| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Schifilliti, Letterio B Santamaria, Giovanni Rosa, Gianfranco Di Nino, Pravat K Mandal, Vincenzo Fodal. Cholinergic central system, Alzheimer's disease, and anesthetics liaison: a vicious circle? Journal of Alzheimer's disease : JAD. vol 22 Suppl 3. 2011-03-04. PMID:20858949. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation and aggregation of amyloid-β peptide and loss of forebrain cholinergic neurons, resulting in progressive loss of memory and irreversible impairment of higher cognitive functions. |
2011-03-04 |
2023-08-12 |
Not clear |
| Brian R Hoover, Miranda N Reed, Jianjun Su, Rachel D Penrod, Linda A Kotilinek, Marianne K Grant, Rose Pitstick, George A Carlson, Lorene M Lanier, Li-Lian Yuan, Karen H Ashe, Dezhi Lia. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. vol 68. issue 6. 2011-01-19. PMID:21172610. |
the microtubule-associated protein tau accumulates in alzheimer's and other fatal dementias, which manifest when forebrain neurons die. |
2011-01-19 |
2023-08-12 |
Not clear |
| Xu Jiang, Dongli Zhang, Jianting Shi, Yiqun Chen, Ping Zhang, Bing Me. Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19584449. |
it has been reported that conditional double knockout of presenilin-1 and presenilin-2 in forebrain of mice (dko mice) induce symptoms most analogous to that of neurodegenerative diseases, especially alzheimer's disease, however, there is no deposition of extra amyloid-beta (abeta(40) or abeta(42)) in dko brain. |
2010-06-30 |
2023-08-12 |
mouse |
| Scott E Counts, Elliott J Mufso. Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity. Journal of neurochemistry. vol 113. issue 3. 2010-05-04. PMID:20132474. |
degeneration of locus coeruleus (lc) noradrenergic forebrain projection neurons is an early feature of alzheimer's disease. |
2010-05-04 |
2023-08-12 |
human |
| Joanne M Ajmo, Lauren A Bailey, Matthew D Howell, Lisa K Cortez, Keith R Pennypacker, Hina N Mehta, Dave Morgan, Marcia N Gordon, Paul E Gottschal. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Journal of neurochemistry. vol 113. issue 3. 2010-05-04. PMID:20180882. |
aggregation of amyloid-beta (abeta) in the forebrain of alzheimer's disease (ad) subjects may disturb the molecular organization of the extracellular microenvironment that modulates neural and synaptic plasticity. |
2010-05-04 |
2023-08-12 |
mouse |
| Ran Inoue, Kenji Hashimoto, Tomomi Harai, Hisashi Mor. NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118183. |
these results suggest that sr is the major enzyme for d-serine production in the brain, d-serine is the predominant endogenous coagonist of the nmda receptor in the forebrain, and d-serine may be involved in controlling the extent of nmda receptor-mediated neurotoxic insults observed in disorders including alzheimer's disease. |
2009-04-09 |
2023-08-12 |
mouse |
| D Kumaran, M Udayabanu, M Kumar, R Aneja, A Katya. Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18621107. |
forebrain cholinergic dysfunction is the hallmark of vascular dementia (vad) and alzheimer's dementia (ad) induced by cerebral hypoperfusion during aging. |
2008-12-18 |
2023-08-12 |
rat |
| Mohammad A Kamal, Xianqin Qu, Qian-Sheng Yu, David Tweedie, Harold W Holloway, Yazhou Li, Yi Tan, Nigel H Grei. Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235987. |
synaptic loss, particularly related to the forebrain cholinergic system, is considered to be an early event that leads to alzheimer's disease (ad) and has led to the development of acetylcholinesterase inhibitors (ache-is) as the mainstay of treatment for several degenerative disorders that culminate in dementia. |
2008-10-03 |
2023-08-12 |
human |
| Qiang Liu, Jie W. Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate beta-amyloid neurotoxicity. Acta pharmacologica Sinica. vol 27. issue 10. 2007-12-11. PMID:17007734. |
alzheimer's disease (ad) is the most common form of brain dementia characterized by the accumulation of beta-amyloid peptides (abeta) and loss of forebrain cholinergic neurons. |
2007-12-11 |
2023-08-12 |
Not clear |
| V Sposato, L Manni, G N Chaldakov, L Alo. Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain. Archives italiennes de biologie. vol 145. issue 2. 2007-08-21. PMID:17639781. |
ngf plays an important role during brain development and may be able to delay or even reverse damaged forebrain cholinergic neurons that undergo degeneration in aged animals and in alzheimer's disease (ad). |
2007-08-21 |
2023-08-12 |
rat |
| A Claudio Cuello, Martin A Brun. The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical research. vol 32. issue 6. 2007-08-01. PMID:17404842. |
this short review discusses the arguments to consider the dismetabolism of the pathway responsible for both the maturation and degradation of ngf as the culprit of vulnerability of the forebrain cholinergic system to the alzheimer's disease neuropathology. |
2007-08-01 |
2023-08-12 |
Not clear |
| A Claudio Cuello, Martin A Brun. The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical research. vol 32. issue 6. 2007-08-01. PMID:17404842. |
this metabolic scenario in alzheimer's disease should result in the failure of ngf trophic support to forebrain cholinergic neurons and thus explaining the vulnerability of these neurons in this neurodegenerative condition. |
2007-08-01 |
2023-08-12 |
Not clear |
| Brian M Bennett, James N Reynolds, Glen T Prusky, Robert M Douglas, Robert J Sutherland, Gregory R J Thatche. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 3. 2007-04-05. PMID:16525416. |
many conditions adversely affecting learning, memory, and cognition are associated with reductions in forebrain acetylcholine (ach), most notably aging and alzheimer's disease. |
2007-04-05 |
2023-08-12 |
rat |
| Farida Sohrabji, Danielle K Lewi. Estrogen-BDNF interactions: implications for neurodegenerative diseases. Frontiers in neuroendocrinology. vol 27. issue 4. 2007-01-17. PMID:17069877. |
this review describes the distribution of bdnf and trkb expressing cells in the forebrain, and the roles of estrogen and the bdnf-trkb neurotrophin system in parkinson's disease, alzheimer's disease and multiple sclerosis. |
2007-01-17 |
2023-08-12 |
Not clear |
| Tony Wyss-Cora. Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's. Current Alzheimer research. vol 3. issue 3. 2006-09-25. PMID:16842094. |
alzheimer's disease (ad) is a fatal neurodegenerative disease characterized by the loss of large numbers of forebrain neurons. |
2006-09-25 |
2023-08-12 |
Not clear |
| H J Koch, S Haas, T Jürgen. On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease. Current medicinal chemistry. vol 12. issue 24. 2006-08-18. PMID:16305479. |
the loss of cholinergic neurons, particularly in the forebrain, plays an important role in the pathophysiology of alzheimer's disease (dat). |
2006-08-18 |
2023-08-12 |
Not clear |
| Andrea Contestabile, Tatiana Fila, Renata Bartesaghi, Antonio Contestabile, Elisabetta Cian. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. Journal of neurochemistry. vol 97. issue 2. 2006-06-08. PMID:16539660. |
thus, alterations of chat activity in these forebrain areas seem to recapitulate those recently described in patients scored as cases of mild cognitive impairment or mild alzheimer's disease. |
2006-06-08 |
2023-08-12 |
mouse |
| Magdalena Blazejczyk, Urszula Wojda, Adam Sobczak, Christina Spilker, Hans-Gert Bernstein, Eckart D Gundelfinger, Michael R Kreutz, Jacek Kuznick. Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain. Biochimica et biophysica acta. vol 1762. issue 1. 2006-06-02. PMID:16257512. |
ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of ca2+-signals to alzheimer's disease-related presenilin 2 in forebrain. |
2006-06-02 |
2023-08-12 |
human |
| Iwo J Boh. Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease? Lipids in health and disease. vol 4. 2006-05-25. PMID:15949039. |
the relationship between alzheimer's disease (ad) and progressive degeneration of the forebrain cholinergic system is very well established, whereas mechanisms linking this disease with cholesterol, apolipoprotein e (apoe) phenotype, and amyloid precursor protein (app) metabolism have not been fully elucidated even though there is a plethora of publications separately on each of these issues. |
2006-05-25 |
2023-08-12 |
Not clear |
| Martin Braddoc. Safely slowing down the decline in Alzheimer's disease: gene therapy shows potential. Expert opinion on investigational drugs. vol 14. issue 7. 2006-04-25. PMID:16022580. |
this anabolic growth factor has been delivered into the forebrain of patients with mild alzheimer's disease using transfer of autologous fibroblasts engineered to produce nerve growth factor. |
2006-04-25 |
2023-08-12 |
Not clear |