| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shenrui Guo, Hui Wang, Yafu Yi. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases. Frontiers in aging neuroscience. vol 14. 2022-03-07. PMID:35250543. |
microglia polarization from m1 to m2 in neurodegenerative diseases. |
2022-03-07 |
2023-08-13 |
Not clear |
| Shenrui Guo, Hui Wang, Yafu Yi. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases. Frontiers in aging neuroscience. vol 14. 2022-03-07. PMID:35250543. |
previous studies showed that balancing microglia m1/m2 polarization had a promising therapeutic prospect in neurodegenerative diseases. |
2022-03-07 |
2023-08-13 |
Not clear |
| Shenrui Guo, Hui Wang, Yafu Yi. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases. Frontiers in aging neuroscience. vol 14. 2022-03-07. PMID:35250543. |
we suggest that shifting microglia from m1 to m2 may be significant and we focus on the modulation of microglia polarization from m1 to m2, especially by important signal pathways, in neurodegenerative diseases. |
2022-03-07 |
2023-08-13 |
Not clear |
| Boyd Kenkhuis, Antonios Somarakis, Lynn R T Kleindouwel, Willeke M C van Roon-Mom, Thomas Höllt, Louise van der Weer. Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease. Neurobiology of disease. 2022-03-05. PMID:35247551. |
microglia have been identified as key players in alzheimer's disease pathogenesis, and other neurodegenerative diseases. |
2022-03-05 |
2023-08-13 |
human |
| Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Ab. 3',4',7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway. Biological & pharmaceutical bulletin. vol 45. issue 3. 2022-03-01. PMID:35228396. |
neuroinflammation induced by activated microglia is a key feature of neurodegenerative diseases such as alzheimer's disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ana Bela Campos, Sara Duarte-Silva, Bruno Fernandes, Sofia Pereira das Neves, Fernanda Marques, Andreia Teixeira-Castro, Andreia Neves-Carvalho, Daniela Monteiro-Fernandes, Camila Cabral Portugal, Renato Socodato, Teresa Summavielle, António Francisco Ambrósio, João Bettencourt Relvas, Patrícia Macie. Profiling Microglia in a Mouse Model of Machado-Joseph Disease. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203447. |
microglia have been increasingly implicated in neurodegenerative diseases (nds), and specific disease associated microglia (dam) profiles have been defined for several of these nds. |
2022-02-25 |
2023-08-13 |
mouse |
| Ana Isabel Sánchez-Castillo, M Rosario Sepúlveda, José Luis Marín-Teva, Miguel A Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E Neubran. Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204722. |
switching roles: beneficial effects of adipose tissue-derived mesenchymal stem cells on microglia and their implication in neurodegenerative diseases. |
2022-02-25 |
2023-08-13 |
Not clear |
| Ana Isabel Sánchez-Castillo, M Rosario Sepúlveda, José Luis Marín-Teva, Miguel A Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E Neubran. Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204722. |
neurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident immune cells of the central nervous system (cns). |
2022-02-25 |
2023-08-13 |
Not clear |
| Martina Blank, Thomas Enzlein, Carsten Hop. LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies. Scientific reports. vol 12. issue 1. 2022-02-22. PMID:35190595. |
pathological microglia activation can promote neuroinflammation in many neurodegenerative diseases, and it has therefore emerged as a potential therapeutic target. |
2022-02-22 |
2023-08-13 |
Not clear |
| Chengzhi Zhang, Yanmei Yang, Yanhui Gao, Dianjun Su. NaF-induced neurotoxicity via activation of the IL-1β/JNK signaling pathway. Toxicology. 2022-02-16. PMID:35172196. |
il-1β, a pro-inflammatory cytokine released by activated microglia, is capable of inducing jnk phosphorylation and is associated with neurodegenerative diseases. |
2022-02-16 |
2023-08-13 |
rat |
| Melinda Barkhuizen, Carole Mathis, Manuel C Peitsch, Marja Talikk. Identifying neuroinflammation in omics datasets with a computational biological network model of reactive astrogliosis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109023. |
neuroimmune responses by astrocytes and microglia play a key role in the pathogenesis of neurodegenerative diseases. |
2022-02-03 |
2023-08-13 |
Not clear |
| Kyusik Ahn, Seung-Jae Lee, Inhee Mook-Jun. White matter-associated microglia: new players in brain aging and neurodegenerative diseases. Ageing research reviews. 2022-01-30. PMID:35093614. |
white matter-associated microglia: new players in brain aging and neurodegenerative diseases. |
2022-01-30 |
2023-08-13 |
mouse |
| Zhijun You, Zhenzhen Yang, Shuang Cao, Shouheng Deng, Yi Che. The novel KLF4/BIG1 regulates LPS-mediated neuro-inflammation and migration in BV2 cells via PI3K/Akt/NF-kB signaling pathway. Neuroscience. 2022-01-29. PMID:35090882. |
excessive microglia activation occurred in many neurodegenerative diseases. |
2022-01-29 |
2023-08-13 |
Not clear |
| Dorota Kaniowska, Kerstin Wenk, Phil Rademacher, Ronald Weiss, Claire Fabian, Isabell Schulz, Max Guthardt, Franziska Lange, Sebastian Greiser, Matthias Schmidt, Ulf-Dietrich Braumann, Frank Emmrich, Ulrike Koehl, Yarúa Jaime. Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by β-amyloid. Stem cell reviews and reports. 2022-01-26. PMID:35080744. |
this inhibition of microglia activation may present an effective strategy for the control/therapy of neurodegenerative diseases such as alzheimer's disease. |
2022-01-26 |
2023-08-13 |
Not clear |
| Hyun-Jung Yoo, Min-Soo Kwo. Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods. Frontiers in aging neuroscience. vol 13. 2022-01-24. PMID:35069173. |
aged microglia in neurodegenerative diseases: microglia lifespan and culture methods. |
2022-01-24 |
2023-08-13 |
Not clear |
| Hyun-Jung Yoo, Min-Soo Kwo. Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods. Frontiers in aging neuroscience. vol 13. 2022-01-24. PMID:35069173. |
microglia have been recognized as macrophages of the central nervous system (cns) that are regarded as a culprit of neuroinflammation in neurodegenerative diseases. |
2022-01-24 |
2023-08-13 |
Not clear |
| Hyun-Jung Yoo, Min-Soo Kwo. Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods. Frontiers in aging neuroscience. vol 13. 2022-01-24. PMID:35069173. |
however, microglia ontogeny, fate, heterogeneity, and their function in health and disease have been defined better with advances in single-cell and imaging technologies, and how to maintain homeostatic microglial function has become an emerging issue for targeting neurodegenerative diseases. |
2022-01-24 |
2023-08-13 |
Not clear |
| Hyun-Jung Yoo, Min-Soo Kwo. Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods. Frontiers in aging neuroscience. vol 13. 2022-01-24. PMID:35069173. |
considering that microglia are long-lived cells and may lose their functional capacity as they age, we can expect that aged microglia contribute to various neurodegenerative diseases. |
2022-01-24 |
2023-08-13 |
Not clear |
| Radhika Sharma, Ariel Mei, Vineetha Mathew, Olga Kashpur, Mary C Wallingfor. Interaction of extraembryonic microglia and neonatal brain development. Experimental neurology. 2022-01-22. PMID:35065053. |
herein, the role of microglia in neonatal brain development is discussed, current understandings of the developmental origins of microglia are described, the ontogeny and phylogeny of microglia, and implications of in vitro microglia-like cell differentiation, with a specific interest on neurodegenerative diseases, are reviewed. |
2022-01-22 |
2023-08-13 |
mouse |
| Radhika Sharma, Ariel Mei, Vineetha Mathew, Olga Kashpur, Mary C Wallingfor. Interaction of extraembryonic microglia and neonatal brain development. Experimental neurology. 2022-01-22. PMID:35065053. |
together, these emphasize the importance of leveraging the extraembryonic origins of microglia to not only better understand neurodevelopment and neurodegenerative diseases, but also to develop protective measures that are specific to human microglia. |
2022-01-22 |
2023-08-13 |
mouse |