| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
microglia and astrocytes have been described as playing important roles in synaptic spreading of toxic tau in several neurodegenerative diseases (nds). |
2022-09-02 |
2023-08-14 |
mouse |
| Hao Jiang, Ying Zhang, Juan Yue, Yuchen Shi, Bo Xiao, Wenbiao Xiao, Zhaohui Lu. Non-coding RNAs: The Neuroinflammatory Regulators in Neurodegenerative Diseases. Frontiers in neurology. vol 13. 2022-08-29. PMID:36034298. |
in this study, we summarize four main mechanisms of lncrnas and mirnas involved in neuroinflammation in neurodegenerative diseases, including the imbalance between proinflammatory and neuroprotective cells in microglia and astrocytes, nlrp3 inflammasome, oxidative stress, and mitochondrial dysfunction, and inflammatory mediators. |
2022-08-29 |
2023-08-14 |
Not clear |
| Yuqian An, Yi Li, Yujun Hou, Shichao Huang, Gang Pe. Alzheimer's Amyloid- Oxidative medicine and cellular longevity. vol 2022. 2022-08-29. PMID:36035216. |
alzheimer's amyloid- microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging-related neurodegenerative diseases including alzheimer's disease, they are malfunctioning. |
2022-08-29 |
2023-08-14 |
Not clear |
| Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Ki. Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012150. |
in collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. |
2022-08-26 |
2023-08-14 |
Not clear |
| Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Ki. Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012150. |
our findings on the expression of ifitm3 in microglia and in aged brains following stroke could establish the basic foundations for the role of ifitm3 in a variety of neurodegenerative diseases, particularly those that are prevalent or enhanced in the aged brain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Toshio Okada, Eisuke Muto, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inaz. Functional Expression of Choline Transporters in Microglia and Their Regulation of Microglial M1/M2 Polarization. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012189. |
microglia are key cells of the immune system in the central nervous system and are suggested to be deeply involved in the development of neurodegenerative diseases. |
2022-08-26 |
2023-08-14 |
Not clear |
| Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu, Yun Deng, Dong Wang, Dale Gu. N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways. Acta biochimica et biophysica Sinica. 2022-08-26. PMID:36017888. |
neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases. |
2022-08-26 |
2023-08-14 |
Not clear |
| Erin John Rieger de Almeida, Hélio Jungkenn Ibrahim, Maria Rosa Chitolina Schetinger, Cinthia Melazzo de Andrade, Andréia Machado Cardos. Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases. Neurochemical research. 2022-08-13. PMID:35962936. |
microglia are known for their immune functions and have multiple reactive phenotypes related to the types of stages involving neurodegenerative diseases. |
2022-08-13 |
2023-08-14 |
Not clear |
| Xian Wu, Teng Wan, Xiaoyu Gao, Mingyuan Fu, Yunfeng Duan, Xiangru Shen, Weiming Gu. Microglia Pyroptosis: A Candidate Target for Neurological Diseases Treatment. Frontiers in neuroscience. vol 16. 2022-08-08. PMID:35937897. |
the pathogenic roles of microglia in a variety of cns diseases such as neurodegenerative diseases, stroke, multiple sclerosis and depression, and many other neurological disorders have been gradually unveiled. |
2022-08-08 |
2023-08-14 |
Not clear |
| Yunfeng Wang, Yan Qi, Jianfei Qi, Jiandong Wu, Francis Lin, Xueling Cui, Jingyan Ge, Zhonghui Li. Activin A is a novel chemoattractant for migration of microglial BV2 cells. Journal of neuroimmunology. vol 371. 2022-08-08. PMID:35939944. |
microglia are involved in many neurodegenerative diseases and repairment of traumatic injury to the cns. |
2022-08-08 |
2023-08-14 |
Not clear |
| Jayson B Ball, Suzanne M Green-Fulgham, Linda R Watkin. Mechanisms of Microglia-Mediated Synapse Turnover and Synaptogenesis. Progress in neurobiology. 2022-08-08. PMID:35940391. |
this is important given that microglia are necessary for a healthy nervous system capable of learning and other neural phenomena based on synaptic modifications and can also cause pathological synaptic disfunctions in immunologically driven neurodegenerative diseases. |
2022-08-08 |
2023-08-14 |
Not clear |
| Roman Kosoy, John F Fullard, Biao Zeng, Jaroslav Bendl, Pengfei Dong, Samir Rahman, Steven P Kleopoulos, Zhiping Shao, Kiran Girdhar, Jack Humphrey, Katia de Paiva Lopes, Alexander W Charney, Brian H Kopell, Towfique Raj, David Bennett, Christopher P Kellner, Vahram Haroutunian, Gabriel E Hoffman, Panos Rousso. Genetics of the human microglia regulome refines Alzheimer's disease risk loci. Nature genetics. vol 54. issue 8. 2022-08-05. PMID:35931864. |
this comprehensive resource capturing variation in the human microglia regulome provides insights into the etiology of neurodegenerative disease. |
2022-08-05 |
2023-08-14 |
human |
| Weipeng Shi, Jing Zhang, Zhen Shang, Yingze Zhang, Yanzhi Xia, Haitao Fu, Tengbo Y. Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseases. Frontiers in immunology. vol 13. 2022-08-01. PMID:35911768. |
activated microglia perform diverse functions in mouse models of cns neurodegenerative diseases or deficits. |
2022-08-01 |
2023-08-14 |
mouse |
| Weipeng Shi, Jing Zhang, Zhen Shang, Yingze Zhang, Yanzhi Xia, Haitao Fu, Tengbo Y. Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseases. Frontiers in immunology. vol 13. 2022-08-01. PMID:35911768. |
in humans, microglia have been linked to various neurodegenerative diseases. |
2022-08-01 |
2023-08-14 |
mouse |
| Vittoria Borgonetti, Nicoletta Galeott. Rosmarinic Acid Reduces Microglia Senescence: A Novel Therapeutic Approach for the Management of Neuropathic Pain Symptoms. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35884774. |
it is now known that cellular ageing of microglia contributes to neurodegenerative diseases, mood disorders, and, even if with less evidence, chronic pain. |
2022-07-27 |
2023-08-14 |
mouse |
| Yan Tao, Yusuke Murakami, Demetrios G Vavvas, Koh-Hei Sonod. Necroptosis and Neuroinflammation in Retinal Degeneration. Frontiers in neuroscience. vol 16. 2022-07-18. PMID:35844208. |
receptor-interacting protein kinase (ripk) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina. |
2022-07-18 |
2023-08-14 |
Not clear |
| Menbere Y Wendimu, Shelley B Hook. Microglia Phenotypes in Aging and Neurodegenerative Diseases. Cells. vol 11. issue 13. 2022-07-09. PMID:35805174. |
microglia phenotypes in aging and neurodegenerative diseases. |
2022-07-09 |
2023-08-14 |
human |
| Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyam. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins. Scientific reports. vol 12. issue 1. 2022-07-08. PMID:35804072. |
considering these results, we propose thatt the ctsd-cko mouse is a useful mouse model to investigate the contribution of cathepsin d to the early phases of neurodegenerative diseases in relation to lipofuscins, proteinopathy-related proteins and activation of microglia and astrocytes. |
2022-07-08 |
2023-08-14 |
mouse |
| Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okan. Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. vol 42. issue 1. 2022-06-30. PMID:35773727. |
microglia are particularly in the spotlight because many genetic risk factors recently identified for neurodegenerative diseases are largely expressed in microglia. |
2022-06-30 |
2023-08-14 |
human |
| Alexander P Young, Eileen M Denovan-Wrigh. Synthetic cannabinoids reduce the inflammatory activity of microglia and subsequently improve neuronal survival in vitro. Brain, behavior, and immunity. 2022-06-28. PMID:35764268. |
microglia are also drivers of neuroinflammation in several neurodegenerative diseases. |
2022-06-28 |
2023-08-14 |
Not clear |