| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenqian Sun, Jian Wang, Zhongjie Ji, Jinlong Ma, Yunzhen Chen, Guangjun Jia. Ortho-silicic Acid Prevents Glucocorticoid-Induced Femoral Head Necrosis by Promoting Akt Phosphorylation to Inhibit Endoplasmic Reticulum Stress-Mediated Apoptosis and Enhance Angiogenesis and Osteogenesis. Biological trace element research. 2024-01-04. PMID:38177717. |
ortho-silicic acid prevents glucocorticoid-induced femoral head necrosis by promoting akt phosphorylation to inhibit endoplasmic reticulum stress-mediated apoptosis and enhance angiogenesis and osteogenesis. |
2024-01-04 |
2024-01-07 |
Not clear |
| Li-Na Ma, Li-Na Wu, Shuai Wei Liu, Xu Zhang, Xia Luo, Shah Nawaz, Zi Min Ma, Xiang-Chun Din. miR-199a/b-3p inhibits HCC cell proliferation and invasion through a novel compensatory signaling pathway DJ-1\Ras\PI3K/AKT. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38168113. |
spearman coefficient r = -0.113, p = 0.031; dual luciferase gene report verified the negative targeting relationship between them p< 0.001; western blotting demonstrated that mir-199a/b-3p could inhibit the protein expression of dj-1, ras and akt(p < 0.05); the results of cck8, cell scratch, transwell migration and flow cytometry showed that oe + dj-1 increased the proliferation, migration and invasion ability of hepg2 cells, and decreased the apoptosis process, and the differences were statistically significant (p < 0.05), while mir-199a/b-3p had the opposite effect (p < 0.05). |
2024-01-03 |
2024-01-06 |
Not clear |
| Shuqin Chen, Jialiang Huang, Ting Liu, Feng Zhang, Chunfang Zhao, Erhui Jin, Shenghe L. PI3K/Akt signaling pathway mediates the effect of low-dose boron on barrier function, proliferation and apoptosis in rat intestinal epithelial cells. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38172276. |
after specifically blocking pi3k and akt signals (using ly294002 and mk-2206 2hcl), 0.8 mmol/l boron had no effects on occludin, pcna level, apoptosis rates, and caspase-3 levels (p < 0.05); however, the proliferation rate and pcna levels decreased significantly (p < 0.01 or p < 0.05). |
2024-01-03 |
2024-01-06 |
rat |
| Xiaohua Zhao, Zhao Gao, Wenbin Wen, Shikang Zhen. Impacts of delta 9-tetrahydrocannabinol against myocardial ischemia/reperfusion injury in diabetic rats: Role of PTEN/PI3K/Akt signaling pathway. The Chinese journal of physiology. vol 66. issue 6. 2023-12-27. PMID:38149557. |
after 24 h of reperfusion, infarct size, cardiac function, lactate dehydrogenase (ldh) and cardiac-specific isoform of troponin-i (ctn-i) levels, myocardial apoptosis, oxidative stress markers, and expression of pten, pi3k, and akt proteins were evaluated. |
2023-12-27 |
2023-12-29 |
rat |
| Daichi Hayashi, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Naoki Mizoshiri, Yuki Mori, Seiji Shimomura, Osam Mazda, Kenji Takahash. A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma. Journal of oncology. vol 2023. 2023-12-22. PMID:38130464. |
the cell viability and half maximal inhibitory concentration (ic50), apoptosis induction, and effect on cell cycle and akt pathways were examined. |
2023-12-22 |
2023-12-24 |
mouse |
| Hong Cheng, Beatriz Ferrer Villahoz, Romina Deza Ponzio, Michael Aschner, Pan Che. Signaling Pathways Involved in Manganese-Induced Neurotoxicity. Cells. vol 12. issue 24. 2023-12-22. PMID:38132161. |
the igf signaling pathway plays a protective role in the neurotoxicity of mn, reducing apoptosis in neurons and motor deficits by regulating its downstream protein kinase b (akt), mitogen-activated protein kinase (mapk), and mammalian target of rapamycin (mtor). |
2023-12-22 |
2023-12-24 |
Not clear |
| Jian-Heng Hao, Yue-Meng Zhao, Hai-Jun Wang, Yu-Xia Cao, Ying Lan, Lai-Xi J. [Mechanism of protective effect of resveratrol on poor ovarian response in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114185. |
animal experiments showed that the model group had higher rate of estrous cycle disorders, lower number and poorer morphology of normally developed follicles at all levels, more atretic follicles, higher apoptosis of ovarian granulosa cells, lower number of retrieved oocytes, lower ovarian wet weight and ovarian index, higher serum levels of fsh and lh, lower levels of amh and e_2, higher expression levels of hif-1α, foxo3a and bax, and lower expression levels of pi3k, akt, and bcl-2 in the ovarian tissue than the normal group. |
2023-12-19 |
2023-12-23 |
mouse |
| Yan Chang, Hui-Qin Jia, Bin Xu, Liu Yang, Ye-Tong Xu, Jing-Yu Zhang, Mei-Qi Wang, Li-Xian Yang, Zhen-Chuan Son. Metadherin inhibits chemosensitivity of triple-negative breast cancer to paclitaxel via activation of AKT/GSK-3β signaling pathway. Chemical biology & drug design. 2023-12-14. PMID:38093418. |
notably, suppression of akt terminated mtdh overexpression-induced cell proliferation and apoptosis. |
2023-12-14 |
2023-12-17 |
mouse |
| Yan Chang, Hui-Qin Jia, Bin Xu, Liu Yang, Ye-Tong Xu, Jing-Yu Zhang, Mei-Qi Wang, Li-Xian Yang, Zhen-Chuan Son. Metadherin inhibits chemosensitivity of triple-negative breast cancer to paclitaxel via activation of AKT/GSK-3β signaling pathway. Chemical biology & drug design. 2023-12-14. PMID:38093418. |
mtdh knockdown or the akt inhibitor mk2206 reduced the p-akt and p-gsk-3β ratio, reduced cell viability and proliferation, increased cell apoptosis, and increased chemosensitivity to ptx. |
2023-12-14 |
2023-12-17 |
mouse |
| Jie Chen, Long Zhao, Meng-Fan Xu, Di Huang, Xiao-Long Sun, Yu-Xin Zhang, Hong-Mei Li, Cheng-Zhu W. Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells. Journal of enzyme inhibition and medicinal chemistry. vol 39. issue 1. 2023-12-12. PMID:38086769. |
the initial mechanism of compound 16 induced cell death in h1975 cells involves the increasing of bax/bcl-2 ratio and cyt c protein level, down-regulating of akt protein level, and cleaving caspase-9 and -3 induced apoptosis; the up-regulation of rip3, p-rip3, mlkl, and p-mlkl levels induced necroptosis. |
2023-12-12 |
2023-12-17 |
human |
| Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing L. MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. The breast journal. vol 2023. 2023-12-11. PMID:38075552. |
moreover, cell migration and invasion, as well as the protein levels of phosphatidylinositol 3-kinase (pi3k), akt, matrix metalloproteinase (mmp) 2, and mmp9, were significantly lower in the groups treated with sirna while the apoptosis was augmented. |
2023-12-11 |
2023-12-17 |
Not clear |
| Hind Al Khashali, Ban Darweesh, Ravel Ray, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Stuti Goel, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067204. |
the addition of anti-vegf antibodies to a549 and h1299 cells decreased cell viability and increased apoptosis; blocked the activities of pi3k, akt, and nfκb in the absence or presence of nicotine; and resulted in increased p53 activation in a549 cells. |
2023-12-09 |
2023-12-17 |
human |
| Momoko Gyoten, Yi Luo, Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Shingo Kishi, Hiroki Kuniyas. Lovastatin Treatment Inducing Apoptosis in Human Pancreatic Cancer Cells by Inhibiting Cholesterol Rafts in Plasma Membrane and Mitochondria. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069135. |
in the three gem-resistant cell lines derived from mia and panc1, the lipid rafts in the cell membrane and the mitochondria were increased to activate egfr and akt and to increase bcl2-bax binding, which suppressed apoptosis. |
2023-12-09 |
2023-12-17 |
human |
| Fang Li, Hongxin Li. MiR- 211 represses apoptosis of nerve cells in rats with cerebral infarction through PI3K/AKT signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063101. |
to investigate the effect of micro ribonucleic acid (mir)-211 on the apoptosis of nerve cells in rats with cerebral infarction through phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2023-12-08 |
2023-12-17 |
rat |
| Daomin Lu, Yuzheng Yang, Wukai Ma, Xueming Yao, Yi Ling, Ying Huang, Qiuyi Wang, Chengyu Xia, Lei Ho. Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats. Alternative therapies in health and medicine. 2023-12-08. PMID:38064612. |
the results showed that stigmasterol significantly inhibited the expression of cyclin d1, cyclin-dependent kinase 4 (cdk4), and retinoblastoma (rb), and decreased the expression of key genes kinase insert domain-containing receptor (kdr), pi3k, akt, phosphorylated pi3k (p-pi3k) and phosphorylated akt (p-akt) in the kdr-mediated pi3k/akt signaling pathway, thus inhibiting the proliferation of fls and promoting the apoptosis of fls. |
2023-12-08 |
2023-12-17 |
rat |
| Yolanda M B Marcello, Daner A Silveira, Shantanu Gupta, José Carlos M Mombac. PTEN expression can be used as a switch between senescence and apoptosis in breast cancer cells according to a logical model of the G2/M checkpoint. Bio Systems. 2023-12-08. PMID:38065398. |
we show that pics is induced by the activity of the positive feedback between akt and mtorc2, and that overexpression of pten will disrupt the feedback, abrogating senescence and only leading to arrest or apoptosis. |
2023-12-08 |
2023-12-17 |
Not clear |
| Nhu Thi Quynh Mai, Ulziituya Batjargal, Won-Seok Kim, Ji-Hoon Kim, Ji-Won Park, Ihn-Sil Kwak, Byoung-San Moo. Microplastic induces mitochondrial pathway mediated cellular apoptosis in mussel (Mytilus galloprovincialis) via inhibition of the AKT and ERK signaling pathway. Cell death discovery. vol 9. issue 1. 2023-12-06. PMID:38057300. |
microplastic induces mitochondrial pathway mediated cellular apoptosis in mussel (mytilus galloprovincialis) via inhibition of the akt and erk signaling pathway. |
2023-12-06 |
2023-12-10 |
Not clear |
| Jia Yu, Xia Wang, Sha Cheng, Xiaoping Zeng, Xinwei Wan, Shinan Wei, Bixue Xu, Heng Luo, Xueling Men. Design, synthesis and bioevaluation of novel prenylated chalcones derivatives as potential antitumor agents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023-12-05. PMID:38052256. |
among of the active compounds, (e)-1-(4-(2-(diethylamino)ethoxy)-2-hydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one (c36) was directly interacted with protein kinase b (pkb), also known as akt, significantly inhibited the ppi3k, pakt(ser473) protein levels to repress the growth of cancer cells by inducing apoptosis, arresting cell cycle. |
2023-12-05 |
2023-12-10 |
human |
| Kehui Zhang, Rui Huang, Ming Ji, Songwen Lin, Fangfang Lai, Deyu Wu, Hua Tian, Jinhui Bi, Shouguo Peng, Jiaqi Hu, Li Sheng, Yan Li, Xiaoguang Chen, Heng X. Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia. European journal of medicinal chemistry. vol 264. 2023-12-04. PMID:38048697. |
furthermore, western blotting analysis shows compounds 36 and 51 suppressed akt phosphorylation and increased h3 acetylation in mv4-11 cells, while flow cytometry analysis reveals both compounds dose-dependently induced cell cycle arrest and cell apoptosis. |
2023-12-04 |
2023-12-10 |
Not clear |
| Mohammad Yasin Zamanian, Mehraveh Sadeghi Ivraghi, Reena Gupta, K D V Prasad, Hashem O Alsaab, Beneen M Hussien, Hazem Ahmed, Montather F Ramadan, Maryam Golmohammadi, Nikta Nikbakht, Tuba Oz, Małgorzata Kujawsk. miR-221 and Parkinson's disease: A biomarker with therapeutic potential. The European journal of neuroscience. 2023-12-03. PMID:38043936. |
according to the results of these studies, (1) mir-221 protects pc12 cells against oxidative stress induced by 6-hydroxydopamine; (2) mir-221 prevents bax/caspase-3 signalling activation by stopping bim; (3) mir-221 has moderate predictive power for pd; (4) mir-221 directly targets pten, and pten over-expression eliminates the protective action of mir-221 on p-akt expression in pc12 cells; and (5) mirna-221 controls cell viability and apoptosis by manipulating the akt signalling pathway in pd. |
2023-12-03 |
2023-12-10 |
Not clear |