| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Kercher, Cynthia Favara, James F Striebel, Rachel LaCasse, Bruce Chesebr. Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. Journal of virology. vol 81. issue 19. 2007-11-06. PMID:17652390. |
activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. |
2007-11-06 |
2023-08-12 |
mouse |
| Birgit Kraus, Horst Wolff, Jörg Heilmann, Erich F Elstne. Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life sciences. vol 81. issue 11. 2007-10-26. PMID:17725929. |
the survival and health of microglia are therefore critical for attenuating and preventing neurodegenerative diseases. |
2007-10-26 |
2023-08-12 |
Not clear |
| Dong-Oh Moon, Sung-Yong Park, Kyeong-Jun Lee, Moon-Soo Heo, Ki-Cheon Kim, Mun-Ock Kim, Jae-Dong Lee, Yung Hyun Choi, Gi-Young Ki. Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia. International immunopharmacology. vol 7. issue 8. 2007-10-24. PMID:17570326. |
these results demonstrate that bv and mel possess a potent suppressive effect on proinflammatory responses of bv2 microglia and suggest that these compounds may offer substantial therapeutic potential for treatment of neurodegenerative diseases that are accompanied by microglial activation. |
2007-10-24 |
2023-08-12 |
bee |
| Lv Li, Jia Lu, Samuel Sam Wah Tay, Shabbir M Moochhala, Bei Ping H. The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain research. vol 1159. 2007-10-12. PMID:17572395. |
opposing functions of activated microglia, namely neuroprotection or neurotrophy versus neurodestruction or neurotoxicity, have been observed in a number of experimental models of neurotrauma and neurodegenerative diseases. |
2007-10-12 |
2023-08-12 |
Not clear |
| Thomas Langman. Microglia activation in retinal degeneration. Journal of leukocyte biology. vol 81. issue 6. 2007-09-17. PMID:17405851. |
accumulating experimental evidence suggests that chronic microglia activation is associated with various neurodegenerative diseases including retinal dystrophies. |
2007-09-17 |
2023-08-12 |
Not clear |
| Nina Svoboda, Susanna Zierler, Hubert H Kerschbau. cAMP mediates ammonia-induced programmed cell death in the microglial cell line BV-2. The European journal of neuroscience. vol 25. issue 8. 2007-07-12. PMID:17445227. |
despite the significance of microglia in neurodegenerative diseases, little is known about their responsiveness to ammonia. |
2007-07-12 |
2023-08-12 |
Not clear |
| Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanb. Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Schizophrenia research. vol 92. issue 1-3. 2007-07-03. PMID:17363222. |
microglia has thus been reported to play an important role in the pathology of neurodegenerative disease, such as alzheimer's disease (ad) and parkinson's disease (pd). |
2007-07-03 |
2023-08-12 |
Not clear |
| D-Y Lu, C-H Tang, H-C Liou, C-M Teng, K-C G Jeng, S-C Kuo, F-Y Lee, W-M F. YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia. British journal of pharmacology. vol 151. issue 3. 2007-06-26. PMID:17401444. |
an inflammatory response in the central nervous system mediated by the activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. |
2007-06-26 |
2023-08-12 |
Not clear |
| Kentaro Hatan. [Microglia imaging]. Nihon rinsho. Japanese journal of clinical medicine. vol 65. issue 2. 2007-04-26. PMID:17302280. |
imaging of microglia cells using the radiolabeled ligand toward peripheral benzodiazepine receptor(pbr) is applied to brain injury and neurodegenerative diseases. |
2007-04-26 |
2023-08-12 |
Not clear |
| Jin-Sun Park, Moon-Sook Woo, Dong-Hyun Kim, Jin-Won Hyun, Won-Ki Kim, Jae-Chul Lee, Hee-Sun Ki. Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharide-stimulated microglial cells. The Journal of pharmacology and experimental therapeutics. vol 320. issue 3. 2007-04-09. PMID:17194798. |
overall, the repression of proinflammatory cytokines and inos gene expression in activated microglia by isoflavones such as irisolidone might have therapeutic potential for various neurodegenerative diseases including ischemic cerebral disease. |
2007-04-09 |
2023-08-12 |
human |
| Dong-Oh Moon, Ki-Cheon Kim, Cheng-Yun Jin, Min-Ho Han, Cheol Park, Kyeong-Jun Lee, Yeong-Min Park, Yung Hyun Choi, Gi-Young Ki. Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia. International immunopharmacology. vol 7. issue 2. 2007-03-21. PMID:17178390. |
upon activation, microglia release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. |
2007-03-21 |
2023-08-12 |
Not clear |
| Chun Fu Wu, Xiu Li Bi, Jing Yu Yang, Jia Yang Zhan, Ying Xu Dong, Jin Hui Wang, Ji Ming Wang, Ruiwen Zhang, Xian L. Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. International immunopharmacology. vol 7. issue 3. 2007-03-21. PMID:17276889. |
the significant suppressive effects of ginsenosides on proinflammatory responses of microglia implicate their therapeutic potential in neurodegenerative diseases accompanied by microglial activation. |
2007-03-21 |
2023-08-12 |
Not clear |
| Michelle L Block, Luigi Zecca, Jau-Shyong Hon. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature reviews. Neuroscience. vol 8. issue 1. 2007-03-06. PMID:17180163. |
overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease. |
2007-03-06 |
2023-08-12 |
Not clear |
| S Rosi, A Vazdarjanova, V Ramirez-Amaya, P F Worley, C A Barnes, G L Wen. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience. vol 142. issue 4. 2007-02-27. PMID:16989956. |
neuroinflammation is reliably associated with the pathogenesis of a number of neurodegenerative diseases, and can be detected by the presence of activated microglia. |
2007-02-27 |
2023-08-12 |
human |
| Amanda Sierra, Andres C Gottfried-Blackmore, Bruce S McEwen, Karen Bulloc. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia. vol 55. issue 4. 2007-02-26. PMID:17203473. |
microglia play a critical role in neurodegenerative diseases and in the brain aging process. |
2007-02-26 |
2023-08-12 |
mouse |
| Zhao Hui Li, Jia Lu, Samuel Sam Wah Tay, Ya Jun Wu, Michael Joseph Strong, Bei Ping H. Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feature in pre-clinical development of neurodegenerative diseases. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16920084. |
mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feature in pre-clinical development of neurodegenerative diseases. |
2006-12-13 |
2023-08-12 |
mouse |
| David R Beers, Jenny S Henkel, Qin Xiao, Weihua Zhao, Jinghong Wang, Albert A Yen, Laszlo Siklos, Scott R McKercher, Stanley H Appe. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 43. 2006-12-06. PMID:17043238. |
this study confirms the importance of microglia as a double-edged sword, and focuses on the importance of targeting microglia to minimize cytotoxicity and maximize neuroprotection in neurodegenerative diseases. |
2006-12-06 |
2023-08-12 |
mouse |
| Luisa Franco, Nicoletta Bodrato, Iliana Moreschi, Cesare Usai, Santina Bruzzone, Sonia Scarf ì, Elena Zocchi, Antonio De Flor. Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line. Journal of neurochemistry. vol 99. issue 1. 2006-11-14. PMID:16987244. |
the identification of cyclic adp-ribose as a key signal metabolite in the complex cascade of events triggered by lipopolysaccharide and eventually leading to enhanced generation of pro-inflammatory molecules may suggest a new therapeutic target for treatment of neurodegenerative diseases related to microglia activation. |
2006-11-14 |
2023-08-12 |
Not clear |
| Ming Hong Lee, Jae Yeon Kim, Jeong Hoon Yoon, Hyo Jin Lim, Tae Hee Kim, Changbae Jin, Wie-Jong Kwak, Chang-Kyun Han, Jae-Ha Ry. Inhibition of nitric oxide synthase expression in activated microglia and peroxynitrite scavenging activity by Opuntia ficus indica var. saboten. Phytotherapy research : PTR. vol 20. issue 9. 2006-11-02. PMID:16807879. |
activated microglia by neuronal injury or inflammatory stimulation overproduce nitric oxide (no) by inducible nitric oxide synthase (inos) and reactive oxygen species (ros) such as superoxide anion, resulting in neurodegenerative diseases. |
2006-11-02 |
2023-08-12 |
Not clear |
| M Dragunow, J M Greenwood, R E Cameron, P J Narayan, S J O'Carroll, A G Pearson, H M Gibbon. Valproic acid induces caspase 3-mediated apoptosis in microglial cells. Neuroscience. vol 140. issue 4. 2006-10-26. PMID:16600518. |
as activated microglia secrete neurotoxins in neurodegenerative diseases such as alzheimer's, parkinson's, and hiv dementia, valproic acid may alleviate these diseases by selectively killing microglia. |
2006-10-26 |
2023-08-12 |
mouse |