| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabia Filipello, Claire Goldsbury, You Shih Feng, Alberto Locca, Celeste M Karch, Laura Picci. Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of disease. 2022-01-18. PMID:35041990. |
trem2 has attracted a lot of interest in the past decade for its critical role in modulating microglia functions under homeostatic conditions and in neurodegenerative diseases. |
2022-01-18 |
2023-08-13 |
Not clear |
| Tal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein, Tamir Ben-Hu. Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation. Journal of neuroinflammation. vol 19. issue 1. 2022-01-07. PMID:34991645. |
infectious agent-derived pathogen-associated molecular patterns (pamps) activate microglia, key players in neurodegenerative diseases. |
2022-01-07 |
2023-08-13 |
mouse |
| Faheem Ullah, Rashmi Gamage, Monokesh K Sen, Erika Gyenges. The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation. Neurochemical research. 2022-01-06. PMID:34988899. |
neuroinflammation is characterized by reactive microglia and astrocytes (collectively called gliosis) in the central nervous system and is considered as one of the main pathological hallmarks in different neurodegenerative diseases such as alzheimer's disease, age-related dementia, and multiple sclerosis. |
2022-01-06 |
2023-08-13 |
Not clear |
| Paul M Kim, Michael D Kornber. Targeting PKC in microglia to promote remyelination and repair in the CNS. Current opinion in pharmacology. vol 62. 2021-12-29. PMID:34965482. |
microglia and cns-infiltrating macrophages play significant roles in the pathogenesis of neuroinflammatory and neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, and multiple sclerosis. |
2021-12-29 |
2023-08-13 |
Not clear |
| Germana Cocozza, Stefano Garofalo, Riccardo Capitani, Giuseppina D'Alessandro, Cristina Limatol. Microglial Potassium Channels: From Homeostasis to Neurodegeneration. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944418. |
the growing interest in the role of microglia in the progression of many neurodegenerative diseases is developing in an ever-expedited manner, in part thanks to emergent new tools for studying the morphological and functional features of the cns. |
2021-12-24 |
2023-08-13 |
human |
| Anja Pišlar, Lara Bolčina, Janko Ko. New Insights into the Role of Cysteine Cathepsins in Neuroinflammation. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944440. |
neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. |
2021-12-24 |
2023-08-13 |
Not clear |
| Seungmin Lee, In Gyoung Ju, Yujin Choi, Sangsu Park, Myung Sook O. Trichosanthis Semen Suppresses Lipopolysaccharide-Induced Neuroinflammation by Regulating the NF-κB Signaling Pathway and HO-1 Expression in Microglia. Toxins. vol 13. issue 12. 2021-12-23. PMID:34941735. |
neuroinflammation, which is mediated by microglia that release various inflammatory cytokines, is a typical feature of neurodegenerative diseases (ndds), such as alzheimer's disease and parkinson's disease. |
2021-12-23 |
2023-08-13 |
Not clear |
| Hefei Fu, Jiapeng Wang, Jie Wang, Langni Liu, Jianxiong Jiang, Jiukuan Ha. 4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation. Brain research bulletin. 2021-12-23. PMID:34942325. |
as major immune responsive cells in the central nervous system (cns), activated microglia can present pro-inflammatory m1 phenotype aggravating the neuronal injury or anti-inflammatory m2 phenotype providing neuroprotection and promoting neuronal survival in neurodegenerative diseases. |
2021-12-23 |
2023-08-13 |
Not clear |
| Shradha Mukherje. Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Heliyon. vol 7. issue 12. 2021-12-20. PMID:34926857. |
this study demonstrates that immune system mediated neurological disease, ms and neurodegenerative diseases (ad, pd and hd), share a common gene network characterized by immune cell type signature genes (microglia, monocytes and macrophages) and are probable targets for therapeutic intervention. |
2021-12-20 |
2023-08-13 |
Not clear |
| Denisa Palova, Natalia Turic Csokova, Karina Markova, Eva Kontsekova, Branislav Kovacech, Monika Zilkov. The engagement of microglia in tau-targeted immunotherapy in Alzheimer's disease. General physiology and biophysics. vol 40. issue 6. 2021-12-13. PMID:34897021. |
broad range of microglia phenotypes, from neuroinflammatory to neuroprotective, found in neurodegenerative diseases make their role difficult to discern. |
2021-12-13 |
2023-08-13 |
Not clear |
| Luyang Xiong, Michael McCoy, Hitoshi Komuro, Xiaoxia Z West, Valentin Yakubenko, Detao Gao, Tejasvi Dudiki, Amanda Milo, Jacqueline Chen, Eugene A Podrez, Bruce Trapp, Tatiana V Byzov. Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis. Free radical biology & medicine. vol 178. 2021-12-11. PMID:34871763. |
in all als cases cep is present in nearly all astrocytes and microglia, however, only in individuals carrying a sod1 mutation cep marks >90% of neurons, thereby emphasizing an importance of cep accumulation as a potential hallmark of oxidative damage in neurodegenerative diseases. |
2021-12-11 |
2023-08-13 |
Not clear |
| Hong-Xi Xiao, Bo Song, Qian Li, Yi-Ming Shao, Yu-Bin Zhang, Xiu-Li Chang, Zhi-Jun Zho. Paraquat mediates BV-2 microglia activation by raising intracellular ROS and inhibiting Akt1 phosphorylation. Toxicology letters. vol 355. 2021-12-10. PMID:34863858. |
microglia mediated neuroinflammation is the key factor affecting the development of neurodegenerative diseases. |
2021-12-10 |
2023-08-13 |
Not clear |
| Kathryn Pellerin, Stephen J Rubino, Jeremy C Burns, Benjamin A Smith, Christie-Ann McCarl, Jing Zhu, Luke Jandreski, Patrick Cullen, Thomas M Carlile, Angela Li, Jorge Vera Rebollar, Jennifer Sybulski, Taylor L Reynolds, Baohong Zhang, Rebecca Basile, Hao Tang, Chelsea Parker Harp, Alex Pellerin, John Silbereis, Nathalie Franchimont, Ellen Cahir-McFarland, Richard M Ransohoff, Thomas O Cameron, Michael Minguenea. MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:34145876. |
moreover, the application of therapeutic antibodies for neurodegenerative disease also highlights the importance of understanding fc receptor signalling in microglia. |
2021-12-08 |
2023-08-13 |
mouse |
| Lucrezia Bruno, Simge Karagil, Almas Mahmood, Ahmed Elbediwy, Michael Stolinski, Francesca E Mackenzi. Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer's Disease Pathogenesis? Cells. vol 10. issue 11. 2021-12-08. PMID:34831369. |
the activation of microglia, the inflammatory cells of the central nervous system (cns), has been linked to the pathogenesis of alzheimer's disease and other neurodegenerative diseases. |
2021-12-08 |
2023-08-13 |
Not clear |
| Séverine Boillé. Local and remote interactions between macrophages and microglia in neurological conditions. Current opinion in immunology. vol 74. 2021-12-08. PMID:34864338. |
in neurodegenerative diseases such as alzheimer's disease or als, mdm mostly do not enter the cns, and instead microglia take several identities. |
2021-12-08 |
2023-08-13 |
Not clear |
| Sandra Amor, Niamh B McNamara, Emma Gerrits, Manuel C Marzin, Susanne M Kooistra, Veronique E Miron, Erik Nutm. White matter microglia heterogeneity in the CNS. Acta neuropathologica. 2021-12-08. PMID:34878590. |
we discuss how microglia are intricately linked to the classical white matter diseases such as multiple sclerosis and genetic white matter diseases, and their putative roles in neurodegenerative diseases in which white matter is also affected. |
2021-12-08 |
2023-08-13 |
Not clear |
| Mahdad Abdi, Parichehr Pasbakhsh, Maryam Shabani, Saied Nekoonam, Asie Sadeghi, Fardin Fathi, Morteza Abouzaripour, Wael Mohamed, Kazem Zibara, Iraj Ragerdi Kashani, Adib Zendede. Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34570348. |
the positive effects of metformin on microglia and remyelination suggest that it could be used as a promising candidate to lessen the incidence of inflammatory neurodegenerative diseases such as ms. |
2021-12-03 |
2023-08-13 |
mouse |
| Kun Shi, Lvyi Chen, Linlin Chen, Aihua Tan, Guangjing Xie, Qinghua Long, Funan Ning, Zhou Lan, Ping Wan. Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway. Journal of ethnopharmacology. vol 284. 2021-12-03. PMID:34688798. |
neuroinflammation induced by microglia is closely related to a variety of neurodegenerative diseases including alzheimer's disease (ad). |
2021-12-03 |
2023-08-13 |
Not clear |
| Kishore Aravind Ravichandran, Michael T Henek. Inflammasome activation in neurodegenerative diseases. Essays in biochemistry. 2021-11-30. PMID:34846519. |
the activation of immune cells, especially microglia, plays a crucial role in the development of neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
mouse |
| Kishore Aravind Ravichandran, Michael T Henek. Inflammasome activation in neurodegenerative diseases. Essays in biochemistry. 2021-11-30. PMID:34846519. |
molecular sensors within these microglia, such as the nlrp3 inflammasome, are activated by signals that represent the hallmarks of neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
mouse |