| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuyuan Zhang, Ruize Zhang, Yinhai Wang, Liang Li, Zong Zhon. CDK5 Upregulated by ELF3 Transcription Promotes IL-1β-induced Inflammation and Extracellular Matrix Degradation in Human Chondrocytes. Cell biochemistry and biophysics. 2024-07-17. PMID:39020088. |
the levels of inflammatory cytokines were estimated using enzyme-linked immunosorbent assay (elisa) while the expressions of proteins implicated in extracellular matrix (ecm) degradation- and apoptosis were detected using western blot. |
2024-07-17 |
2024-07-20 |
human |
| Fang-Fang Zhong, Bo Wei, Guo-Xiang Bao, Yi-Ping Lou, Ming-Er Wei, Xin-Yue Wang, Xiao Xiao, Jin-Jin Tia. FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury. Neurotoxicity research. vol 42. issue 4. 2024-07-15. PMID:39008165. |
brain tissue injury, infarct volume ratio in the ischemic penumbra, neurologic deficits, behavioral abilities, neuronal apoptosis, apoptotic factors, inflammatory factors, and lipid peroxidation markers were assessed using h&e staining, ttc staining, longa scoring, rotation experiments, immunofluorescence staining, and western blot. |
2024-07-15 |
2024-07-18 |
mouse |
| Fang-Fang Zhong, Bo Wei, Guo-Xiang Bao, Yi-Ping Lou, Ming-Er Wei, Xin-Yue Wang, Xiao Xiao, Jin-Jin Tia. FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury. Neurotoxicity research. vol 42. issue 4. 2024-07-15. PMID:39008165. |
cell viability, apoptosis rate, mitochondrial oxidative stress, morphology, autophagosome formation, membrane potential, lc3 protein levels, and colocalization of autophagosomes and mitochondria were evaluated using mtt assay, ldh release assay, flow cytometry, ros/mda/gsh-px measurement, transmission electron microscopy, mitotracker staining, jc-1 method, western blot, and immunofluorescence staining. |
2024-07-15 |
2024-07-18 |
mouse |
| Xinke Chen, Lijuan Ouyang, Ning Ke, Lianhong Pi, Xiyuan Zho. Study on the role of MYCN in retinoblastoma by inhibiting p53 and activating wnt/βcatenin/Fra-1 signaling pathway by reducing DKK3. Drug development research. vol 85. issue 5. 2024-07-14. PMID:39003564. |
cell proliferation was evaluated using the cell counting kit-8 assay and 5-ethynyl-2'-deoxyuridine staining, while cell cycle progression and apoptosis were analyzed by flow cytometry and western blot analysis, respectively. |
2024-07-14 |
2024-07-16 |
Not clear |
| Salar Mahmoudi-Nejad, Sina Ahmadi, Mahssa Hassan-Nejhad, Mahdieh Azimi, Hanieh Dadvand, Morteza Bagher. Zinc Supplementation Reduces ROS Production and Prevents MDMA-Induced Apoptosis in TM3 Leydig Cells via the Inhibition of Pro-Apoptotic Proteins. Biological trace element research. 2024-07-14. PMID:39004669. |
the effect of different treatment groups in causing oxidative stress and apoptosis in tm3 cells was measured by dcf, tunnel, and western blot tests, respectively. |
2024-07-14 |
2024-07-18 |
Not clear |
| Fei Zhao, Dan-Yang Chen, Bo Jing, Yu Jiang, Lan-Yue Liu, Hui Son. Effect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells. Scientific reports. vol 14. issue 1. 2024-07-12. PMID:38997305. |
the results of flow cytometry experiments and mitochondrial membrane potential, rt-qpcr, and western blot showed that fvp-s1 and fvp-c were able to decrease the mitochondrial membrane potential, increase the expression level of apoptotic proteins casepase-3 and casepase-9 proteins, and at the same time, increase the ratio of bax and bcl-2, which promoted apoptosis of tumor cells. |
2024-07-12 |
2024-07-15 |
Not clear |
| Kaiqiang Zhong, Yingui Huang, Rui Chen, Qiusha Pan, Jun Li, Xiaotu X. The protective effect of ginsenoside Rg1 against sepsis-induced lung injury through PI3K-Akt pathway: insights from molecular dynamics simulation and experimental validation. Scientific reports. vol 14. issue 1. 2024-07-11. PMID:38992150. |
western blot results indicated that grg1 increased the bcl-2/bax protein expression ratio to reduce apoptosis and decreased the high expression of cleaved caspase-3 in lps-induced mle-12 cells. |
2024-07-11 |
2024-07-14 |
mouse |
| Qais Ibrahee. The Role of Matrix Metalloproteinase-2 (MMP2) in Colorectal Cancer Progression: Correlation With Clinicopathological Features and Impact on Cellular Processes. Cureus. vol 16. issue 6. 2024-07-10. PMID:38978899. |
the human crc cell line sw480 was treated with an mmp2 inhibitor, arp100, and evaluated for changes in cell migration, invasion, proliferation, and apoptosis using various assays, including mtt, wound-healing, transwell, caspase activity, and western blot analysis. |
2024-07-10 |
2024-07-12 |
human |
| Pengzhen Lei, Xiaoqing Wang, Xiaodong Qu, Rui Qi, Duanmingyu Chen, Yanhai Chan. The expression of SOCS1 is regulated by promoter DNA methylation and is associated with mitochondria-mediated apoptosis of T-2 induced chondrocytes. Experimental cell research. 2024-07-06. PMID:38971518. |
the expression of apoptosis related proteins (caspase-3 and caspase-9) and cytochrome c were detected using western blot. |
2024-07-06 |
2024-07-12 |
Not clear |
| Yongzhen Duan, Peixian Huang, Lu Sun, Panxia Wang, Yi Cai, Tingting Shi, Yuliang Li, Yuhua Zhou, Shanshan Y. Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway. Chemico-biological interactions. 2024-07-04. PMID:38964637. |
western blot and flow cytometry were used to measure apoptosis of cardiomyocytes. |
2024-07-04 |
2024-07-11 |
Not clear |
| Huixia Chen, Yulin Wu, Jiazheng Wang, Yike Li, Yongxue Chen, Xinbo Wang, Hangyu Lv, Xinyan Li. Tilianin enhances the antitumor effect of sufentanil on non-small cell lung cancer. Journal of biochemical and molecular toxicology. vol 38. issue 7. 2024-07-02. PMID:38952040. |
the functions of tilianin and sufentanil on nsclc cell viability, apoptosis, mitochondrial dysfunction, and immunity in vitro were examined using cell counting kit-8 assay, flow cytometry, reactive oxygen species level analysis, cd8+ t cell percentage analysis, western blot, and enzyme-linked immunosorbent assay, respectively. |
2024-07-02 |
2024-07-04 |
mouse |
| Huixia Chen, Yulin Wu, Jiazheng Wang, Yike Li, Yongxue Chen, Xinbo Wang, Hangyu Lv, Xinyan Li. Tilianin enhances the antitumor effect of sufentanil on non-small cell lung cancer. Journal of biochemical and molecular toxicology. vol 38. issue 7. 2024-07-02. PMID:38952040. |
meanwhile, the roles of tilianin and sufentanil in nsclc tumor growth, apoptosis, and immunity in vivo were determined by establishing a tumor xenograft mouse model, immunohistochemistry, and western blot assays. |
2024-07-02 |
2024-07-04 |
mouse |
| Ru Chen, Yanfei Zhang, Junhua Wang, Minghua Tao, Jiantao Ran, Jie Yang, Zi Wang, Li Pan, Qi Ha. [Knock-down of long noncoding RNA H19 (lncRNA H19) promotes human colorectal cell autophagy and inhibits cell apoptosis induced by lipopolysaccharide]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 6. 2024-07-02. PMID:38952094. |
cell apoptosis was detected by flow cytometry, and the protein expression levels of apoptosis and autophagy markers were analyzed through western blot. |
2024-07-02 |
2024-07-04 |
human |
| Zhaoheng Wang, Daxue Zhu, Fengguang Yang, Haiwei Chen, Jihe Kang, Wenzhao Liu, Aixin Lin, Xuewen Kan. POSTN knockdown suppresses IL-1β-induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF-κB pathway and alleviates intervertebral disc degeneration. Journal of cell communication and signaling. vol 18. issue 2. 2024-07-01. PMID:38946726. |
western blot, immunofluorescence, and tunel staining were used to detect the expression changes of inflammation, apoptosis and nf-κb pathway-related proteins in npcs. |
2024-07-01 |
2024-07-03 |
human |
| Ayşegül Çebi, Yalçın Tepe, İmren Alioglu, Ferda Ar. Inducing Effect of Corylus avellana on Cytotoxic Activity in Lung and Breast Cancer Cells via Apoptosis. Plant foods for human nutrition (Dordrecht, Netherlands). 2024-07-01. PMID:38949744. |
apoptosis was determined by performing caspase-mediated cytokeratin 18 (m30 elisa) and western blot analysis. |
2024-07-01 |
2024-07-03 |
Not clear |
| Kai Fu, Chuchu Gao, Xue Li, Hong Zhang, Boxin Xu. 3-chloro-1,2-propanediol induces oxidative stress and promotes testicular damage and infertility in rats through CYP2C9. Reproductive toxicology (Elmsford, N.Y.). 2024-06-29. PMID:38944211. |
cell viability, blood-testis barrier (btb) related protein, progesterone content, reactive oxygen species (ros) generation, and cell apoptosis were determined by a cck8 assay, western blot, elisa, flow cytometry, and tunel staining, respectively. |
2024-06-29 |
2024-07-02 |
mouse |
| Abdulhamid S Fatani, Andreas G Schätzlein, Ijeoma F Uchegb. Targeting Intracranial Tumours with a Combination of RNA and Chemotherapy. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931949. |
a downregulation of itch, an upregulation of p73 and enhanced apoptosis were observed in vitro in u87-mg cells, using qpcr, western blot analysis, confocal laser scanning microscopy, flow cytometry and cytotoxicity assays. |
2024-06-27 |
2024-06-29 |
mouse |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
western blot was employed to detect the expression of proteins related to apoptosis and nlrp3 inflammasome signaling. |
2024-06-27 |
2024-06-30 |
Not clear |
| Nunzio Antonio Cacciola, Paola De Cicco, Rebecca Amico, Fabrizia Sepe, Yan Li, Laura Grauso, Maria Francesca Nanì, Silvia Scarpato, Christian Zidorn, Alfonso Mangoni, Francesca Borrell. Zosterabisphenone B, a new diarylheptanoid heterodimer from the seagrass Zostera marina, induces apoptosis cell death in colon cancer cells and reduces tumour growth in mice. Phytotherapy research : PTR. 2024-06-26. PMID:38923111. |
flow cytometry and western blot analyses were used to assess apoptosis and autophagy. |
2024-06-26 |
2024-06-29 |
mouse |
| Rui-Tao Wang, Hao-En Liu, Hui-Yuan Su. In vitro modulation the Notch pathway by piperine: A therapeutic strategy for docetaxel-resistant and non-resistant prostate cancer. Chemical biology & drug design. vol 103. issue 6. 2024-06-19. PMID:38898371. |
through a series of assays, including mtt for cell viability, flow cytometry for apoptosis, transwell for cell migration and invasion, and western blot for protein expression analysis, we assessed the effects of piperine on these cellular functions and on the notch signaling pathway components. |
2024-06-19 |
2024-06-22 |
Not clear |