| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Insup Choi, George R Heaton, You-Kyung Lee, Zhenyu Yu. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Science advances. vol 8. issue 43. 2022-10-26. PMID:36288297. |
current studies have demonstrated that dysfunctional microglia contribute to neurodegenerative diseases. |
2022-10-26 |
2023-08-14 |
Not clear |
| Hazel Quek, Anthony R Whit. Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254974. |
patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases. |
2022-10-18 |
2023-08-14 |
human |
| Hazel Quek, Anthony R Whit. Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254974. |
microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. |
2022-10-18 |
2023-08-14 |
human |
| Booker T Davis, Zhangying Chen, Mecca B A R Islam, Madeline E Timken, Daniele Procissi, Steven J Schwuls. POSTINJURY FECAL MICROBIOME TRANSPLANT DECREASES LESION SIZE AND NEUROINFLAMMATION IN TRAUMATIC BRAIN INJURY. Shock (Augusta, Ga.). vol 58. issue 4. 2022-10-18. PMID:36256625. |
the constitutive activation of microglia after tbi has been linked to long-term neurocognitive deficits and the progression of neurodegenerative disease. |
2022-10-18 |
2023-08-14 |
mouse |
| Booker T Davis, Zhangying Chen, Mecca B A R Islam, Madeline E Timken, Daniele Procissi, Steven J Schwuls. POSTINJURY FECAL MICROBIOME TRANSPLANT DECREASES LESION SIZE AND NEUROINFLAMMATION IN TRAUMATIC BRAIN INJURY. Shock (Augusta, Ga.). vol 58. issue 4. 2022-10-18. PMID:36256625. |
microglia from fmt-treated mice enriched pathways in the heat-shock response, which is known to play a neuroprotective role in tbi and other neurodegenerative disease processes. |
2022-10-18 |
2023-08-14 |
mouse |
| Hannah Ennerfelt, Elizabeth L Frost, Daniel A Shapiro, Coco Holliday, Kristine E Zengeler, Gabrielle Voithofer, Ashley C Bolte, Catherine R Lammert, Joshua A Kulas, Tyler K Ulland, John R Luken. SYK coordinates neuroprotective microglial responses in neurodegenerative disease. Cell. 2022-10-18. PMID:36257314. |
recent studies have begun to reveal critical roles for the brain's professional phagocytes, microglia, and their receptors in the control of neurotoxic amyloid beta (aβ) and myelin debris accumulation in neurodegenerative disease. |
2022-10-18 |
2023-08-14 |
mouse |
| Robert K Doot, Anthony J Young, Ilya M Nasrallah, Reagan R Wetherill, Andrew Siderowf, Robert H Mach, Jacob G Dubrof. [ Cells. vol 11. issue 19. 2022-10-14. PMID:36231041. |
[ neuroinflammation is implicated as a key pathologic mechanism in many neurodegenerative diseases and is thought to be mediated in large part by microglia, native phagocytic immune cells of the cns. |
2022-10-14 |
2023-08-14 |
human |
| Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Li. TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway. Journal of neuroinflammation. vol 19. issue 1. 2022-10-14. PMID:36241997. |
dysregulated microglia, on the other hand, are associated with neurodegenerative diseases, yet the mechanisms underlying pro-inflammatory gene expression in microglia are incompletely understood. |
2022-10-14 |
2023-08-14 |
Not clear |
| Grace M E P Lawrence, Caroline L Holley, Kate Schrode. Parkinson's disease: connecting mitochondria to inflammasomes. Trends in immunology. 2022-10-13. PMID:36229358. |
activated microglia foster a neurotoxic, inflammatory environment in the mammalian central nervous system (cns) that drives the pathology of neurodegenerative diseases including parkinson's disease (pd). |
2022-10-13 |
2023-08-14 |
Not clear |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalve. Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. Journal of neuroinflammation. vol 19. issue 1. 2022-10-11. PMID:36221097. |
neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play key roles in the activation and maintenance of inflammatory responses in the central nervous system. |
2022-10-11 |
2023-08-14 |
rat |
| Hazel Quek, Carla Cuní-López, Romal Stewart, Yi Chieh Lim, Tara L Roberts, Anthony R Whit. A robust approach to differentiate human monocyte-derived microglia from peripheral blood mononuclear cells. STAR protocols. vol 3. issue 4. 2022-10-06. PMID:36201317. |
microglia are implicated in most neurodegenerative diseases. |
2022-10-06 |
2023-08-14 |
human |
| Wei Xiong, Ye Liu, Heng Zhou, Shuili Jing, Yan He, Qingsong Y. Alzheimer's disease: Pathophysiology and dental pulp stem cells therapeutic prospects. Frontiers in cell and developmental biology. vol 10. 2022-10-03. PMID:36187488. |
there is a growing consensus that the development of ad has several molecular mechanisms similar to those of other neurodegenerative diseases, including excessive accumulation of misfolded proteins and neurotoxic substances produced by hyperactivated microglia. |
2022-10-03 |
2023-08-14 |
Not clear |
| T Yvanka de Soysa, Martine Therrien, Alicia C Walker, Beth Steven. Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases. Seminars in immunology. vol 60. 2022-09-27. PMID:36155944. |
redefining microglia states: lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases. |
2022-09-27 |
2023-08-14 |
mouse |
| Ruqayya Afridi, Md Habibur Rahman, Kyoungho Su. Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases. Neurobiology of disease. 2022-09-26. PMID:36154877. |
distinct metabolic perturbations in microglia and astrocytes, including altered carbohydrate, lipid, and amino acid metabolism have been documented in neurodegenerative diseases. |
2022-09-26 |
2023-08-14 |
Not clear |
| Sheng Gao, Luyue Bai, Shu Jia, Chunyang Men. Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs. Genes. vol 13. issue 9. 2022-09-23. PMID:36140770. |
polarized microglia play a vital role in neurodegenerative diseases. |
2022-09-23 |
2023-08-14 |
Not clear |
| Haoran Jia, Tianwu Xi. Tracers progress for positron emission tomography imaging of glial-related disease. Journal of biomedical research. 2022-09-22. PMID:36131689. |
extensive studies have shown that astrocytes and microglia play an important role in neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, huntington's disease, as well as glioma, epilepsy, ischemic stroke, and infections. |
2022-09-22 |
2023-08-14 |
human |
| Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, Chia-Yang L. Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of inflammation research. vol 15. 2022-09-22. PMID:36131784. |
neurodegenerative diseases are associated with neuroinflammation along with activation of microglia and oxidative stress, but currently lack effective treatments. |
2022-09-22 |
2023-08-14 |
Not clear |
| Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen, Thomas Langman. Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration. Journal of neuroinflammation. vol 19. issue 1. 2022-09-17. PMID:36115971. |
galectin-3, a β-galactose binding protein, is a potent driver of macrophage and microglia activation and has been implicated in neuroinflammation, including neurodegenerative diseases of the brain. |
2022-09-17 |
2023-08-14 |
Not clear |
| Jian Jing Siew, Yijuang Chern, Kay-Hooi Khoo, Takashi Angat. Roles of Siglecs in neurodegenerative diseases. Molecular aspects of medicine. 2022-09-11. PMID:36089405. |
recent studies have revealed the involvement of microglia in neurodegenerative diseases, such as alzheimer's disease, through the modulation of neuroinflammation. |
2022-09-11 |
2023-08-14 |
Not clear |
| Qixue Wang, Mengna Lu, Xinyu Zhu, Xinyi Gu, Ting Zhang, Chenyi Xia, Li Yang, Ying Xu, Mingmei Zho. The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076537. |
this paper provides an overview of the metabolic reprogramming of microglia, the major pathways involved in recent advances in five major neurodegenerative diseases of aging (ndas), including alzheimer's disease (ad), parkinson's disease (pd), multiple sclerosis (ms), amyotrophic lateral sclerosis (als), and frontotemporal dementia (ftd), etc. |
2022-09-09 |
2023-08-14 |
Not clear |