| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Takano, Y Nakamura, Y Yoned. Microglial cell death induced by a low concentration of polyamines. Neuroscience. vol 120. issue 4. 2003-11-10. PMID:12927202. |
pathological activation of microglia, which reside quiescently in physiological cns, contributes various neurodegenerative diseases. |
2003-11-10 |
2023-08-12 |
rat |
| Julie K Olson, Scott S Zamvil, Stephen D Mille. Efficient technique for immortalization of murine microglial cells relevant for studies in murine models of multiple sclerosis. Journal of neuroscience methods. vol 128. issue 1-2. 2003-11-05. PMID:12948546. |
microglia have been implicated as playing critical roles in various cns diseases including multiple sclerosis (ms), a human autoimmune demyelinating disease, as well as in other neurodegenerative diseases. |
2003-11-05 |
2023-08-12 |
mouse |
| Jae K Ryu, Atsushi Nagai, Jean Kim, Min C Lee, James G McLarnon, Seung U Ki. Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies. Neurobiology of disease. vol 12. issue 2. 2003-05-30. PMID:12667467. |
the present results indicate that metabolic impairment in the cns could involve both activation and cell death of microglia and contribute to pathology in neurodegenerative diseases. |
2003-05-30 |
2023-08-12 |
human |
| Michal Schwart. Macrophages and microglia in central nervous system injury: are they helpful or harmful? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 4. 2003-05-08. PMID:12679714. |
accordingly, in the context of traumatic injuries or chronic neurodegenerative diseases in the central nervous system (cns), activated microglia have been viewed as detrimental and attempts have been made to treat both conditions by antiinflammatory therapy. |
2003-05-08 |
2023-08-12 |
Not clear |
| Anita Greco, Maria Antonietta Ajmone-Cat, Alessia Nicolini, Maria Gina Sciulli, Luisa Minghett. Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. Journal of neuroscience research. vol 71. issue 6. 2003-05-07. PMID:12605411. |
as microglia play an important role in cns inflammation and pathogenesis of neurodegenerative diseases, we investigate the effect of paracetamol on rat microglial cultures. |
2003-05-07 |
2023-08-12 |
rat |
| Mei-Jen Wang, Wan-Wan Lin, Huan-Lian Chen, Ying-Hsin Chang, Hsio-Chung Ou, Jon-Son Kuo, Jau-Shyong Hong, Kee-Ching G Jen. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. The European journal of neuroscience. vol 16. issue 11. 2003-03-25. PMID:12473078. |
an inflammatory response in the central nervous system mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. |
2003-03-25 |
2023-08-12 |
Not clear |
| Mario Delgado, Javier Leceta, Doina Gane. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia. Journal of leukocyte biology. vol 73. issue 1. 2003-03-21. PMID:12525573. |
however, activation of microglia is a histopathological hallmark of several neurodegenerative diseases. |
2003-03-21 |
2023-08-12 |
Not clear |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Paola Tirassa, Luisa Minghett. Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells. Journal of neuropathology and experimental neurology. vol 62. issue 2. 2003-03-05. PMID:12578230. |
we proposed that upon interaction with ps-expressing apoptotic neurons, microglia no longer act as a promoter of the inflammatory cascade and that the specific microglial functional state induced by ps-ptdserr may be relevant for the final outcome of neurodegenerative diseases. |
2003-03-05 |
2023-08-12 |
rat |
| Christopher A Baker, Laura Manuelidi. Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 2. 2003-02-24. PMID:12525699. |
transcript profiles unique for cjd microglia and other myeloid cells provide opportunities for more sensitive preclinical diagnoses of infectious and noninfectious neurodegenerative diseases. |
2003-02-24 |
2023-08-12 |
Not clear |
| Bin Liu, Jau-Shyong Hon. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490568. |
role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. |
2003-01-23 |
2023-08-12 |
Not clear |
| Bin Liu, Jau-Shyong Hon. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490568. |
in this article, we summarize recent advances on the study of the role of microglia based on findings from animal and cell culture models in the pathogenesis of neurodegenerative diseases, with particular emphasis on parkinson's disease. |
2003-01-23 |
2023-08-12 |
Not clear |
| Milla Koistinaho, Jari Koistinah. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia. vol 40. issue 2. 2003-01-14. PMID:12379905. |
although microglial cells are thought to play a beneficial role in the regeneration and plasticity of the central nervous system (cns), recent studies have indicated that at least some molecules released by microglia may be harmful in acute brain insults and neurodegenerative diseases. |
2003-01-14 |
2023-08-12 |
Not clear |
| Shun-Fen Tzeng, Jia-Ling Lee, Jon-Sun Kuo, Chung-Shi Yang, Periyagamy Murugan, Lin Ai Tai, Kuo Chu Hwan. Effects of malonate C60 derivatives on activated microglia. Brain research. vol 940. issue 1-2. 2002-08-29. PMID:12020876. |
activated microglia in acute and chronic neurodegenerative disease of the central nervous system (cns) can produce large amounts of free radicals, such as reactive oxygen species (ros), which subsequently contribute to neuropathogenesis. |
2002-08-29 |
2023-08-12 |
Not clear |
| P Rosenstiel, R Lucius, G Deuschl, J Sievers, H Wilm. From theory to therapy: implications from an in vitro model of ramified microglia. Microscopy research and technique. vol 54. issue 1. 2002-05-07. PMID:11526952. |
an increasing number of studies have focused on the role of microglia in the pathogenesis of neurodegenerative diseases. |
2002-05-07 |
2023-08-12 |
Not clear |
| S H Appel, E P Simpso. Activated microglia: the silent executioner in neurodegenerative disease? Current neurology and neuroscience reports. vol 1. issue 4. 2002-04-09. PMID:11898534. |
activated microglia: the silent executioner in neurodegenerative disease? |
2002-04-09 |
2023-08-12 |
Not clear |
| S Kullberg, H Aldskogius, B Ulfhak. Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord. Brain research. vol 899. issue 1-2. 2002-04-02. PMID:11311878. |
activated microglia has been implicated in cytotoxic and inflammatory processes in neurodegenerative diseases as well as during aging. |
2002-04-02 |
2023-08-12 |
rat |
| H Neuman. Control of glial immune function by neurons. Glia. vol 36. issue 2. 2002-01-04. PMID:11596127. |
in contrast, in a variety of inflammatory and neurodegenerative diseases, including multiple sclerosis, infections, trauma, stroke, neoplasia, and alzheimer's disease, glial cells such as microglia gain antigen-presenting capacity through the expression of major histocompatibility complex (mhc) molecules. |
2002-01-04 |
2023-08-12 |
Not clear |
| K Kawahara, T Gotoh, S Oyadomari, M Kajizono, A Kuniyasu, K Ohsawa, Y Imai, S Kohsaka, H Nakayama, M Mor. Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells. Brain research. Molecular brain research. vol 90. issue 2. 2001-09-13. PMID:11406294. |
nitric oxide (no) produced by activated microglia has been implicated in many pathophysiological events in the brain including neurodegenerative diseases. |
2001-09-13 |
2023-08-12 |
rat |
| E Vegeto, C Bonincontro, G Pollio, A Sala, S Viappiani, F Nardi, A Brusadelli, B Viviani, P Ciana, A Magg. Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245665. |
after neuronal injury and in several neurodegenerative diseases, activated microglia secrete proinflammatory molecules that can contribute to the progressive neural damage. |
2001-06-07 |
2023-08-12 |
rat |
| S Cho, Y Kim, M O Cruz, E M Park, C K Chu, G Y Song, T H Jo. Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism. Glia. vol 33. issue 4. 2001-06-07. PMID:11246231. |
thus, repressing proinflammatory cytokines and nos2 gene expression in activated microglia by namda may provide new therapeutic strategies for ischemic cerebral disease as well as other neurodegenerative diseases. |
2001-06-07 |
2023-08-12 |
Not clear |