| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Chen, Yuan Long, Min Han, Ting Wang, Qiang Chen, Rui Wan. Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485465. |
these results indicated that wsdp may mitigate amnesia in vivo through inhibition of ache activity in the hippocampus, which suggested propolis may have potential as a pharmaceutical of brain protection with elderly population for preventing alzheimer's disease (ad) and other neurodegenerative diseases. |
2008-08-25 |
2023-08-12 |
mouse |
| Ming-Ou Lu, Xing-Mei Zhang, Eilhard Mix, Hernan Concha Quezada, Tao Jin, Jie Zhu, Abdu Ade. TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice. Journal of neuroscience research. vol 86. issue 7. 2008-07-08. PMID:18189316. |
to address this issue, the kainic acid (ka)-induced hippocampal injury model, a well-characterized model of human neurodegenerative diseases, was used in tnf-alpha receptor 1 (tnfr1)-knockout (tnfr1-/-) mice in the present study. |
2008-07-08 |
2023-08-12 |
mouse |
| Kimmo J Hatanpaa, Eileen H Bigio, Nigel J Cairns, Kyle B Womack, Sandra Weintraub, John C Morris, Chan Foong, Guanghua Xiao, Christa Hladik, Tina Y Mantanona, Charles L Whit. TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. Journal of neuropathology and experimental neurology. vol 67. issue 4. 2008-06-12. PMID:18379440. |
we studied tdp-43 pathology in the hippocampus and frontal cortex of autopsy brains from patients with ftld-u (n = 68), dementia lacking distinctive histopathology (n = 4), other neurodegenerative diseases (n = 23), and controls (n = 12) using a sensitive immunohistochemistry protocol. |
2008-06-12 |
2023-08-12 |
Not clear |
| Kimmo J Hatanpaa, Eileen H Bigio, Nigel J Cairns, Kyle B Womack, Sandra Weintraub, John C Morris, Chan Foong, Guanghua Xiao, Christa Hladik, Tina Y Mantanona, Charles L Whit. TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. Journal of neuropathology and experimental neurology. vol 67. issue 4. 2008-06-12. PMID:18379440. |
of the cases with other neurodegenerative diseases, 43% showed tdp-43 pathology in the hippocampus, but only 4% showed tdp-43 pathology in the frontal cortex. |
2008-06-12 |
2023-08-12 |
Not clear |
| Keun W Park, Byung K Ji. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:18183616. |
this strongly suggests that thrombin can act as an endogenous neurotoxin, and inhibitors of thrombin and/or antioxidants can be useful agents for treating oxidative stress-mediated hippocampal neurodegenerative diseases, such as alzheimer's disease. |
2008-04-23 |
2023-08-12 |
Not clear |
| Shohreh Majd, Karim Rastegar, Asadollah Zarifkar, Mohammad Ali Takhshi. Fibrillar beta-amyloid (Abeta) (1-42) elevates extracellular Abeta in cultured hippocampal neurons of adult rats. Brain research. vol 1185. 2008-03-28. PMID:17961521. |
in the present study, we used adult hippocampal neuronal culture as an in vitro model which is favorable for adult neurodegenerative diseases' studies. |
2008-03-28 |
2023-08-12 |
rat |
| Jung Hoon Choi, Choong Hyun Lee, In Koo Hwang, Moo Ho Won, Je Kyung Seong, Yeo Sung Yoon, Heungshik S Lee, In Se Le. Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region. The Journal of veterinary medical science. vol 69. issue 11. 2008-01-10. PMID:18057827. |
this result may be associated with an age-dependent susceptibility to neurodegenerative diseases associated with the hippocampus. |
2008-01-10 |
2023-08-12 |
Not clear |
| Michael J Chumley, Timothy Catchpole, Robert E Silvany, Steven G Kernie, Mark Henkemeye. EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057206. |
our data strongly suggest that ephb1 and ephrin-b3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus and should be added to a short list of candidate target molecules for modulating the production and integration of new neurons as a treatment for neurodegenerative diseases or brain injury. |
2007-12-27 |
2023-08-12 |
mouse |
| Lenka Munoz, Hantamalala Ralay Ranaivo, Saktimayee M Roy, Wenhui Hu, Jeffrey M Craft, Laurie K McNamara, Laura Wing Chico, Linda J Van Eldik, D Martin Watterso. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. Journal of neuroinflammation. vol 4. 2007-12-10. PMID:17784957. |
an accumulating body of evidence is consistent with the hypothesis that excessive or prolonged increases in proinflammatory cytokine production by activated glia is a contributor to the progression of pathophysiology that is causally linked to synaptic dysfunction and hippocampal behavior deficits in neurodegenerative diseases such as alzheimer's disease (ad). |
2007-12-10 |
2023-08-12 |
mouse |
| Aleksandra Mladenovic, Milka Perovic, Nikola Tanic, Suzana Petanceska, Sabera Ruzdijic, Selma Kanazi. Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus. Synapse (New York, N.Y.). vol 61. issue 9. 2007-11-29. PMID:17568432. |
the aim of this study was to assess the effects of dr on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. |
2007-11-29 |
2023-08-12 |
rat |
| Andrea R Genazzani, Nicola Pluchino, Letizia Freschi, Filippo Ninni, Michele Luis. Androgens and the brain. Maturitas. vol 57. issue 1. 2007-07-19. PMID:17386983. |
androgens play a pivotal neuroactive role during the "organizational/developmental" phase, mainly in the fetal-neonatal period, when participated to the formation of neuronal circuits, as well as during the aging process when it has been demonstrated to directly affect hippocampal spine synapse density, suggesting a physiopathological role for androgen in the modulation cognitive function and development of neurodegenerative disease. |
2007-07-19 |
2023-08-12 |
Not clear |
| Michael C Veronesi, Michael Yard, James Jackson, Debomoy K Lahiri, Michael J Kube. An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17125753. |
these results provide support for an important neuroprotective effect of trh/analogs against glutamate toxicity in primary hippocampal neuronal culture and implicate a potentially beneficial role of trh/analogs in neurodegenerative diseases. |
2007-03-27 |
2023-08-12 |
rat |
| P M Gonçalves-Pereira, E Oliveira, R Insaust. [Quantitative volumetric analysis of the hippocampus, amygdala and entorhinal cortex: normative database for the adult Portuguese population]. Revista de neurologia. vol 42. issue 12. 2006-10-18. PMID:16775796. |
atrophy of the hippocampus, amygdala and entorhinal cortex can be found in neurodegenerative diseases, head trauma and epilepsy and are expressed by means of volume reductions. |
2006-10-18 |
2023-08-12 |
Not clear |
| Sa Forslin Aronsson, Stefan Spulber, Laurentiu M Popescu, Bengt Winblad, Claes Post, Mircea Oprica, Marianne Schultzber. alpha-Melanocyte-stimulating hormone is neuroprotective in rat global cerebral ischemia. Neuropeptides. vol 40. issue 1. 2006-06-22. PMID:16414116. |
in conclusion, post-ischemic administration of alpha-msh was found to provide neuroprotection in the ca1 pyramidal cell layer in the hippocampus, concomitant with a reduction in glial activation, indicating that alpha-msh or mimetics thereof may have a potential in the treatment of stroke or other neurodegenerative diseases. |
2006-06-22 |
2023-08-12 |
rat |
| Beata D Przybyla-Zawislak, Brett T Thorn, Syed F Ali, Richard A Dennis, Antonino Amato, Ashraf Virmani, Zbigniew K Biniend. Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3-NPA. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179520. |
it is known that the hippocampal degeneration caused by mitochondrial dysfunction affects learning and memory, cognitive functions commonly disturbed in neurodegenerative diseases. |
2006-06-06 |
2023-08-12 |
rat |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. Journal of pharmacological sciences. vol 99. issue 4. 2006-03-10. PMID:16340157. |
importantly, neurogenesis, that is, birth/maturation of functional new neurons, continues to occur throughout the lifetime in human adult brains (e.g., hippocampus); the neurogenesis is impaired by multiple not-fully defined factors (e.g., aging, chronic stress-induced increase of glucocorticoids, and excitotoxicity), accounting for brain atrophy in patients with depressive illness and neurodegenerative diseases. |
2006-03-10 |
2023-08-12 |
human |
| Daniela Puzzo, Ottavio Vitolo, Fabrizio Trinchese, Joel P Jacob, Agostino Palmeri, Ottavio Aranci. Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 29. 2006-02-15. PMID:16033898. |
these results strongly suggest that, when modulating hippocampal synaptic plasticity, abeta downregulates the no/cgmp/cgk/creb pathway; thus, enhancement of the no/cgmp signaling may provide a novel approach to the treatment of ad and other neurodegenerative diseases with elevated production of abeta. |
2006-02-15 |
2023-08-12 |
Not clear |
| Baolu Zha. Natural antioxidants for neurodegenerative diseases. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953828. |
the author reviews the studies on the preventing effects of natural antioxidants, such as vitamins e and c, flavonoids, and polyphenols on neurodegenerative diseases, especially summarizing the results on the protective effect of ginkgo biloba extract on neuron cells, preventing effects of green tea polyphenols on apoptosis of pc12 cells (parkison's disease model), preventing effects of genestien on amyloid-beta-induced apoptosis of hippocampal neuronal cells (alzhemer's disease model), and preventing effect of crataegus flavonoids on ischemic-reperfusion damage to the brain of the mongolian gerbil (stroke model) in the laboratory. |
2006-01-24 |
2023-08-12 |
Not clear |
| Kenji Yoshimi, Yong-Ri Ren, Tatsunori Seki, Masanori Yamada, Hideki Ooizumi, Masafumi Onodera, Yuko Saito, Shigeo Murayama, Hideyuki Okano, Yoshikuni Mizuno, Hideki Mochizuk. Possibility for neurogenesis in substantia nigra of parkinsonian brain. Annals of neurology. vol 58. issue 1. 2005-09-06. PMID:15912513. |
recent studies of enhanced hippocampal neurogenesis by antidepressants suggest enhancement of neurogenesis is a potentially effective therapy in neurodegenerative diseases. |
2005-09-06 |
2023-08-12 |
human |
| Sylvain Bouix, Jens C Pruessner, D Louis Collins, Kaleem Siddiq. Hippocampal shape analysis using medial surfaces. NeuroImage. vol 25. issue 4. 2005-07-11. PMID:15850726. |
in magnetic resonance imaging (mri) research, significant attention has been paid to the analysis of the hippocampus (hc) within the medial temporal lobe because of its importance in memory and learning, and its role in neurodegenerative diseases. |
2005-07-11 |
2023-08-12 |
human |