| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siranush A Sargsyan, Peter N Monk, Pamela J Sha. Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis. Glia. vol 51. issue 4. 2005-10-03. PMID:15846792. |
this review integrates the current knowledge of the role of microglia in an adult-onset neurodegenerative disease, amyotrophic lateral sclerosis (als), and pays particular attention to the possible mechanisms of initiation and propagation of neuronal damage during disease onset and progression. |
2005-10-03 |
2023-08-12 |
mouse |
| Ravi Shankar Akundi, Eduardo Candelario-Jalil, Sandra Hess, Michael Hüll, Klaus Lieb, Peter J Gebicke-Haerter, Bernd L Fiebic. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia. vol 51. issue 3. 2005-09-08. PMID:15800925. |
this potential nature of ceramides in activating microglia suggests that endogenously produced ceramides during neuronal apoptosis in ischemia or neurodegenerative diseases could also contribute to the amplification of neuroinflammatory events. |
2005-09-08 |
2023-08-12 |
rat |
| Siming Shen, Sue Yu, Joshua Binek, Malgorzata Chalimoniuk, Xiaolin Zhang, Shih-Ching Lo, Mark Hannink, Jinmei Wu, Kevin Fritsche, Rosario Donato, Grace Y Su. Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochemistry international. vol 47. issue 4. 2005-09-08. PMID:15955597. |
nitric oxide (no) release upon microglial cell activation has been implicated in the tissue injury and cell death in many neurodegenerative diseases. |
2005-09-08 |
2023-08-12 |
Not clear |
| Ai Ling Wang, Albert C H Yu, Lok Ting Lau, Chong Lee, Le Meng Wu, Xiu'An Zhu, Mark O M Ts. Minocycline inhibits LPS-induced retinal microglia activation. Neurochemistry international. vol 47. issue 1-2. 2005-09-01. PMID:15904993. |
retinal neurodegenerative disease involves an inflammatory response in the retina characterized by an increase in inflammatory cytokines and activation of microglia. |
2005-09-01 |
2023-08-12 |
Not clear |
| Luisa Minghett. Role of inflammation in neurodegenerative diseases. Current opinion in neurology. vol 18. issue 3. 2005-08-09. PMID:15891419. |
in neurodegenerative diseases inflammation occurs as a local response driven by microglia, in the absence of leucocyte infiltration. |
2005-08-09 |
2023-08-12 |
Not clear |
| Xiu Li Bi, Jing Yu Yang, Ying Xu Dong, Ji Ming Wang, Yong Hong Cui, Takashi Ikeshima, Yu Qing Zhao, Chun Fu W. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. International immunopharmacology. vol 5. issue 1. 2005-08-08. PMID:15589480. |
upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. |
2005-08-08 |
2023-08-12 |
mouse |
| Xiu Li Bi, Jing Yu Yang, Ying Xu Dong, Ji Ming Wang, Yong Hong Cui, Takashi Ikeshima, Yu Qing Zhao, Chun Fu W. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. International immunopharmacology. vol 5. issue 1. 2005-08-08. PMID:15589480. |
these results demonstrate a potent suppressive effect of resveratrol on proinflammatory responses of microglia, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation. |
2005-08-08 |
2023-08-12 |
mouse |
| Andis Klegeris, Patrick L McGee. Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity. Glia. vol 51. issue 1. 2005-07-27. PMID:15779083. |
activated microglia have been observed in various neurodegenerative diseases, including alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis, and multiple sclerosis. |
2005-07-27 |
2023-08-12 |
human |
| S Thameem Dheen, Yan Jun, Zhou Yan, Samuel S W Tay, Eng Ang Lin. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia. vol 50. issue 1. 2005-06-16. PMID:15602748. |
the release of proinflammatory mediators such as tumor necrosis factor-alpha (tnf-alpha) and nitric oxide by microglia has been implicated in neurotoxicity in chronic neurodegenerative diseases such as alzheimer's disease. |
2005-06-16 |
2023-08-12 |
rat |
| Jana Mehlhase, Grit Sandig, Kostas Pantopoulos, Tilman Grun. Oxidation-induced ferritin turnover in microglial cells: role of proteasome. Free radical biology & medicine. vol 38. issue 2. 2005-05-19. PMID:15607911. |
highly oxidized protein aggregates accumulating in the brain during neurodegenerative diseases are often surrounded by microglia. |
2005-05-19 |
2023-08-12 |
Not clear |
| Carol A Colton, Candice M Brown, Michael P Vite. Sex steroids, APOE genotype and the innate immune system. Neurobiology of aging. vol 26. issue 3. 2005-04-19. PMID:15639315. |
our studies have shown that the presence of the apoe4 gene, a known risk factor for ad and other neurodegenerative diseases, promotes a pro-inflammatory macrophage phenotype in neonatal microglia. |
2005-04-19 |
2023-08-12 |
mouse |
| Seong Soo Joo, Tae Joon Won, Do Ik Le. Potential role of ursodeoxycholic acid in suppression of nuclear factor kappa B in microglial cell line (BV-2). Archives of pharmacal research. vol 27. issue 9. 2005-02-11. PMID:15473667. |
moreover, an nf-kappab inhibitor such as a20 can collaborate and at least enhance the anti-inflammatory effect in microglia, thus giving a potent benefit for the treatment of neurodegenerative diseases such as ad. |
2005-02-11 |
2023-08-12 |
Not clear |
| Katsura Takano, Yoichi Nakamura, Yukio Yoned. [Microglial cell death induced by polyamines]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 4. 2004-11-30. PMID:15484815. |
pathological activation of microglia, which quiescently reside in physiological cns, causes various neurodegenerative diseases. |
2004-11-30 |
2023-08-12 |
rat |
| B Giunta, J Ehrhart, K Townsend, N Sun, M Vendrame, D Shytle, J Tan, F Fernande. Galantamine and nicotine have a synergistic effect on inhibition of microglial activation induced by HIV-1 gp120. Brain research bulletin. vol 64. issue 2. 2004-11-29. PMID:15342104. |
chronic brain inflammation is the common final pathway in the majority of neurodegenerative diseases and central to this phenomenon is the immunological activation of brain mononuclear phagocyte cells, called microglia. |
2004-11-29 |
2023-08-12 |
Not clear |
| b' Bared Safieh-Garabedian, John J Haddad, Nayef E Saad\\xc3\\xa. Cytokines in the central nervous system: targets for therapeutic intervention. Current drug targets. CNS and neurological disorders. vol 3. issue 4. 2004-11-23. PMID:15379603.' |
accumulating evidence implicates inflammatory processes in the development of a number of neurodegenerative diseases and demonstrates that neurons and microglia can be a source for various cytokines, which are believed to be involved in neuropathology, and therefore can serve as targets for therapeutic treatment. |
2004-11-23 |
2023-08-12 |
Not clear |
| Sung-Soo Kim, Pil-Jae Kong, Bong-Seog Kim, Dong-Hyuk Sheen, Su-Youn Nam, Wanjoo Chu. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Archives of pharmacal research. vol 27. issue 3. 2004-11-04. PMID:15089037. |
microglia are the major inflammatory cells in the central nervous system and become activated in response to brain injuries such as ischemia, trauma, and neurodegenerative diseases including alzheimer's disease (ad). |
2004-11-04 |
2023-08-12 |
Not clear |
| Won-Ki Kim, Pil-Geum Jang, Moon-Sook Woo, In-Oc Han, Hua Zi Piao, Keumho Lee, Heesoon Lee, Tong H Joh, Hee-Sun Ki. A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia. Neuropharmacology. vol 47. issue 2. 2004-09-28. PMID:15223303. |
thus, repressing proinflammatory cytokines and inos gene expression in activated microglia by kl-1037 may provide potential therapeutic strategies for various neurodegenerative diseases including ischemic cerebral disease. |
2004-09-28 |
2023-08-12 |
mouse |
| Antonin Bukovsky, Korakod Indrapichate, Hiroshi Fujiwara, Maria Cekanova, Maria E Ayala, Roberto Dominguez, Michael R Caudle, Jay Wimalsena, Robert F Elder, Pleas Copas, James S Foster, Romaine I Fernando, Donald C Henley, Nirmala B Upadhyay. Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12816543. |
since chorionic gonadotropin increases secretion of a variety of cytokines by monocytes, and induces their inflammatory reaction and phagocytic activity, high lh levels in aging individuals may also activate microglia (mononuclear phagocyte system in the central nervous system) and contribute to the development of alzheimer's disease and other inflammation-mediated neurodegenerative diseases. |
2004-09-08 |
2023-08-12 |
mouse |
| Keisuke Ishizawa, Takashi Komori, Shoichi Sasaki, Nobutaka Arai, Toshio Mizutani, Takanori Hiros. Microglial activation parallels system degeneration in multiple system atrophy. Journal of neuropathology and experimental neurology. vol 63. issue 1. 2004-03-10. PMID:14748560. |
taken together, considering the known toxic effects of microglia in neurodegenerative diseases, microglia may play a part in the development of system-specific tissue injuries, contributing to the system-bound clinical and pathological phenotypes. |
2004-03-10 |
2023-08-12 |
Not clear |
| Alon Monsonego, Jaime Imitola, Victor Zota, Takatoku Oida, Howard L Weine. Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 5. 2003-11-17. PMID:12928365. |
secretion of no by stimulated microglia may underlie a more general pathway of t cell death in the cns seen in neurodegenerative diseases. |
2003-11-17 |
2023-08-12 |
Not clear |