| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
cd36, a class b scavenger receptor, is expressed on microglia in alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. |
2002-07-05 |
2023-08-12 |
mouse |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
a pathological hallmark of alzheimer's disease is the senile plaque, composed of beta-amyloid fibrils, microglia, astrocytes, and dystrophic neurites. |
2002-07-05 |
2023-08-12 |
mouse |
| Indra Sethy Coraci, Jens Husemann, Joan W Berman, Christine Hulette, Jennifer H Dufour, Gabriele K Campanella, Andrew D Luster, Samuel C Silverstein, Joseph B El-Khour. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. The American journal of pathology. vol 160. issue 1. 2002-07-05. PMID:11786404. |
we also found that cd36 is expressed on microglia and on vascular endothelial cells in the brains of alzheimer's disease patients. |
2002-07-05 |
2023-08-12 |
mouse |
| Jürgen Haas, Brigitte Storch-Hagenlocher, Annette Biessmann, Brigitte Wildeman. Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro. Neuroscience letters. vol 322. issue 2. 2002-05-29. PMID:11958858. |
in alzheimer's disease (ad), amyloid plaques within the brain are surrounded by activated glial cells (microglia and astrocytes). |
2002-05-29 |
2023-08-12 |
rat |
| Zhong Xie, Min Wei, Todd E Morgan, Paola Fabrizio, Derick Han, Caleb E Finch, Valter D Long. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978825. |
these results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in abeta1-42 neurotoxicity and alzheimer's disease. |
2002-05-20 |
2023-08-12 |
rat |
| Xiaorei Sai, Yuuki Kawamura, Koichi Kokame, Haruyasu Yamaguchi, Hirohisa Shiraishi, Ryo Suzuki, Toshiharu Suzuki, Masashi Kawaichi, Toshiyuki Miyata, Toshio Kitamura, Bart De Strooper, Katsuhiko Yanagisawa, Hiroto Koman. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. The Journal of biological chemistry. vol 277. issue 15. 2002-05-16. PMID:11799129. |
moreover, the antibody strongly stained activated microglia in senile plaques in the brain of patients with alzheimer disease. |
2002-05-16 |
2023-08-12 |
human |
| Giovanni Perini, Vittorina Della-Bianca, Valeria Politi, Giuliano Della Valle, Ilaria Dal-Pra, Filippo Rossi, Ubaldo Armat. Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. The Journal of experimental medicine. vol 195. issue 7. 2002-05-09. PMID:11927634. |
the neurodegenerative changes in alzheimer's disease (ad) are elicited by the accumulation of beta-amyloid peptides (abeta), which damage neurons either directly by interacting with components of the cell surface to trigger cell death signaling or indirectly by activating astrocytes and microglia to produce inflammatory mediators. |
2002-05-09 |
2023-08-12 |
Not clear |
| M Hüll, K Lieb, B L Fiebic. Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs. Current medicinal chemistry. vol 9. issue 1. 2002-04-18. PMID:11860350. |
in alzheimer's disease (ad), signs of an inflammatory activation of microglia and astroglia are present inside and outside amyloid deposits. |
2002-04-18 |
2023-08-12 |
human |
| Douglas G Walker, Lih-Fen Lue, Thomas G Beac. Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains. Brain research. vol 926. issue 1-2. 2002-04-04. PMID:11814408. |
its role in inflammatory responses of microglia in alzheimer's disease (ad) has not been previously investigated. |
2002-04-04 |
2023-08-12 |
human |
| G M Szpak, W Lechowicz, E Lewandowska, E Bertrand, T Wierzba-Bobrowicz, E Gwiazda, B Schmidt-Sidor, J Dymeck. Neurones and microglia in central nervous system immune response to degenerative processes. Part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study. Folia neuropathologica. vol 39. issue 3. 2002-03-19. PMID:11770129. |
the quantitative correlation between neurone loss and brain immune response, assessed by intensity of microglia inflammatory reaction in cortical association area and limbic cortex, was investigated and compared in previously immunohistochemistry (ihc) and ultrastructural confirmed 11 cases of alzheimer's disease (ad), 7 cases mixed form of dementia with ad findings and lewy bodies (ad/dlb) reported, in accordance with consortium on dementia, as lewy body variant of ad (lbv) and 6 non-demented autopsy control cases from 63 to 86 years old. |
2002-03-19 |
2023-08-12 |
Not clear |
| G M Szpak, W Lechowicz, E Lewandowska, E Bertrand, T Wierzba-Bobrowicz, E Gwiazda, B Schmidt-Sidor, J Dymeck. Neurones and microglia in central nervous system immune response to degenerative processes. Part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study. Folia neuropathologica. vol 39. issue 3. 2002-03-19. PMID:11770129. |
in alzheimer's disease, neurone loss in association temporal cortex made up 51% of control values with simultaneous 8-fold increase in the density of mhc ii-positive activated microglia, whereas in lbv, both the loss of neurone density and the increase in activated microglia density, was not so high (up to 41% and 4-5-fold, respectively). |
2002-03-19 |
2023-08-12 |
Not clear |
| R E Mrak, W S Griffinb. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754999. |
astrocytic overexpression of s100b, in turn, is promoted by high levels of interleukin-1 (il-1), originating from activated microglia that are also constant components of abeta plaques in alzheimer's disease. |
2002-02-28 |
2023-08-12 |
Not clear |
| L Meda, P Baron, G Scarlat. Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754995. |
a common feature of alzheimer's disease (ad) pathology is the abundance of reactive astrocytes and activated microglia in close proximity to neuritic plaques containing amyloid-beta protein (abeta). |
2002-02-28 |
2023-08-12 |
Not clear |
| L Guo, A Sawkar, M Zasadzki, D M Watterson, L J Van Eldi. Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11755006. |
activated glia (astrocytes and microglia) surrounding neuritic plaques in alzheimer's disease (ad) overexpress an array of detrimental inflammatory molecules. |
2002-02-28 |
2023-08-12 |
rat |
| D G Walker, L F Lue, T G Beac. Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11755004. |
activation of microglia is a central part of the chronic inflammatory processes in alzheimer's disease (ad). |
2002-02-28 |
2023-08-12 |
human |
| B Van Everbroeck, E Dewulf, Ph Pals, U Lübke, J-J Martin, P Cra. The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease. Neurobiology of aging. vol 23. issue 1. 2002-02-28. PMID:11755020. |
our results showed increased numbers of astrocytes in cjd and increased numbers of microglia and apoptotic neurons both in cjd and alzheimer's disease (ad) as compared to controls. |
2002-02-28 |
2023-08-12 |
Not clear |
| R von Bernhardi, G Ramire. Microglia-astrocyte interaction in Alzheimer's disease: friends or foes for the nervous system? Biological research. vol 34. issue 2. 2002-01-24. PMID:11715204. |
activated microglia and astrocytes closely associate to amyloid plaques in alzheimer disease (ad). |
2002-01-24 |
2023-08-12 |
Not clear |
| H Neuman. Control of glial immune function by neurons. Glia. vol 36. issue 2. 2002-01-04. PMID:11596127. |
in contrast, in a variety of inflammatory and neurodegenerative diseases, including multiple sclerosis, infections, trauma, stroke, neoplasia, and alzheimer's disease, glial cells such as microglia gain antigen-presenting capacity through the expression of major histocompatibility complex (mhc) molecules. |
2002-01-04 |
2023-08-12 |
Not clear |
| J G Sheng, R A Jones, X Q Zhou, J M McGinness, L J Van Eldik, R E Mrak, W S Griffi. Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578769. |
we found frequent colocalization of hyperphosphorylated tau protein (at8 antibody) and activated mapk-p38 in neurons and in dystrophic neurites in alzheimer brain, and frequent association of these structures with activated microglia overexpressing il-1. |
2001-12-28 |
2023-08-12 |
rat |
| J Rogers, L F Lu. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578768. |
microglia are widely held to play important pathophysiologic roles in alzheimer's disease (ad). |
2001-12-28 |
2023-08-12 |
Not clear |