| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongmin Xiang, Vahram Haroutunian, Lap Ho, Dushant Purohit, Giulio Maria Pasinett. Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia. Disease markers. vol 22. issue 1-2. 2006-03-17. PMID:16410654. |
microglia activation in the brain as inflammatory biomarker of alzheimer's disease neuropathology and clinical dementia. |
2006-03-17 |
2023-08-12 |
human |
| Zhongmin Xiang, Vahram Haroutunian, Lap Ho, Dushant Purohit, Giulio Maria Pasinett. Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia. Disease markers. vol 22. issue 1-2. 2006-03-17. PMID:16410654. |
in this study, postmortem brain sections from ad and control cases were subjected to human leukocyte antigen (hla)-dr immunohistochemistry to examine microglia activation in the progression of ad assessed by pre-mortem clinical dementia rating (cdr) and postmortem pathological manifestations of neuritic plaque (np) and neurofibrillary tangle (nt) according to the consortium to establish a registry for alzheimer's disease (cerad). |
2006-03-17 |
2023-08-12 |
human |
| Edith G McGeer, Andis Klegeris, Patrick L McGee. Inflammation, the complement system and the diseases of aging. Neurobiology of aging. vol 26 Suppl 1. 2006-03-14. PMID:16198446. |
neuropathological evidence of activated microglia and activated astrocytes in lesioned areas, combined with epidemiological evidence of sparing of alzheimer's disease (ad), parkinson's disease (pd) and age-related macular degeneration (amd) in long-term users of anti-inflammatory agents, indicates that inflammation is autodestructive of neurons. |
2006-03-14 |
2023-08-12 |
Not clear |
| Olivera M Mitrasinovic, Alicia Grattan, Christopher C Robinson, Nicolae B Lapustea, Clara Poon, Heather Ryan, Connie Phong, Greer M Murph. Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858070. |
microglia with increased expression of the macrophage colony-stimulating factor receptor (m-csfr; c-fms) are found surrounding plaques in alzheimer's disease (ad) and in mouse models for ad and after ischemic or traumatic brain injury. |
2006-03-09 |
2023-08-12 |
mouse |
| Angela M Floden, Shanshan Li, Colin K Comb. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758166. |
although abundant reactive microglia are found associated with beta-amyloid (abeta) plaques in alzheimer's disease (ad) brains, their contribution to cell loss remains speculative. |
2006-03-02 |
2023-08-12 |
mouse |
| Jessica Koenigsknecht-Talboo, Gary E Landret. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 36. 2006-03-02. PMID:16148231. |
microglia undergo a phenotypic activation in response to fibrillar beta-amyloid (fabeta) deposition in the brains of alzheimer's disease (ad) patients, resulting in their elaboration of inflammatory molecules. |
2006-03-02 |
2023-08-12 |
Not clear |
| Ghania Ait-Ghezala, Venkatarajan S Mathura, Vincent Laporte, Amita Quadros, Daniel Paris, Nikunj Patel, Claude-Henry Volmar, Deepak Kolippakkam, Fiona Crawford, Mike Mulla. Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease. Brain research. Molecular brain research. vol 140. issue 1-2. 2006-02-03. PMID:16182406. |
genomic regulation after cd40 stimulation in microglia: relevance to alzheimer's disease. |
2006-02-03 |
2023-08-12 |
mouse |
| Jennifer Chen, Yungui Zhou, Sarah Mueller-Steiner, Lin-Feng Chen, Hakju Kwon, Saili Yi, Lennart Mucke, Li Ga. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. The Journal of biological chemistry. vol 280. issue 48. 2006-02-03. PMID:16183991. |
here we demonstrate that nf-kappab signaling in microglia is critically involved in neuronal death induced by amyloid-beta (abeta) peptides, which are widely presumed to cause alzheimer disease. |
2006-02-03 |
2023-08-12 |
Not clear |
| Terrence Town, Veljko Nikolic, Jun Ta. The microglial "activation" continuum: from innate to adaptive responses. Journal of neuroinflammation. vol 2. 2006-01-23. PMID:16259628. |
this interpretation has relevance for neurodegenerative/neuroinflammatory diseases where reactive microglia play an etiological role; in particular viral/bacterial encephalitis, multiple sclerosis and alzheimer disease. |
2006-01-23 |
2023-08-12 |
Not clear |
| Jeroen J M Hoozemans, Elise S van Haastert, Robert Veerhuis, Thomas Arendt, Wiep Scheper, Piet Eikelenboom, Annemieke J M Rozemulle. Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. Journal of neuroinflammation. vol 2. 2006-01-23. PMID:16300681. |
maximal cox-2 and pprb expression in neurons occurs during early braak stages prior to the maximal activation of astrocytes and microglia in alzheimer's disease. |
2006-01-23 |
2023-08-12 |
Not clear |
| Seong Soo Joo, Do Ik Le. Potential effects of microglial activation induced by ginsenoside Rg3 in rat primary culture: enhancement of type A Macrophage Scavenger Receptor expression. Archives of pharmacal research. vol 28. issue 10. 2005-12-23. PMID:16276974. |
brain microglia are phagocytic cells that are the major inflammatory response cells of the central nervous system and widely held to play important pathophysiologic roles in alzheimer's disease (ad) in both potentially neurotoxic responses and potentially beneficial phagocytic responses. |
2005-12-23 |
2023-08-12 |
rat |
| Nada A Abumrad, Mohammad Ajmal, Kostas Pothakos, John K Robinso. CD36 expression and brain function: does CD36 deficiency impact learning ability? Prostaglandins & other lipid mediators. vol 77. issue 1-4. 2005-12-15. PMID:16099393. |
this article first presents an overview of published literature documenting the role of the scavenger receptor cd36 in activation of brain microglia with reference to brain pathologies such as alzheimer's and malaria. |
2005-12-15 |
2023-08-12 |
mouse |
| Annemieke J M Rozemuller, Willem A van Gool, Piet Eikelenboo. The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: therapeutic implications. Current drug targets. CNS and neurological disorders. vol 4. issue 3. 2005-11-15. PMID:15975026. |
the amyloid plaques in alzheimer's disease (ad) brains are co-localised with a broad variety of inflammation-related proteins (complement proteins, acute-phase proteins, pro-inflammatory cytokines) and clusters of activated microglia. |
2005-11-15 |
2023-08-12 |
mouse |
| L-F Lue, S D Yan, D M Stern, D G Walke. Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease. Current drug targets. CNS and neurological disorders. vol 4. issue 3. 2005-11-15. PMID:15975028. |
analysis of rage expression in non-demented and alzheimer's disease (ad) brains indicated that increases in rage protein and percentage of rage-expressing microglia paralleled the severity of disease. |
2005-11-15 |
2023-08-12 |
human |
| S Rosi, C B Pert, M R Ruff, K McGann-Gramling, G L Wen. Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience. vol 134. issue 2. 2005-11-15. PMID:15979806. |
chemokine receptor 5 antagonist d-ala-peptide t-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of alzheimer's disease. |
2005-11-15 |
2023-08-12 |
rat |
| James G McLarnon, Hyun B Choi, Lih-Fen Lue, Douglas G Walker, Seung U Ki. Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15948178. |
perturbations in calcium-mediated signal transduction in microglia from alzheimer's disease patients. |
2005-11-07 |
2023-08-12 |
human |
| James G McLarnon, Hyun B Choi, Lih-Fen Lue, Douglas G Walker, Seung U Ki. Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15948178. |
calcium-sensitive fluorescence microscopy has been used to study ca2+-dependent signal transduction pathways in microglia obtained from alzheimer's disease (ad) patients and non-demented (nd) individuals. |
2005-11-07 |
2023-08-12 |
human |
| Seung U Kim, Jean de Velli. Microglia in health and disease. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15954124. |
it was del rio hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there has been wide recognition that microglia are immune effectors in the cns that respond to pathological conditions and participate in initiation and progression of neurological disorders including alzheimer's disease, parkinson's disease, multiple sclerosis, and acquired immune deficiency syndrome dementia complex by releasing potentially cytotoxic molecules such as proinflammatory cytokines, reactive oxygen intermediates, proteinases and complement proteins. |
2005-11-07 |
2023-08-12 |
Not clear |
| D G Walker, L-F Lu. Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15957156. |
investigations with cultured human microglia on pathogenic mechanisms of alzheimer's disease and other neurodegenerative diseases. |
2005-11-07 |
2023-08-12 |
mouse |
| C E Shepherd, G C Gregory, J C Vickers, G M Hallida. Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease. Neuropathology and applied neurobiology. vol 31. issue 5. 2005-10-27. PMID:16150121. |
inflammation, in the form of reactive astrocytes and microglia, is thought to play an important role in alzheimer's disease (ad) pathogenesis where it correlates with brain atrophy and disease severity. |
2005-10-27 |
2023-08-12 |
Not clear |