| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
toxic change of activated microglia may also occur in alzheimer's disease and other neurodegenerative diseases in which inflammatory process is found. |
2006-10-24 |
2023-08-12 |
mouse |
| A Cagnin, M Kassiou, S R Meikle, R B Banat. In vivo evidence for microglial activation in neurodegenerative dementia. Acta neurologica Scandinavica. Supplementum. vol 185. 2006-10-02. PMID:16866919. |
evidence from numerous neuropathological observations and in vivo clinical imaging studies suggests a prominent role of activated microglia, the main effector cell of the brain's innate immune system, in alzheimer's disease and other neurodegenerative diseases. |
2006-10-02 |
2023-08-12 |
Not clear |
| Matt Baker, Ian R Mackenzie, Stuart M Pickering-Brown, Jennifer Gass, Rosa Rademakers, Caroline Lindholm, Julie Snowden, Jennifer Adamson, A Dessa Sadovnick, Sara Rollinson, Ashley Cannon, Emily Dwosh, David Neary, Stacey Melquist, Anna Richardson, Dennis Dickson, Zdenek Berger, Jason Eriksen, Todd Robinson, Cynthia Zehr, Chad A Dickey, Richard Crook, Eileen McGowan, David Mann, Bradley Boeve, Howard Feldman, Mike Hutto. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. vol 442. issue 7105. 2006-09-22. PMID:16862116. |
moreover, pgrn expression is increased in activated microglia in many neurodegenerative diseases including creutzfeldt-jakob disease, motor neuron disease and alzheimer's disease. |
2006-09-22 |
2023-08-12 |
Not clear |
| Jessica R Conde, Wolfgang J Strei. Effect of aging on the microglial response to peripheral nerve injury. Neurobiology of aging. vol 27. issue 10. 2006-09-18. PMID:16159684. |
microglial morphology and immunophenotype have been studied extensively in aging-related neurodegenerative diseases, but to a lesser extent in the normally aged cns, and little is known about how aging affects the ability of microglia to respond to neuronal injury. |
2006-09-18 |
2023-08-12 |
rat |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
glutamate released by activated microglia induces excitoneurotoxicity and may contribute to neuronal damage in neurodegenerative diseases, including alzheimer disease, parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
2006-09-18 |
2023-08-12 |
Not clear |
| Nicolas G Bazan, Victor L Marcheselli, Kasie Cole-Edward. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179516. |
lipid signaling at the neurovascular unit (neurons, astrocytes, oligodendrocytes, microglia, and cells of the microvasculature) is altered in early cerebrovascular and neurodegenerative disease. |
2006-06-06 |
2023-08-12 |
Not clear |
| Antonietta Bernardo, Laura Gasparini, Ennio Ongini, Luisa Minghett. Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiology of disease. vol 22. issue 1. 2006-06-01. PMID:16307889. |
the dynamic regulation of the functional state of activated microglia by ncx 2216 helps explaining recent findings in alzheimer's disease animal models and may offer new therapeutic opportunities for treating neurodegenerative diseases. |
2006-06-01 |
2023-08-12 |
Not clear |
| Oleg Butovsky, Gennady Landa, Gilad Kunis, Yaniv Ziv, Hila Avidan, Nadav Greenberg, Adi Schwartz, Igor Smirnov, Ayala Pollack, Steffen Jung, Michal Schwart. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. The Journal of clinical investigation. vol 116. issue 4. 2006-05-16. PMID:16557302. |
the role of activated microglia (mg) in demyelinating neurodegenerative diseases such as multiple sclerosis is controversial. |
2006-05-16 |
2023-08-12 |
Not clear |
| K Saud, R Herrera-Molina, R Von Bernhard. Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371322. |
activated glial cells (astrocytes and microglia) are associated to the inflammatory process in neurodegenerative diseases. |
2006-04-27 |
2023-08-12 |
Not clear |
| David M Thomas, Dina M Francescutti-Verbeem, Donald M Kuh. Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 3. 2006-04-21. PMID:16384912. |
the pathogenesis of various neurodegenerative diseases has been associated with microglial activation, but the signaling pathways that program a neuronally protective or destructive phenotype in microglia are not known. |
2006-04-21 |
2023-08-12 |
Not clear |
| Michal Schwartz, Oleg Butovsky, Wolfgang Brück, Uwe-Karsten Hanisc. Microglial phenotype: is the commitment reversible? Trends in neurosciences. vol 29. issue 2. 2006-04-12. PMID:16406093. |
microglia, the standby cells for immune defense in the cns, have a reputation for exacerbating the neural damage that occurs in neurodegenerative diseases. |
2006-04-12 |
2023-08-12 |
Not clear |
| Deanna L Taylor, Fleur Jones, Eva S F Chen Seho Kubota, Jennifer M Pococ. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 11. 2006-03-13. PMID:15772355. |
activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. |
2006-03-13 |
2023-08-12 |
rat |
| Pyeongjae Lee, Jinyoung Hur, Jongseok Lee, Jeongmin Kim, Jueun Jeong, Insook Kang, Sun Yeou Kim, Hocheol Ki. 15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. Neurochemistry international. vol 48. issue 1. 2006-03-02. PMID:16298020. |
therefore, inhibition of inflammation mediated by microglia is a strategy in neurodegenerative disease therapy. |
2006-03-02 |
2023-08-12 |
Not clear |
| Jie Zhao, Diane M Brooks, Diana I Luri. Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. Glia. vol 53. issue 3. 2006-02-22. PMID:16265671. |
accumulating evidence suggests a deleterious role for activated microglia in facilitating neuronal death by producing neurocytotoxic substances during injury, infection, or neurodegenerative diseases. |
2006-02-22 |
2023-08-12 |
mouse |
| Michelle L Block, Jau-Shyong Hon. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Progress in neurobiology. vol 76. issue 2. 2005-12-15. PMID:16081203. |
in the following review, we discuss the common thread of microglial activation across numerous neurodegenerative diseases, define current perceptions of how microglia are damaging neurons, and explain how the microglial response to neuronal damage results in a self-propelling cycle of neuron death. |
2005-12-15 |
2023-08-12 |
Not clear |
| Pablo Iribarren, Keqiang Chen, Jinyue Hu, Xia Zhang, Wanghua Gong, Ji Ming Wan. IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 9. 2005-11-29. PMID:16237106. |
microglia are phagocytic cells in the cns and actively participate in proinflammatory responses in neurodegenerative diseases. |
2005-11-29 |
2023-08-12 |
mouse |
| K Takano, M Ogura, Y Yoneda, Y Nakamur. Oxidative metabolites are involved in polyamine-induced microglial cell death. Neuroscience. vol 134. issue 4. 2005-11-15. PMID:16019149. |
pathological activation of microglia, which reside quiescently in physiological cns, is associated with various neurodegenerative diseases. |
2005-11-15 |
2023-08-12 |
rat |
| Wolfgang J Streit, Jessica R Conde, Sarah E Fendrick, Barry E Flanary, Christopher L Marian. Role of microglia in the central nervous system's immune response. Neurological research. vol 27. issue 7. 2005-11-08. PMID:16197805. |
here we discuss the involvement of microglia during brain aging and aging-related neurodegenerative disease, i.e. |
2005-11-08 |
2023-08-12 |
Not clear |
| D G Walker, L-F Lu. Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15957156. |
investigations with cultured human microglia on pathogenic mechanisms of alzheimer's disease and other neurodegenerative diseases. |
2005-11-07 |
2023-08-12 |
mouse |
| D G Walker, L-F Lu. Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15957156. |
the use of human microglia cultures, in particular those derived from elderly diseased human brains, offers an experimental system that can closely model the cell type activated in human neurodegenerative diseases. |
2005-11-07 |
2023-08-12 |
mouse |