| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
triggering receptor on myeloid cells 2 (trem2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in alzheimer's disease (ad). |
2022-12-08 |
2023-08-14 |
mouse |
| Ruxin Zhang, Yanrong Song, Xuefeng S. Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463451. |
the keywords in the search included: "necroptosis", "alzheimer's disease", "signaling pathways", "aβ", aβo", "tau", "p-tau", "neuronal death", "bbb damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "nec-1", "nec-1s", "gsk872", "nsa", "oga", "ripk1", "ripk3", and "mlkl". |
2022-12-04 |
2023-08-14 |
Not clear |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the activation of microglia and astrocytes present in this area causes neuro-degenerative diseases, such as alzheimer's disease (ad) and parkinson's disease (pd). |
2022-11-26 |
2023-08-14 |
Not clear |
| Rezwanul Islam, Robin Rajan, Hadi Choudhary, Frank Vrionis, Khalid A Hanaf. Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis. Journal of cellular physiology. 2022-11-21. PMID:36409648. |
gender differences in alzheimer's may be associated with tlr4-lyn expression in damage associated microglia and neuronal phagocytosis. |
2022-11-21 |
2023-08-14 |
mouse |
| Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Isabel Carreras, Alpaslan Dedeogl. Dysregulation of Sphingosine-1-Phosphate (S1P) and S1P Receptor 1 Signaling in the 5xFAD Mouse Model of Alzheimer's Disease. Brain research. 2022-11-21. PMID:36410428. |
our recent studies have shown that treatment with fingolimod, an analog of sphingosine, provides neuroprotective effects in five familiar alzheimer disease (5xfad) transgenic mice, resulting in the reduction of amyloid-β (aβ) neurotoxicity, inhibition of activation of microglia and astrocytes, increased hippocampal neurogenesis, and improved learning and memory. |
2022-11-21 |
2023-08-14 |
mouse |
| Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A Garcia, Christopher D Link, Charles Hoeffer, Anushree Chatterjee, Prashant Nagpa. Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine. ACS chemical neuroscience. 2022-11-21. PMID:36410860. |
however, chronic neuroinflammation leading to the activation of immune cells like microglia and astrocytes causes damage to the nervous tissue, and it is causally linked to a range of neurodegenerative diseases such as alzheimer's diseases (ad), multiple sclerosis (ms), parkinson's disease (pd), and many others. |
2022-11-21 |
2023-08-14 |
mouse |
| Mohsen Farhangian, Forouzan Azarafrouz, Sara Chavoshinezhad, Leila Dargah. Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model. Neuroscience letters. 2022-11-17. PMID:36396023. |
intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an alzheimer's disease model. |
2022-11-17 |
2023-08-14 |
human |
| Sam J Washer, Marta Perez-Alcantara, Yixi Chen, Juliette Steer, William S James, Gosia Trynka, Andrew R Bassett, Sally A Cowle. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Scientific reports. vol 12. issue 1. 2022-11-14. PMID:36376339. |
there is increasing genetic evidence for the role of microglia in neurodegenerative diseases, including alzheimer's, parkinson's, and motor neuron disease. |
2022-11-14 |
2023-08-14 |
human |
| José A Fernández-Albarral, Elena Salobrar-García, José A Matamoros, Cristina Fernández-Mendívil, Eric Del Sastre, Lejing Chen, Rosa de Hoz, Inés López-Cuenca, Lidia Sánchez-Puebla, José M Ramírez, Juan J Salazar, Manuela G Lopez, Ana I Ramíre. Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358522. |
with aging and, especially, in alzheimer's patients, the inducible enzyme heme oxygenase 1 (ho-1) progressively increases in microglia, causing iron accumulation, neuroinflammation, and neurodegeneration. |
2022-11-11 |
2023-08-14 |
mouse |
| Lukas Busch, Simone Eggert, Kristina Endres, Bernd Buf. The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease. Cells. vol 11. issue 21. 2022-11-11. PMID:36359817. |
recent advances have placed the pro-inflammatory activity of amyloid β (aβ) on microglia cells as the focus of research on alzheimer's disease (ad). |
2022-11-11 |
2023-08-14 |
Not clear |
| Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gess. Microglia and Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361780. |
microglia and alzheimer's disease. |
2022-11-11 |
2023-08-14 |
Not clear |
| Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan L. Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in immunology. vol 13. 2022-11-10. PMID:36353622. |
neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as alzheimer's disease, parkinson's disease, depression, and stroke. |
2022-11-10 |
2023-08-14 |
Not clear |
| Guodong Yang, Yufu Liu, Yonglin Liu, Yu Ma, Yiguang Li, Jie Che. Integrating network pharmacology and an experimental validation strategy elucidates the protective effect and mechanism of callicarpa nudiflora against neuroinflammation. RSC advances. vol 12. issue 48. 2022-11-09. PMID:36349022. |
abnormal activation of microglia promotes neuroinflammation (ni) in alzheimer's disease (ad). |
2022-11-09 |
2023-08-14 |
Not clear |
| Sanjeevini Babu Reddiar, Michael de Veer, Brett M Paterson, Tara Sepehrizadeh, Dorothy C C Wai, Agota Csoti, Gyorgy Panyi, Joseph A Nicolazzo, Raymond S Norto. A Biodistribution Study of the Radiolabeled Kv1.3-Blocking Peptide DOTA-HsTX1[R14A] Demonstrates Brain Uptake in a Mouse Model of Neuroinflammation. Molecular pharmaceutics. 2022-11-04. PMID:36331024. |
the voltage-gated potassium channel kv1.3 regulates the pro-inflammatory function of microglia and is highly expressed in the post-mortem brains of individuals with alzheimer's and parkinson's diseases. |
2022-11-04 |
2023-08-14 |
mouse |
| Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tan. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. 2022-11-01. PMID:36318443. |
numerous studies have proven that microglia can participate in the occurrence and progression of neurodegenerative diseases (ndds), such as alzheimer's disease (ad), by regulating synaptic plasticity. |
2022-11-01 |
2023-08-14 |
Not clear |
| Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L Poliani, Wandy L Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H Ellebedy, Susan Gilfillan, Gordon D Brown, David M Holtzman, Simone Brioschi, Marco Colonn. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell. vol 185. issue 22. 2022-10-28. PMID:36306735. |
genetic studies have highlighted microglia as pivotal in orchestrating alzheimer's disease (ad). |
2022-10-28 |
2023-08-14 |
human |
| Moonseok Choi, Dongsoo Kim, Young-Jin Youn, Junghwa Ryu, Yun Ha Jeon. Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer's Disease in High-Fat Diet-Fed Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293147. |
the typical pathological features of alzheimer's disease (ad) are the accumulation of amyloid plaques in the brain and reactivity of glial cells such as astrocytes and microglia. |
2022-10-27 |
2023-08-14 |
mouse |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
dysfunctional microglia and tau pathology in alzheimer's disease. |
2022-10-27 |
2023-08-14 |
human |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in alzheimer's disease (ad) and other tauopathies. |
2022-10-27 |
2023-08-14 |
human |
| Insup Choi, George R Heaton, You-Kyung Lee, Zhenyu Yu. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Science advances. vol 8. issue 43. 2022-10-26. PMID:36288297. |
in alzheimer's disease animal models, microglia play a critical role in regulating amyloid plaque formation and neurotoxicity. |
2022-10-26 |
2023-08-14 |
Not clear |