hagenlocher, Annette Biessmann, Brigitte Wildeman. Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro. Neuroscience letters. vol 322. issue 2. 2002-05-29. PMID:11958858. |
in alzheimer's disease (ad), amyloid plaques within the brain are surrounded by activated glial cells (microglia and astrocytes). |
2002-05-29 |
2023-08-12 |
rat |
| Zhong Xie, Min Wei, Todd E Morgan, Paola Fabrizio, Derick Han, Caleb E Finch, Valter D Long. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978825. |
these results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in abeta1-42 neurotoxicity and alzheimer's disease. |
2002-05-20 |
2023-08-12 |
rat |