| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chan Yang, Hanyu Liu, Ziyan Xie, Qiangfei Yang, Lian Du, Chunguang Xi. The protective role of shenqi compound in type 2 diabetes: A comprehensive investigation of pancreatic β-cell function and mass. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-12. PMID:37572639. |
the results demonstrate multiple beneficial effects of sqc, including significant control of blood glucose levels (p < 0.05), inhibition of insulin resistance (measured by western blot), reduction of hyperinsulinemia (p < 0.05), attenuation of oxidative stress (p < 0.05), suppression of inflammation (p < 0.05), protection against islet hypertrophy and beta cell proliferation (evaluated through pathological staining), and inhibition of β-cell apoptosis and senescence (also assessed through pathological staining). |
2023-08-12 |
2023-08-16 |
rat |
| Jiayang Yin, Feng Zhang, Jiamin Cao, Zhaochangci Chen, Wei Xion. Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555853. |
the effect and mechanism of gps on growth, apoptosis, invasion, and emt were determined by cell counting kit-8 (cck-8), western blot, flow cytometry, and transwell assays in retinoblastoma cells. |
2023-08-09 |
2023-08-16 |
mouse |
| Zhongzhu Tang, Lei Wang, Yunwang Chen, Xiaomin Zheng, Runyu Wang, Bingxue Liu, Shiqi Zhang, Huimin Wan. Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway. European journal of histochemistry : EJH. vol 67. issue 3. 2023-08-07. PMID:37548240. |
after cells were treated with 5-fu (10, 40 μg/ml), que (10 μm, 40 μm), or 5-fu in combination with que, cell proliferation, apoptosis, oxidative stress-related factors, reactive oxygen species (ros), and nuclear factor erythroid 2-related factor (nrf2)/heme oxygenase-1 (ho-1) pathway-related factors were examined by colony formation assay, flow cytometry, elisa, ros kit, immunofluorescence assay, and western blot. |
2023-08-07 |
2023-08-14 |
cat |
| Qian Liu, Yuyang Wu, Sisi Li, Somy Yoon, Jiaxin Zhang, Xiaoyi Wang, Luoshuang Hu, Chenying Su, Chunwu Zhang, Yungang W. Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation. Toxicology and applied pharmacology. 2023-08-03. PMID:37536651. |
moreover, the results of western blot and tunel experiments showed that ua could delay the disease progression of sanfh in mice by inhibiting apoptosis. |
2023-08-03 |
2023-08-14 |
mouse |
| Nunzio Antonio Cacciola, Fabrizia Sepe, Salvatore Fioriniello, Orsolina Petillo, Sabrina Margarucci, Marcello Scivicco, Gianfranco Peluso, Anna Balestrieri, Giovanna Bifulco, Brunella Restucci, Lorella Severin. The Carnitine Palmitoyltransferase 1A Inhibitor Teglicar Shows Promising Antitumour Activity against Canine Mammary Cancer Cells by Inducing Apoptosis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513899. |
the expression of mediators of apoptosis signalling (e.g., caspase-9, caspase-8, and caspase-3) was assessed by quantitative real-time polymerase chain reaction and western blot analyses. |
2023-07-29 |
2023-08-14 |
Not clear |
| Muhammad Shoaib Khan, Chunliang Liu, Fanbi Meng, Mengnan Yang, Kangxi Zhou, Renping Hu, Xuexiang Wang, Kesheng Da. X-rays Stimulate Granular Secretions and Activate Protein Kinase C Signaling in Human Platelets. Current issues in molecular biology. vol 45. issue 7. 2023-07-28. PMID:37504296. |
flow cytometry, aggregometry, and western blot were performed to investigate the effect of x-rays on platelet degranulation, integrin activation, platelet aggregation, and apoptosis. |
2023-07-28 |
2023-08-14 |
human |
| Yiwen Zang, Chen Yang, Meng-Shi Dai, Wenye Zhang, Lujia Zou, Jimeng Hu, Yun Hu, Chenyang Xu, Rongzong Liu, Hao Wang, Zuquan Xion. Protective Autophagy Attenuates the Cytotoxicity of MTI-31 in Renal Cancer Cells by Activating the ERK Pathway. Applied biochemistry and biotechnology. 2023-07-26. PMID:37493819. |
after treating the rcc cells with the autophagy inhibitor chloroquine (cq), cck8 and western blot assays demonstrated that cq could effectively enhance cell apoptosis induced by mti-31 and that the autophagy induced by mti-31 was cytoprotective. |
2023-07-26 |
2023-08-14 |
Not clear |
| Sema Serter Kocoglu, Ceren Oy, Mücahit Secme, F Bahar Suna. Investigation of the anticancer mechanism of monensin via apoptosis-related factors in SH-SY5Y neuroblastoma cells. Clinical and translational science. 2023-07-21. PMID:37477356. |
the effects of monensin on apoptosis were determined by rt-pcr, tunel, western blot, and annexin v assay. |
2023-07-21 |
2023-08-14 |
Not clear |
| Shouxing Hu, Xianbin Wang, Xianglian Yang, Shuai Ouyang, Xiao Pan, Yingxue Fu, Shuang W. Long-term iTBS improves neural functional recovery by reducing the inflammatory response and inhibiting neuronal apoptosis via miR-34c-5p/p53/Bax signaling pathway in cerebral ischemic rats. Neuroscience. 2023-07-19. PMID:37468029. |
we further explored the morphological and molecular biological alterations associated with neuronal apoptosis and neuroinflammation by ttc staining, he staining, nissl staining, immunofluorescence staining, elisa, small rna sequencing, rt-pcr, and western blot assays. |
2023-07-19 |
2023-08-14 |
rat |
| Chen Wu, Lin Xia, Bin Zhang, Zhongying Bai, Ling Yuan, Dongsheng X. Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide. Archives of biochemistry and biophysics. 2023-07-16. PMID:37454920. |
we used cck-8, western blot, qpcr and flow cytometry to analyze cell viability, related protein and mrna expression, and cell apoptosis. |
2023-07-16 |
2023-08-14 |
human |
| Qiuhua Ying, Jinjie Lou, Daibo Zhen. Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2. Clinical and experimental pharmacology & physiology. 2023-07-15. PMID:37452691. |
the cell apoptosis and cycle arrest were detected by flow cytometry and western blot. |
2023-07-15 |
2023-08-14 |
Not clear |
| Yinggang Wang, Mingdi Fu, Weiwei Xiao, Yajing Zhao, Pingping Yuan, Xinchi Zhang, Wei W. 3d Elastomeric Stent Functionalized with Antioxidative And Perivascular Tissue Regenerative Activities Ameliorated Pvt Deprivation-Induced Vein Graft Failure. Advanced healthcare materials. 2023-07-13. PMID:37440681. |
proteomics, western blot and in vitro blocking tests reveal that metformin resists endothelial apoptosis through ampk/mtor and nfκb signaling pathways. |
2023-07-13 |
2023-08-14 |
Not clear |
| Xiaoli Gao, Pengfei Wang, Zunqiang Yan, Qiaoli Yang, Xiaoyu Huang, Shengwei Zhang, Shuangbao Gu. Molecular characterization and function of JAK/STAT pathway in IPEC-J2 cells during Clostridium perfringens beta2 toxin stimulation. Veterinary research communications. 2023-07-12. PMID:37436554. |
the expression of jak/stat genes or proteins in ipec-j2 cells induced by cpb2 were observed by qrt-pcr and western blot, and further used wp1066 to explore the effect of jak2/stat3 on mechanism employed by cpb2 on apoptosis, cytotoxicity, oxidative stress and inflammatory cytokines of ipec-j2 cells. |
2023-07-12 |
2023-08-14 |
Not clear |
| Pamela Rosso, Elena Fico, Serena Colafrancesco, Mario Giuseppe Bellizzi, Roberta Priori, Bruna Cerbelli, Martina Leopizzi, Carla Giordano, Antonio Greco, Paola Tirassa, Cinzia Severini, Massimo Fuscon. Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjögren's Syndrome (pSS) Pathogenesis. Cells. vol 12. issue 10. 2023-07-06. PMID:37408182. |
using western blot analysis and immunofluorescence studies, we examined the expression levels of sp and its preferred g protein-coupled tk receptor 1 (nk1r) and apoptosis markers in biopsies of the minor salivary gland (msg) from pss patients compared with patients with idiopathic sicca syndrome. |
2023-07-06 |
2023-08-14 |
human |
| Xiaohong Fei, Xuejiang Cen, Ruochi Zhao, Jian Wang, Hanbin Cu. PRMT5 knockdown enhances cell viability and suppresses cell apoptosis, oxidative stress, inflammation and endothelial dysfunction in ox-LDL-induced vascular endothelial cells via interacting with PDCD4. International immunopharmacology. vol 122. 2023-07-03. PMID:37399609. |
the viability and apoptosis of huvecs were determined using cck-8, flow cytometry and western blot assays. |
2023-07-03 |
2023-08-14 |
Not clear |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Mudan Guo, En Zhang, Guiling Wang, Rui Ding, Xiuying Xu, Pengjue Fan, Yimin Zheng, Doudou X. Synthesis and in-vitro study of a novel ligustrazine diselenide as a potential chemotherapy drug for lung adenocarcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-06-29. PMID:37385210. |
flow cytometry showed that se2 induced cell arrest and apoptosis in s and g2/m phase, and the apoptotic effect of se2 were associated with the increase of caspase 3 and parp-1 level approved by western blot assay. |
2023-06-29 |
2023-08-14 |
human |
| Min Sung Choi, Ji Hyeon Kim, Chae Yeon Lee, Yul Min Lee, Sukmook Lee, Ha Kyun Chang, Hyun Jung Kim, Kyun He. Gentian Violet Inhibits Cell Proliferation through Induction of Apoptosis in Ovarian Cancer Cells. Biomedicines. vol 11. issue 6. 2023-06-28. PMID:37371752. |
results of transferase dutp nick and labeling (tunel) assay and western blot assay indicated that the inhibitory effect of gv on ovarian cancer cells was due to the induction of apoptosis. |
2023-06-28 |
2023-08-14 |
Not clear |
| Olga Sularz, Aneta Koronowicz, Sylwester Smoleń, Cayla Boycott, Barbara Stefansk. Iodine-Biofortified Lettuce Can Promote Mitochondrial Dependent Pathway of Apoptosis in Human Gastrointestinal Cancer Cells. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373017. |
western blot analysis revealed that iodine-fortified lettuce leads to cell death through the release of cytochrome c to the cytosolic fraction and activation of the primary drivers of apoptosis: caspase-3, caspase-7, and caspase-9. |
2023-06-28 |
2023-08-14 |
human |
| Boram Kim, Seon-Mi Lee, Sang-Jun Park, Sanghoon Lee, Tak Ki. Role of Klotho and N-acetylcysteine in Oxidative Stress Associated with the Vitrification of Ovarian Tissue Cytoprotective Function of Klotho in Cryopreservation. Tissue engineering and regenerative medicine. 2023-06-23. PMID:37351787. |
the cell morphological change, dna damage, senescence, and apoptosis of each group after the freeze-thaw process were compared using transmission electron microscopy, immunohistochemistry, and western blot analysis. |
2023-06-23 |
2023-08-14 |
Not clear |