| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingfang Weng, Zhen Deng, Shuijing Huang, Xiaowen Lin, Na Xu, Xinghui Sun, Weizhen Wu, Jun Lu, Dong Wan. Fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the Akt pathway in vitro and in vivo. Journal of biochemical and molecular toxicology. 2023-10-23. PMID:37867445. |
fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the akt pathway in vitro and in vivo. |
2023-10-23 |
2023-11-08 |
mouse |
| Mingfang Weng, Zhen Deng, Shuijing Huang, Xiaowen Lin, Na Xu, Xinghui Sun, Weizhen Wu, Jun Lu, Dong Wan. Fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the Akt pathway in vitro and in vivo. Journal of biochemical and molecular toxicology. 2023-10-23. PMID:37867445. |
in conclusion, the growth inhibitory properties of fraxetin against bladder cancer may be mediated via an akt inhibitory effect and cell apoptosis promotion. |
2023-10-23 |
2023-11-08 |
mouse |
| Xin-Jun Wu, Zhigang Zhang, Jason P Wong, Ricardo Rivera-Soto, Maria C White, Aryan A Rai, Blossom Damani. Kaposi's sarcoma-associated herpesvirus viral protein kinase augments cell survival. Cell death & disease. vol 14. issue 10. 2023-10-20. PMID:37852997. |
treatment of huvec-vpk cells with a pan-akt inhibitor miransertib (arq 092) reduced the overall phosphorylation of akt, resulting in the cleavage of caspase-3 and the induction of apoptosis. |
2023-10-20 |
2023-11-08 |
human |
| Liuying Wu, Zhelin Chen, Qing Yu, Jinxin Fang, Yong Chen, Yuhan Chen, Kai Wang, Yan Xu, Wei Song, Zhihong Pen. NAD (P)H Quinone Dehydrogenase 1-Targeting Triptolide Analogue Causes Tumor Regression and Sensitizes Cisplatin-Resistant Lung Cancer to Chemotherapy. ACS pharmacology & translational science. vol 6. issue 10. 2023-10-20. PMID:37854615. |
further investigations revealed that cx-23 exerts its effects by blocking akt phosphorylation, leading to reduced expression of mcl-1 and bcl-2, and upregulating cleaved-caspase-3 levels, ultimately inducing apoptosis in cancer cells. |
2023-10-20 |
2023-11-08 |
mouse |
| Hojun Lee, Garam An, Junho Park, Jeankyoung You, Gwonhwa Song, Whasun Li. Mevinphos induces developmental defects via inflammation, apoptosis, and altered MAPK and Akt signaling pathways in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-10-20. PMID:37858660. |
mevinphos induces developmental defects via inflammation, apoptosis, and altered mapk and akt signaling pathways in zebrafish. |
2023-10-20 |
2023-11-08 |
zebrafish |
| Hojun Lee, Garam An, Junho Park, Jeankyoung You, Gwonhwa Song, Whasun Li. Mevinphos induces developmental defects via inflammation, apoptosis, and altered MAPK and Akt signaling pathways in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-10-20. PMID:37858660. |
in addition, mapk and akt signaling pathways, which control apoptosis, inflammation, and proper development of various organs, were also altered by the treatment of mevinphos. |
2023-10-20 |
2023-11-08 |
zebrafish |
| Anna Radajewska, Jakub Szyller, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Grzegorz Sawicki, Iwona Bil-Lul. Mitoquinone Alleviates Donation after Cardiac Death Kidney Injury during Hypothermic Machine Perfusion in Rat Model. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834219. |
we compared the activation of the apoptosis pathway (caspase 3 and 9), the concentration of phosphorylated akt (pakt), and the pakt/total akt ratio. |
2023-10-14 |
2023-10-15 |
rat |
| Paola Briseño-Díaz, Michael Schnoor, Martiniano Bello-Ramirez, Jose Correa-Basurto, Arturo Rojo-Domínguez, Leticia Arregui, Libia Vega, Enrique Núñez-González, Luis Andres Palau-Hernández, Carlos Guadalupe Parra-Torres, Oscar Manuel García Córdova, Ernesto Zepeda-Castilla, Eduardo Torices-Escalante, Leticia Domínguez-Camacho, Beatriz Xoconostle-Cazares, Marco Antonio Meraz-Ríos, Sandra Delfín-Azuara, Dayan Andrea Carrión-Estrada, Nicolas Villegas-Sepúlveda, Rosaura Hernández-Rivas, Maria Del Rocio Thompson-Bonilla, Miguel Varga. Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer. Life science alliance. vol 6. issue 12. 2023-10-11. PMID:37813486. |
mechanistically, c14 and p8 reduced tumor growth by inhibiting akt and erk signaling downstream of k-ras leading to apoptosis, specifically in pdac cells. |
2023-10-11 |
2023-10-15 |
human |
| Nan Nan, Xiao-Li DU, Miao Chen, Jia-Qi Lu. [Qirong Tablets inhibits apoptosis of ovarian granulosa cells via PI3K/Akt/ HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 17. 2023-10-06. PMID:37802816. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling(tunel) assay was used to detect the apoptosis of granulosa cells, and western blot to determine the expression levels of b-cell lymphoma-2(bcl-2), bcl-2-associated x protein(bax), caspase-3, pi3k, akt, and hif-1. |
2023-10-06 |
2023-10-15 |
mouse |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
compared with the control group, the morin groups showed decreased viability of sk-hep-1 cells in a time-and concentration-dependent manner, increased number of apoptotic cells, up-regulated expression level of apoptosis marker parp, up-regulated phosphorylation level of apoptosis-regulating protein h2ax, decreased number of positive cells and the colony formation rate, an upward trend of expression levels of autophagy-related proteins lc3-Ⅱ, atg5, and atg7, and decreased phosphorylation levels of akt, mtor, and stat3. |
2023-10-06 |
2023-10-15 |
human |
| Zhaobin Pan, Zhiming Tan, Hongyan Li, Yang Wang, Haiyan Du, Jinhui Sun, Chunchao Li, Shicai Ye, Xin Li, Juanhua Qua. Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways. Medical oncology (Northwood, London, England). vol 40. issue 11. 2023-10-05. PMID:37796396. |
notably, pretreatment of igf-1, an akt activator, attenuated the diosmetin-induced apoptosis. |
2023-10-05 |
2023-10-07 |
human |
| Yuanjiao Zhang, Jiacheng Qian, Mingmei Jiang, Shu Yang, Lianxin Zhou, Qin Zhang, Liping Lin, Ye Yan. LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473. Frontiers in oncology. vol 13. 2023-10-02. PMID:37781194. |
lte2 induces cell apoptosis in multiple myeloma by suppressing akt phosphorylation at thr308 and ser473. |
2023-10-02 |
2023-10-07 |
mouse |
| Bo Liu, Han Xie, Xiongbing Du, Yuyang Zhou, Jiashun Huan. Catalpol Inhibits Autophagy to Ameliorate Doxorubicin-Induced Cardiotoxicity via the AKT-mTOR Pathway. International heart journal. vol 64. issue 5. 2023-10-01. PMID:37778994. |
in addition, ctp decreased the levels of beclin1 and lc3ii/lc3i, increased the levels of p62, and activated the protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway in dox-treated mice.ctp ameliorated dox-induced cardiotoxicity by inhibiting oxidative stress, myocardial apoptosis, and autophagy via the akt-mtor pathway. |
2023-10-01 |
2023-10-07 |
mouse |
| Min Wu, Ruixue Li, Jianyan Qin, Ziyuan Wang, Jiasen Guo, Fenghong Lv, Guoqin Wang, Youguang Huan. ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway. Journal of molecular histology. 2023-09-30. PMID:37776473. |
rescue assays revealed that akt activator 740y-p could reverse the effects on proliferation and apoptosis of ero1α knockdown in crc cells. |
2023-09-30 |
2023-10-07 |
Not clear |
| Wenjing Diao, Caiying Zhu, Qisang Guo, Yuankui Cao, Yu Song, Hua Feng, Jun Li, Xiaohong Xue, Pei L. [Retracted] Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway. Molecular medicine reports. vol 28. issue 5. 2023-09-29. PMID:37772390. |
[retracted] tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the akt signaling pathway. |
2023-09-29 |
2023-10-07 |
Not clear |
| Kuang-Chen Hung, Ni Tien, Da-Tian Bau, Chun-Hsu Yao, Chan-Hung Chen, Jiun-Long Yang, Meng-Liang Lin, Shih-Shun Che. Cells. vol 12. issue 18. 2023-09-28. PMID:37759534. |
subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of kirsten rat sarcoma viral oncogene homolog (kras) with p110α in lipid rafts with the use of naringenin (ngn), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (pi3k)-gtp-ras-related c3 botulinum toxin substrate 1 (rac1)-protein kinase b (akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (oxphos), leading to apoptosis in human nasopharyngeal carcinoma (npc) cells. |
2023-09-28 |
2023-10-07 |
human |
| Liuxiong Wang, Jianguo Zhu, Peng Xie, Daoqing Gon. Pigeon during the Breeding Cycle: Behaviors, Composition and Formation of Crop Milk, and Physiological Adaptation. Life (Basel, Switzerland). vol 13. issue 9. 2023-09-28. PMID:37763270. |
meanwhile, signaling pathways, such as target of rapamycin (tor), janus kinase/signal transducer and activator of transcription proteins (jak/stat), protein kinase b (akt), etc., influence the production of crop milk by either enhancing protein synthesis in crop cells or inducing apoptosis of crop epidermal cells. |
2023-09-28 |
2023-10-07 |
pigeon |
| Junzhe Li, Xiayu Wu, Xiang-Bo Ji, Changhao He, Shijie Xu, Xianhua X. Biphasic function of GSK3β in gefitinib‑resistant NSCLC with or without EGFR mutations. Experimental and therapeutic medicine. vol 26. issue 4. 2023-09-25. PMID:37745038. |
furthermore, akt inhibition reduced the proliferation, migration and invasion, and induced the apoptosis of pc-9, pc-9g and h1975 cells, the effects of which were reversed following akt activation; notably, the tumor suppressor function of gsk3β was inconsistent with the tumor promotor role of the akt pathway in pc-9g cells without egfr mutation. |
2023-09-25 |
2023-10-07 |
Not clear |
| Syu-Ichi Kanno, Akiyoshi Har. Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-22. PMID:37739323. |
everolimus prevents doxorubicin-induced apoptosis in h9c2 cardiomyocytes but not in mcf-7 cancer cells: cardioprotective roles of autophagy, mitophagy, and akt. |
2023-09-22 |
2023-10-07 |
human |