| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syu-Ichi Kanno, Akiyoshi Har. Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-22. PMID:37739323. |
furthermore, evl suppressed dox-induced cardiotoxicity through autophagy/mitophagy and akt activation but did not attenuate dox-induced apoptosis or reduction in viability in mcf-7 cells. |
2023-09-22 |
2023-10-07 |
human |
| Cho-Young Park, Ji-Hoon Jang, In-Hwan Song, Joo-Young Kim, Kyung-Oh Doh, Tae-Jin Le. Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells. Genes & genomics. 2023-09-19. PMID:37725269. |
suppression of tbck enhances trail-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma caki-1 cells. |
2023-09-19 |
2023-10-07 |
human |
| Tangen Chen, Shuyun Zeng, Quanyuan Liu, Yufeng Chen, Junjiang L. LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 7. 2023-09-16. PMID:37715432. |
in summary, loxl1-as1 induced cell proliferation and suppresses cell apoptosis in primary hccvia activating akt pathway, sponging mir-1224-5p and upregulating itpripl2, which may provide some fresh thoughts for researches about the molecular regulation mechanism of lncrna in hcc. |
2023-09-16 |
2023-10-07 |
Not clear |
| Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Ten. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. European journal of medicinal chemistry. vol 261. 2023-09-14. PMID:37708799. |
the results in vitro indicated that compounds 3g and 3j can induce mda-mb-231 cells apoptosis, and inhibit its migration and angiogenesis through influencing protein expression such as bcl-2, bax, bcl-xl, p38, mmp2, mmp9, akt and egfr. |
2023-09-14 |
2023-10-07 |
Not clear |
| Ping Chen, Yan Cheng, Jing Hu, Rui Fang, Li-Qi Yan. Recombinant CXCL17 Treatment Alleviates Hyperoxia-Induced Lung Apoptosis and Inflammation In Vivo and Vitro by Activating the AKT Pathway: A Possible Therapeutic Approach for Bronchopulmonary Dysplasia. Molecular biotechnology. 2023-09-14. PMID:37710083. |
recombinant cxcl17 treatment alleviates hyperoxia-induced lung apoptosis and inflammation in vivo and vitro by activating the akt pathway: a possible therapeutic approach for bronchopulmonary dysplasia. |
2023-09-14 |
2023-10-07 |
mouse |
| Hazem A Al-Bustany, Hawzheen A Muhammad, Mahmoud A Chawsheen, Phil R Das. Fenretinide induces apoptosis and synergises the apoptosis inducing effect of gemcitabine through inhibition of key signalling molecules involved in A549 cell survival in in silico and in vitro analyses. Cellular signalling. 2023-09-13. PMID:37704095. |
in conclusion, akt may be exploited as a good target for induction of apoptosis in a549 cells and fenretinide has great potentials to fulfil this task. |
2023-09-13 |
2023-10-07 |
human |
| Wei Gao, Rongxing She. Nanogel enhances the efficacy of MLN8237 in treating hepatocellular carcinoma. Journal of biomaterials applications. 2023-09-11. PMID:37695622. |
subsequently, cck8 assay, cell cycle assay, apoptosis assay, real-time pcr, western blotting assay and animal experiments were used to detect the effects of mln8237 nanogel on the proliferation, cell cycle, apoptosis, tumor growth, mrna and protein levels of aurora-a and puma, and akt phosphorylation levels in hcc cell lines. |
2023-09-11 |
2023-10-07 |
Not clear |
| Wei Gao, Rongxing She. Nanogel enhances the efficacy of MLN8237 in treating hepatocellular carcinoma. Journal of biomaterials applications. 2023-09-11. PMID:37695622. |
moreover, the mln8237-loaded nanogel has a stronger ability to inhibit hcc cell proliferation, block cell cycle, promote apoptosis and inhibit tumor growth than free mln8237 by suppressing aurora-a and akt phosphorylation. |
2023-09-11 |
2023-10-07 |
Not clear |
| El-Habib Dakir, Consuelo Gajate, Faustino Mollined. Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-08. PMID:37683591. |
daily oral administration of edelfosine in murine prostate restricted akt kinase transgenic mice, expressing active akt in a prostate-specific manner, and in a du145 xenograft mouse model resulted in significant tumor regression and apoptosis in tumor cells. |
2023-09-08 |
2023-10-07 |
mouse |
| Chunguang Sun, Lin Lia. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023-09-06. PMID:37670707. |
antithyroid cancer studies of shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial-mesenchymal transition; induced cell cycle arrest; induced dna damage and apoptosis by producing excessive reactive oxygen species; upregulated bax; increased the stability of p53; decreased the expression of mdm2; downregulated slug and mmp-2, mmp-9, and mmp-14; repressed the phosphorylation of erk and akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of dnmt1; reduced the pten gene methylation; increased the expression of pten, leading to the inhibition of migration; increased lc3-ii to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βii-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. |
2023-09-06 |
2023-10-07 |
mouse |
| Shuangze Han, Xinfang Yu, Ruirui Wang, Xiaocong Wang, LuLu Liu, Qing Zhao, RongBo Xie, Ming Li, Zhong Su Zho. Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma. Journal of Cancer. vol 14. issue 13. 2023-09-06. PMID:37670974. |
moreover, tan iia inhibited akt activation from inducing foxo3a dephosphorylation and puma-mediated apoptosis. |
2023-09-06 |
2023-10-07 |
Not clear |
| Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. |
allicin was proven to inhibit hypoxia-induced astrocyte apoptosis by increasing gpx1 expression, activating proto-oncogene tyrosine-protein kinase src (src)- protein kinase b (akt)-extracellular signal-regulated kinase (erk) phosphorylation, and decreasing lipid peroxidation. |
2023-09-06 |
2023-10-07 |
mouse |
| Garam An, Junho Park, Jeankyoung You, Hahyun Park, Taeyeon Hong, Whasun Lim, Gwonhwa Son. Developmental toxicity of flufenacet including vascular, liver, and pancreas defects is mediated by apoptosis and alters the Mapk and PI3K/Akt signal transduction in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-09-02. PMID:37659609. |
to address intracellular actions of flufenacet in zebrafish, cellular responses including apoptosis, cell cycle modulation, and mapk and akt signaling pathway were verified in transcriptional and protein levels. |
2023-09-02 |
2023-09-07 |
zebrafish |
| Zahra Taghinejad, Tohid Kazemi, Manouchehr Fadaee, Majid Farshdousti Hagh, Saeed Solal. Pharmacological and therapeutic potentials of cordycepin in hematological malignancies. Biochemical and biophysical research communications. vol 678. 2023-08-27. PMID:37634411. |
cordycepin induces apoptosis in different subtypes of hms by triggering adenosine receptors, death receptors, and several vital signaling pathways such as mapk, erk, pi3k, akt, and gsk-3β/β-catenin. |
2023-08-27 |
2023-09-07 |
Not clear |
| Hui Zhang, Qing-Qing Dong, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Ya. Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes. Archives of biochemistry and biophysics. 2023-08-26. PMID:37633586. |
western blots and flow cytometry showed that cur could inhibit adriamycin (adr) induced apoptosis, oxidative stress damage, and attenuate podocyte epithelial-mesenchymal transition (emt) by repressing the akt signaling pathway. |
2023-08-26 |
2023-09-07 |
Not clear |
| Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Stephany Celeste Gutiérrez-Ruíz, Hector Hernández-Parra, Alejandra Romero-Montero, María Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Hernán Cortés, Sheila I Peña-Corona, Lashyn Kiyekbayeva, Dilek Arslan Ateşşahin, Tamar Goloshvili, Gerardo Leyva-Gómez, Javad Sharifi-Ra. 3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways. Cancer cell international. vol 23. issue 1. 2023-08-26. PMID:37633886. |
we have also summarized; (i) the recent advancements in the use of i3c/dim as therapeutic molecules since they represent potentially appealing anti-cancer agents, (ii) the available literature on the i3c and dim characterization, and the challenges related to pharmacologic properties such as low solubility, and poor bioavailability, (iii) the synthesis and semi-synthetic derivatives, (iv) the mechanism of anti-tumor action in vitro/in vivo, (v) the action in cellular signaling pathways related to the regulation of apoptosis and anoikis as well as the cell cycle progression and cell proliferation such as peroxisome proliferator-activated receptor and pparγ agonists; sr13668, akt inhibitor, cyclins regulation, er-dependent-independent pathways, and their current medical applications, to recognize research opportunities to potentially use these compounds instead chemotherapeutic synthetic drugs. |
2023-08-26 |
2023-09-07 |
Not clear |
| Adriana Cortés, Javier Marqués, Álvaro Pejenaute, Elena Ainzúa, Eduardo Ansorena, Gloria Abizanda, Felipe Prósper, Carlos de Miguel, Guillermo Zalb. Endothelial NOX5 overexpression induces changes in the cardiac gene profile: potential impact in myocardial infarction? Journal of physiology and biochemistry. 2023-08-11. PMID:37566320. |
we found many alterations in the mrna expression of components involved in cardiac fibrosis as collagen type i or tgf-β and in key players of cardiac apoptosis such as akt, bcl-2, or p53. |
2023-08-11 |
2023-08-16 |
mouse |
| Chuan-Yu Hu, Guo-Yan Li, Chun-Tian L. Thiopental sodium attenuates hypoxia/reoxygenation-induced injury in osteoblasts by modulating AKT signaling. In vitro cellular & developmental biology. Animal. 2023-08-09. PMID:37556024. |
tpts exerted protective effects against cell injury and apoptosis induced by the h/r conditions, which were associated with its regulation of akt signaling. |
2023-08-09 |
2023-08-16 |
Not clear |
| Shadia Hamoud Alshahrani, Nodir Rakhimov, Jitendra Gupta, Zahraa F Hassan, Ali Alsalamy, Ebraheem Abdu Musad Saleh, Hashem O Alsaab, Firas Kanawy Al-Aboudy, Ahmed Radhi Alawadi, Yasser Fakri Mustaf. The mechanisms, functions and clinical applications of miR-542-3p in human cancers. Pathology, research and practice. vol 248. 2023-08-05. PMID:37542861. |
mir-542-3p is engaged in various cancer-related behaviors like glycolysis, metastasis, epithelial-to-mesenchymal transition (emt), cell cycle, apoptosis, and proliferation via targeting at least 18 genes and some important signaling pathways like wnt/β-catenin, extracellular signal-regulated protein kinases 1 and 2 (erk1/2) and janus kinase 2 (jak2) signaling, and phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling. |
2023-08-05 |
2023-08-14 |
human |
| Tanzeeba Amin, Rajneesh Paul Sharma, Khalid Bashir Mir, Nancy Slathia, Sonali Chhabra, Dolma Tsering, Pankul Kotwal, Madhulika Bhagat, Utpal Nandi, Raman Parkesh, Kamal K Kapoor, Anindya Goswam. Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential. European journal of pharmacology. 2023-08-04. PMID:37541376. |
quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of akt and erk instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential. |
2023-08-04 |
2023-08-14 |
Not clear |