| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ciesielski-Treska, G Ulrich, S Chasserot-Golaz, J Zwiller, M O Revel, D Aunis, M F Bade. Mechanisms underlying neuronal death induced by chromogranin A-activated microglia. The Journal of biological chemistry. vol 276. issue 16. 2001-05-31. PMID:11124958. |
the neurotoxic effects of activated microglia in neurodegenerative diseases are well established. |
2001-05-31 |
2023-08-12 |
rat |
| E Sapp, K B Kegel, N Aronin, T Hashikawa, Y Uchiyama, K Tohyama, P G Bhide, J P Vonsattel, M DiFigli. Early and progressive accumulation of reactive microglia in the Huntington disease brain. Journal of neuropathology and experimental neurology. vol 60. issue 2. 2001-03-29. PMID:11273004. |
microglia may contribute to cell death in neurodegenerative diseases. |
2001-03-29 |
2023-08-12 |
Not clear |
| R Beschorner, D Adjodah, J M Schwab, M Mittelbronn, I Pedal, R Mattern, H J Schluesener, R Meyerman. Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans. Acta neuropathologica. vol 100. issue 4. 2001-02-01. PMID:10985695. |
thus, expression of ho-1 is considered to be a protective mechanism against oxidative stress and has been described in microglia, astrocytes and neurons following distinct experimental models of pathological alterations to the brain such as subarachnoidal hemorrhage, ischemia and traumatic brain injury (tbi) and in human neurodegenerative diseases. |
2001-02-01 |
2023-08-12 |
human |
| J Ryu, H Pyo, I Jou, E Jo. Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. The Journal of biological chemistry. vol 275. issue 39. 2000-10-27. PMID:10893407. |
thrombin induces no release from cultured rat microglia via protein kinase c, mitogen-activated protein kinase, and nf-kappa b. microglia, brain resident macrophages, become activated in brains injured due to trauma, ischemia, or neurodegenerative diseases. |
2000-10-27 |
2023-08-12 |
rat |
| M L Labat, G Milhaud, M Pouchelet, P Boirea. On the track of a human circulating mesenchymal stem cell of neural crest origin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 54. issue 3. 2000-09-15. PMID:10840592. |
the monocytoid ectomesenchymal stem/preprogenitor cell might also be involved in brain neurodegenerative diseases characterized by an accumulation of microglia. |
2000-09-15 |
2023-08-12 |
human |
| I Hide, M Tanaka, A Inoue, K Nakajima, S Kohsaka, K Inoue, Y Nakat. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. Journal of neurochemistry. vol 75. issue 3. 2000-09-12. PMID:10936177. |
brain microglia are a major source of inflammatory cytokines, such as tumor necrosis factor-alpha (tnf-alpha), which have been implicated in the progression of neurodegenerative diseases. |
2000-09-12 |
2023-08-12 |
rat |
| B Liu, L Du, L Y Kong, P M Hudson, B C Wilson, R C Chang, H H Abel, J S Hon. Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures. Neuroscience. vol 97. issue 4. 2000-07-24. PMID:10842020. |
an inflammatory response in the cns mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. |
2000-07-24 |
2023-08-12 |
mouse |
| Q Si, Y Nakamura, K Kataok. A serum factor enhances production of nitric oxide and tumor necrosis factor-alpha from cultured microglia. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716891. |
the pathological activation of microglia has been implicated in ischemic neuronal damage and some neurodegenerative diseases; however, the mechanism of microglial activation is not well understood. |
2000-04-18 |
2023-08-12 |
rat |
| H Pyo, E Joe, S Jung, S H Lee, I Jo. Gangliosides activate cultured rat brain microglia. The Journal of biological chemistry. vol 274. issue 49. 2000-02-03. PMID:10574921. |
microglia, brain resident macrophages, are activated in brain injuries and several neurodegenerative diseases. |
2000-02-03 |
2023-08-12 |
rat |
| M P Marzolo, R von Bernhardi, N C Inestros. Mannose receptor is present in a functional state in rat microglial cells. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518112. |
the presence of a functional manr in microglia opens the possibility that manr could participate in multiple physiologic and pathologic conditions in the central nervous system (cns), including inflammation, ischaemia, and neurodegenerative diseases such as ad. |
1999-11-23 |
2023-08-12 |
human |
| J M Long, A N Kalehua, N J Muth, J M Hengemihle, M Jucker, M E Calhoun, D K Ingram, P R Mouto. Stereological estimation of total microglia number in mouse hippocampus. Journal of neuroscience methods. vol 84. issue 1-2. 1999-01-26. PMID:9821640. |
the combination of immunocytochemistry and stereology provides a reliable means to assess microglia number that can easily be adopted for studies of transgenic and lesion-based models of aging and neurodegenerative diseases. |
1999-01-26 |
2023-08-12 |
mouse |
| K C Flanders, R F Ren, C F Lipp. Transforming growth factor-betas in neurodegenerative disease. Progress in neurobiology. vol 54. issue 1. 1998-03-17. PMID:9460794. |
tgf-beta 1 expression increases in astrocytes and microglia in animal models of cerebral ischemia, while tgf-beta 2 expression increases in activated astroglial cells in human neurodegenerative diseases. |
1998-03-17 |
2023-08-12 |
mouse |
| Q S Si, Y Nakamura, K Kataok. Albumin enhances superoxide production in cultured microglia. Glia. vol 21. issue 4. 1998-01-30. PMID:9419017. |
these results imply that albumin leaked out through impaired bbb may activate microglia and that the potentiation of o2- production by albumin results in the pathogenesis of neuronal damage in cerebral ischemia and some neurodegenerative diseases. |
1998-01-30 |
2023-08-12 |
human |
| K Pahan, F G Sheikh, A M Namboodiri, I Sing. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. The Journal of clinical investigation. vol 100. issue 11. 1998-01-14. PMID:9389730. |
this study delineates a novel role of the mevalonate pathway in controlling the expression of inos and different cytokines in rat astrocytes, microglia, and macrophages that may be important in developing therapeutics against cytokine- and no-mediated neurodegenerative diseases. |
1998-01-14 |
2023-08-12 |
rat |
| Y Yoshie, H Ohshim. Synergistic induction of DNA strand breakage caused by nitric oxide together with catecholamine: implications for neurodegenerative disease. Chemical research in toxicology. vol 10. issue 9. 1998-01-13. PMID:9305584. |
our results implicate a synergistic interaction of catecholamines formed in dopaminergic neurons and no formed by microglia or astrocytes or the two compounds produced within the same neuronal cells to produce a potent oxidant(s) which could cause damage in cells and dna, thus playing an important role in the pathogenesis of various neurodegenerative diseases. |
1998-01-13 |
2023-08-12 |
Not clear |
| P Schubert, T Ogata, K Rudolphi, C Marchini, A McRae, S Ferron. Support of homeostatic glial cell signaling: a novel therapeutic approach by propentofylline. Annals of the New York Academy of Sciences. vol 826. 1997-11-13. PMID:9329704. |
a pathological glial cell activation, which forces microglia to transform into immunocompetent cells with cytotoxic properties and astrocytes to "de-differentiate," presumably adds to neurodegenerative diseases. |
1997-11-13 |
2023-08-12 |
Not clear |
| W R Anderson, A Martella, Z M Drake, S Hu, P K Peterson, C C Cha. Correlative transmission and scanning electron microscopy study of microglia activated by interferon-gamma and tumor necrosis factor-alpha in vitro. Pathology, research and practice. vol 191. issue 10. 1996-12-03. PMID:8838370. |
since activated microglia have been implicated in the pathogenesis of a number of neurodegenerative diseases, application of the ultrastructural findings in the in vitro study may prove useful in determining the state of activation of microglia in brain specimens from patients with these neurological disorders. |
1996-12-03 |
2023-08-12 |
Not clear |
| C C Chao, S Hu, P K Peterso. Glia: the not so innocent bystanders. Journal of neurovirology. vol 2. issue 4. 1996-11-14. PMID:8799214. |
activated glial cells (microglia and astrocytes) are a hallmark of a variety of neurodegenerative diseases. |
1996-11-14 |
2023-08-12 |
Not clear |
| R J Oke. Towards a unifying hypothesis of neurodegenerative diseases and a concomitant rational strategy for their prophylaxis and therapy. Medical hypotheses. vol 45. issue 4. 1996-03-13. PMID:8577296. |
many neurodegenerative diseases have been found to present activated microglia, implying that immunologic processes operate which might exacerbate their basic pathologies. |
1996-03-13 |
2023-08-12 |
Not clear |
| R B Banati, J Gehrmann, M Kellner, F Holsboe. Antibodies against microglia/brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia. Clinical neuropathology. vol 14. issue 4. 1996-01-19. PMID:8521621. |
this finding extends previous observations of csf autoantibodies against microglia in neurodegenerative diseases. |
1996-01-19 |
2023-08-12 |
human |