| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montin. Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-05-14. PMID:37173305. |
here we assessed 43 research participants meeting stringent criteria, 11 healthy controls, 12 resilience to alzheimer's disease and 20 alzheimer's disease with dementia and analyzed matched isocortical regions, hippocampus, and caudate nucleus by mass spectrometry-based proteomics. |
2023-05-14 |
2023-08-14 |
human |
| Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montin. Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-05-14. PMID:37173305. |
of 7115 differentially expressed soluble proteins, lower isocortical and hippocampal soluble aβ levels is a significant feature of resilience when compared to healthy control and alzheimer's disease dementia groups. |
2023-05-14 |
2023-08-14 |
human |
| Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Rina Susilowat. Moderate-Intensity Intermittent Exercise Prevents Memory Deficit, Hippocampal Neuron Loss, and Elevated Level of Alzheimer's Dementia Markers in the Hippocampus of Trimethyltin-Induced Rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023-05-14. PMID:37182815. |
moderate-intensity intermittent exercise prevents memory deficit, hippocampal neuron loss, and elevated level of alzheimer's dementia markers in the hippocampus of trimethyltin-induced rats. |
2023-05-14 |
2023-08-14 |
rat |
| Pulak R Manna, Sudhir Kshirsagar, Jangampalli Adi Pradeepkiran, Priyanka Rawat, Subodh Kumar, Arubala P Reddy, P Hemachandra Redd. Protective function of StAR in amyloid-β accumulated hippocampal neurotoxicity and neurosteroidogenesis: Mechanistic insights into Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-05-04. PMID:37142132. |
these findings provide novel insights into the molecular events by which star acts to protect mapp-induced hippocampal neurotoxicity, mitochondrial dysfunction, and neurosteroidogenesis, and these measures are fundamental for ameliorating and/or delaying dementia in individuals with ad. |
2023-05-04 |
2023-08-14 |
Not clear |
| Chengcheng Guo, Yang Yao, Chunchao Ma, Zhiyun Wan. High-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. Neuroreport. vol 34. issue 8. 2023-04-27. PMID:37104097. |
high-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. |
2023-04-27 |
2023-08-14 |
rat |
| Courtney M Kloske, Mary D Gearon, Erica M Weekman, Colin Rogers, Ela Patel, Adam Bachstetter, Peter T Nelson, Donna M Wilcoc. Association between APOE genotype and microglial cell morphology. Journal of neuropathology and experimental neurology. 2023-04-22. PMID:37087107. |
analysis of ionized calcium-binding adaptor molecule 1 (iba1) immunoreactivity indicated greater microglial activation in both the hippocampus and superior and middle temporal gyrus (smtg) in dementia participants versus non-demented controls. |
2023-04-22 |
2023-08-14 |
human |
| Juri-Alexander Witt, Albert J Becker, Christoph Helmstaedte. The multifactorial etiology of cognitive deficits in epilepsy and the neuropathology of mesial temporal lobe epilepsy beyond hyperphosphorylated tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-18. PMID:37070290. |
in response to the recent review by zawar and kapur on the overlap between mesial temporal lobe epilepsy (mtle) and alzheimer's disease (ad), we (1) underscore that the bidirectionality between epilepsy and dementia is of high interest, also from the epileptological perspective; (2) outline the multifactorial etiology of cognitive deficits in epilepsy; (3) emphasize that the most prevalent neuropathological findings in mtle comprise hippocampal sclerosis, dysplastic lesions, and neurodevelopmental neoplasm; and (4) state that anti-seizure medication can also have adverse effects on cognition. |
2023-04-18 |
2023-08-14 |
Not clear |
| Marília da Cunha Feio Leal, Fabio Leite do Amaral Junior, Bernardo Freire da Silva Arruda, Juliana Ayumi Azevedo Kurosawa, Amanda Almeida Vieira, Júlia Corrêa Campos Maia, Viviana Virgínia Bezerra Scalfoni, Antonio Morais da Silveira Junior, Matheus Oliveira Feijó, Fernanda Beatriz Araújo de Albuquerque, Maria Helena Moutinho Marta, Marina Paula Nobre Normando, Alana Gabriele Oliveira Cabeça da Silva, Fernanda Catharina Pires da Trindade, Fabíola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthene. The Masticatory Activity Interference in Quantitative Estimation of CA1, CA3 and Dentate Gyrus Hippocampal Astrocytes of Aged Murine Models and under Environmental Stimulation. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047502. |
in this sense, with scarce detailed data on the subfields of hippocampus in dementia neurodegeneration, there is no information about astrocytic responses in its different layers. |
2023-04-13 |
2023-08-14 |
mouse |
| Diana Ortega-Cruz, Juan Eugenio Iglesias, Alberto Rabano, Bryan Strang. Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945448. |
hippocampal sclerosis of aging (hs) is an important component of combined dementia neuropathology. |
2023-03-22 |
2023-08-14 |
Not clear |
| N Giroud, M K Pichora-Fuller, P Mick, W Wittich, F Al-Yawer, S Rehan, J B Orange, N A Phillip. Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer's disease. Aging brain. vol 1. 2023-03-13. PMID:36911511. |
using data from the compass-nd study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (scd), mild cognitive impairment (mci), and alzheimer's dementia (ad). |
2023-03-13 |
2023-08-14 |
human |
| Abbie C Johnso. Hippocampal Vascular Supply and Its Role in Vascular Cognitive Impairment. Stroke. vol 54. issue 3. 2023-02-27. PMID:36848422. |
this review focuses on the hippocampal vascular supply, presenting what is known about hippocampal hemodynamics and blood-brain barrier function during health and disease, and discusses evidence that supports its contribution to vascular cognitive impairment and dementia. |
2023-02-27 |
2023-08-14 |
Not clear |
| Abbie C Johnso. Hippocampal Vascular Supply and Its Role in Vascular Cognitive Impairment. Stroke. vol 54. issue 3. 2023-02-27. PMID:36848422. |
the hippocampus and its vasculature may represent one such therapeutic target to mitigate the dementia epidemic. |
2023-02-27 |
2023-08-14 |
Not clear |
| Taku Homma, Yoko Mochizuki, Shinsuke Tobisawa, Takashi Komori, Kazushi Takahash. Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features. Journal of neuropathology and experimental neurology. 2023-02-25. PMID:36840692. |
although hippocampal pathologies of multiple system atrophy (msa) and their association with dementia have been reported, no studies have reported clinicopathological differences among msa patients with and without neuronal cytoplasmic inclusions (ncis) in the dentate gyrus (dntncis). |
2023-02-25 |
2023-08-14 |
Not clear |
| Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan, Xiangjian Zhan. Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling. Journal of translational medicine. vol 21. issue 1. 2023-02-24. PMID:36823656. |
low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal fndc5/irisin signaling. |
2023-02-24 |
2023-08-14 |
mouse |
| Chi Him Poon, Yanzhi Liu, Sojeong Pak, Robert Chunhua Zhao, Luca Aquili, George Lim Tipoe, Gilberto Ka-Kit Leung, Ying-Shing Chan, Sungchil Yang, Man-Lung Fung, Ed Xuekui Wu, Lee Wei Li. Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818556. |
our findings implicate hippocampal dnmt as a therapeutic target for prl dbs and pave way for the potential use of non-invasive neuromodulation modalities against dementia. |
2023-02-23 |
2023-08-14 |
Not clear |
| Wenhui Zhao, Lei Zhao, Xiangyu Chang, Xuejing Lu, Yiheng T. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 9. 2023-02-21. PMID:36802440. |
elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. |
2023-02-21 |
2023-08-14 |
human |
| Wenhui Zhao, Lei Zhao, Xiangyu Chang, Xuejing Lu, Yiheng T. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 9. 2023-02-21. PMID:36802440. |
we found that individuals with mcp were associated with significantly higher dementia risk, broader and faster cognitive impairment, and greater hippocampal atrophy than both pf individuals and those with scp. |
2023-02-21 |
2023-08-14 |
human |
| Wenhui Zhao, Lei Zhao, Xiangyu Chang, Xuejing Lu, Yiheng T. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 9. 2023-02-21. PMID:36802440. |
moreover, the detrimental effects of mcp on dementia risk and hippocampal volume aggravated along with the number of coexisting cp sites. |
2023-02-21 |
2023-08-14 |
human |
| Wenhui Zhao, Lei Zhao, Xiangyu Chang, Xuejing Lu, Yiheng T. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 9. 2023-02-21. PMID:36802440. |
our results suggested that cognitive decline and hippocampal atrophy interact biologically and may underlie the increased risk of dementia associated with mcp. |
2023-02-21 |
2023-08-14 |
human |
| Lei Gao, Fushun Liu, Ruilian Li. The Mechanism of Aerobic Exercise Regulating the PI3K/Akt-mTOR Signaling Pathway Intervenes in Hippocampal Neuronal Apoptosis in Vascular Dementia Rats. International journal of environmental research and public health. vol 20. issue 3. 2023-02-11. PMID:36767264. |
the mechanism of aerobic exercise regulating the pi3k/akt-mtor signaling pathway intervenes in hippocampal neuronal apoptosis in vascular dementia rats. |
2023-02-11 |
2023-08-14 |
rat |