| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Arnold, J Q Trojanowsk. Recent advances in defining the neuropathology of schizophrenia. Acta neuropathologica. vol 92. issue 3. 1997-02-03. PMID:8870823. |
while substantial controversy exists in all areas, in sum: (1) diagnostic neuropathological investigations find only assorted and nonspecific abnormalities in the brains of schizophrenics that are likely to be representative of lesions found in age-compatible control groups; (2) morphometric studies of gross structures generally confirm the clinical in vivo neuroimaging findings of enlarged ventricles, decreased size of ventromedial temporal lobe structures, and decreased parahippocampal cortical thickness; (3) morphometric microscopy studies find frequent alterations in neuron density and decreased neuron size in limbic, temporal, and frontal regions; (4) investigations of connectivity are at an early stage but describe abnormal dendritic spine densities in the cortex, various changes in synaptic vesicle protein expression in limbic, temporal, and frontal cortices, and alterations in glutamatergic, catecholaminergic, and intrinsic innervation in anterior cingulate cortex- together, these findings suggest a "miswiring" in the schizophrenic brain; (5) investigations of aberrant neurodevelopment in schizophrenia describe abnormalities in cortical cytoarchitecture and several developmentally regulated proteins in the hippocampal region suggesting abnormal neuronal migration, differentiation, and/or cell pruning; and (6) studies of neurodegeneration and neural injury find a general lack of neurodegenerative disease lesions or ongoing astrocytosis that would indicate post-maturational neural injury. |
1997-02-03 |
2023-08-12 |
Not clear |
| B S McEwen, E Gould, M Orchinik, N G Weiland, C S Woolle. Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing and neurodegenerative processes. Ciba Foundation symposium. vol 191. 1996-03-20. PMID:8582205. |
this paper describes three actions of oestrogens that are especially relevant to brain mechanisms involved in memory processes and their alterations during ageing and neurodegenerative diseases: (1) the regulation of cholinergic neurons by oestradiol in the rat basal forebrain, involving induction of choline acetyltransferase and acetylcholinesterase according to a sexually dimorphic pattern; (2) the regulation of synaptogenesis in the ca1 region of the hippocampus by oestrogens and progestins during the four- to five-day oestrus cycle of the female rat. |
1996-03-20 |
2023-08-12 |
rat |
| D A Eberhard, M D Brown, S R VandenBer. Alterations of annexin expression in pathological neuronal and glial reactions. Immunohistochemical localization of annexins I, II (p36 and p11 subunits), IV, and VI in the human hippocampus. The American journal of pathology. vol 145. issue 3. 1994-10-04. PMID:8080046. |
to address the possible involvement of annexins in cellular reactions to brain injury and neurodegenerative disease, we studied the immunohistochemical localization of annexins i, ii (p36 and p11), iv, and vi in the adult human hippocampus. |
1994-10-04 |
2023-08-12 |
human |
| D W Dickson, D Ruan, H Crystal, M H Mark, P Davies, Y Kress, S H Ye. Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology. vol 41. issue 9. 1991-10-11. PMID:1653914. |
in the systematic application of ubiquitin immunocytochemistry to sections of hippocampus from control subjects and patients with a wide spectrum of neurodegenerative diseases, we noted the frequent occurrence of ubiquitin-immunoreactive neurites in the ca2-3 region in dlbd. |
1991-10-11 |
2023-08-11 |
human |
| E J Mufson, D R Brady, R G Care. Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry in the hippocampal formation of the New World monkey (Saimiri sciureus). Brain research. vol 516. issue 2. 1990-08-13. PMID:2364290. |
the distribution patterns of this select neuronal population may be relevant to the study of hippocampal and entorhinal areas in neurodegenerative diseases. |
1990-08-13 |
2023-08-11 |
monkey |
| S Yoshida, Y Yase, S Iwata, K Sasagawa, K M Che. [Relationship between metal metabolism and senile changes in the hippocampal cortex of neurodegenerative disease cases in Japan and Guam]. Rinsho shinkeigaku = Clinical neurology. vol 27. issue 1. 1987-05-29. PMID:3568504. |
[relationship between metal metabolism and senile changes in the hippocampal cortex of neurodegenerative disease cases in japan and guam]. |
1987-05-29 |
2023-08-11 |
Not clear |
| L O'Brien, K Shelley, J Towfighi, A McPherso. Crystalline ribosomes are present in brains from senile humans. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 4. 1980-07-12. PMID:6929549. |
paracrystalline inclusions known as hirano bodies characteristically appear in the hippocampal region of the brains of humans exhibiting senile and presenile dementias as well as several other neurodegenerative diseases. |
1980-07-12 |
2023-08-12 |
Not clear |