| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Ni, Jiannan Qiu, Guoqing Liu, Xiaohu Sun, Wenjie Zhu, Peng Wu, Zheng Chen, Jiajing Qiu, Ziming Wu, Yang Zhang, Feng Zhang, Changyong Li, Yuan Gao, Jun Zhou, Qiang Zh. Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway. Cell death & disease. vol 15. issue 2. 2024-02-15. PMID:38360839. |
tsc1 activation promotes phosphorylation of akt and mst1, which in turn increases nrf2 expression and inhibits ros production and tlr4/nf-κb activation, resulting in reduced hepatocellular apoptosis in i/r-triggered liver injury. |
2024-02-15 |
2024-02-18 |
mouse |
| Vincenzo Gianluca Messana, Amelia Fascì, Nicoletta Vitale, Matilde Micillo, Matteo Rovere, Noemi Anna Pesce, Claudio Martines, Dimitar Efremov, Tiziana Vaisitti, Silvia Deagli. A molecular circuit linking the BCR to the NAD biosynthetic enzyme NAMPT is an actionable target in Richter's syndrome. Blood advances. 2024-02-15. PMID:38359376. |
consistently, pharmacological inhibition or silencing of sirtuin 1 and 2 impairs akt activation and induces apoptosis of rs cells in combination with pi3ki or btki. |
2024-02-15 |
2024-02-18 |
mouse |
| Jiazhou Li, Jing Xie, Xuedong Zho. [Stromal Cell-Derived Factor 1α Inhibits Chondrocyte Apoptosis and Promotes Autophagy Through the Akt Signaling Pathway]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 55. issue 1. 2024-02-07. PMID:38322539. |
[stromal cell-derived factor 1α inhibits chondrocyte apoptosis and promotes autophagy through the akt signaling pathway]. |
2024-02-07 |
2024-02-09 |
Not clear |
| Renuga Devi Navaneethan, Packia Lekshmi N C J, Mariselvam Ramaiah, Rajeswari Ravindran, Ananth Kumar S, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Ananthi Sivagnanam, Ponnanikajamideen Mohemedibrahi. Caralluma pauciflora based Ag-NPs activate ROS - induced apoptosis through down-regulation of AKT, mTOR and pI3K signaling in human Gastric Cancer (AGS) cells. Nanotechnology. 2024-02-06. PMID:38320329. |
caralluma pauciflora based ag-nps activate ros - induced apoptosis through down-regulation of akt, mtor and pi3k signaling in human gastric cancer (ags) cells. |
2024-02-06 |
2024-02-09 |
human |
| Chun Yu Zhang, Cheng-Huei Hung, Yi-Ling Hsiao, Tung-Miao Chang, Yu-Chieh Su, Li-Chiu Wang, Shih-Min Wang, Shun-Hua Che. Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation. Antiviral research. 2024-02-03. PMID:38309307. |
parasite and cancer studies showed that the cellular protein kinase b (akt) decreases interferon (ifn), apoptosis, and interleukin (il)-6-induced stat3 responses, which suppress cvb3 replication. |
2024-02-03 |
2024-02-06 |
mouse |
| Chun Yu Zhang, Cheng-Huei Hung, Yi-Ling Hsiao, Tung-Miao Chang, Yu-Chieh Su, Li-Chiu Wang, Shih-Min Wang, Shun-Hua Che. Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation. Antiviral research. 2024-02-03. PMID:38309307. |
furthermore, miltefosine, the akt inhibitor used in the clinic for parasite infections, enhances il-6, ifn, and apoptosis responses in treated patients, suggesting that miltefosine could be the potential antiviral for cvb3. |
2024-02-03 |
2024-02-06 |
mouse |
| Mengjia Shen, Shiyu Cao, Xinyi Long, Lin Xiao, Libo Yang, Peichuan Zhang, Li Li, Fei Chen, Ting Lei, Hongwei Gao, Feng Ye, Hong B. DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT. Redox biology. vol 70. 2024-02-02. PMID:38306757. |
dnajc12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of akt. |
2024-02-02 |
2024-02-05 |
Not clear |
| Yun Li, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Shenglei Zhang, Yaling Bai, Jinsheng X. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification. Aging. vol 16. 2024-02-01. PMID:38301049. |
microtubule affinity-regulating kinase 4 (mark4), known as a serine/threonine protein kinase, can induce cell apoptosis and autophagy by modulating akt phosphorylation. |
2024-02-01 |
2024-02-04 |
human |
| Lei Zhuo, Zhenfeng Hu, Jin Chang, Qing Guo, Jing Gu. MicroRNA‑203a‑3p improves bleomycin and pingyangmycin sensitivity by inactivating the PI3K/AKT pathway in hemangioma. Experimental and therapeutic medicine. vol 27. issue 2. 2024-01-26. PMID:38274341. |
cell viability, rate of apoptosis and the expression levels of proteins involved in the pi3k/akt pathway, including phosphorylated (p)-pi3k, pi3k, p-akt and akt, were detected. |
2024-01-26 |
2024-01-28 |
human |
| Ragini Singh, Aishwarya Jaiswal, Rana P Sing. Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells. Biochimica et biophysica acta. Molecular cell research. 2024-01-25. PMID:38272357. |
smg triggered apoptosis simultaneously via erk1/2 and akt activation, and inhibition of gsk3β activity which was reversed by mek1 and pi3k inhibitors. |
2024-01-25 |
2024-01-28 |
Not clear |
| Ragini Singh, Aishwarya Jaiswal, Rana P Sing. Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells. Biochimica et biophysica acta. Molecular cell research. 2024-01-25. PMID:38272357. |
taken together, our study revealed that microgravity is a strong stressor to trigger dna damage and apoptosis through activation of erk1/2 and akt, and impairment of dna repair capacity, albeit with a cell-type difference in ddr and nhej regulation, in microglial and glioblastoma cells. |
2024-01-25 |
2024-01-28 |
Not clear |
| Antoine Beurton, Maxime Michot, François-Xavier Hérion, Mario Rienzo, Claire Oddos, Thierry Couffinhal, Julien Imbault, Alexandre Ouattar. Systemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2024-01-23. PMID:38261663. |
upon completion of the experiment, the hearts were removed for assessment of infarct size, histology, apoptosis measurements, and phosphorylation statuses of p38 and protein kinase b (akt), and extracellular signal-regulated kinase mitogen-activated protein kinases (erk-mapk). |
2024-01-23 |
2024-01-26 |
Not clear |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
the development of esophageal squamous cell carcinoma (escc) involves various genetic abnormalities that affect key cell signaling pathways, including wnt, hh, apoptosis, mapk, egfr, akt, notch, and emt. |
2024-01-17 |
2024-01-19 |
Not clear |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
furthermore, pygo2 gene expression induction analysis showed the correlation of several involved genes in wnt, hh, apoptosis, mapk, egfr, akt, and emt pathways with various lncrnas. |
2024-01-17 |
2024-01-19 |
Not clear |
| Yuanyuan Che, Wei Wu, Xiao Qian, Zhengwei Sheng, Wang Zhang, Jie Zheng, Junhui Chen, Yuhai Wan. The neuroprotection of controlled decompression after traumatic epidural intracranial hypertension through suppression of autophagy via PI3K/Akt signaling pathway. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226265. |
herein, we observed the functional recovery, the degree of brain edema, the level of apoptosis, the expressions of neuronal cell autophagy-related signaling pathway proteins (including akt, |
2024-01-16 |
2024-01-18 |
rat |
| Dong Min Lee, In Young Kim, Hong Jae Lee, Min Ji Seo, Mi-Young Cho, Hae In Lee, Gyesoon Yoon, Jae-Hoon Ji, Seok Soon Park, Seong-Yun Jeong, Eun Kyung Choi, Yong Hyeon Choi, Chae-Ok Yun, Mirae Yeo, Eunhee Kim, Kyeong Sook Cho. Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis. Cell death & disease. vol 15. issue 1. 2024-01-13. PMID:38218922. |
given that hyperactive akt counteracts chemotherapeutic-induced apoptosis, vcp inhibition presents a promising therapeutic avenue to exploit akt-associated vulnerabilities in cancer cells by triggering paraptosis while safeguarding normal cells. |
2024-01-13 |
2024-01-16 |
Not clear |
| Stuti Bhagat, Sanjay Sing. Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells. Biomedical materials (Bristol, England). 2024-01-12. PMID:38215478. |
other cellular events such as caspase-7 overexpression and pi3k, akt, parp, and mtor inhibition led to the apoptosis in hepatic cancer cells. |
2024-01-12 |
2024-01-15 |
Not clear |
| Chunyu Qin, Hui Wang, Jincheng Zhong, Hongbiao Ran, Wei Pen. miR-129 Regulates Yak Intramuscular Preadipocyte Proliferation and Differentiation through the PI3K/AKT Pathway. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203803. |
further investigation revealed that mir-129 enhances akt and p-akt activity in the akt pathway without affecting cell apoptosis, and a specific inhibitor (ly294002) was used to confirm that mir-129 regulates yimas proliferation and differentiation through the pi3k/akt pathway. |
2024-01-11 |
2024-01-13 |
Not clear |
| Vincent Peng, Tihana Trsan, Raki Sudan, Bishan Bhattarai, Victor S Cortez, Martina Molgora, Jean Vacher, Marco Colonn. Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway. The Journal of experimental medicine. vol 221. issue 3. 2024-01-10. PMID:38197946. |
inpp4b-deficient cells display increased rates of apoptosis and reduced activation of the prosurvival molecule akt. |
2024-01-10 |
2024-01-13 |
Not clear |
| Ruizhen Cao, Shuilong Guo, Li Min, Peng L. Roles of Rictor alterations in gastrointestinal tumors (Review). Oncology reports. vol 51. issue 2. 2024-01-08. PMID:38186315. |
the aim of the present study was to critically discuss the following: i) mutation and biological characteristics of rictor in tumors with a detailed overview of rictor in cell proliferation, angiogenesis, apoptosis, autophagy and drug resistance; ii) the role of rictor in tumors of the digestive system, particularly colorectal, hepatobiliary, gastric, esophageal and pancreatic cancer and cholangiocarcinoma; and iii) the current status and prospects of targeted therapy for rictor by inhibiting akt activation. |
2024-01-08 |
2024-01-10 |
human |