| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Houlden, P Rizzu, M Stevens, P de Knijff, C M van Duijn, J C van Swieten, P Heutink, J Perez-Tur, V Thomas, M Baker, H Morris, M Rossor, J C Jannsen, R C Petersen, P Dodd, F Dark, B Boeve, D Dickson, P Davies, S Pickering-Brown, D Mann, J Adamson, T Lynch, H Payami, J Hard. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience letters. vol 260. issue 3. 1999-05-17. PMID:10076900. |
apolipoprotein e genotype does not affect the age of onset of dementia in families with defined tau mutations. |
1999-05-17 |
2023-08-12 |
Not clear |
| H Houlden, P Rizzu, M Stevens, P de Knijff, C M van Duijn, J C van Swieten, P Heutink, J Perez-Tur, V Thomas, M Baker, H Morris, M Rossor, J C Jannsen, R C Petersen, P Dodd, F Dark, B Boeve, D Dickson, P Davies, S Pickering-Brown, D Mann, J Adamson, T Lynch, H Payami, J Hard. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience letters. vol 260. issue 3. 1999-05-17. PMID:10076900. |
we have assessed whether apolipoprotein e (apoe) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. |
1999-05-17 |
2023-08-12 |
Not clear |
| S S Mirra, J R Murrell, M Gearing, M G Spillantini, M Goedert, R A Crowther, A I Levey, R Jones, J Green, J M Shoffner, B H Wainer, M L Schmidt, J Q Trojanowski, B Ghett. Tau pathology in a family with dementia and a P301L mutation in tau. Journal of neuropathology and experimental neurology. vol 58. issue 4. 1999-05-06. PMID:10218629. |
tau pathology in a family with dementia and a p301l mutation in tau. |
1999-05-06 |
2023-08-12 |
Not clear |
| E H Bigio, D F Brown, C L Whit. Progressive supranuclear palsy with dementia: cortical pathology. Journal of neuropathology and experimental neurology. vol 58. issue 4. 1999-05-06. PMID:10218631. |
the accumulation of cortical neuronoglial tau in psp cases with dementia suggests that neurofibrillary pathology is central to the cause of dementia in psp. |
1999-05-06 |
2023-08-12 |
Not clear |
| T Fladby, J Maehle. [The amyloid and tau hypothesis in degenerative dementia]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 119. issue 7. 1999-05-04. PMID:10210960. |
[the amyloid and tau hypothesis in degenerative dementia]. |
1999-05-04 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantini, R A Crowther, S G Chen, P Parchi, M Tabaton, D J Lanska, W R Markesbery, K C Wilhelmsen, D W Dickson, R B Petersen, P Gambett. Tau gene mutation in familial progressive subcortical gliosis. Nature medicine. vol 5. issue 4. 1999-04-29. PMID:10202939. |
the mutations associated with psg and other atypical dementias can be subdivided into three groups according to their tau gene locations and effects on tau. |
1999-04-29 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantini, R A Crowther, S G Chen, P Parchi, M Tabaton, D J Lanska, W R Markesbery, K C Wilhelmsen, D W Dickson, R B Petersen, P Gambett. Tau gene mutation in familial progressive subcortical gliosis. Nature medicine. vol 5. issue 4. 1999-04-29. PMID:10202939. |
the existence of tau mutations with distinct pathogenetic mechanisms may explain the phenotypic heterogeneity of atypical dementias that previously led to their classification into separate disease entities. |
1999-04-29 |
2023-08-12 |
Not clear |
| J Hardy, K Duff, K G Hardy, J Perez-Tur, M Hutto. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196523. |
genetic dissection of alzheimer's disease and related dementias: amyloid and its relationship to tau. |
1999-04-28 |
2023-08-12 |
Not clear |
| J Hardy, K Duff, K G Hardy, J Perez-Tur, M Hutto. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196523. |
recent data also suggests that dysfunction in the cytoskeletal protein tau is on the pathway that leads to neurodegeneration and dementia. |
1999-04-28 |
2023-08-12 |
Not clear |
| J Hardy, K Duff, K G Hardy, J Perez-Tur, M Hutto. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196523. |
these data support are refine the amyloid cascade hypothesis for ad and suggest that understanding the causes and consequences of tau dysfunction is an important priority for dementia research. |
1999-04-28 |
2023-08-12 |
Not clear |
| R Dayanandan, M Van Slegtenhorst, T G Mack, L Ko, S H Yen, K Leroy, J P Brion, B H Anderton, M Hutton, S Loveston. Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation. FEBS letters. vol 446. issue 2-3. 1999-04-20. PMID:10100846. |
in vitro evidence has suggested a change in the ability of tau bearing mutations associated with fronto-temporal dementia to promote microtubule assembly. |
1999-04-20 |
2023-08-12 |
Not clear |
| A Kurz, M Riemenschneider, K Buch, F Willoch, P Bartenstein, U Müller, W Gude. Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease. Alzheimer disease and associated disorders. vol 12. issue 4. 1999-03-18. PMID:9876968. |
a significant increase of csf tau was found in the ad patients, even in 19 subjects with very mild dementia as defined by a mini-mental state examination score of 25 and above. |
1999-03-18 |
2023-08-12 |
human |
| A Kurz, M Riemenschneider, K Buch, F Willoch, P Bartenstein, U Müller, W Gude. Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease. Alzheimer disease and associated disorders. vol 12. issue 4. 1999-03-18. PMID:9876968. |
this finding suggests that csf tau could be a biological marker of ad even before dementia has developed. |
1999-03-18 |
2023-08-12 |
human |
| H Arai, T Satoh-Nakagawa, M Higuchi, Y Morikawa, M Miura, H Kawakami, H Seki, S Takase, H Sasak. No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia. Neuroscience letters. vol 256. issue 3. 1999-03-12. PMID:9855368. |
no increase in cerebrospinal fluid tau protein levels in patients with vascular dementia. |
1999-03-12 |
2023-08-12 |
Not clear |
| P Mecocci, A Cherubini, M Bregnocchi, F Chionne, R Cecchetti, D T Lowenthal, U Seni. Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease? Alzheimer disease and associated disorders. vol 12. issue 3. 1999-01-26. PMID:9772026. |
to evaluate the usefulness of csf tau in the diagnosis of ad we measured it in patients with ad, frontal lobe dementia (fld), vascular dementia (vd), and in healthy controls by means of a specific enzyme-linked immunosorbent assay test. |
1999-01-26 |
2023-08-12 |
Not clear |
| K Buch, M Riemenschneider, P Bartenstein, F Willoch, U Müller, M Schmolke, T Nolde, C Steinmann, W G Guder, A Kur. [Tau protein. A potential biological indicator for early detection of Alzheimer disease]. Der Nervenarzt. vol 69. issue 5. 1998-08-11. PMID:9629553. |
in 40 patients with alzheimer's disease (ad), in 5 patients with non-ad dementia and in 36 cognitively normal controls the concentration of protein tau was determined in the cerebrospinal fluid (csf). |
1998-08-11 |
2023-08-12 |
Not clear |
| M G Spillantini, J R Murrell, M Goedert, M R Farlow, A Klug, B Ghett. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 13. 1998-08-06. PMID:9636220. |
mutation in the tau gene in familial multiple system tauopathy with presenile dementia. |
1998-08-06 |
2023-08-12 |
Not clear |
| M G Spillantini, J R Murrell, M Goedert, M R Farlow, A Klug, B Ghett. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 13. 1998-08-06. PMID:9636220. |
familial multiple system tauopathy with presenile dementia (mstd) is a neurodegenerative disease with an abundant filamentous tau protein pathology. |
1998-08-06 |
2023-08-12 |
Not clear |
| M Kanai, E Matsubara, K Isoe, K Urakami, K Nakashima, H Arai, H Sasaki, K Abe, T Iwatsubo, T Kosaka, M Watanabe, Y Tomidokoro, M Shizuka, K Mizushima, T Nakamura, Y Igeta, Y Ikeda, M Amari, T Kawarabayashi, K Ishiguro, Y Harigaya, K Wakabayashi, K Okamoto, S Hirai, M Shoj. Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Annals of neurology. vol 44. issue 1. 1998-07-22. PMID:9667589. |
these findings suggest that csf tau may increase with the clinical progression of dementia and that the alteration of the csf level of a beta1-42(43) and the ratio of a beta1-40 to a beta1-42(43) may start at early stages in ad. |
1998-07-22 |
2023-08-12 |
human |
| M Hutton, C L Lendon, P Rizzu, M Baker, S Froelich, H Houlden, S Pickering-Brown, S Chakraverty, A Isaacs, A Grover, J Hackett, J Adamson, S Lincoln, D Dickson, P Davies, R C Petersen, M Stevens, E de Graaff, E Wauters, J van Baren, M Hillebrand, M Joosse, J M Kwon, P Nowotny, L K Che, J Norton, J C Morris, L A Reed, J Trojanowski, H Basun, L Lannfelt, M Neystat, S Fahn, F Dark, T Tannenberg, P R Dodd, N Hayward, J B Kwok, P R Schofield, A Andreadis, J Snowden, D Craufurd, D Neary, F Owen, B A Oostra, J Hardy, A Goate, J van Swieten, D Mann, T Lynch, P Heutin. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. vol 393. issue 6686. 1998-07-01. PMID:9641683. |
association of missense and 5'-splice-site mutations in tau with the inherited dementia ftdp-17. |
1998-07-01 |
2023-08-12 |
Not clear |