| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Malchiodi-Albedi, M R Domenici, S Paradisi, A Bernardo, M A Ajmone-Cat, L Minghett. Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons. Glia. vol 34. issue 1. 2001-06-14. PMID:11284021. |
astrocytosis is a common feature of amyloid plaques, the hallmark of alzheimer's disease (ad), along with activated microglia, neurofibrillary tangles, and beta-amyloid (beta a) deposition. |
2001-06-14 |
2023-08-12 |
rat |
| J Tan, T Town, T Mori, Y Wu, M Saxe, F Crawford, M Mulla. CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027218. |
reactive microglia have been suggested to play a role in the alzheimer's disease (ad) process, and previous studies have shown that expression of cd45, a membrane-bound protein-tyrosine phosphatase (ptp), is elevated in microglia in ad brain compared with controls. |
2001-06-07 |
2023-08-12 |
mouse |
| C K Combs, J C Karlo, S C Kao, G E Landret. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 4. 2001-06-07. PMID:11160388. |
reactive microglia associated with the beta-amyloid plaques in alzheimer's disease (ad) brains initiate a sequence of inflammatory events integral to the disease process. |
2001-06-07 |
2023-08-12 |
mouse |
| C K Combs, J C Karlo, S C Kao, G E Landret. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 4. 2001-06-07. PMID:11160388. |
this study demonstrates a functional linkage between beta-amyloid-dependent activation of microglia and several characteristic markers of neuronal death occurring in alzheimer's disease brains. |
2001-06-07 |
2023-08-12 |
mouse |
| R Tehranian, H Hasanvan, K Iverfeldt, C Post, M Schultzber. Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576. Neuroscience letters. vol 301. issue 1. 2001-06-07. PMID:11239715. |
the neuropathological changes in alzheimer's disease (ad) include the occurrence of activated microglia and astrocytes. |
2001-06-07 |
2023-08-12 |
mouse |
| S Chabot, D Charlet, T L Wilson, V W Yon. Cytokine production consequent to T cell--microglia interaction: the PMA/IFN gamma-treated U937 cells display similarities to human microglia. Journal of neuroscience methods. vol 105. issue 2. 2001-05-31. PMID:11275268. |
since this interaction can occur in a non-antigen-dependent manner, it is relevant to a variety of cns diseases where activated t cells, regardless of specificities, come into contact with microglia; these disorders include multiple sclerosis, trauma, stroke and alzheimer's disease. |
2001-05-31 |
2023-08-12 |
human |
| J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santo. CD45: new jobs for an old acquaintance. Nature immunology. vol 2. issue 5. 2001-05-31. PMID:11323691. |
in addition, loss of cd45 can affect microglia activation in a mouse model for alzheimer's disease. |
2001-05-31 |
2023-08-12 |
mouse |
| K Imamura, M Sawada, N Ozaki, H Naito, N Iwata, R Ishihara, T Takeuchi, H Shibayam. Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease. Alzheimer disease and associated disorders. vol 15. issue 1. 2001-05-10. PMID:11236824. |
activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with alzheimer disease. |
2001-05-10 |
2023-08-12 |
human |
| K Imamura, M Sawada, N Ozaki, H Naito, N Iwata, R Ishihara, T Takeuchi, H Shibayam. Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease. Alzheimer disease and associated disorders. vol 15. issue 1. 2001-05-10. PMID:11236824. |
in this study, we investigated the distribution of human leukocyte antigen (hla)-dr-positive activated microglia in postmortem brain tissue of six patients with dntc and six patients with alzheimer disease (ad). |
2001-05-10 |
2023-08-12 |
human |
| J Satoh, Y Kurod. Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 20. issue 4. 2001-04-12. PMID:11211053. |
because activated microglia and astrocytes play a role in amyloidogenesis in alzheimer's disease, the constitutive and glial cytokine/growth factor-regulated expression of bace was studied in human neural cell lines. |
2001-04-12 |
2023-08-12 |
human |
| J Kakimura, Y Kitamura, T Taniguchi, S Shimohama, P J Gebicke-Haerte. Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. Biochemical and biophysical research communications. vol 281. issue 1. 2001-04-05. PMID:11178952. |
in the brains of alzheimer's disease (ad) patients, fibrillar amyloid-beta peptides (abeta) are markedly accumulated and the microglia associate with the amyloid plaques. |
2001-04-05 |
2023-08-12 |
Not clear |
| J Husemann, S C Silverstei. Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain. The American journal of pathology. vol 158. issue 3. 2001-04-05. PMID:11238031. |
in alzheimer's disease (ad), fibrillar beta-amyloid protein (fabeta) accumulates in the walls of cerebral vessels associated with vascular smooth muscle cells (smcs), endothelium, and pericytes, and with microglia and astrocytes in plaques in the brain parenchyma. |
2001-04-05 |
2023-08-12 |
mouse |
| J J Hoozemans, A J Rozemuller, I Janssen, C J De Groot, R Veerhuis, P Eikelenboo. Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain. Acta neuropathologica. vol 101. issue 1. 2001-03-22. PMID:11194936. |
cyclooxygenase expression in microglia and neurons in alzheimer's disease and control brain. |
2001-03-22 |
2023-08-12 |
human |
| J P Konsman, D Blond, S Vigue. Neurobiology of interleukin-1 receptors: getting the message. European cytokine network. vol 11. issue 4. 2001-03-08. PMID:11125316. |
two years later, il-1 immunoreactivity was shown in microglia of patients with alzheimer's disease [2]. |
2001-03-08 |
2023-08-12 |
Not clear |
| A M Szczepanik, S Funes, W Petko, G E Ringhei. IL-4, IL-10 and IL-13 modulate A beta(1--42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. Journal of neuroimmunology. vol 113. issue 1. 2001-02-08. PMID:11137576. |
a hallmark of the immunopathology associated with alzheimer's disease (ad) is the presence of activated microglia surrounding senile plaque deposits of beta-amyloid (a beta) peptides. |
2001-02-08 |
2023-08-12 |
human |
| L Bertram, D Blacker, K Mullin, D Keeney, J Jones, S Basu, S Yhu, M G McInnis, R C Go, K Vekrellis, D J Selkoe, A J Saunders, R E Tanz. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (New York, N.Y.). vol 290. issue 5500. 2001-01-04. PMID:11125142. |
recent studies suggest that insulin-degrading enzyme (ide) in neurons and microglia degrades abeta, the principal component of beta-amyloid and one of the neuropathological hallmarks of alzheimer's disease (ad). |
2001-01-04 |
2023-08-12 |
Not clear |
| O Ogawa, H Umegaki, D Sumi, T Hayashi, A Nakamura, N K Thakur, J Yoshimura, H Endo, A Iguch. Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells. European journal of pharmacology. vol 408. issue 2. 2000-12-27. PMID:11080519. |
recent studies show that a mononuclear phagocyte lineage, including microglia, plays a possible role in the pathogenesis of alzheimer's disease through nitric oxide (no)-mediated neurotoxicity. |
2000-12-27 |
2023-08-12 |
Not clear |
| P L McGeer, E G McGeer, K Yasojim. Alzheimer disease and neuroinflammation. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961418. |
it is now generally accepted that the lesions of alzheimer disease (ad) are associated with a host of inflammatory molecules, including complement proteins, as well as with many activated microglia. |
2000-12-22 |
2023-08-12 |
Not clear |
| Q Xu, Y Li, C Cyras, D A Sanan, B Cordel. Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle. The Journal of biological chemistry. vol 275. issue 41. 2000-11-13. PMID:10918055. |
it is unclear if microglia can modulate pathogenesis of alzheimer's disease by secreting lipoprotein particles. |
2000-11-13 |
2023-08-12 |
rat |
| S O'Barr, N R Coope. The C5a complement activation peptide increases IL-1beta and IL-6 release from amyloid-beta primed human monocytes: implications for Alzheimer's disease. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996210. |
alzheimer's disease (ad) brains contain large numbers of amyloid-beta peptide (abeta) deposits associated with activated microglia, astrocytes and dystrophic neurites. |
2000-10-12 |
2023-08-12 |
human |