| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wolfgang J Streit, Kelly R Miller, Kryslaine O Lopes, Emalick Nji. Microglial degeneration in the aging brain--bad news for neurons? Frontiers in bioscience : a journal and virtual library. vol 13. 2008-09-19. PMID:18508444. |
in recent years, we have reported on the presence of degenerating microglial cells, which are prominent in the brains of aged humans and humans with neurodegenerative diseases, and this has led us to propose a hypothesis stating that loss of microglia and microglial neuroprotective functions could, at least in part, account for aging-related neurodegeneration. |
2008-09-19 |
2023-08-12 |
Not clear |
| Seong Soo Joo, Yeong Min Yoo, Byung Woo Ahn, Sang Yun Nam, Yun-Bae Kim, Kwang Woo Hwang, Do Ik Le. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological & pharmaceutical bulletin. vol 31. issue 7. 2008-09-02. PMID:18591781. |
our results indicate that inhibition of the inflammatory repertoire of microglia, neuroprotection, and increased msra expression induced by rg3 may at least partly explain its therapeutic effects in chronic neurodegenerative diseases. |
2008-09-02 |
2023-08-12 |
Not clear |
| Hyo Jin Lim, Hyun-Sun Lee, Jae-Ha Ry. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from Farfarae flos in BV-2 microglial cells. Archives of pharmacal research. vol 31. issue 5. 2008-08-22. PMID:18481023. |
activated microglia produce diverse neurotoxic factors such as nitric oxide (no) and prostaglandin e(2) (pge(2)) that may cause neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2008-08-22 |
2023-08-12 |
Not clear |
| Long Tai Zheng, Geun-Mu Ryu, Byoung-Mog Kwon, Won-Ha Lee, Kyoungho Su. Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity. European journal of pharmacology. vol 588. issue 1. 2008-08-22. PMID:18499097. |
the anti-inflammatory and neuroprotective properties of the catechols in cultured microglia and neuroblastoma cells suggest a therapeutic potential of these compounds for the treatment of neurodegenerative diseases that are associated with an excessive microglial activation. |
2008-08-22 |
2023-08-12 |
rat |
| Claudia Schwab, Patrick L McGee. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. Journal of Alzheimer's disease : JAD. vol 13. issue 4. 2008-08-07. PMID:18487845. |
alzheimer and a number of other neurodegenerative diseases are characterized by the presence of reactive microglia and reactive astrocytes in association with the lesions. |
2008-08-07 |
2023-08-12 |
Not clear |
| Claudia Schwab, Patrick L McGee. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. Journal of Alzheimer's disease : JAD. vol 13. issue 4. 2008-08-07. PMID:18487845. |
in ad and other neurodegenerative diseases, both microglia and astrocytes are in a pro-inflammatory state. |
2008-08-07 |
2023-08-12 |
Not clear |
| Nadia G Innamorato, Ana I Rojo, Angel J García-Yagüe, Masayuki Yamamoto, María L de Ceballos, Antonio Cuadrad. The transcription factor Nrf2 is a therapeutic target against brain inflammation. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 1. 2008-07-28. PMID:18566435. |
because chronic neuroinflammation is a hallmark of neurodegenerative diseases and compromises neuron viability, it is imperative to discover pharmacologic targets to modulate the activation of immune brain cells, the microglia. |
2008-07-28 |
2023-08-12 |
mouse |
| b' Koyi Choi, Hean Zhuang, Barbara Crain, Sylvain Dor\\xc3\\xa. Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls. Journal of neuroimmunology. vol 195. issue 1-2. 2008-07-10. PMID:18353443.' |
neuroinflammation, a major contributor to neurodegenerative diseases, involves the contribution of activated microglia, reactive astrocytes, and infiltrating inflammatory cells. |
2008-07-10 |
2023-08-12 |
Not clear |
| Sang Keun Ha, Pyeongjae Lee, Jeong A Park, Hye Rim Oh, Sang Yeon Lee, Ji-Ho Park, Eunjoo H Lee, Jong Hoon Ryu, Kang Ro Lee, Sun Yeou Ki. Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochemistry international. vol 52. issue 4-5. 2008-06-20. PMID:18037535. |
recent studies suggest that inflammation mediated by microglia may play a role in neurodegenerative diseases. |
2008-06-20 |
2023-08-12 |
mouse |
| Makoto Sawada, Hirohide Sawada, Toshiharu Nagats. Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322405. |
effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. |
2008-05-15 |
2023-08-12 |
mouse |
| Makoto Sawada, Hirohide Sawada, Toshiharu Nagats. Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322405. |
the inflammatory process in the brain, which is accompanied by changes in the levels of proinflammatory cytokines and neurotrophins, along with the presence of activated microglia, has recently gained much attention in neurodegenerative diseases. |
2008-05-15 |
2023-08-12 |
mouse |
| Yoichi Kondo, Cynthia A Lemere, Timothy J Seabroo. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. Journal of neuroinflammation. vol 4. 2008-04-08. PMID:18093340. |
activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. |
2008-04-08 |
2023-08-12 |
mouse |
| Long Tai Zheng, Jiyeon Ock, Byoung-Mog Kwon, Kyoungho Su. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. International immunopharmacology. vol 8. issue 3. 2008-04-08. PMID:18279803. |
activation of microglia plays an important role in the processes of several neurodegenerative diseases including alzheimer's disease, parkinson's disease, and hiv dementia. |
2008-04-08 |
2023-08-12 |
Not clear |
| Bahareh Ajami, Jami L Bennett, Charles Krieger, Wolfram Tetzlaff, Fabio M V Ross. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nature neuroscience. vol 10. issue 12. 2008-03-17. PMID:18026097. |
we found no evidence of microglia progenitor recruitment from the circulation in denervation or cns neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of cns resident cells in these models. |
2008-03-17 |
2023-08-12 |
Not clear |
| M L Block, J-S Hon. Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochemical Society transactions. vol 35. issue Pt 5. 2008-02-05. PMID:17956294. |
inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative diseases, such as pd. |
2008-02-05 |
2023-08-12 |
Not clear |
| Jennifer M Pocock, Helmut Kettenman. Neurotransmitter receptors on microglia. Trends in neurosciences. vol 30. issue 10. 2008-01-09. PMID:17904651. |
understanding how microglia respond to different neurotransmitters will thus have important implications for controlling the reactivity of these cells in acute injury, as well as for treating chronic neurodegenerative diseases. |
2008-01-09 |
2023-08-12 |
Not clear |
| Gwenn A Garden, Thomas Mölle. Microglia biology in health and disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 1. issue 2. 2007-12-27. PMID:18040779. |
this review presents the current understanding of the biology of microglia during normal cns function as well as in response to cns injury or neurodegenerative disease. |
2007-12-27 |
2023-08-12 |
Not clear |
| Seija Lehnardt, Julia Wennekamp, Dorette Freyer, Christian Liedtke, Christina Krueger, Robert Nitsch, Ingo Bechmann, Joerg R Weber, Philipp Hennek. TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 9. 2007-12-06. PMID:17947688. |
microglia are involved in a number of neurodegenerative diseases in which their activation may be detrimental to neurons. |
2007-12-06 |
2023-08-12 |
Not clear |
| Young Ae Kim, Gi-Young Kim, Kun-Young Park, Yung Hyun Cho. Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia. Journal of medicinal food. vol 10. issue 2. 2007-11-26. PMID:17651055. |
these results demonstrate a potent suppressive effect of resveratrol on pro-inflammatory responses of microglia by modulation of nf-kappab activity, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation. |
2007-11-26 |
2023-08-12 |
rat |
| Der-Zen Liu, Hong-Jen Liang, Chien-Ho Chen, Ching-Hua Su, Tzong-Huei Lee, Chun-Ting Huang, Wen-Chi Hou, Shyr-Yi Lin, Wen-Bin Zhong, Pei-Jung Lin, Ling-Fang Hung, Yu-Chih Lian. Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. Journal of ethnopharmacology. vol 113. issue 1. 2007-11-13. PMID:17590297. |
in this study, we used taiwanofungus camphoratus extracts from wild fruiting bodies and two types of artificial cultivation (solid-state culture and liquid-state fermentation) to examine their anti-inflammatory effects in microglia cells and their possible roles in protection against neurodegenerative diseases. |
2007-11-13 |
2023-08-12 |
Not clear |