| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul A Yushkevich, Hongzhi Wang, John Pluta, Sandhitsu R Das, Caryne Craige, Brian B Avants, Michael W Weiner, Susanne Muelle. Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI. NeuroImage. vol 53. issue 4. 2011-01-03. PMID:20600984. |
these results support the feasibility of subfield-specific hippocampal morphometry in clinical studies of memory and neurodegenerative disease. |
2011-01-03 |
2023-08-12 |
human |
| Ludmila A Voloboueva, Star W Lee, John F Emery, Theo D Palmer, Rona G Giffar. Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 37. 2010-10-25. PMID:20844120. |
the impairment of hippocampal neurogenesis has been linked to the pathogenesis of neurological disorders from chronic neurodegenerative disease to the progressive cognitive impairment of children who receive brain irradiation. |
2010-10-25 |
2023-08-12 |
mouse |
| Roberto Piacentini, Carlo Gangitano, Sabrina Ceccariglia, Aurora Del Fà, Gian Battista Azzena, Fabrizio Michetti, Claudio Grass. Dysregulation of intracellular calcium homeostasis is responsible for neuronal death in an experimental model of selective hippocampal degeneration induced by trimethyltin. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18284612. |
trimethyltin (tmt) intoxication is considered a suitable experimental model to study the molecular basis of selective hippocampal neurodegeneration as that occurring in several neurodegenerative diseases. |
2010-08-13 |
2023-08-12 |
rat |
| Chiung-Chun Huang, Cheng-Che Lee, Kuei-Sen Hs. The role of insulin receptor signaling in synaptic plasticity and cognitive function. Chang Gung medical journal. vol 33. issue 2. 2010-08-06. PMID:20438663. |
several lines of work in both laboratory animals and humans suggest that when neurons in cognitive brain regions such as the hippocampus and cerebral cortex do not make enough insulin or cannot respond to insulin properly, everything from very mild memory loss to severe neurodegenerative diseases can result. |
2010-08-06 |
2023-08-12 |
Not clear |
| Ricardo Gredilla, Christian Garm, Rikke Holm, Vilhelm A Bohr, Tinna Stevnsne. Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions. Neurobiology of aging. vol 31. issue 6. 2010-07-13. PMID:18701195. |
in the current study we investigated the efficiency of the ber pathway throughout the murine lifespan in mitochondria from cortex and hippocampus, regions that are central in mammalian cognition, and which are severely affected during aging and in neurodegenerative diseases. |
2010-07-13 |
2023-08-12 |
mouse |
| M Omer Bostanci, Orhan Bas, Faruk Bagiric. Alpha-tocopherol decreases iron-induced hippocampal and nigral neuron loss. Cellular and molecular neurobiology. vol 30. issue 3. 2010-07-01. PMID:19798567. |
findings of the present study suggest that alpha-tocopherol may have neuroprotective effects against iron-induced hippocampal and nigral neurotoxicity and it may have a therapeutic significance for neurodegenerative diseases involved iron. |
2010-07-01 |
2023-08-12 |
rat |
| Marina O Ziehn, Andrea A Avedisian, Seema Tiwari-Woodruff, Rhonda R Voskuh. Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 5. 2010-06-07. PMID:20157291. |
neuronal injury and synaptic loss have been shown to occur within the hippocampus in other neurodegenerative disease models, and these pathologies have been correlated with cognitive impairment. |
2010-06-07 |
2023-08-12 |
Not clear |
| Stephen M Massa, Tao Yang, Youmei Xie, Jian Shi, Mehmet Bilgen, Jeffrey N Joyce, Dean Nehama, Jayakumar Rajadas, Frank M Long. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of clinical investigation. vol 120. issue 5. 2010-05-20. PMID:20407211. |
in in vitro models of neurodegenerative disease, it prevented neuronal degeneration with efficacy equal to that of bdnf, and when administered in vivo, it caused hippocampal and striatal trkb activation in mice and improved motor learning after traumatic brain injury in rats. |
2010-05-20 |
2023-08-12 |
mouse |
| I Mateo, J Infante, P Sánchez-Juan, I García-Gorostiaga, E Rodríguez-Rodríguez, J L Vázquez-Higuera, J Berciano, O Combarro. Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease. Acta neurologica Scandinavica. vol 121. issue 2. 2010-03-04. PMID:19785642. |
oxidative stress is implicated in parkinson's disease (pd) and alzheimer's disease (ad), and heme oxygenase-1 (ho-1) is a potent antioxidant overexpressed in pd substantia nigra and ad cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. |
2010-03-04 |
2023-08-12 |
Not clear |
| Hideo Hagihara, Keiko Toyama, Nobuyuki Yamasaki, Tsuyoshi Miyakaw. Dissection of hippocampal dentate gyrus from adult mouse. Journal of visualized experiments : JoVE. issue 33. 2009-12-28. PMID:19920804. |
the hippocampus is one of the most widely studied areas in the brain because of its important functional role in memory processing and learning, its remarkable neuronal cell plasticity, and its involvement in epilepsy, neurodegenerative diseases, and psychiatric disorders. |
2009-12-28 |
2023-08-12 |
mouse |
| J C Talpos, B D Winters, R Dias, L M Saksida, T J Busse. A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. Psychopharmacology. vol 205. issue 1. 2009-09-02. PMID:19357840. |
a novel touchscreen-automated paired-associate learning (pal) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. |
2009-09-02 |
2023-08-12 |
Not clear |
| Susanne G Mueller, Michael W Weine. Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields. Hippocampus. vol 19. issue 6. 2009-08-06. PMID:19405132. |
based on these findings, we conclude that subfield volumetry provides regional selective information that allows to distinguish between different normal and pathological processes affecting the hippocampus and thus for an improved differential diagnosis of neurodegenerative diseases affecting the hippocampus. |
2009-08-06 |
2023-08-12 |
human |
| Josephine Barnes, Sebastien Ourselin, Nick C Fo. Clinical application of measurement of hippocampal atrophy in degenerative dementias. Hippocampus. vol 19. issue 6. 2009-08-06. PMID:19405145. |
volumetry of the hippocampus using t1-weighted magnetic resonance imaging (mri) has been used not only to assess hippocampal involvement in different neurodegenerative diseases as a potential diagnostic biomarker, but also to understand the natural history of diseases, and to track changes in volume over time. |
2009-08-06 |
2023-08-12 |
Not clear |
| Ghiam Yami. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. Journal of neuroscience research. vol 87. issue 8. 2009-07-30. PMID:19170166. |
alzheimer's disease (ad), the most common neurodegenerative disease in the elderly population, is characterized by the hippocampal deposition of fibrils formed by amyloid beta-protein (a beta), a 40- to 42-amino-acid peptide. |
2009-07-30 |
2023-08-12 |
mouse |
| Thomas Hauser, Fabienne Klaus, Hans-Peter Lipp, Irmgard Amrei. No effect of running and laboratory housing on adult hippocampal neurogenesis in wild caught long-tailed wood mouse. BMC neuroscience. vol 10. 2009-06-30. PMID:19419549. |
studies of adult hippocampal neurogenesis (ahn) in laboratory rodents have raised hopes for therapeutic interventions in neurodegenerative diseases and mood disorders, as ahn can be modulated by physical exercise, stress and environmental changes in these animals. |
2009-06-30 |
2023-08-12 |
mouse |
| Baolu Zha. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:19125328. |
the author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases, especially summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal pd models, and of genestine and nicotine on neurons against a beta-induced apoptosis of hippocampal neuronal and transgenic mouse ad models. |
2009-06-03 |
2023-08-12 |
mouse |
| S V Sarantseva, O I Bol'shakova, S I Timoshenko, D I Rodin, M P Vitek, A L Shvartsma. [Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin]. Genetika. vol 45. issue 1. 2009-03-27. PMID:19239106. |
alzheimer's disease (ad) is a progressive neurodegenerative disease whose main pathomorphological sign is synapse degeneration in the cortex and hippocampus. |
2009-03-27 |
2023-08-12 |
human |
| Daniel Gardner, David H Goldberg, Bernice Grafstein, Adrian Robert, Esther P Gardne. Terminology for neuroscience data discovery: multi-tree syntax and investigator-derived semantics. Neuroinformatics. vol 6. issue 3. 2009-02-19. PMID:18958630. |
semantics enabling nif data discovery were selected at one or more workshops by investigators expert in particular systems (vision, olfaction, behavioral neuroscience, neurodevelopment), brain areas (cerebellum, thalamus, hippocampus), preparations (molluscs, fly), diseases (neurodegenerative disease), or techniques (microscopy, computation and modeling, neurogenetics). |
2009-02-19 |
2023-08-12 |
human |
| Dong-Hwan Kim, Richard C Davis, Ruth Furukawa, Marcus Fechheime. Autophagy contributes to degradation of Hirano bodies. Autophagy. vol 5. issue 1. 2009-01-15. PMID:18989098. |
hirano bodies are actin-rich inclusions reported most frequently in the hippocampus in association with a variety of conditions including neurodegenerative diseases, and aging. |
2009-01-15 |
2023-08-12 |
Not clear |
| Qingsong Wang, Yashu Liu, Xiao Zou, Qian Wang, Mingrui An, Xin Guan, Jintang He, Yuanpeng Tong, Jianguo J. The hippocampal proteomic analysis of senescence-accelerated mouse: implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8. Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18307031. |
hippocampus, a critical brain region associated with cognitive decline during normal aging and various neurodegenerative diseases, appeared a series of abnormalities in samp8. |
2008-10-31 |
2023-08-12 |
mouse |