| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiguo Chen, Rui-Sheng Duan, Hernan Concha Quezada, Eilhard Mix, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice. Journal of neurobiology. vol 62. issue 2. 2005-04-11. PMID:15459893. |
in mice, intranasal administration of kainic acid (ka), an analogue of the excitotoxin glutamate, results in hippocampal cell death and provides a well-characterized model for studies of human neurodegenerative diseases. |
2005-04-11 |
2023-08-12 |
mouse |
| Melissa Ray, Iwo Bohr, J Michael McIntosh, Clive Ballard, Ian McKeith, Sylvie Chalon, Denis Guilloteau, Robert Perry, Elaine Perry, J A Court, Margaret Piggot. Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum. Neuroscience letters. vol 372. issue 3. 2005-01-05. PMID:15542244. |
dementia with lewy bodies (dlb) is a neurodegenerative disease associated with a range of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine receptors (nachrs) in neocortex, hippocampus, thalamus and basal ganglia. |
2005-01-05 |
2023-08-12 |
Not clear |
| P Hemachandra Reddy, Shannon McWeeney, Byung S Park, Maria Manczak, Ramana V Gutala, Dara Partovi, Youngsin Jung, Vincent Yau, Robert Searles, Motomi Mori, Joseph Quin. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115763. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the impairment of cognitive functions and by beta amyloid (abeta) plaques in the cerebral cortex and the hippocampus. |
2004-12-22 |
2023-08-12 |
mouse |
| Zhiguo Chen, Rui-Sheng Duan, Q Hernan Concha, Qinyang Wu, Eilhard Mix, Bengt Winblad, Hans-Gustaf Ljunggren, Jie Zh. IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474355. |
to address this issue, we used the model of kainic acid (ka)-induced hippocampal injury in il-12p35 knockout (ko) mice, a well-characterized model for human neurodegenerative diseases. |
2004-12-21 |
2023-08-12 |
mouse |
| Yoon Hee Chung, Soo In Kim, Kyeung Min Joo, Yang Soo Kim, Won Bok Lee, Kyu Wol Yun, Choong Ik Ch. Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats. Brain research. vol 1018. issue 1. 2004-10-06. PMID:15262216. |
the first demonstration of age-related decreases in epo expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases, suggesting that age-related decreases in epo may contribute to degenerative events following age-related decreases in brain flow and oxygen supply. |
2004-10-06 |
2023-08-12 |
rat |
| Akhlaq A Farooqui, Wei-Yi Ong, Lloyd A Horrock. Neuroprotection abilities of cytosolic phospholipase A2 inhibitors in kainic acid-induced neurodegeneration. Current drug targets. Cardiovascular & haematological disorders. vol 4. issue 1. 2004-05-10. PMID:15058300. |
treatment of rat brain hippocampal slices with antimalarial drugs (non-specific cpla2 inhibitors) not only inhibits cpla2 activity but also blocks neurodegeneration suggesting that cpla2 inhibitors can be used as neuroprotective and anti-inflammatory agents in neurodegenerative diseases. |
2004-05-10 |
2023-08-12 |
rat |
| Muddanna S Rao, Ashok K Shett. Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. The European journal of neuroscience. vol 19. issue 2. 2004-03-18. PMID:14725617. |
this could be particularly useful for analysing changes in dentate neurogenesis in human hippocampal tissues as a function of ageing or neurodegenerative diseases. |
2004-03-18 |
2023-08-12 |
human |
| Zhiguo Chen, Hans-Gustaf Ljunggren, Shun-Wei Zhu, Bengt Winblad, Jie Zh. Reduced susceptibility to kainic acid-induced excitoxicity in T-cell deficient CD4/CD8(-/-) and middle-aged C57BL/6 mice. Journal of neuroimmunology. vol 146. issue 1-2. 2004-03-02. PMID:14698844. |
kainic acid (ka)-induced hippocampal injury is a good model for studying human neurodegenerative diseases. |
2004-03-02 |
2023-08-12 |
mouse |
| Takatoshi Ueki, Masamitsu Tanaka, Kanna Yamashita, Sumiko Mikawa, ZheFu Qiu, Nicholas J Maragakis, Robert F Hevner, Naoyuki Miura, Haruhiko Sugimura, Kohji Sat. A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 37. 2004-01-16. PMID:14684875. |
these findings suggest endogenous mechanisms that induce adult hippocampal neurogenesis and propose an innovative treatment for the neurodegenerative diseases that cause loss of hippocampal neurons. |
2004-01-16 |
2023-08-12 |
Not clear |
| Vandana Zaman, Ashok K Shett. Pretreatment of donor cells with FGF-2 enhances survival of fetal hippocampal CA3 cell transplants in the chronically lesioned young adult hippocampus. Experimental neurology. vol 183. issue 1. 2003-10-02. PMID:12957484. |
these results have significance toward advancement of clinically feasible cell grafting strategies for repair of the damaged young adult hippocampus, particularly at extended periods after the injury or the onset of neurodegenerative diseases. |
2003-10-02 |
2023-08-12 |
rat |
| Vandana Zaman, Ashok K Shett. Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy. Hippocampus. vol 13. issue 5. 2003-09-26. PMID:12921351. |
these results have implications toward the development of suitable cell grafting strategies for repair of the lesioned aging hippocampus in neurodegenerative diseases, particularly the temporal lobe epilepsy, stroke, and alzheimer's disease. |
2003-09-26 |
2023-08-12 |
rat |
| Yoon Hee Chung, Eun Jung Kim, Chung Min Shin, Kyeung Min Joo, Myeung Ju Kim, Haing Won Woo, Choong Ik Ch. Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats. Brain research. vol 956. issue 2. 2003-04-22. PMID:12445700. |
the first demonstration of age-related decreases in cbp expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases and depression. |
2003-04-22 |
2023-08-12 |
rat |
| Karsten Schmidt, Stefan Kins, Andreas Schild, Roger M Nitsch, Brian A Hemmings, Jürgen Göt. Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. The European journal of neuroscience. vol 16. issue 11. 2003-03-25. PMID:12473071. |
pr55/balpha and bbeta protein expression varies significantly in areas of the brain affected by neurodegenerative diseases such as the hippocampus or cerebellum. |
2003-03-25 |
2023-08-12 |
human |
| Yoon Hee Chung, Chung Min Shin, Kyeung Min Joo, Myeung Ju Kim, Choong Ik Ch. Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats. Brain research. vol 946. issue 2. 2002-11-12. PMID:12137935. |
our first morphological data concerning the differential regulation of igf-i receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as alzheimer's disease. |
2002-11-12 |
2023-08-12 |
rat |
| Nahid K El-Bakri, A Adem, I A Suliman, E Mulugeta, E Karlsson, J U Lindgren, B Winblad, A Isla. Estrogen and progesterone treatment: effects on muscarinic M(4) receptor subtype in the rat brain. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383964. |
the effect of estrogen on the hippocampal muscarinic m(4) receptor subtype is a novel finding and may have functional significance for cholinergic receptors especially in relation to postmenopausal memory problems and neurodegenerative disease like alzheimer's disease. |
2002-10-30 |
2023-08-12 |
rat |
| Marina A Lync. Interleukin-1 beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions. Vitamins and hormones. vol 64. 2002-04-08. PMID:11898392. |
there is now a great deal of evidence suggesting that il-1 beta plays a significant role in hippocampal synaptic function, and the possibility that il-1 beta may trigger some of the detrimental changes in certain neurodegenerative diseases is currently being assessed. |
2002-04-08 |
2023-08-12 |
Not clear |
| Kentaro Tanemura, Miyuki Murayama, Takumi Akagi, Tsutomu Hashikawa, Takashi Tominaga, Michinori Ichikawa, Haruyasu Yamaguchi, Akihiko Takashim. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756496. |
v337m tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for nfts in human neurodegenerative diseases. |
2002-02-04 |
2023-08-12 |
mouse |
| S S Ingrand, A Wahl, S Favrelière, F Barbot, C Tallinea. Quantification of long-chain aldehydes by gas chromatography coupled to mass spectrometry as a tool for simultaneous measurement of plasmalogens and their aldehydic breakdown products. Analytical biochemistry. vol 280. issue 1. 2000-06-30. PMID:10805522. |
two of these are affected in neurodegenerative diseases (cerebral cortex and hippocampus) and one is rich in white matter (cerebellum). |
2000-06-30 |
2023-08-12 |
rat |
| M Cyr, O Ghribi, T Di Paol. Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain. Journal of neuroendocrinology. vol 12. issue 5. 2000-05-31. PMID:10792584. |
the effect of oestradiol in the hippocampus confirmed in the present study and our novel findings in the frontal cortex, striatum and nucleus accumbens may have functional significance for schizophrenia and neurodegenerative diseases. |
2000-05-31 |
2023-08-12 |
rat |
| A R McQuiston, D V Madiso. Muscarinic receptor activity induces an afterdepolarization in a subpopulation of hippocampal CA1 interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 14. 1999-08-02. PMID:10407011. |
cholinergic input to the hippocampus may be involved in important behavioral functions and the pathophysiology of neurodegenerative diseases. |
1999-08-02 |
2023-08-12 |
rat |