| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo Chen, Xinyuan Li, Xiang Zhou, Yang Li, Haitao Yu, Xiang Peng, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Yuhua Mei, Li Li, Yu Liu, Xin Gou, Yuanbin Jian. Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis. Scientific reports. vol 14. issue 1. 2024-03-21. PMID:38509215. |
overall, this study revealed an effect of hucmsc-sevs on inhibiting apoptosis; hucmsc-sevs reduced renal ir injury by delivering mir-100-5p to hk-2 cells, targeting fkbp5 and thereby promoting akt-473 phosphorylation to activate the akt pathway. |
2024-03-21 |
2024-03-23 |
mouse |
| Qian Deng, Jia-Qi Liang, Chen-Hui Gao, Xia Ge, Jin-Jin Zheng, Qing-Ping Zhan. Effects of electroacupuncture on the PI3K/Akt/CREB signaling pathway and hippocampal neuronal apoptosis in diabetic cognitive impairment rats. Zhen ci yan jiu = Acupuncture research. vol 49. issue 3. 2024-03-19. PMID:38500323. |
to observe the effects of electroacupuncture (ea) on the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/camp response element binding protein (creb) signaling pathway-related proteins and hippocampal neuron apoptosis in diabetic cognitive impairment (dci) rats, and to explore the mechanisms of ea in treating dci. |
2024-03-19 |
2024-03-21 |
rat |
| Liqiao Chen, Liangliang Wang, Zongqi Han, Peng Qin, Guangxu Niu, Jingxia D. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. The Tohoku journal of experimental medicine. vol 262. issue 3. 2024-03-18. PMID:38123304. |
then, sphk1/2 activity, cell viability, proliferation, apoptosis, invasion, and protein expressions of phosphorylated-protein kinase b (p-akt), akt, phosphorylated-mammalian target of rapamycin (p-mtor) and mtor were detected. |
2024-03-18 |
2024-03-20 |
Not clear |
| Sara M Elgendy, Dana M Zaher, Nadin H Sarg, Nour N Abu Jayab, Dima W Alhamad, Taleb H Al-Tel, Hany A Oma. Autophagy inhibition potentiates energy restriction-induced cell death in hepatocellular carcinoma cells. IUBMB life. 2024-03-18. PMID:38497226. |
the treatment combination promoted hcc death through apoptosis, cell cycle arrest, and inhibition of akt and erk activation, which are known to play a key role in cellular proliferation. |
2024-03-18 |
2024-03-20 |
human |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
cdc-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through akt signaling pathway. |
2024-03-04 |
2024-03-07 |
mouse |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
mechanistically, clk3 regulated the phosphorylation status of akt, a key player in the regulation of apoptosis. |
2024-03-04 |
2024-03-07 |
mouse |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
furthermore, overexpression of akt rescued hypoxia-induced apoptosis in nrvms caused by clk3 deficiency. |
2024-03-04 |
2024-03-07 |
mouse |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
taken together, clk3 deficiency promotes hypoxia-induced cardiomyocyte apoptosis through akt signaling pathway. |
2024-03-04 |
2024-03-07 |
mouse |
| Bahareh Shateri Amiri, Neda Sabernia, Behdokht Abouali, Parya Amini, Hadi Rezaeeya. Evaluation of MicroRNA as Minimal Residual Disease in Leukemia: Diagnostic and Prognostic Approach: A Review. Iranian journal of public health. vol 52. issue 12. 2024-03-04. PMID:38435763. |
among the studied mirnas, mir-99a, and mir-181a play an essential role in apoptosis, proliferation and oncogenesis via akt, mapk, ras, and mtor signaling pathways. |
2024-03-04 |
2024-03-06 |
Not clear |
| Hojun Lee, Wonhyoung Park, Garam An, Junho Park, Whasun Lim, Gwonhwa Son. Hexaconazole induces developmental toxicities via apoptosis, inflammation, and alterations of Akt and MAPK signaling cascades. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-02-29. PMID:38423198. |
hexaconazole induces developmental toxicities via apoptosis, inflammation, and alterations of akt and mapk signaling cascades. |
2024-02-29 |
2024-03-03 |
zebrafish |
| Guy Nadel, Zhong Yao, Avital Hacohen-Lev-Ran, Ehud Wainstein, Galia Maik-Rachline, Tamar Ziv, Zvi Naor, Arie Admon, Rony Sege. Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis. Cell communication and signaling : CCS. vol 22. issue 1. 2024-02-28. PMID:38419089. |
phosphorylation of pp2ac by pkc is a key regulatory step in the pp2a-switch-dependent akt dephosphorylation that leads to apoptosis. |
2024-02-28 |
2024-03-02 |
Not clear |
| Guy Nadel, Zhong Yao, Avital Hacohen-Lev-Ran, Ehud Wainstein, Galia Maik-Rachline, Tamar Ziv, Zvi Naor, Arie Admon, Rony Sege. Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis. Cell communication and signaling : CCS. vol 22. issue 1. 2024-02-28. PMID:38419089. |
although gqpcr activation often leads to cell survival by activating the pi3k/akt pathway, it was previously shown that in several cell types akt activity is reduced and leads to jnk activation and apoptosis. |
2024-02-28 |
2024-03-02 |
Not clear |
| Guojian Shi, Xiaohua Li, Weiping Wang, Lili Hou, Lei Yin, Li Wan. Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway. Cell biochemistry and biophysics. 2024-02-27. PMID:38411783. |
cck-8, colony formation, flow cytometry, rt-qpcr, and western blotting assays were performed to investigate the effects of allicin and/or doxorubicin treatment on the viability, proliferation and apoptosis and the expression of nrf2, ho-1, phosphate akt and akt in doxorubicin-resistant bc cells. |
2024-02-27 |
2024-03-02 |
Not clear |
| Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Rigant. The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition. Translational oncology. vol 43. 2024-02-27. PMID:38412661. |
roginolisib induced apoptosis in mpm cells and enhanced the anti-tumor efficacy of akt and mtor kinase inhibitors by suppressing pi3k-δ/akt/mtor and erk1/2 signaling. |
2024-02-27 |
2024-03-01 |
Not clear |
| Jing-Long Cao, Shu-Mei Li, Yan-Jun Tang, Wen-Shuang Hou, An-Qi Wang, Tian-Zhu Li, Cheng-Hao Ji. Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells. Drug development research. vol 85. issue 2. 2024-02-24. PMID:38400652. |
overall, iso induced cell apoptosis and cell cycle arrest and inhibited cell migration by ros-mediated egfr, akt, and mapk signaling pathways in hepg2 cells. |
2024-02-24 |
2024-02-26 |
Not clear |
| Guoyang Sun, Jinjin Wang, Futao Liu, Cai Zhao, Shanshan Cui, Zhaoyang Wang, Zhen Liu, Qian Zhang, Cen Xiang, Yongmin Zhang, Herve Galons, Peng Yu, Yuou Ten. G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. Biochemical pharmacology. 2024-02-23. PMID:38395264. |
flow cytometry and immunoblotting showed that g-4 not only arrested the s phase of the cell cycle, but also induced apoptosis in tnbc cells via the mitochondrial pathway through inhibiting epidermal growth factor receptor (egfr), akt and mapk pathways. |
2024-02-23 |
2024-02-26 |
Not clear |
| Jina Jiang, Tingting Qi, Li Li, Yunzhi Pan, Lijuan Huang, Lijuan Zhu, Dongyang Zhang, Xiaoqing Ma, Yinghui Qi. MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-02-21. PMID:38381220. |
in cells treated with the specific pi3k/akt/mtor inhibitor ly294002, phosphorylation levels of akt and mtor were decreased, cell viability decreased, and apoptosis increased compared to the mrps9 overexpression group. |
2024-02-21 |
2024-02-23 |
mouse |
| Zhifeng Li, Jinglei Liu, Ping Wang, Boyu Zhang, Guanghui He, Liwei Yan. The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy. Functional & integrative genomics. vol 24. issue 2. 2024-02-16. PMID:38363382. |
western blotting was used to determine the levels of ywhae, pi3k, akt, emt, apoptosis, and autophagy-related proteins. |
2024-02-16 |
2024-02-18 |
Not clear |
| Haoyu Wang, Jingchun Liu, Zihui Zhang, Jiaxin Peng, Zhi Wang, Lian Yang, Xinqi Wang, Siyuan Hu, Hong L. β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer. Free radical biology & medicine. 2024-02-16. PMID:38364944. |
the suppression of akt signaling disrupted downstream pathways associated with cell cycle, cell survival, apoptosis, migration, and invasion, ultimately culminating in the death of oc cells. |
2024-02-16 |
2024-02-19 |
Not clear |
| Ming Ni, Jiannan Qiu, Guoqing Liu, Xiaohu Sun, Wenjie Zhu, Peng Wu, Zheng Chen, Jiajing Qiu, Ziming Wu, Yang Zhang, Feng Zhang, Changyong Li, Yuan Gao, Jun Zhou, Qiang Zh. Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway. Cell death & disease. vol 15. issue 2. 2024-02-15. PMID:38360839. |
furthermore, overexpression akt or mst1 in tsc1-knockout macrophages upregulated nrf2 expression, downregulated tlr4/nf-κb, resulting in reduced inflammatory factors, ros and inflammatory cytokine-mediated hepatocyte apoptosis. |
2024-02-15 |
2024-02-18 |
mouse |