| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mo Zhang, Philippa Malko, Lin-Hua Jian. Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282460. |
mechanosensitive piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation. |
2023-06-07 |
2023-08-14 |
Not clear |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Bojian Ye, Dewei He, Jinping Hu, Shuo Yang, Xiyu Gao, Mingchi Cui, Zhe Li, Hefei Wang, Bingxu Huang, Shoupeng Fu, Dianfeng Li. Notopterol inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf2/HO-1 signaling axis. International immunopharmacology. vol 120. 2023-05-27. PMID:37244113. |
accumulating research has indicated that inordinate activation of microglia releases inflammatory cytokines, damages neurons, and causes neuroinflammation, which eventually could lead to neurodegenerative diseases such as parkinson's disease and huntington's disease, etc. |
2023-05-27 |
2023-08-14 |
Not clear |
| Ranabir Chakraborty, Takashi Nonaka, Masato Hasegawa, Chiara Zurzol. Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria. Cell death & disease. vol 14. issue 5. 2023-05-18. PMID:37202391. |
besides describing novel tnt-mediated communication between neuronal and microglial cells, this work allows us to better understand the cellular mechanisms of spreading neurodegenerative diseases, shedding light on the role of microglia. |
2023-05-18 |
2023-08-14 |
human |
| Ashley Payne, Equar Taka, Getinet M Adinew, Karam F A Solima. Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190597. |
several natural compounds with anti-inflammatory and antioxidant properties, such as epigallocatechin 3-gallate (egcg), may provide a promising strategy for inflammation-related neurodegenerative diseases involving activated microglia cells. |
2023-05-16 |
2023-08-14 |
Not clear |
| Mingkai Lin, Hongwen Yu, Qiuyan Xie, Zhiyun Xu, Pei Shan. Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases. Frontiers in aging neuroscience. vol 14. 2023-05-15. PMID:37180741. |
role of microglia autophagy and mitophagy in age-related neurodegenerative diseases. |
2023-05-15 |
2023-08-14 |
Not clear |
| Mingkai Lin, Hongwen Yu, Qiuyan Xie, Zhiyun Xu, Pei Shan. Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases. Frontiers in aging neuroscience. vol 14. 2023-05-15. PMID:37180741. |
emerging evidence suggests that microglia coordinate the inflammatory responses in cns system and play a pivotal role in the pathogenesis of age-related neurodegenerative diseases (ndds). |
2023-05-15 |
2023-08-14 |
Not clear |
| Si-Jia Peng, Ya Feng, Xuan Li, Xi-Xi Wang, Yu Wang, Bu-Tian Zhou, Ye Liu, Te Liu, Yun-Cheng W. Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway. International immunopharmacology. vol 119. 2023-04-30. PMID:37121113. |
neuroinflammation plays a pivotal role in neurodegenerative diseases, including parkinson's disease, alzheimer's disease, amyotrophic lateral sclerosis and stroke, and is accompanied by excessive release of inflammatory cytokines and mediators by activated microglia. |
2023-04-30 |
2023-08-14 |
mouse |
| Maria Ester La Torre, Antonia Cianciulli, Vincenzo Monda, Marcellino Monda, Francesca Martina Filannino, Laura Antonucci, Anna Valenzano, Giuseppe Cibelli, Chiara Porro, Giovanni Messina, Maria Antonietta Panaro, Antonietta Messina, Rita Polit. α-Tocopherol Protects Lipopolysaccharide-Activated BV2 Microglia. Molecules (Basel, Switzerland). vol 28. issue 8. 2023-04-28. PMID:37110573. |
the pathogenesis of various neurodegenerative diseases is closely related to the constant activation of microglia due to their fundamental role as a mediator of inflammation in the brain environment. |
2023-04-28 |
2023-08-14 |
Not clear |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
a better understanding of how microglial lipid metabolism and lysosomal machinery are altered in nhd and how these defects impact microglia activation may provide new insights into mechanisms underlying nhd and other neurodegenerative diseases. |
2023-04-28 |
2023-08-14 |
human |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
additionally, changes in mitochondrial dynamics may precede microglia activation in several chronic neurodegenerative diseases; however, the underlying mechanism remains largely unknown.here using lps (1 mg/kg i.p. |
2023-04-28 |
2023-08-14 |
mouse |
| Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C Rubinsztei. Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration. Neuron. 2023-04-27. PMID:37105172. |
in neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. |
2023-04-27 |
2023-08-14 |
mouse |
| Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C Rubinsztei. Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration. Neuron. 2023-04-27. PMID:37105172. |
here, we show that activated microglia mediate non-cell-autonomous inhibition of neuronal autophagy, a degradative pathway critical for the removal of toxic, aggregate-prone proteins accumulating in neurodegenerative diseases. |
2023-04-27 |
2023-08-14 |
mouse |
| Ignazio Antignano, Yingxiao Liu, Nina Offermann, Melania Capass. Aging microglia. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-04-20. PMID:37081238. |
given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. |
2023-04-20 |
2023-08-14 |
human |
| Frida Lind-Holm Mogensen, Andrea Scafidi, Aurélie Poli, Alessandro Michelucc. PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target. Journal of neuroinflammation. vol 20. issue 1. 2023-04-19. PMID:37072827. |
microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes in neurodegenerative diseases, including parkinson's disease (pd). |
2023-04-19 |
2023-08-14 |
Not clear |
| Sydney Sunna, Christine A Bowen, Christina C Ramelow, Juliet V Santiago, Prateek Kumar, Srikant Rangaraj. Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. 2023-04-15. PMID:37060300. |
in disease states, microglia transform from homeostatic to diverse molecular phenotypic states that play complex and causal roles in neurologic disease pathogenesis, as evidenced by the identification of microglial genes as genetic risk factors for neurodegenerative disease. |
2023-04-15 |
2023-08-14 |
human |
| Sydney Sunna, Christine A Bowen, Christina C Ramelow, Juliet V Santiago, Prateek Kumar, Srikant Rangaraj. Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. 2023-04-15. PMID:37060300. |
in this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain. |
2023-04-15 |
2023-08-14 |
human |
| Joshua D Samuels, Katelyn A Moore, Hannah E Ennerfelt, Alexis M Johnson, Adeline E Walsh, Richard J Price, John R Luken. The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-15. PMID:37061460. |
while inpp5d expression is almost exclusively restricted to microglia in the brain, little is known regarding how ship-1 affects neurobiology or neurodegenerative disease pathogenesis. |
2023-04-15 |
2023-08-14 |
Not clear |
| Danbi Jo, Gwangho Yoon, Yeonghwan Lim, Youngkook Kim, Juhyun Son. Profiling and Cellular Analyses of Obesity-Related circRNAs in Neurons and Glia under Obesity-like In Vitro Conditions. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047207. |
after suppressing the expression of these circrnas using sirnas, we observed that these circrnas regulate genes related to inflammatory responses, formation of synaptic vesicles, synaptic density, and fatty acid oxidation in neurons; scavenger receptors in microglia; and fatty acid signaling, inflammatory signaling cyto that may play important roles in metabolic disorders associated with neurodegenerative diseases. |
2023-04-13 |
2023-08-14 |
mouse |
| Sevim Isik, Bercem Yeman Kiyak, Rumeysa Akbayir, Rama Seyhali, Tahire Arpac. Microglia Mediated Neuroinflammation in Parkinson's Disease. Cells. vol 12. issue 7. 2023-04-13. PMID:37048085. |
when m1 microglia are persistent, they will contribute to various inflammatory diseases, including neurodegenerative diseases, such as pd. |
2023-04-13 |
2023-08-14 |
Not clear |