| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-Ying Liu, Tian-Shu DU, Yang Liu, Zhen Zhang, Ai-Niwaer Aizier, Xiao-Li Gong, Xiao-Min Wang, Ting Zhan. [Phagocytosis of microglia in neurodegenerative diseases]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503076. |
in this review, we summarize the important roles of microglia in neurodegenerative diseases, and further analyze the functions and molecular mechanisms of microglia phagocytosis and trogocytosis. |
2022-05-03 |
2023-08-13 |
Not clear |
| Kaori Endo-Umeda, Eunyoung Kim, David G Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Åke Gustafsson, Makoto Makishima, Muredach P Reilly, Nan Wang, Alan R Tal. Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2022-04-28. PMID:35477277. |
single-cell rna sequencing has identified foam cells as trem2 (triggering receptor expressed on myeloid cells 2) positive populations with low expression of inflammatory genes, resembling the trem2 positive microglia of neurodegenerative diseases. |
2022-04-28 |
2023-08-13 |
Not clear |
| Hao-Chang Hung, Sheng-Feng Tsai, Shih-Ren Sie, Yu-Min Ku. High glucose enhances lipopolysaccharide-induced inflammation in cultured BV2 microglial cell line. Immunity, inflammation and disease. vol 10. issue 5. 2022-04-28. PMID:35478445. |
activated microglia are known to play active roles in the pathogenesis of neurodegenerative diseases. |
2022-04-28 |
2023-08-13 |
Not clear |
| Mengjiao Sun, Xiaoling Li, Jing Sun, Hongxia Wang, Qinfang Xie, Manxia Wan. The Top-Cited Original Articles on the Role of Microglia in Neurodegenerative Diseases: A Bibliometric and Visualized Study. Frontiers in aging neuroscience. vol 14. 2022-04-28. PMID:35478696. |
the top-cited original articles on the role of microglia in neurodegenerative diseases: a bibliometric and visualized study. |
2022-04-28 |
2023-08-13 |
human |
| Jiqin Zhou, Wei Ni, Yating Ling, Xiaorui Lv, Dongdong Niu, Yu Zeng, Yun Qiu, Yu Si, Ziyu Wang, Jiabo H. Human neural stem cells secretome inhibits lipopolysaccharide-induced neuroinflammation through modulating microglia polarization by activating PPAR-γ. Stem cells and development. 2022-04-28. PMID:35481777. |
neuroinflammation is one of the typical events in multiple neurodegenerative diseases, whereas microglia are the critical participants in the pathogenesis of neuroinflammation. |
2022-04-28 |
2023-08-13 |
mouse |
| Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon G. Menthae Herba Attenuates Neuroinflammation by Regulating CREB/Nrf2/HO-1 Pathway in BV2 Microglial Cells. Antioxidants (Basel, Switzerland). vol 11. issue 4. 2022-04-23. PMID:35453334. |
chronic inflammation and oxidative stress cause microglia to be abnormally activated in the brain, resulting in neurodegenerative diseases such as alzheimer's disease (ad). |
2022-04-23 |
2023-08-13 |
Not clear |
| Whitney A Thiel, Zachary I Blume, Diana M Mitchel. Compensatory engulfment and Müller glia reactivity in the absence of microglia. Glia. 2022-04-22. PMID:35451181. |
therefore, effects of microglial deficiency or depletion on other glial cell types should be well-considered in experimental manipulations, in neurodegenerative disease, and in therapeutic approaches that target microglia. |
2022-04-22 |
2023-08-13 |
zebrafish |
| Mei-Ling Gao, Xiao Zhang, Fang Han, Jia Xu, Si-Jian Yu, Kangxin Jin, Zi-Bing Ji. Functional microglia derived from human pluripotent stem cells empower retinal organ. Science China. Life sciences. 2022-04-22. PMID:35451725. |
microglia are known to play essential roles in the development, progression and treatment of diverse neurodegenerative diseases in the central nervous system, including the retina, brain and spinal cord. |
2022-04-22 |
2023-08-13 |
human |
| Keigo Takahashi, Hemanth R Nelvagal, Jenny Lange, Jonathan D Coope. Glial Dysfunction and Its Contribution to the Pathogenesis of the Neuronal Ceroid Lipofuscinoses. Frontiers in neurology. vol 13. 2022-04-21. PMID:35444603. |
research into glial cells including astrocytes, microglia, and oligodendrocytes have revealed many of their critical functions in brain homeostasis and potential contributions to neurodegenerative diseases. |
2022-04-21 |
2023-08-13 |
mouse |
| Katarina Milosevic, Ivana Stevanovic, Iva D Bozic, Ana Milosevic, Marija M Janjic, Danijela Laketa, Ivana Bjelobaba, Irena Lavrnja, Danijela Savi. Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408922. |
neuroinflammation and microglial activation, common components of most neurodegenerative diseases, can be imitated in vitro by challenging microglia cells with lps. |
2022-04-12 |
2023-08-13 |
mouse |
| Daniela Maftei, Tommaso Schirinzi, Nicola B Mercuri, Roberta Lattanzi, Cinzia Severin. Potential Clinical Role of Prokineticin 2 (PK2) in Neurodegenerative Diseases. Current neuropharmacology. 2022-04-12. PMID:35410604. |
the role of the immune system in neurodegenerative diseases such as alzheimer's disease (ad) and parkinson's disease (pd) has become clear in recent decades, as evidenced by the presence of activated microglia and astrocytes and numerous soluble mediators in the brain and peripheral tissues of affected patients. |
2022-04-12 |
2023-08-13 |
human |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
neuroinflammation is a critical pathological process of neurodegenerative diseases, and alleviating the inflammatory response caused by abnormally activated microglia might be valuable for treatment. |
2022-04-11 |
2023-08-13 |
Not clear |
| Jinming Han, Violeta Chitu, E Richard Stanley, Zbigniew K Wszolek, Virginija Danylaité Karrenbauer, Robert A Harri. Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges. Cellular and molecular life sciences : CMLS. vol 79. issue 4. 2022-04-02. PMID:35366105. |
colony stimulating factor 1-receptor (csf-1r) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. |
2022-04-02 |
2023-08-13 |
Not clear |
| Mario Vailati-Riboni, Laurie Rund, Maria Elisa Caetano-Silva, Noah T Hutchinson, Selena S Wang, Katiria Soto-Díaz, Jeffrey A Woods, Andrew J Steelman, Rodney W Johnso. Dietary Fiber as a Counterbalance to Age-Related Microglial Cell Dysfunction. Frontiers in nutrition. vol 9. 2022-04-01. PMID:35360677. |
with increasing age, microglia shift toward a pro-inflammatory phenotype that may predispose individuals to neurodegenerative disease. |
2022-04-01 |
2023-08-13 |
mouse |
| Rui Zhou, Shufang Qian, William C S Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W C Chan, Hong Zhan. Microbiota-microglia connections in age-related cognition decline. Aging cell. 2022-03-29. PMID:35349746. |
it has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. |
2022-03-29 |
2023-08-13 |
Not clear |
| Rui Zhou, Shufang Qian, William C S Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W C Chan, Hong Zhan. Microbiota-microglia connections in age-related cognition decline. Aging cell. 2022-03-29. PMID:35349746. |
here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (alzheimer's disease and parkinson's disease). |
2022-03-29 |
2023-08-13 |
Not clear |
| Hyeokjin Lee, Ji-Hun Park, Hyunjung Kim, Sang-Keun Woo, Joon Young Choi, Kyung-Han Lee, Yearn Seong Cho. Synthesis and Evaluation of a Pharmaceuticals (Basel, Switzerland). vol 15. issue 3. 2022-03-26. PMID:35337075. |
synthesis and evaluation of a neuroinflammation involves activation of glial cells in the brain, and activated microglia play a particularly important role in neurodegenerative diseases such as alzheimer's disease (ad). |
2022-03-26 |
2023-08-13 |
Not clear |
| Xue Han, Yu-Jia Liu, Bin-Wen Liu, Zheng-Liang Ma, Tian-Jiao Xia, Xiao-Ping G. TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain. Journal of molecular neuroscience : MN. 2022-03-20. PMID:35306602. |
neuroinflammation is mediated by microglia and occurs in age-related neurodegenerative diseases. |
2022-03-20 |
2023-08-13 |
mouse |
| Prashant Tarale, Mahabub Maraj Ala. Colony-stimulating factor 1 receptor signaling in the central nervous system and the potential of its pharmacological inhibitors to halt the progression of neurological disorders. Inflammopharmacology. 2022-03-15. PMID:35290551. |
aberrant and sustained activation of microglia along with continued proliferation and release of neurotoxic proinflammatory cytokines have been reported in various neurological and neurodegenerative diseases. |
2022-03-15 |
2023-08-13 |
human |
| Min Cao, Jing Liu, Xiaomin Zhang, Tingting Yang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yifei Wang, Peichang Wan. ABI3 Is a Novel Early Biomarker of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-03-11. PMID:35275543. |
the abi3 gene has been suggested to be an important regulator of microglia during alzheimer's disease (ad), but the diagnostic power of abi3 in neurodegenerative disease has rarely been reported. |
2022-03-11 |
2023-08-13 |
Not clear |