| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippa Malko, Sharifah A Syed Mortadza, Joseph McWilliam, Lin-Hua Jian. TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30914955. |
however, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of cns pathologies, including ischemic stroke, traumatic brain damage, alzheimer's disease, parkinson's disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Anele Romeo, Alberto Faggioni, Mara Ciron. Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease? Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089040. |
moreover, herpesvirus infection of central nervous system cells such as glia and microglia can increase the production of oxidant species through the alteration of mitochondrial dynamics and promote inflammation, another hallmark of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
human |
| Run-Hong Tang, Rui-Qun Qi, Hua-Yan Li. Interleukin-4 affects microglial autophagic flux. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089059. |
these results indicate that interleukin-4 pretreated microglia increases uptake and degradation of amyloid-β in a process partly mediated by autophagy, which may play a protective role against alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Suvi Pöyhönen, Safak Er, Andrii Domanskyi, Mikko Airavaar. Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury. Frontiers in physiology. vol 10. 2020-10-01. PMID:31105589. |
an increasing amount of evidence points to the critical importance of glia in mediating neurodegeneration in alzheimer's and parkinson's diseases (ad, pd), and in ischemic stroke, where microglia are involved in initial tissue clearance, and astrocytes in the subsequent formation of a glial scar. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. |
phagocytosis of apoptotic cells is specifically upregulated in apoe4 expressing microglia alzheimer's disease (ad) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (aβ). |
2020-10-01 |
2023-08-13 |
human |
| Tamar Gefen, Garam Kim, Kabriya Bolbolan, Andrew Geoly, Daniel Ohm, Carly Oboudiyat, Ryan Shahidehpour, Alfred Rademaker, Sandra Weintraub, Eileen H Bigio, M-Marsel Mesulam, Emily Rogalski, Changiz Geul. Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31139072. |
activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related neurodegenerative disorders, such as alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
human |
| Mathilde Cheray, Vassilis Stratoulias, Bertrand Joseph, Kathleen Graber. The Rules of Engagement: Do Microglia Seal the Fate in the Inverse Relation of Glioma and Alzheimer's Disease? Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31824268. |
the rules of engagement: do microglia seal the fate in the inverse relation of glioma and alzheimer's disease? |
2020-10-01 |
2023-08-13 |
Not clear |
| Atreyi Ghatak, Colin K Comb. Iba1 immunoreactivity is enhanced following an antigen retrieval treatment with EDTA, pH 6.0. MethodsX. vol 1. 2020-09-30. PMID:25485234. |
in this study, we tested whether antigen retrieval methods would increase the sensitivity or improve the morphologic visualization of iba1 immunoreactive microglia in the brains of wild type c57bl/6 mice and an app/ps1 mouse model of alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
mouse |
| Julia E Love, Ryan J Day, Justin W Gause, Raquel J Brown, Xinzhu Pu, Dustin I Theis, Chad A Caraway, Wayne W Poon, Abir A Rahman, Brad E Morrison, Troy T Roh. Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain. International journal of physiology, pathophysiology and pharmacology. vol 9. issue 2. 2020-09-30. PMID:28533891. |
nuclear uptake of an amino-terminal fragment of apolipoprotein e4 promotes cell death and localizes within microglia of the alzheimer's disease brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xingzhi Guo, Peng Tang, Li Chen, Peng Liu, Chen Hou, Xin Zhang, Yue Liu, Li Chong, Xiaoqing Li, Rui L. Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28769785. |
impaired clearance of amyloid β (aβ) by microglia in the brain may be associated with the senile plaque formation, a pathological hallmark relevant to alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kevin A Clayton, Alicia A Van Enoo, Tsuneya Ikez. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:29311768. |
alzheimer's disease: the role of microglia in brain homeostasis and proteopathy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zsuzsanna Szepesi, Oscar Manouchehrian, Sara Bachiller, Tomas Deierbor. Bidirectional Microglia-Neuron Communication in Health and Disease. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30319362. |
we summarize the current state of knowledge of physiological role and function of microglia during brain development and in the mature brain and further highlight microglial contribution to brain pathologies such as alzheimer's and parkinson's disease, brain ischemia, traumatic brain injury, brain tumor as well as neuropsychiatric diseases (depression, bipolar disorder, and schizophrenia). |
2020-09-30 |
2023-08-13 |
Not clear |
| Thomas M Piers, Emma East, Claudio Villegas-Llerena, Ioanna G Sevastou, Mar Matarin, John Hardy, Jennifer M Pococ. Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30524237. |
here we show that the blood coagulation factor fibrinogen (fg), implicated in the pathogenesis of dementias such as alzheimer's disease (ad), induces an inflammatory microglial phenotype as identified through genetic microarray analysis of a microglial cell line, and proteome cytokine profiling of primary microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bhaskar C Das, Somsankar Dasgupta, Swapan K Ra. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural regeneration research. vol 14. issue 11. 2020-09-30. PMID:31290437. |
retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Christa Løth Myhre, Camilla Thygesen, Birgitte Villadsen, Jeanette Vollerup, Laura Ilkjær, Katrine Tækker Krohn, Manuela Grebing, Shuainan Zhao, Asif Manzoor Khan, Lasse Dissing-Olesen, Morten Skovgaard Jensen, Alicia A Babcock, Bente Finse. Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31417357. |
knowing the capacity of chronically activated microglia to produce igf-1 may therefore show essential to promote beneficial microglial functions in alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Anne-Laure Hemonnot, Jennifer Hua, Lauriane Ulmann, Hélène Hirbe. Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31543810. |
microglia in alzheimer disease: well-known targets and new opportunities. |
2020-09-30 |
2023-08-13 |
human |
| Anne-Laure Hemonnot, Jennifer Hua, Lauriane Ulmann, Hélène Hirbe. Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31543810. |
in alzheimer disease (ad), microglia reaction was initially thought to be incidental and triggered by amyloid deposits and dystrophic neurites. |
2020-09-30 |
2023-08-13 |
human |
| Hailan Yao, Kyle Coppola, Jonas Elias Schweig, Fiona Crawford, Michael Mullan, Daniel Pari. Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31649511. |
several genetic variants of the triggering receptor expressed on myeloid cells-2 (trem2) have been shown to increase the risk of developing alzheimer's disease (ad) supporting a role of microglia and immune cells in the pathobiology of ad. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jenny U Johansson, Nathaniel S Woodling, Holden D Brown, Qian Wang, Katrin I Andreasso. Microarray analysis of the in vivo response of microglia to Aβ peptides in mice with conditional deletion of the prostaglandin EP2 receptor. Genomics data. vol 5. 2020-09-29. PMID:26251825. |
amyloid-β (aβ) peptides accumulate in the brains of patients with alzheimer's disease (ad), where they generate a persistent inflammatory response from microglia, the innate immune cells of the brain. |
2020-09-29 |
2023-08-13 |
mouse |
| Douglas G Walker, Tiffany M Tang, Lih-Fen Lu. Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:28848420. |
studies on colony stimulating factor receptor-1 and ligands colony stimulating factor-1 and interleukin-34 in alzheimer's disease brains and human microglia. |
2020-09-29 |
2023-08-13 |
human |