| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Ye, Xinquan Li, Peng Zhou, Shu Ye, Huawu Gao, Rupeng Hua, Junlong Ma, Yan Wang, Biao Ca. Chrysophanol improves memory ability of d-galactose and Aβ 3 Biotech. vol 10. issue 3. 2021-03-02. PMID:32117672. |
an alzheimer's disease rat model was established using an intraperitoneal injection of d-galactose combined with an intracerebral injection of amyloid-β peptide (25-35), and the effect of chr on the learning and memory ability, the hippocampal neurons change, the ultrastructure of the hippocampal ca1 region, the protein levels of cam, camkk, camkiv, p-camkiv and p-tau in the hippocampus of rats were studied. |
2021-03-02 |
2023-08-13 |
rat |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
alzheimer's disease is characterized by the presence of amyloid-β and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43 and tau have also been linked to hippocampal atrophy in cases of primary age-related tauopathy, a pathological entity with features that strongly overlap with those of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
we therefore aimed to model how these proteins, particularly tdp-43, influence non-linear trajectories of hippocampal and neocortical atrophy in alzheimer's disease and primary age-related tauopathy. |
2021-03-01 |
2023-08-13 |
Not clear |
| Cyrille Sur, James Kost, David Scott, Katarzyna Adamczuk, Nick C Fox, Jeffrey L Cummings, Pierre N Tariot, Paul S Aisen, Bruno Vellas, Tiffini Voss, Erin Mahoney, Yuki Mukai, Matthew E Kennedy, Christopher Lines, David Michelson, Michael F Ega. BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33253354. |
in the phase 3 epoch trial (clinicaltrials.gov; nct01739348), treatment with the bace inhibitor verubecestat failed to improve cognition in patients with mild-to-moderate alzheimer's disease, but was associated with reduced hippocampal volume after 78 weeks as assessed by mri. |
2021-03-01 |
2023-08-13 |
human |
| Aydin Saribudak, Adarsha A Subick, Na Hyun Kim, Joshua A Rutta, M Umit Uya. Gene Expressions, Hippocampal Volume Loss, and MMSE Scores in Computation of Progression and Pharmacologic Therapy Effects for Alzheimer's Disease. IEEE/ACM transactions on computational biology and bioinformatics. vol 17. issue 2. 2021-03-01. PMID:31722481. |
gene expressions, hippocampal volume loss, and mmse scores in computation of progression and pharmacologic therapy effects for alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Aydin Saribudak, Adarsha A Subick, Na Hyun Kim, Joshua A Rutta, M Umit Uya. Gene Expressions, Hippocampal Volume Loss, and MMSE Scores in Computation of Progression and Pharmacologic Therapy Effects for Alzheimer's Disease. IEEE/ACM transactions on computational biology and bioinformatics. vol 17. issue 2. 2021-03-01. PMID:31722481. |
expressions of ad related genes, mini mental state examination (mmse) scores, and hippocampal volume measurements of mci patients are obtained from the alzheimer's disease neuroimaging initiative (adni) database. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sheng-Tao Yang, Min Wang, Veronica Galvin, Yang Yang, Amy F T Arnste. Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance. Psychopharmacology. vol 238. issue 1. 2021-02-26. PMID:32939596. |
metabotropic glutamate type 5 receptor (mglur5) antagonists are under development for treating cognitive disorders such as fragile x syndrome and alzheimer's disease, largely based on success in mouse models, where post-synaptic mglur5 stimulation weakens synaptic functions in hippocampus. |
2021-02-26 |
2023-08-13 |
mouse |
| Alena O Burnyasheva, Tatiana A Kozlova, Natalia A Stefanova, Nataliya G Kolosova, Ekaterina A Rudnitskay. Cognitive Training as a Potential Activator of Hippocampal Neurogenesis in the Rat Model of Sporadic Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:32977423. |
cognitive training as a potential activator of hippocampal neurogenesis in the rat model of sporadic alzheimer's disease. |
2021-02-23 |
2023-08-13 |
rat |
| Hossein Tabatabaei-Jafari, Marnie E Shaw, Erin Walsh, Nicolas Cherbui. Cognitive/Functional Measures Predict Alzheimer's Disease, Dependent on Hippocampal Volume. The journals of gerontology. Series B, Psychological sciences and social sciences. vol 75. issue 7. 2021-02-23. PMID:30668830. |
cognitive/functional measures predict alzheimer's disease, dependent on hippocampal volume. |
2021-02-23 |
2023-08-13 |
Not clear |
| Hossein Tabatabaei-Jafari, Marnie E Shaw, Erin Walsh, Nicolas Cherbui. Cognitive/Functional Measures Predict Alzheimer's Disease, Dependent on Hippocampal Volume. The journals of gerontology. Series B, Psychological sciences and social sciences. vol 75. issue 7. 2021-02-23. PMID:30668830. |
this study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (hcv) on the probability of conversion from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2021-02-23 |
2023-08-13 |
Not clear |
| Abdallah Ahnaou, Daniela Rodriguez-Manrique, Ria Biermans, Sofie Embrechts, Nikolay V Manyakov, Wilhelmus H Drinkenbur. Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 15. 2021-02-22. PMID:32751531. |
functional alterations in the olfactory neuronal circuit occur before hippocampal plasticity deficits in the p301s mouse model of tauopathy: implications for early diagnosis and translational research in alzheimer's disease. |
2021-02-22 |
2023-08-13 |
mouse |
| Volkan Nurdal, Alfie Wearn, Michael Knight, Risto Kauppinen, Elizabeth Coulthar. Prospective memory in prodromal Alzheimer's disease: Real world relevance and correlations with cortical thickness and hippocampal subfield volumes. NeuroImage. Clinical. vol 26. 2021-02-22. PMID:32151996. |
prospective memory in prodromal alzheimer's disease: real world relevance and correlations with cortical thickness and hippocampal subfield volumes. |
2021-02-22 |
2023-08-13 |
Not clear |
| Thomas Shaw, Ashley York, Maryam Ziaei, Markus Barth, Steffen Bollman. Longitudinal Automatic Segmentation of Hippocampal Subfields (LASHiS) using multi-contrast MRI. NeuroImage. vol 218. 2021-02-22. PMID:32311467. |
the volumetric and morphometric examination of hippocampus formation subfields in a longitudinal manner using in vivo mri could lead to more sensitive biomarkers for neuropsychiatric disorders and diseases including alzheimer's disease, as the anatomical subregions are functionally specialised. |
2021-02-22 |
2023-08-13 |
human |
| Aihua Qu, Maozhong Sun, Ji-Young Kim, Liguang Xu, Changlong Hao, Wei Ma, Xiaoling Wu, Xiaogang Liu, Hua Kuang, Nicholas A Kotov, Chuanlai X. Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies. Nature biomedical engineering. vol 5. issue 1. 2021-02-19. PMID:33106615. |
when implanted in the hippocampus of a mouse model of alzheimer's disease, neural stem cells illuminated following a polarity-optimized protocol reduced the formation of amyloid plaques by more than 70%. |
2021-02-19 |
2023-08-13 |
mouse |
| Sonam Dubey, Stefan Heinen, Slavica Krantic, JoAnne McLaurin, Donald R Branch, Kullervo Hynynen, Isabelle Auber. Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 51. 2021-02-19. PMID:33288687. |
clinically approved ivig delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of alzheimer's disease. |
2021-02-19 |
2023-08-13 |
mouse |
| Roshni Patel, Michael Aschne. Commonalities between Copper Neurotoxicity and Alzheimer's Disease. Toxics. vol 9. issue 1. 2021-02-18. PMID:33430181. |
alzheimer's disease, a highly prevalent form of dementia, targets neuron function beginning from the hippocampal region and expanding outwards. |
2021-02-18 |
2023-08-13 |
Not clear |
| Roshni Patel, Michael Aschne. Commonalities between Copper Neurotoxicity and Alzheimer's Disease. Toxics. vol 9. issue 1. 2021-02-18. PMID:33430181. |
our review corroborates that both copper and alzheimer's disease target the hippocampus, cerebral cortex, cerebellum, and brainstem, affecting motor skills and critical thinking. |
2021-02-18 |
2023-08-13 |
Not clear |
| Manhua Liu, Fan Li, Hao Yan, Kundong Wang, Yixin Ma, Li Shen, Mingqing X. A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer's disease. NeuroImage. vol 208. 2021-02-17. PMID:31837471. |
a multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in alzheimer's disease. |
2021-02-17 |
2023-08-13 |
human |