| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Yasin Zamanian, Mehraveh Sadeghi Ivraghi, Reena Gupta, K D V Prasad, Hashem O Alsaab, Beneen M Hussien, Hazem Ahmed, Montather F Ramadan, Maryam Golmohammadi, Nikta Nikbakht, Tuba Oz, Małgorzata Kujawsk. miR-221 and Parkinson's disease: A biomarker with therapeutic potential. The European journal of neuroscience. 2023-12-03. PMID:38043936. |
according to the results of these studies, (1) mir-221 protects pc12 cells against oxidative stress induced by 6-hydroxydopamine; (2) mir-221 prevents bax/caspase-3 signalling activation by stopping bim; (3) mir-221 has moderate predictive power for pd; (4) mir-221 directly targets pten, and pten over-expression eliminates the protective action of mir-221 on p-akt expression in pc12 cells; and (5) mirna-221 controls cell viability and apoptosis by manipulating the akt signalling pathway in pd. |
2023-12-03 |
2023-12-10 |
Not clear |
| Mohamed R Mousa, Marwa M Attia, Heba M Salem, Nawal Al-Hoshani, Hasnaa Thabit, Marwa A Ibrahim, Haleema H Albohiri, Samar Ahmad Khan, Mohamed T El-Saadony, Khaled A El-Tarabily, Mohamed A El-Saie. Coinfection of the gut with protozoal and metazoal parasites in broiler and laying chickens. Poultry science. vol 103. issue 1. 2023-12-02. PMID:38041891. |
conversely, the il-10, bcl-2, and akt mrna levels were downregulated, indicating that nematode triggered apoptosis. |
2023-12-02 |
2023-12-10 |
chicken |
| Chun Wang, Zhihang Chen, Yun Yi, Yang Ding, Fei Xu, Hui Kang, Kun Lin, Xiawen Shu, Zibiao Zhong, Zhonglin Zhang, Jing Liu, Zhong Xu, Lan Liu, Xingxing He, Ying Chang, Qiu Zha. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4. Oncogene. 2023-12-01. PMID:38040804. |
when the first-line chemotherapy drug sorafenib is combined with a pi3k/akt/mtor pathway inhibitor (mk2206 is an akt inhibitor, rapamycin is a mtor inhibitor, and inhibiting rbm45 can significantly inhibit rictor), cell cycle, proliferation, lipid metabolism reprogramming, and hepatocarcinogenesis can be significantly inhibited, while apoptosis can be significantly enhanced. |
2023-12-01 |
2023-12-10 |
mouse |
| Zhongni Li, Feng Zhang, Li Huang, Jiehong Deng, Yutong Pan, Ting Xu, Jingyi Liu, Na Gao, Rongrong Duan, Chunyan Shao, Chan Wu, Minrong Wang, Liqun L. Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia. Neurochemical research. 2023-11-28. PMID:38015410. |
therefore, in this study, we aimed to confirm whether regulation of autophagy by using the akt phosphorylation agonist sc79 can inhibit abnormal apoptosis of opcs and promote myelin maturation and white matter development in neonatal rats with wmd. |
2023-11-28 |
2023-11-29 |
rat |
| Zhiyu Liu, Chunlin Li, Ling Mu, Haiyang Hu, Xiong Qi. Menthol induces apoptosis and inhibits proliferation and migration of nonsmall cell lung carcinoma in vitro and in vivo through Akt pathway. The clinical respiratory journal. 2023-11-27. PMID:38012058. |
menthol induces apoptosis and inhibits proliferation and migration of nonsmall cell lung carcinoma in vitro and in vivo through akt pathway. |
2023-11-27 |
2023-11-29 |
human |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the rats fed with copper-laden diet for 12 weeks, and the effect of chr on the copper content in liver and 24-h urine, the learning and memory ability, the morphological changes and the apoptosis level of neurons in hippocampal ca1 region, the expression level of bax, bcl-2, cleaved caspase-3, p-pi3k, pi3k, p-akt, and akt proteins were detected. |
2023-11-24 |
2023-11-29 |
human |
| Yongli Liu, Fang Xie, Changhuai Lu, Zongbo Zhou, Shudong Li, Jia Zhong, Qian Li, Xianfang Sha. Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways. General physiology and biophysics. vol 42. issue 6. 2023-11-23. PMID:37994428. |
overexpression of akt led to increased phosphorylation levels of akt, p38, and p65 proteins, as well as il-1β levels and cell apoptosis. |
2023-11-23 |
2023-11-29 |
Not clear |
| Yongli Liu, Fang Xie, Changhuai Lu, Zongbo Zhou, Shudong Li, Jia Zhong, Qian Li, Xianfang Sha. Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways. General physiology and biophysics. vol 42. issue 6. 2023-11-23. PMID:37994428. |
polydatin inhibited tnf-α-induced apoptosis of c2c12 cells by regulating nf-κb and p38 mapk signaling pathways through akt. |
2023-11-23 |
2023-11-29 |
Not clear |
| Jian Hao, Zhenhan Li, Li Xie, Bingbing Yu, Boyuan Ma, Yubiao Yang, Xuchen Ma, Bitao Wang, Xianhu Zho. Syringaresinol promotes the recovery of spinal cord injury by inhibiting neuron apoptosis via activating the ubiquitination factor E4B/AKT Serine/Threonine kinase signal pathway. Brain research. 2023-11-22. PMID:37992795. |
results showed that syringaresinol could inhibit the apoptosis of glutamate-treated shsy5y cells by upregulating the expression of ubiquitination factor e4b (ube4b) and activating the akt serine/threonine kinase (akt) signaling pathway. |
2023-11-22 |
2023-11-29 |
rat |
| Ling-Ling Wang, Jun Li, Hang Xue, Li Zhang, Da-Yong Yu, Ning Yang, Wen-Jing Yun, Ming-Zhen Zhao, Hang Xu. The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer. Histology and histopathology. 2023-11-20. PMID:37982578. |
grin2d overexpression promoted proliferation, migration, and invasion in esophageal cancer cells but blocked apoptosis (p<0.05) and increased the expression of pi3k, akt and p-mtor. |
2023-11-20 |
2023-11-29 |
Not clear |
| Shanhe Liu, Dongmei Su, Zhaoyi Sun, Tianhua Piao, Sijia Li, Lina Guan, Yanjiang Fu, Gaobo Zhang, Tingsong Cui, Wenna Zhu, Xu Ma, Shanshan H. Epigallocatechin gallate delays age-related cataract development via the RASSF2/AKT pathway. European journal of pharmacology. 2023-11-18. PMID:37979829. |
further studies showed that rassf2 mediates the inhibitory effect of egcg on apoptosis and arcogenesis in lecs by regulating akt (ser473) phosphorylation. |
2023-11-18 |
2023-11-20 |
mouse |
| Su Hwan Park, Gyuri Kim, Gi-Eun Yang, Hye Jin Yun, Tae Hwan Shin, Sun Tae Kim, Kyuhong Lee, Hyuk Soon Kim, Seok-Ho Kim, Sun-Hee Leem, Wan-Seob Cho, Jong-Ho Le. Disruption of phosphofructokinase activity and aerobic glycolysis in human bronchial epithelial cells by atmospheric ultrafine particulate matter. Journal of hazardous materials. vol 464. 2023-11-17. PMID:37976851. |
additionally, intratracheal instillation of supm reduced the phosphorylation of erk, akt, and pfk2, decreased proliferation, and increased the apoptosis of bronchial epithelial cells in mice. |
2023-11-17 |
2023-11-20 |
mouse |
| Jiayuan Li, Kuangqi Chen, Xiang Li, Xuhong Zhang, Liyue Zhang, Qianjie Yang, Yutong Xia, Chen Xie, Xiawei Wang, Jianping Tong, Ye She. Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell death discovery. vol 9. issue 1. 2023-11-17. PMID:37978169. |
in the early stages of diabetic retinopathy (dr), diabetes-related hyperglycemia directly inhibits the akt signaling pathway by increasing oxidative stress or inhibiting growth factor expression, which leads to retinal cell apoptosis, nerve proliferation and fundus microvascular disease. |
2023-11-17 |
2023-11-20 |
Not clear |
| Jiayuan Li, Kuangqi Chen, Xiang Li, Xuhong Zhang, Liyue Zhang, Qianjie Yang, Yutong Xia, Chen Xie, Xiawei Wang, Jianping Tong, Ye She. Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell death discovery. vol 9. issue 1. 2023-11-17. PMID:37978169. |
inactivated akt fails to inhibit foxo and thus causes apoptosis. |
2023-11-17 |
2023-11-20 |
Not clear |
| Jingying Chen, Guoqi Kang, Weidong Lei, Jizhuo Li, Huiling Wang, Yuanlin Bi, Wanru Zhang, Liming Zhang, Lihui Chai, Peiling Wang, Xia L. DUSP22 suppresses tumor progression by directly dephosphorylating AKT in non-small cell lung cancer. Molecular carcinogenesis. 2023-11-08. PMID:37937915. |
protein kinase b (akt) plays a pivotal in regulating cell migration, proliferation, apoptosis, and survival, making it a prominent target for anticancer therapy. |
2023-11-08 |
2023-11-20 |
Not clear |
| Jiang Liu, Wei Zhou, Liang Yang, Yan Li, Jizhang Qiu, Xun Fu, Pengfei Ren, Feng Guo, Yongying Zhou, Jianmin Liu, Ping Chen, Michael E DiSanto, Xinhua Zhan. STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia. Cellular signalling. vol 113. 2023-11-03. PMID:37866665. |
we further examined akt / mtor, p38mapk / p-p38mapk, and wnt/ β-catenin signaling pathway and demonstrated that steap4 regulated the proliferation and apoptosis of prostate cells through akt / mtor signaling, rather than p38mapk / p-p38mapk and wnt/ β-catenin pathways. |
2023-11-03 |
2023-11-08 |
human |
| Jiang Liu, Wei Zhou, Liang Yang, Yan Li, Jizhang Qiu, Xun Fu, Pengfei Ren, Feng Guo, Yongying Zhou, Jianmin Liu, Ping Chen, Michael E DiSanto, Xinhua Zhan. STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia. Cellular signalling. vol 113. 2023-11-03. PMID:37866665. |
furthermore, activating akt / mtor signaling with sc79 significantly reversed apoptosis triggered by steap4 deficiency, whereas suppressing akt / mtor signaling with mk2206 reduced the increase of cell viability triggered by steap4 overproduction. |
2023-11-03 |
2023-11-08 |
human |
| Tong Chen, Lin Zhang, Liangyu Yao, Jiaochen Luan, Xiang Zhou, Rong Cong, Xuejiang Guo, Chao Qin, Ninghong Son. Zinc oxide nanoparticles-induced testis damage at single-cell resolution: Depletion of spermatogonia reservoir and disorder of Sertoli cell homeostasis. Environment international. vol 181. 2023-11-02. PMID:37918063. |
mechanically, zno nps triggered fatty acid accumulation in gc-1 cells through protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling and peroxisome proliferator-activated receptor alpha (pparα)/acyl-coa oxidase 1 (acox1) axis, contributing to cell apoptosis. |
2023-11-02 |
2023-11-08 |
rat |
| Seung-On Lee, Mee-Hyun Lee, Ah-Won Kwak, Jin-Young Lee, Goo Yoon, Sang Hoon Joo, Yung Hyun Choi, Jin Woo Park, Jung-Hyun Shi. Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899744. |
taken together lch inhibits the growth of ox-sensitive and ox-resistant crc cells by targeting egfr and akt, and inducing ros generation and er stress-mediated apoptosis. |
2023-10-30 |
2023-11-08 |
Not clear |
| Baoyuan Zhang, Xuesong Zhang, Moussa Omorou, Kai Zhao, Yang Ruan, Haiyan Lua. Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-28. PMID:37897975. |
activated dip2a interacts with several pathways, such as ampk/mtor and akt pathways, to contribute to many biological processes, such as oxidative stress, transcriptional regulation, and apoptosis. |
2023-10-28 |
2023-11-08 |
Not clear |